EGFR1 signaling pathway (Rattus norvegicus)

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1CYNUNUMACYPMReceptorPMNUPMPMCYCYPMMAPMMACYPhosphorylationExtracellularProteins in a complex interactionCYCYPMPMDAutophosphorylationERInhibitionPlasma membraneNUPMCYCYEnzyme complexCYPMTranslocationMAPMPMCYMACYCYCYDephosphorylationNUDeubiquitinationPMDesumoylationPMGene SymbolCYPMCYPMAcetylationECNUProteolytic cleavageENCYPMMANUMAReaction through unknown mechanisms/moleculesPMCYCYUbiquitinationMAMAMAActivationNucleusMethylationCYDMACYNUNUGolgi apparatusMACYCYNUNUAccession Number : NetPath 4; cellmap:4PMCYCytoplasmNUMACYEndosomeENEndoplasmic reticulumDemethylationNUMitochondrionNUGlycosylationMANUDeacetylationPMCYNU(Protein-protein interaction)PMPMPalmitoylationRecruitmentENMolecule in the pathwayMANUCYNUAutodephosphorylationNUDSumoylationCYMACYCYMACYCYGOCYMolecular associationCYMAMTMALigandMANUMAControlCYCebpaMAPK7Hip1Map3k14Krt17Pik3r2YwhabStat1Smad2JundCamk2aPik3r3PTPN5Krt8Stat1Zfp259Grb10Pik3cbStat5bCreb1Epn1Tnk2Pik3cdRab5aRps6ka1Arf4Smad3Errfi1Stat3Mapk1Stat3Asap1Ptpn11Shc1Pld1Jak1Dusp1Ptk6Stat2Stat1Eps15Arf4Mapk14Grb14EgfrAkt1Eps15Grb7Rasa1Map3k2EgfrCav1Sos1Appl2Krt18Reps2ItchRalbp1PrkcaPIK3CAElf3SncaNck1Sh2d3cEppk1Map2k3Ctnnd1WASLSOS2Pak1Mapk3Zfp259Eps8Raf1Prkd1Rbbp7Map3k1RfxankHrasGab1Arf4Stat5aCblcMycPrkcgPlcg2Plcg2Smad3Map2k5CebpbJak2Abi1EgfKrt7Sh3gl2Mapk1Snrpd2PxnNck2Sh3kbp1Cav2Reps1Gab2Stat5aVav3Sp1Mta2Map2k7Tgif1Raf1Ptpn12Spry2Eef1a2l1Dusp1Rps6ka2PrkczCblRps6ka5Sh3gl3PRKAR1APebp1Rps6ka3Plcg1Elk1Bcar1Ripk1Spry2Map2k1HIST3H3Map3k2APPLPrkciSh3bgrlDok2Pik3c2bCasp9Pkn2Socs1CEACAM1Shoc2Foxo1Pik3cgPik3r1CrklVav2Ptpn6Ptk2bMap3k4Mapk8SrcAtf1PtprrEps15l1Vav1Sh2d3cElf3WNK1APPLMap2k1Mcf2Appl2Ndufa13KrasHttCDC42Gja1Map2k2Socs3Plec1Rgs16PitpnaCrkFoxo1Tnip1Git1EgfrRalgdsHdac1NrasHat1Inppl1Grb2PrkcaEgfSmad2Gab1Plcg1EgfrStxbp1APPLDnm1CskUsp6nlRps6ka3CblbAp2a1Sin3aElk4Tcfcp2l2Shc1EgfStat2FosPtpn6Pld2Eef1a2l1ArafPlscr1RalbStxbp1Sh3gl2PrkcbJunMap3k3Pld1Bcar1Rac1Stat3


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 94% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116955view10:07, 16 May 2021EweitzModified title
69392view18:58, 8 July 2013MaintBotUpdated to 2013 gpml schema
67177view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41710view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
35718view23:29, 12 February 2010AlexanderPico
35438view11:35, 12 February 2010MichielAdded ref
34089view19:15, 9 December 2009MaintBotAutomatic update of empty xrefs
30926view00:36, 30 July 2009MaintBotConverted from Homo sapiens
20683view11:29, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:EGFR1 NetPath 4]] moved to [[Pathway:WP5]]: Moved to stable identifier
8000view13:46, 7 January 2008MaintBot[[Pathway:Rat:EGFR1 NetPath 4]] moved to [[Pathway:Rattus norvegicus:EGFR1 NetPath 4]]: Renaming species
7623view16:05, 18 December 2007MaintBotfixed category names
7217view12:41, 4 November 2007MaintBotAdded categories to GPML
6532view22:19, 22 May 2007A.Pandeygpml file for [[Rat:EGFR1_NetPath_4]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APPLGeneProduct
Abi1GeneProduct79249 (Entrez Gene)
Akt1GeneProduct24185 (Entrez Gene)
Ap2a1GeneProduct308578 (Entrez Gene)
Appl2GeneProduct362860 (Entrez Gene)
ArafGeneProduct64363 (Entrez Gene)
Arf4GeneProduct79120 (Entrez Gene)
Asap1GeneProduct314961 (Entrez Gene)
Atf1GeneProduct315305 (Entrez Gene)
Bcar1GeneProduct25414 (Entrez Gene)
CDC42GeneProduct64465 (Entrez Gene)
CEACAM1GeneProduct81613 (Entrez Gene)
Camk2aGeneProduct25400 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
Cav1GeneProduct25404 (Entrez Gene)
Cav2GeneProduct363425 (Entrez Gene)
CblGeneProduct500985 (Entrez Gene)
CblbGeneProduct171136 (Entrez Gene)
CblcGeneProduct292699 (Entrez Gene)
CebpaGeneProduct24252 (Entrez Gene)
CebpbGeneProduct24253 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
CrklGeneProduct287942 (Entrez Gene)
CskGeneProduct315707 (Entrez Gene)
Ctnnd1GeneProduct311163 (Entrez Gene)
Dnm1GeneProduct140694 (Entrez Gene)
Dok2GeneProduct290361 (Entrez Gene)
Dusp1GeneProduct114856 (Entrez Gene)
Eef1a2l1GeneProduct29652 (Entrez Gene)
EgfGeneProduct25313 (Entrez Gene)
EgfrGeneProduct24329 (Entrez Gene)
Elf3GeneProduct304815 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
Elk4GeneProduct304786 (Entrez Gene)
Epn1GeneProduct117277 (Entrez Gene)
Eppk1GeneProduct680860 (Entrez Gene)
Eps15GeneProduct313474 (Entrez Gene)
Eps15l1GeneProduct361120 (Entrez Gene)
Eps8GeneProduct312812 (Entrez Gene)
Errfi1GeneProduct313729 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene)
Foxo1GeneProduct84482 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Gab2GeneProduct84477 (Entrez Gene)
Git1GeneProduct83709 (Entrez Gene)
Gja1GeneProduct24392 (Entrez Gene)
Grb10GeneProduct498416 (Entrez Gene)
Grb14GeneProduct58844 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Grb7GeneProduct84427 (Entrez Gene)
HIST3H3GeneProduct287352 (Entrez Gene)
Hat1GeneProduct296501 (Entrez Gene)
Hdac1GeneProduct297893 (Entrez Gene)
Hip1GeneProduct192154 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
HttGeneProduct29424 (Entrez Gene)
Inppl1GeneProduct65038 (Entrez Gene)
ItchGeneProduct311567 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
JundGeneProduct24518 (Entrez Gene)
KrasGeneProduct24525 (Entrez Gene)
Krt17GeneProduct287702 (Entrez Gene)
Krt18GeneProduct294853 (Entrez Gene)
Krt7GeneProduct300242 (Entrez Gene)
Krt8GeneProduct25626 (Entrez Gene)
MAPK7GeneProduct114509 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Map2k3GeneProduct303200 (Entrez Gene)
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Map2k7GeneProduct363855 (Entrez Gene)
Map3k1GeneProduct116667 (Entrez Gene)
Map3k14GeneProduct360640 (Entrez Gene)
Map3k2GeneProduct171492 (Entrez Gene)
Map3k3GeneProduct303604 (Entrez Gene)
Map3k4GeneProduct308106 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mcf2GeneProduct317598 (Entrez Gene)
Mta2GeneProduct361724 (Entrez Gene)
MycGeneProduct24577 (Entrez Gene)
Nck1GeneProduct300955 (Entrez Gene)
Nck2GeneProduct316369 (Entrez Gene)
Ndufa13GeneProduct314759 (Entrez Gene)
NrasGeneProduct24605 (Entrez Gene)
PIK3CAGeneProduct170911 (Entrez Gene)
PRKAR1AGeneProduct25725 (Entrez Gene)
PTPN5GeneProduct29644 (Entrez Gene)
Pak1GeneProduct29431 (Entrez Gene)
Pebp1GeneProduct29542 (Entrez Gene)
Pik3c2bGeneProduct289021 (Entrez Gene)
Pik3cbGeneProduct85243 (Entrez Gene)
Pik3cdGeneProduct366508 (Entrez Gene)
Pik3cgGeneProduct298947 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Pik3r3GeneProduct60664 (Entrez Gene)
PitpnaGeneProduct29525 (Entrez Gene)
Pkn2GeneProduct207122 (Entrez Gene)
Plcg1GeneProduct25738 (Entrez Gene)
Plcg2GeneProduct29337 (Entrez Gene)
Pld1GeneProduct25096 (Entrez Gene)
Pld2GeneProduct25097 (Entrez Gene)
Plec1GeneProduct64204 (Entrez Gene)
Plscr1GeneProduct117540 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcgGeneProduct24681 (Entrez Gene)
PrkciGeneProduct84006 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Prkd1GeneProduct85421 (Entrez Gene)
Ptk2bGeneProduct50646 (Entrez Gene)
Ptk6GeneProduct366275 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
Ptpn12GeneProduct117255 (Entrez Gene)
Ptpn6GeneProduct116689 (Entrez Gene)
PtprrGeneProduct94202 (Entrez Gene)
PxnGeneProduct360820 (Entrez Gene)
Rab5aGeneProduct64633 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
RalbGeneProduct116546 (Entrez Gene)
Ralbp1GeneProduct84014 (Entrez Gene)
RalgdsGeneProduct29622 (Entrez Gene)
Rasa1GeneProduct25676 (Entrez Gene)
Rbbp7GeneProduct83712 (Entrez Gene)
Reps1GeneProduct292944 (Entrez Gene)
Reps2GeneProduct363466 (Entrez Gene)
RfxankGeneProduct306353 (Entrez Gene)
Rgs16GeneProduct360857 (Entrez Gene)
Ripk1GeneProduct306886 (Entrez Gene)
Rps6ka1GeneProduct81771 (Entrez Gene)
Rps6ka2GeneProduct117269 (Entrez Gene)
Rps6ka3GeneProduct501560 (Entrez Gene)
Rps6ka5GeneProduct314384 (Entrez Gene)
SOS2GeneProduct85384 (Entrez Gene)
Sh2d3cGeneProduct362111 (Entrez Gene)
Sh3bgrlGeneProduct302363 (Entrez Gene)
Sh3gl2GeneProduct116743 (Entrez Gene)
Sh3gl3GeneProduct81921 (Entrez Gene)
Sh3kbp1GeneProduct84357 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Shoc2GeneProduct309548 (Entrez Gene)
Sin3aGeneProduct363067 (Entrez Gene)
Smad2GeneProduct29357 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
SncaGeneProduct29219 (Entrez Gene)
Snrpd2GeneProduct680309 (Entrez Gene)
Socs1GeneProduct252971 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene)
Spry2GeneProduct306141 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat2GeneProduct288774 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
Stxbp1GeneProduct25558 (Entrez Gene)
Tcfcp2l2GeneProduct313994 (Entrez Gene)
Tgif1GeneProduct316742 (Entrez Gene)
Tnip1GeneProduct363599 (Entrez Gene)
Tnk2GeneProduct303882 (Entrez Gene)
Usp6nlGeneProduct291309 (Entrez Gene)
Vav1GeneProduct25156 (Entrez Gene)
Vav2GeneProduct296603 (Entrez Gene)
Vav3GeneProduct295378 (Entrez Gene)
WASLGeneProduct682507 (Entrez Gene)
WNK1GeneProduct116477 (Entrez Gene)
YwhabGeneProduct56011 (Entrez Gene)
Zfp259GeneProduct500989 (Entrez Gene)

Annotated Interactions

No annotated interactions
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