Overview of proinflammatory and profibrotic mediators (Homo sapiens)

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2Shared receptorsIL-1Common β chain (CD131) receptor ligandsShared IL-2β chain (CD122)Type III IFNType II IFNAdaptive immunityTNFαIL-17Common γ chain receptor ligandsType I IFNColony stimulating factorsEPOIL11IL6IL10EBI3TSLPIL27TNFIL37IL22IFNL2IL1AIL36AIL5OSMIL12BCTF1IFNA17IL1RNIL23AIFNA16IL1BSPP1CSF2IL31IL1F10IFNA2IL19IFNA8IFNA14IFNKCSF1IL13IL36RNIL26IFNA5IFNB1IL25IFNA13IFNA4IFNW1IL12AIFNA7CNTFIFNL1IL2IFNA1IL24LIFIFNA6IL4IL21IL3IL15IFNGIL24IL33IL20IL12BIFNL3IL9IL7IFNL2IL18Cytokine stormIL2IL-8MMP3CSF3CCL2CSF2ROSCXCL10TNF alphaIL-12NF-kappa-B IL-1 BetaMMP1IL-6IL-6IL-1 BetaIL-8CCL2TNF alphaIL-12VEGFAMMP9TGFB1CXCL1CSF1AREGIL17FIL17AIL22CXCL9IFNGIFNA1Prostaglandin E21Prostaglandin I21Pro-inflammatory signallingAnti-inflammatory signallingIL15IL2IL36BIL36GLymphotoxin-alphaTNFSF13BTNFSF13IL17AIL17BIL17DIL17FIL17CIFNA10IFNA21IL12AIFNL3IFNL1CSF3CSF2IL-6


Description

Inflammatory cytokines leading to cytokine storm after NF-kappa-B and prostaglandin activation. KEGG pathway 05171 and a paper by Robb et al. was referenced for the pathway development.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Turner MD, Nedjai B, Hurst T, Pennington DJ; ''Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.''; Biochim Biophys Acta, 2014 PubMed Europe PMC Scholia
  2. Robb CT, Goepp M, Rossi AG, Yao C; ''Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.''; Br J Pharmacol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128722view02:09, 21 February 2024EweitzEconomize layout
128721view01:58, 21 February 2024EweitzColor metabolites, standardize font, ecoonomize layout
120801view12:31, 10 January 2022DuyguddOntology Term : 'pro-inflammatory cytokine mediated pathway' added !
116868view20:50, 14 May 2021Marvin M2Added chemokines
116764view09:58, 12 May 2021Marvin M2Added cytokines
116697view18:36, 9 May 2021AriajadhavModified description
116696view18:31, 9 May 2021AriajadhavAdded references to Prostaglandin pathways
116695view18:27, 9 May 2021AriajadhavAdded Prostaglandin mediated cytokine release to pathway
116384view11:18, 6 May 2021RaatsSModified description
116383view11:17, 6 May 2021RaatsSchanged title format. capitalized letters.
116382view11:16, 6 May 2021RaatsSAdded upstream genes and metabolites
116381view11:14, 6 May 2021RaatsSNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AREGGeneProductENSG00000109321 (Ensembl)
CCL2GeneProduct6347 (Entrez Gene)
CNTFGeneProductENSG00000242689 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CTF1GeneProductENSG00000150281 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL9GeneProductENSG00000138755 (Ensembl)
EBI3GeneProductENSG00000105246 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl)
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNKGeneProductENSG00000147896 (Ensembl)
IFNL1GeneProductENSG00000182393 (Ensembl)
IFNL2GeneProductENSG00000183709 (Ensembl)
IFNL3GeneProductENSG00000197110 (Ensembl)
IFNW1GeneProductENSG00000177047 (Ensembl)
IL-1 BetaGeneProductENSG00000125538 (Ensembl)
IL-12GeneProductIL12A (HGNC)
IL-6GeneProductENSG00000136244 (Ensembl)
IL-8GeneProductENSG00000169429 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL13GeneProductENSG00000169194 (Ensembl)
IL15GeneProductENSG00000164136 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL17CGeneProductENSG00000124391 (Ensembl)
IL17DGeneProductENSG00000172458 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL18GeneProductENSG00000150782 (Ensembl)
IL19GeneProductENSG00000142224 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1F10GeneProductENSG00000136697 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
IL20GeneProductENSG00000162891 (Ensembl)
IL21GeneProductENSG00000138684 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL22GeneProductIL22 (HGNC)
IL23AGeneProductENSG00000110944 (Ensembl)
IL24GeneProductENSG00000162892 (Ensembl)
IL25GeneProductENSG00000166090 (Ensembl)
IL26GeneProductENSG00000111536 (Ensembl)
IL27GeneProductENSG00000197272 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL31GeneProductENSG00000204671 (Ensembl)
IL33GeneProductENSG00000137033 (Ensembl)
IL36AGeneProductENSG00000136694 (Ensembl)
IL36BGeneProductENSG00000136696 (Ensembl)
IL36GGeneProductENSG00000136688 (Ensembl)
IL36RNGeneProductENSG00000136695 (Ensembl)
IL37GeneProductENSG00000125571 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL7GeneProductENSG00000104432 (Ensembl)
IL9GeneProductENSG00000145839 (Ensembl)
LIFGeneProductENSG00000128342 (Ensembl)
Lymphotoxin-alphaProteinP01374 (Uniprot-TrEMBL)
MMP1GeneProductENSG00000196611 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NF-kappa-B ProteinD6RC45 (Uniprot-TrEMBL)
OSMGeneProductENSG00000099985 (Ensembl)
Prostaglandin E2Metabolite15551 (ChEBI)
Prostaglandin I2Metabolite35121-78-9 (CAS)
ROSMetaboliteCHEBI:26523 (ChEBI)
SPP1GeneProductENSG00000118785 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNF alphaGeneProductENSG00000232810 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFSF13BGeneProductENSG00000102524 (Ensembl)
TNFSF13GeneProductENSG00000161955 (Ensembl)
TSLPGeneProductENSG00000145777 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)

Annotated Interactions

No annotated interactions

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