Overview of proinflammatory and profibrotic mediators (Homo sapiens)

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Inflammatory cytokinesCytokine stormIL2IL-8MMP3CSF3CCL2CSF2ROSCXCL10TNF alphaIL-12NF-kappa-B IL-1 BetaMMP1IL-6IL-6IL-1 BetaIL-8CCL2TNF alphaIL-12


Description

Inflammatory cytokines leading to cytokine storm after NF-kappa-B activation. KEGG pathway 05171 was referenced for the pathway development.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Turner MD, Nedjai B, Hurst T, Pennington DJ; ''Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.''; Biochim Biophys Acta, 2014 PubMed Europe PMC Scholia
  2. Robb CT, Goepp M, Rossi AG, Yao C; ''Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.''; Br J Pharmacol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128722view02:09, 21 February 2024EweitzEconomize layout
128721view01:58, 21 February 2024EweitzColor metabolites, standardize font, ecoonomize layout
120801view12:31, 10 January 2022DuyguddOntology Term : 'pro-inflammatory cytokine mediated pathway' added !
116868view20:50, 14 May 2021Marvin M2Added chemokines
116764view09:58, 12 May 2021Marvin M2Added cytokines
116697view18:36, 9 May 2021AriajadhavModified description
116696view18:31, 9 May 2021AriajadhavAdded references to Prostaglandin pathways
116695view18:27, 9 May 2021AriajadhavAdded Prostaglandin mediated cytokine release to pathway
116384view11:18, 6 May 2021RaatsSModified description
116383view11:17, 6 May 2021RaatsSchanged title format. capitalized letters.
116382view11:16, 6 May 2021RaatsSAdded upstream genes and metabolites
116381view11:14, 6 May 2021RaatsSNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCL2GeneProduct6347 (Entrez Gene)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
IL-1 BetaGeneProductENSG00000125538 (Ensembl)
IL-12GeneProductIL12A (HGNC)
IL-6GeneProductENSG00000136244 (Ensembl)
IL-8GeneProductENSG00000169429 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
NF-kappa-B ProteinD6RC45 (Uniprot-TrEMBL)
ROSMetaboliteCHEBI:26523 (ChEBI)
TNF alphaGeneProductENSG00000232810 (Ensembl)

Annotated Interactions

No annotated interactions

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