Alpha 6 beta 4 integrin signaling pathway (Mus musculus)

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DeubiquitinationGlycosylationSumoylationDCY->NULaminin 11ActivationDPlasma membraneGene SymbolAutophosphorylationMethylationCY->PMControlCY->NUDemethylationAccession Number: NetPath 1; cellmap:1Laminin 1PalmitoylationProteins in a complex interactionLaminin 2ReceptorMolecule in the pathwayEndoplasmic reticulumCY->NUPhosphorylationNURecruitmentDesumoylationECDMTPMGOGolgi apparatusENEREndosomeNucleusAcetylation(Protein-protein interaction)DLaminin 10DDeacetylationProteolytic cleavageLigandInhibitionTranslocationExtracellularCytoplasmDDephosphorylationDDCYEnzyme complexMitochondrionMolecular AssociationUbiquitinationLaminin 5Reaction through unknown mechanisms/moleculesLaminin 4DAkt1VimIrs1BadSmad2Eif6MtorItga6PrkcdPik3r2Ptk2Lamc1Smad3RhoaPik3r3Clca5Erbb2ipIrs2Rac1Smad2Pak1Eif4ebp1Ntn1Lamb1-1Lamb2Erbb2Itga6Itgb4PrkcaYwhabPik3r1Lama5Itgb4Trp73Lamb1-1DstLamb3Itga6Itga6YwhahSrcPlec1Itgb4Lama1Smad3Abl1Cd151RhoaEif6Grb2YwhaeLamc1Itgb4Lama2ArPik3caLama5MetItgb4Yes1Mmp7DspMst1rClca3Lamc1Col17a1Lama3Lama2Itgb4YwhazLamb2Itga6RpsaRtknPik3cbGm2423Eif4eLamb1-1FynLamc1Pik3cdSfnShc1Casp3Cdkn1aLamc2EgfrItga6Lamc1Pik3cg


Description

Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_1

Comments

GenMAPP notes 
NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP244(r21193) with a 98% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117859view10:14, 23 May 2021EweitzModified title
72049view16:57, 24 October 2013Mkutmonupdated annotation for Gm2423
69084view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
67039view09:57, 26 June 2013Christine ChichesterOntology Term : 'integrin mediated signaling pathway' added !
41271view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35653view21:46, 12 February 2010KhanspersModified description
32709view22:21, 2 September 2009MaintBotfixed xrefs
32695view17:32, 1 September 2009KhanspersAdded xref
31464view21:17, 13 August 2009MaintBotFixed text labels
30827view00:00, 30 July 2009MaintBotConverted from Homo sapiens
21706view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:WP488]]: Moved to stable identifier
7898view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:Mus musculus:Alpha6-Beta4-Integrin NetPath 1]]: Renaming species
7574view16:00, 18 December 2007MaintBotfixed category names
7193view12:33, 4 November 2007MaintBotAdded categories to GPML
6413view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:Alpha6-Beta4-Integrin_NetPath_1]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abl1GeneProduct11350 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
ArGeneProduct11835 (Entrez Gene)
BadGeneProduct12015 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Cd151GeneProduct12476 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Clca3GeneProduct23844 (Entrez Gene)
Clca5GeneProduct229933 (Entrez Gene)
Col17a1GeneProduct12821 (Entrez Gene)
DspGeneProduct109620 (Entrez Gene)
DstGeneProduct13518 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Eif4eGeneProduct13684 (Entrez Gene)
Eif4ebp1GeneProduct13685 (Entrez Gene)
Eif6GeneProduct16418 (Entrez Gene)
Erbb2GeneProduct13866 (Entrez Gene)
Erbb2ipGeneProduct59079 (Entrez Gene)
FynGeneProduct14360 (Entrez Gene)
Gm2423GeneProduct100039786 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Irs1GeneProduct16367 (Entrez Gene)
Irs2GeneProduct384783 (Entrez Gene)
Itga6GeneProduct16403 (Entrez Gene)
Itgb4GeneProduct192897 (Entrez Gene)
Lama1GeneProduct16772 (Entrez Gene)
Lama2GeneProduct16773 (Entrez Gene)
Lama3GeneProduct16774 (Entrez Gene)
Lama5GeneProduct16776 (Entrez Gene)
Lamb1-1GeneProduct16777 (Entrez Gene)
Lamb2GeneProduct16779 (Entrez Gene)
Lamb3GeneProduct16780 (Entrez Gene)
Lamc1GeneProduct226519 (Entrez Gene)
Lamc2GeneProduct16782 (Entrez Gene)
MetGeneProduct17295 (Entrez Gene)
Mmp7GeneProduct17393 (Entrez Gene)
Mst1rGeneProduct19882 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
Ntn1GeneProduct18208 (Entrez Gene)
Pak1GeneProduct18479 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
Plec1GeneProduct18810 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
RpsaGeneProduct16785 (Entrez Gene)
RtknGeneProduct20166 (Entrez Gene)
SfnGeneProduct55948 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Smad2GeneProduct17126 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Trp73GeneProduct22062 (Entrez Gene)
VimGeneProduct22352 (Entrez Gene)
Yes1GeneProduct22612 (Entrez Gene)
YwhabGeneProduct54401 (Entrez Gene)
YwhaeGeneProduct22627 (Entrez Gene)
YwhahGeneProduct22629 (Entrez Gene)
YwhazGeneProduct22631 (Entrez Gene)

Annotated Interactions

No annotated interactions
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