Airway smooth muscle cell contraction (Homo sapiens)

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1sarcoplasmic reticulumMuscle contractionBeta agonistsLabelCa2+ channelsaka CP-17Myosin light chain phosphataseinactiveautophosphorylationGEFsMYLGDIPPP1R14AMYLKDAGGNAQGCPRIL13ITPR3cADPRPIP2RhoGAPPKCROCK1VGCCCD38Ca2+MLCPCalmodulinPLCB1IP3PPCa2+MYLPCa2+Ca2+RYRSOCCROCCCa2+Ca2+MLCPPGTPRHOARHOAGDPROCK2ROCK1ROCK2


Signal transduction pathways involved in airway smooth muscle cell contraction. Based on figure 1 from Belaia et al..

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Ontology Terms



  1. Pelaia G, Renda T, Gallelli L, Vatrella A, Busceti MT, Agati S, Caputi M, Cazzola M, Maselli R, Marsico SA; ''''; , PubMed Europe PMC Scholia


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122013view09:45, 9 March 2022SElBoudllaliOntology Term : 'PW:0000003' removed !
120588view19:23, 17 December 2021EweitzRefine graphics, datanode types
115210view22:04, 4 February 2021KhanspersOntology Term : 'signaling pathway' added !
115209view21:39, 4 February 2021KhanspersModified description
115208view21:38, 4 February 2021Khanspersupdated xrefs etc
115206view21:09, 4 February 2021KhanspersModified description
112916view03:33, 20 October 2020AngelcymakAnnotations
112915view03:33, 20 October 2020AngelcymakUpdate annotations
112914view03:12, 20 October 2020AngelcymakAdded annotations
111347view01:19, 29 July 2020AngelcymakMinor layout modification
111346view01:18, 29 July 2020AngelcymakRhoA pathway added
111345view22:57, 28 July 2020AngelcymakUpdate literature
111344view22:51, 28 July 2020AngelcymakOntology Term : 'allergic asthma' added !
111343view22:51, 28 July 2020AngelcymakOntology Term : 'bronchial smooth muscle cell' added !
111342view22:49, 28 July 2020AngelcymakNew pathway

External references


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NameTypeDatabase referenceComment
CD38GeneProductENSG00000004468 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CalmodulinProteinG3V226 (Uniprot-TrEMBL)
DAGMetaboliteCHEBI:18035 (ChEBI)
GCPRGeneProductENSG00000169252 (Ensembl) GPCR
GDIGeneProductENSG00000203879 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GNAQGeneProductENSG00000156052 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
IL13ProteinENSG00000169194 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
ITPR3GeneProductENSG00000096433 (Ensembl)
MLCPProteinENSG00000213639 (Ensembl)
  • Myosin light chain phosphatase
  • Type your comment here
MYLGeneProductENSG00000168530 (Ensembl)
MYLKGeneProductENSG00000065534 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PKCProteinL7RSM7 (Ensembl)
PLCB1GeneProductENSG00000182621 (Ensembl)
PPP1R14AGeneProductENSG00000167641 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCCComplexreceptor-operated Ca2+ channels
ROCK1GeneProductENSG00000067900 (Ensembl) Rho kinase
ROCK2GeneProductENSG00000134318 (Ensembl) Rho kinase
RYRGeneProductENSG00000196218 (Ensembl)
RhoGAPProteinRho GTPase activating proteins
SOCCComplexstore-operated Ca2+ channels
VGCCComplexvoltage-operated Ca2+ channels
cADPRMetaboliteCHEBI:31445 (ChEBI)

Annotated Interactions

No annotated interactions

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