Prostaglandin signaling (Homo sapiens)

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21621613122718142649, 29FibroblastsNK cellsProtection against viral infectionDecreased recruitment of CCR2 expressing monocytes and macrophagesDecreased platelet activationHuman Plasmacytoid Dendritic CellscAMPIRF7Ca2+ effluxProstaglandin E2 receptorProstaglandin E2Prostaglandin E receptor 4IFNA1VEGFAIL6Prostaglandin E receptor 4CSF1IL6IL8COX2Prostaglandin E2MMP9IL17AIL6IL8IL1BMonocytes, macrophages, fibroblasts, airway epithelial cellsTh17 cellsProstaglandin E2 receptorCCL2CXCL1MacrophageAREGVEGFATGFB1M2 MacrophageTissue repair, potential lung fibrosisProstaglandin E2 receptorProstaglandin E receptor 4NET formationProstaglandin E2 receptorProstaglandin E receptor 4PKAT cell activation and proliferationTh17 cellsIL17AIL17FAHR Inflammatory Th17 cell expansion8IFNGIL12AProstaglandin E receptor 4Natural killer cells antigen CD94NK and CD8+ T cell cytolytic activity1, 28CXCL9CXCL10NK cell migration252473, 30cAMPcAMPNFKB1Cytokine storm, hyperinflammation (postive feedback loop)IL1BProstaglandin I2IFNA1IL1BIL6TNF15TNFCCL222Th17 cells5Th1 cellsIL17AIFNGIP-activated cAMP10IFN SignalingProstaglandin E synthaseCOX2Prostaglandin E27IL6IL8TNFIL1ACCL2CXCL10CCL3IL1BNF-κB signalingEpithelial cells, monocytes, macrophages17FibroblastsProstaglandin E receptor 4Prostaglandin E2 receptor11, 20, 2319IL6 SignalingASCNLRP3CASP1Macrophages and monocytesInflammasome ActivationCCR2Monocytes and neutrophilsMonocyte and Macrophage FunctionsNeutrophil Extracellular Trap (NET) ReleasePI3K14CD2814T Cell Function8Myeloid cellsNK Cell FunctionsT Cell Responses


Description

This pathway describes elements of Prostaglandin signaling in Homo sapiens affected by COVID-19. Prostaglandins are amongst the many inflammatory mediators that incite a cytokine storm in COVID-19 after Bradykinin receptor B1 (BDKRB1) activation. This pathway mainly focuses on PGE2 and PGI2 and their interactions that lead to hyperinflammation via cytokine storms, immunothrombosis as well as the recruitment of fibrosis-mediating factors (VEGF, TGFB1, AREG). These pathways take place in multiple cell types such as: Monocytes, Macrophages, Fibroblasts, Th17 cells, Nk cells, et cetera.

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Bibliography

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  20. Zeddou M, Greimers R, de Valensart N, Nayjib B, Tasken K, Boniver J, Moutschen M, Rahmouni S; ''Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes bya cAMP-dependent protein kinase A type I pathway.''; Biochem Pharmacol, 2005 PubMed Europe PMC Scholia
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  24. Chen BC, Liao CC, Hsu MJ, Liao YT, Lin CC, Sheu JR, Lin CH; ''Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B.''; J Immunol, 2006 PubMed Europe PMC Scholia
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  26. Gustafsson K, Junevik K, Werlenius O, Holmgren S, Karlsson-Parra A, Andersson PO; ''Tumour-loaded α-type 1-polarized dendritic cells from patients with chronic lymphocytic leukaemia produce a superior NK-, NKT- and CD8+ T cell-attracting chemokine profile.''; Scand J Immunol, 2011 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
128022view16:11, 21 January 2024EweitzOntology Term : 'plasmacytoid dendritic cell' added !
128021view16:10, 21 January 2024EweitzOntology Term : 'natural killer cell' added !
128020view16:10, 21 January 2024EweitzOntology Term : 'T-helper 17 cell' added !
128019view16:10, 21 January 2024EweitzOntology Term : 'fibroblast' added !
128018view16:09, 21 January 2024EweitzOntology Term : 'macrophage' added !
128017view16:09, 21 January 2024EweitzOntology Term : 'monocyte' added !
127698view00:21, 23 November 2023EweitzFurther optimize layout of components
127697view23:03, 22 November 2023EweitzTrim more empty space, further standardize font size, etc.
127696view21:52, 22 November 2023EweitzCenter-align components
127695view21:46, 22 November 2023EweitzOptimize component offsets
127692view20:59, 22 November 2023EweitzShift diagram left, to trim excess negative space
127690view13:11, 22 November 2023EweitzOptimize layout in T cell function component
127689view12:58, 22 November 2023EweitzOptimize layout in NK cell functions component
127688view12:47, 22 November 2023EweitzOptimize layout in NF-kB signaling component
127687view12:30, 22 November 2023EweitzStandardize case
127685view12:20, 22 November 2023EweitzModified description
119639view06:34, 27 July 2021EgonwNot a conversion
119319view13:32, 23 June 2021AriajadhavUpdated and restructured pathway. Added legend
119018view19:19, 9 June 2021EgonwNot a human gene id
118971view12:33, 5 June 2021EgonwNot a human gene ID
117086view20:38, 16 May 2021AriajadhavMade the pathway compact
116865view14:51, 14 May 2021AriajadhavConnected lines
116773view00:28, 14 May 2021AriajadhavUpdated pathway, added references
116698view18:38, 9 May 2021AriajadhavModified description
116418view09:09, 7 May 2021EweitzModified title
116320view11:27, 30 April 2021Marvin M2Ontology Term : 'prostaglandin I2 signaling pathway' added !
116319view11:25, 30 April 2021Marvin M2Ontology Term : 'prostaglandin E2 signaling pathway' added !
116318view11:25, 30 April 2021Marvin M2Ontology Term : 'COVID-19' added !
116317view11:23, 30 April 2021Marvin M2connected lines
116312view15:10, 29 April 2021AriajadhavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AHR ProteinENSG00000106546 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
ASCGeneProductENSG00000103490 (Ensembl)
CASP1GeneProductENSG00000137752 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL3GeneProductENSG00000277632 (Ensembl)
CCR2GeneProductENSG00000121807 (Ensembl)
CD28GeneProductENSG00000178562 (Ensembl)
COX2 GeneProductENSSSCG00000018078 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL9GeneProductENSG00000138755 (Ensembl)
Ca2+ effluxMetaboliteCHEBI:29108 (ChEBI)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNGProteinIFNG (HGNC)
IL12AGeneProductENSG00000168811 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL8 GeneProductENSG00000169429 (Ensembl)
IP-activated cAMPMetaboliteHMDB0000058 (HMDB)
IRF7GeneProductENSG00000185507 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
Natural killer cells antigen CD94ProteinE9PCX9 (Uniprot-TrEMBL)
PI3KGeneProductENSG00000105851 (Ensembl)
PKAProteinEC 2.7.11.11 (KEGG Genes)
Prostaglandin E receptor 4ProteinENSG00000171522 (Ensembl)
Prostaglandin E synthaseProteinO14684 (Uniprot-TrEMBL)
Prostaglandin E2 receptorProteinG3V2Y6 (Uniprot-TrEMBL)
Prostaglandin E2 receptorProteinP43116 (Uniprot-TrEMBL)
Prostaglandin E2Metabolite363-24-6 (CAS)
Prostaglandin I2Metabolite35121-78-9 (CAS)
TGFB1GeneProductTGFB1 (HGNC)
TNFGeneProductENSG00000232810 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions

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