Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins (Homo sapiens)

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Accumulation of autophagy receptors LegendPhospho(S/T) siteAutophagosome/HOPS COMPLEXPhagophoreSNAREscargo sequestrationHOPS COMPLEXAutophagy receptors ATG12TAX1BP1FIP200ULK1P70S6KAKT1S1ORF3ORF3ATG9AAMPKVPS11RPTORVPS16ATG4ARPS6DEPTORMLST8VPS18OPTNPPP1R9AMLST8AKT1S1ATG16LLARP1VPS36RPTORATG13RHEBVPS33AMAP1LC3BSQSTM1GABARAPL2VPS41MTORCALCOCO2TSC2RAB7AATG7MTORAKT1GSK3ATG5PKMATG3S238K24T269 S361K157S272T525T1162K82S355S735K143 S366S18S240K74S766K435S1347K281K97S479S203S477S738S202K46K149S638LysosomeAutophagolysosomeFusionLate endosomeUbiqutination (K) siteBindingInteractionUpregulationSARS-CoV-2 proteinInhibitionNSP61DEPTOR


Description

Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection.

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Ontology Terms

 

Bibliography

  1. Alexey Stukalov, Virginie Girault, Vincent Grass, Valter Bergant, Ozge Karayel, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, Sabri M. Hamad, Antonio Piras, Maria Tanzer, Fynn M. Hansen, Thomas Enghleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro, Matthias Mann, Andreas Pichlmair; ''Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV''; Nature, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129410view09:13, 12 April 2024EgonwUpdated a few more NCBI Gene data sources
129409view08:44, 12 April 2024EgonwUpdated a number of NCBI Gene data sources
124645view13:04, 18 November 2022NhungPupdate viral proteins shapes and labels
124432view12:50, 27 October 2022Mkutmonlower case SARS-CoV-2 protein names
123344view09:47, 17 July 2022EgonwORF3a is the only one with enough amino acids to be structure in Figure 3, and must be the ORF3 in the article
120658view18:36, 22 December 2021EweitzModified title
119426view22:47, 28 June 2021KhanspersAdded more ptm comments
119425view22:28, 28 June 2021KhanspersAdded phosphorylation comments for data mapping
119424view21:47, 28 June 2021Khanspersupdated based on the published figure
119389view21:19, 25 June 2021KhanspersAdded nodes and updated layout
119332view21:15, 23 June 2021Khanspersupdated style and specified ptms
119110view13:21, 17 June 2021Finterlyadded PMID
118873view12:01, 3 June 2021EweitzOntology Term : 'COVID-19' added !
115858view15:54, 18 March 2021Marvin M2Changed legend to graphical elements
115855view15:44, 18 March 2021Marvin M2added annotations
115839view14:52, 18 March 2021Marvin M2corrected ref
115836view14:35, 18 March 2021Marvin M2connected lines, some annotations
114087view08:27, 21 December 2020EgonwTyped 'phagophore' and give it an identifier
114075view06:17, 21 December 2020EgonwConverted a label involved in an interaction into a DataNode
112887view13:08, 15 October 2020Fehrhartfixed unconnected lines
111196view04:21, 24 July 2020Rex D A BConnections
111139view16:37, 17 July 2020EgonwColored the proteins according to the COVID19 Disease Maps convention
111028view06:22, 1 July 2020EgonwUpdated the UniProt data source
110916view04:32, 21 June 2020Rex D A BOntology Term : 'altered autophagy pathway' added !
110915view04:30, 21 June 2020Rex D A BOntology Term : 'infectious disease pathway' added !
110914view04:18, 21 June 2020Rex D A BModified description
110913view04:17, 21 June 2020Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1ProteinP31749 (Uniprot-TrEMBL)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AMPKProtein5563 (NCBI Protein)
ATG12Protein9140 (NCBI Protein)
ATG13Protein9776 (NCBI Protein)
ATG16LProtein55054 (NCBI Protein)
ATG3Protein64422 (NCBI Protein)
ATG4AGeneProductENSG00000101844 (Ensembl)
ATG5Protein9474 (NCBI Protein)
ATG7Protein10533 (NCBI Protein)
ATG9AProtein79065 (NCBI Protein)
CALCOCO2Protein10241 (NCBI Protein)
DEPTORProtein64798 (NCBI Protein)
FIP200Protein9821 (NCBI Protein)
GABARAPL2Protein11345 (NCBI Protein)
GSK3ProteinP31749 (NCBI Protein)
LARP1GeneProductENSG00000155506 (Ensembl)
MAP1LC3BGeneProduct81631 (NCBI Protein)
MLST8Protein64223 (NCBI Protein)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORProtein2475 (NCBI Protein)
MTORGeneProductENSG00000198793 (Ensembl)
NSP6ProteinYP_009725302 (NCBI Protein)
OPTNProtein10133 (NCBI Protein)
ORF3GeneProductORF3 has no identifiers. ORF3a and ORF3b do, but it's not clear which one(s) to use
ORF3GeneProductORF3
P70S6KGeneProductENSG00000108443 (Ensembl)
PKMProtein5315 (NCBI Protein)
PPP1R9AGeneProductENSG00000158528 (Ensembl) Also known as NRB1
PhagophoreCellularComponentQ34360359 (Wikidata)
RAB7AProtein7879 (NCBI Protein)
RHEBProtein6009 (NCBI Protein)
RPS6Protein6194 (NCBI Protein)
RPTORProtein57521 (NCBI Protein)
RPTORGeneProductENSG00000141564 (Ensembl)
SQSTM1Protein8878 (NCBI Protein)
TAX1BP1Protein8887 (NCBI Protein)
TSC2ProteinP31749 (NCBI Protein)
ULK1Protein8408 (NCBI Protein)
VPS11Protein55823 (NCBI Protein)
VPS16Protein64601 (NCBI Protein)
VPS18GeneProductENSG00000104142 (Ensembl)
VPS33AProtein65082 (NCBI Protein)
VPS36Protein51028 (NCBI Protein)
VPS41Protein27072 (NCBI Protein)

Annotated Interactions

No annotated interactions

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