Regulation of actin cytoskeleton (Homo sapiens)

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RTKRTKFocal complexassemblyRASLamellipodiaChemotatic factorGPCRChemotactic factor+pRASPI3Kstress fiber?FilipodiaStabilizationof actinFocal adhesionassemblyGPCRActomyosinassembly contractionGrowth Factor (GF)Actin polymerizationActin polymerizationstress fiber-pGene ExpressionPI3KGFActin polymerizationPPP1R12AARHGEF4MAPK1CHRM5RAC1P4GNA12PDGFRAPIK3CDPIP5KL1GNA13FGF3BAIAP2ITGA1EGFRNCKAP1WASF1CHRM3IQGAP1TMSB4XPIK3CAAdherens junctionpathwayINS1DIAP3PAK6CHRM2FGF8MAP2K2FN1SSH3VCLARHGEF7PIP5K1ABAIAP2ARHGEF6PAK7FGF18GIT1ACTBPAK2NRASGRLF1FGFR2RRASFGF12MOSRRAS2DOCK1CRKROCK2PIP2BRAFPIK3R1FGF14VIL1PIP5K2APXNARHGEF6CDC42MYH10FGF15ACTG1C3orf10PFN1F2FGF20FGFR4FGF9FGD1ACTG1MYL1PDGFBACTG1FGF10ACTBPIP2FGF4CD14APCWASAcetylcholineMSNSOS2Focal AdhesionpathwayC11orf13PIP5K1CACTN1PIK3R4PIP5K1BFGFR1PIK3R3FGF21SLC9A1PIP3LOC442775Pik3c2bMAPK SignalingpathwayVAV1SSH1Apc2VIL2KRASMAPK4MYLKFGF22FGF6RDXINS2LIMK1MYL3GSNGNG12PIP5K2CMAPK3PIP5K2ACYFIP2ARPC5MAP2K1PDGFAFGF7RHOAPIK3C3LPSFGF23PIK3R5MAPK6FGF17CSKFGFR3PIK3C2GFGF2BDKRB2CHRM4PIK3C2ARAC2ARHGEF1FGF11FGF1ARPC5PAK3FGF16ROCK1ABI2PAK1CHRM1RAC3RAC1SSH2PTK2EGFF2RRAF1Focal AdhesionpathwayPIP5K2BENAHPIK3R2PFN1PDGFRBACTBFGF5CFL1PIK3CBWASF2FGF13VCLBradykininPAK4CFL2SOS1MRASPIK3CGDIAP1BDKRB1BCAR1


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Schmitz AA, Govek EE, Böttner B, Van Aelst L; ''Rho GTPases: signaling, migration, and invasion.''; Exp Cell Res, 2000 PubMed Europe PMC Scholia
  2. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K; ''Cell adhesion and Rho small GTPases.''; J Cell Sci, 1999 PubMed Europe PMC Scholia
  3. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR; ''Cell migration: integrating signals from front to back.''; Science, 2003 PubMed Europe PMC Scholia
  4. Pollard TD; ''The cytoskeleton, cellular motility and the reductionist agenda.''; Nature, 2003 PubMed Europe PMC Scholia
  5. Takai Y, Sasaki T, Matozaki T; ''Small GTP-binding proteins.''; Physiol Rev, 2001 PubMed Europe PMC Scholia
  6. Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC Scholia
  7. Sastry SK, Burridge K; ''Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.''; Exp Cell Res, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128023view16:16, 21 January 2024EweitzStandardize case
126235view16:55, 17 April 2023EgonwLicense is CCZero
116716view09:57, 11 May 2021EweitzModified title
113897view20:49, 7 December 2020FinterlyAdded link to KEGG Pathway. Small graphical update.
113834view09:50, 30 November 2020Finterlysmall graphical updates
107553view23:44, 19 October 2019AlexanderPicoModified description
106499view21:45, 4 September 2019KhanspersModified description
105801view22:50, 15 August 2019KhanspersModified description
94816view02:38, 6 October 2017Khanspersadded literature from KEGG
94815view02:35, 6 October 2017Khanspersconnected interactions
79977view12:56, 29 April 2015Zarichanged LOC442775 to official name and annotated FGF15
79526view10:02, 24 March 2015Zariadded ID for DIAP1 gene
79445view06:57, 22 March 2015EgonwReplaced a gene name with its Entrez Gene identifier.
72124view07:38, 25 October 2013Mkutmonadded datasource for "Focal Adhesion pathway" and "MAPK Signaling pathway"
71376view18:38, 17 October 2013MaintBotAutomated update of data sources
71254view20:57, 16 October 2013MaintBotAutomated update of data sources
68950view17:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67623view11:34, 26 June 2013DdiglesOntology Term : 'cell adhesion signaling pathway' added !
49262view23:46, 11 July 2012AlexanderPicoReverted to version '12:02, 7 October 2011' by AlexanderPico
49261view22:24, 11 July 2012Diana.gcoPeriodical save, work in progress
45278view19:02, 7 October 2011Khanspersremoved genmapp comments
45276view19:00, 7 October 2011KhanspersOntology Term : 'regulatory pathway' added !
41107view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38855view18:06, 24 September 2010Khanspers
38768view23:31, 23 September 2010KhanspersAdded pathway links, chnaged interactions
34470view18:32, 10 December 2009MaintBotAutomatic update of empty xrefs
32449view17:21, 15 August 2009MaintBotFixed text labels
32129view13:54, 14 August 2009MaintBotFixed group labels
20783view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Regulation of Actin Cytoskeleton KEGG]] moved to [[Pathway:WP51]]: Moved to stable identifier
14231view03:25, 22 May 2008AlexanderPicoConnected!
14227view03:16, 22 May 2008AlexanderPicoPeriodical save, work in progress
14225view03:06, 22 May 2008AlexanderPicoPeriodical save, work in progress
14223view02:55, 22 May 2008AlexanderPicoPeriodical save, work in progress
14221view02:47, 22 May 2008AlexanderPicoAdditional work with aliases
14219view02:45, 22 May 2008AlexanderPicoPeriodical save, work in progress
14217view02:22, 22 May 2008AlexanderPicoFixed datanodes and aliases
14215view02:13, 22 May 2008AlexanderPicoPeriodical save, work in progress
14213view02:02, 22 May 2008AlexanderPicoFixed small molecules
14211view01:50, 22 May 2008AlexanderPicoFixed labels
14209view01:42, 22 May 2008AlexanderPicoPeriodical save, work in progress
14207view01:13, 22 May 2008AlexanderPicoGrouped complexes and paralogs
13114view11:16, 17 May 2008MaintBotautomated metabolite conversion
12940view10:42, 17 May 2008MaintBotSticky edges patch by Sjoerd
8354view13:46, 7 January 2008MaintBot[[Pathway:Human:Regulation of Actin Cytoskeleton KEGG]] moved to [[Pathway:Homo sapiens:Regulation of Actin Cytoskeleton KEGG]]: Renaming species
7795view16:18, 18 December 2007MaintBotfixed category names
7289view12:41, 4 November 2007MaintBotAdded categories to GPML
6366view22:18, 22 May 2007169.230.77.174gpml file for [[Human:Regulation_of_Actin_Cytoskeleton_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI2GeneProduct10152 (Entrez Gene)
ACTBGeneProduct60 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
ACTN1GeneProduct87 (Entrez Gene)
APCGeneProduct324 (Entrez Gene)
ARHGEF1GeneProduct9138 (Entrez Gene)
ARHGEF4GeneProduct50649 (Entrez Gene)
ARHGEF6GeneProduct9459 (Entrez Gene)
ARHGEF7GeneProduct8874 (Entrez Gene)
ARPC5GeneProduct10092 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
Adherens junction pathwayPathway
Apc2GeneProductAPC2 (Entrez Gene)
BAIAP2GeneProduct10458 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
BDKRB1GeneProduct623 (Entrez Gene)
BDKRB2GeneProduct624 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
BradykininMetabolite58-82-2 (CAS)
C11orf13GeneProduct8045 (Entrez Gene)
C3orf10GeneProduct55845 (Entrez Gene)
CD14GeneProduct929 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CFL1GeneProduct1072 (Entrez Gene)
CFL2GeneProduct1073 (Entrez Gene)
CHRM1GeneProduct1128 (Entrez Gene)
CHRM2GeneProduct1129 (Entrez Gene)
CHRM3GeneProduct1131 (Entrez Gene)
CHRM4GeneProduct1132 (Entrez Gene)
CHRM5GeneProduct1133 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CSKGeneProduct1445 (Entrez Gene)
CYFIP2GeneProduct26999 (Entrez Gene)
DIAP1GeneProduct
DIAP3GeneProduct
DOCK1GeneProduct1793 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ENAHGeneProduct55740 (Entrez Gene)
F2GeneProduct2147 (Entrez Gene)
F2RGeneProduct2149 (Entrez Gene)
FGD1GeneProduct2245 (Entrez Gene)
FGF10GeneProduct2255 (Entrez Gene)
FGF11GeneProduct2256 (Entrez Gene)
FGF12GeneProduct2257 (Entrez Gene)
FGF1GeneProduct2246 (Entrez Gene)
FGF13GeneProduct2258 (Entrez Gene)
FGF14GeneProduct2259 (Entrez Gene)
FGF15GeneProduct
FGF16GeneProduct8823 (Entrez Gene)
FGF17GeneProduct8822 (Entrez Gene)
FGF18GeneProduct8817 (Entrez Gene)
FGF20GeneProduct26281 (Entrez Gene)
FGF21GeneProduct26291 (Entrez Gene)
FGF2GeneProduct2247 (Entrez Gene)
FGF22GeneProduct27006 (Entrez Gene)
FGF23GeneProduct8074 (Entrez Gene)
FGF3GeneProduct2248 (Entrez Gene)
FGF4GeneProduct2249 (Entrez Gene)
FGF5GeneProduct2250 (Entrez Gene)
FGF6GeneProduct2251 (Entrez Gene)
FGF7GeneProduct2252 (Entrez Gene)
FGF8GeneProduct2253 (Entrez Gene)
FGF9GeneProduct2254 (Entrez Gene)
FGFR1GeneProduct2260 (Entrez Gene)
FGFR2GeneProduct2263 (Entrez Gene)
FGFR3GeneProduct2261 (Entrez Gene)
FGFR4GeneProduct2264 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
Focal Adhesion pathwayPathwayWP306
GIT1GeneProduct28964 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GNA13GeneProduct10672 (Entrez Gene)
GNG12GeneProduct55970 (Entrez Gene)
GRLF1GeneProduct2909 (Entrez Gene)
GSNGeneProduct2934 (Entrez Gene)
INS1GeneProduct
INS2GeneProduct
IQGAP1GeneProduct8826 (Entrez Gene)
ITGA1GeneProduct3672 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LIMK1GeneProduct3984 (Entrez Gene)
LOC442775GeneProduct442775 (Entrez Gene)
LPSMetaboliteC00338 (Kegg Compound)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK Signaling pathwayPathwayWP382
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MOSGeneProduct4342 (Entrez Gene)
MRASGeneProduct22808 (Entrez Gene)
MSNGeneProduct4478 (Entrez Gene)
MYH10GeneProduct4628 (Entrez Gene)
MYL1GeneProduct4632 (Entrez Gene)
MYL3GeneProduct4634 (Entrez Gene)
MYLKGeneProduct4638 (Entrez Gene)
NCKAP1GeneProduct10787 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
PAK7GeneProduct57144 (Entrez Gene)
PDGFAGeneProduct5154 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
PDGFRBGeneProduct5159 (Entrez Gene)
PFN1GeneProduct5216 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
PIP2MetaboliteC04637 (Kegg Compound)
PIP3MetaboliteC05981 (Kegg Compound)
PIP5K1AGeneProduct8394 (Entrez Gene)
PIP5K1BGeneProduct8395 (Entrez Gene)
PIP5K1CGeneProduct23396 (Entrez Gene)
PIP5K2AGeneProduct5305 (Entrez Gene)
PIP5K2BGeneProduct8396 (Entrez Gene)
PIP5K2CGeneProduct79837 (Entrez Gene)
PIP5KL1GeneProduct138429 (Entrez Gene)
PPP1R12AGeneProduct4659 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
Pik3c2bGeneProduct5287 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC1P4GeneProduct286472 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAC3GeneProduct5881 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RDXGeneProduct5962 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
RRAS2GeneProduct22800 (Entrez Gene)
RRASGeneProduct6237 (Entrez Gene)
SLC9A1GeneProduct6548 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SSH1GeneProduct54434 (Entrez Gene)
SSH2GeneProduct85464 (Entrez Gene)
SSH3GeneProduct54961 (Entrez Gene)
TMSB4XGeneProduct7114 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VCLGeneProduct7414 (Entrez Gene)
VIL1GeneProduct7429 (Entrez Gene)
VIL2GeneProduct7430 (Entrez Gene)
WASGeneProduct7454 (Entrez Gene)
WASF1GeneProduct8936 (Entrez Gene)
WASF2GeneProduct10163 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP51"