SARS coronavirus and innate immunity (Homo sapiens)

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1EndocytosisDNAphosphorylized proteinIFN-alpha groupNucleusCellISRE Response elementSIFNA2IFNA16IKBKEIFNA10TLR3IFNA17STAT1STAT2IFNA13TBK1IFNA6MAVSJAK1IRF3IFNA1IFNA21IFNB1DDX58IFNA4TRAF3IFNA8STICAM1IFNA14IFNA5IFNAR1IFNA7IFNAR2ACE2IFIH1IRF9TYK2IFN-betaIRF3IRF3IRF3ACE2SSSARS virus protein (Spike)STAT1STAT2IRF9IFN-betaResponse elementMitochondriaVesicle


Description

SARS-CoV triggers the hosts innate immune system via the type I interferon system in dendritic cells and macrophages, which activate ISRE and IFN-b sentitive promoter elements.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, Weber F; ''Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.''; J Virol, 2005 PubMed Europe PMC Scholia
  2. Frieman M, Heise M, Baric R; ''SARS coronavirus and innate immunity.''; Virus Res, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124650view13:12, 18 November 2022JfigueirahasbunUpdated viral protein shape and identifier
115852view15:35, 18 March 2021L DupuisAdded literature reference to interaction from IRF3 to IFN-beta Response Element
113956view09:30, 11 December 2020EgonwType response elements as GeneProduct
113632view11:32, 8 November 2020EgonwConverted three interacting Labels to DataNodes.
110359view17:32, 7 May 2020Fehrhartgraphical improvements
110248view06:52, 30 April 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
110247view06:52, 30 April 2020FehrhartOntology Term : 'viral infectious disease' added !
110246view06:52, 30 April 2020FehrhartOntology Term : 'type I interferon signaling pathway' added !
110239view15:24, 29 April 2020FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE2GeneProductENSG00000130234 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl) RIG-I
IFIH1GeneProductENSG00000115267 (Ensembl) MDA5
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNAR1GeneProduct3454 (Entrez Gene)
IFNAR2GeneProduct3455 (Entrez Gene)
IFNB1GeneProductENSG00000171855 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl) IKK-e
IRF3GeneProductENSG00000126456 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
MAVSGeneProductENSG00000088888 (Ensembl)
SGeneProduct694009 (Uniprot-TrEMBL)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TICAM1GeneProduct148022 (Entrez Gene) TRIF
TLR3GeneProductENSG00000164342 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)

Annotated Interactions

No annotated interactions

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