SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation (Homo sapiens)

From WikiPathways

Description

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Ontology Terms

Bibliography

1. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J; ''Activation and evasion of type I interferon responses by SARS-CoV-2.''; Nat Commun, 2020 PubMed Europe PMC Scholia
2. Oh SJ, Shin OS; ''SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response.''; Cells, 2021 PubMed Europe PMC Scholia
3. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D; ''Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.''; Cell, 2020 PubMed Europe PMC Scholia
4. Lucy G Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Ben Polacco, Adrian Pelin, Jyoti Batra, Matthew V.X. Whelan, Manisha Ummadi, Ajda Rojc, Jane Turner, Kirsten Obernier, Hannes Braberg, Margaret Soucheray, Alicia Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, Myra Hosmillo, Joseph Hiatt, Aminu Jahun, Ian G. Goodfellow, Jacqueline M. Fabius, Kevan Shokat, Natalia Jura, Klim Verba, Mahdad Noursadeghi, Pedro Beltrao, Danielle L. Swaney, Adolfo Garcia-Sastre, Clare Jolly, Greg J. Towers, Nevan J. Krogan; ''Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant''; bioRxiv, https://www.biorxiv.org/content/10.1101/2021.06.06.446826v1.full, 2021 PubMed Europe PMC Scholia
5. Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC; ''SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.''; Cell Mol Immunol, 2020 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	125318	view	21:49, 31 January 2023	Larsgw	Add PMID to reference
	124652	view	13:15, 18 November 2022	NhungP	Update viral protein shapes
	124428	view	12:32, 27 October 2022	Mkutmon	fix identifier of N protein
	124427	view	12:31, 27 October 2022	Mkutmon	lower case SARS-CoV-2 protein names
	120336	view	18:17, 26 November 2021	NhungP	Update n protein identifier to SARS-COV 2
	119052	view	16:07, 12 June 2021	Khanspers	adding xrefs for sgRNA
	119044	view	22:33, 11 June 2021	Khanspers	Modified description
	119043	view	22:25, 11 June 2021	Khanspers	Final touches
	119042	view	21:49, 11 June 2021	Khanspers	Modified description
	119041	view	21:47, 11 June 2021	Khanspers	layout and updated orf name
	119040	view	21:25, 11 June 2021	Khanspers	Modified description
	119039	view	21:10, 11 June 2021	Khanspers	Updated layout
	119038	view	17:54, 11 June 2021	Khanspers	updated lit ref
	119037	view	17:47, 11 June 2021	Khanspers	work in progress
	119036	view	16:20, 11 June 2021	Khanspers	Ontology Term : 'innate immune response pathway' added !
	119035	view	16:19, 11 June 2021	Khanspers	Ontology Term : 'epithelial cell of upper respiratory tract' added !
	119034	view	16:17, 11 June 2021	Khanspers	Ontology Term : 'severe acute respiratory syndrome' added !
	119033	view	16:17, 11 June 2021	Khanspers	Ontology Term : 'COVID-19' added !
	119029	view	00:25, 11 June 2021	Khanspers	Added literature references for orf6 and N interactions, added subgenomic RNA
	119028	view	23:09, 10 June 2021	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
DDX58	GeneProduct	ENSG00000107201 (Ensembl)
IFNB1	GeneProduct	ENSG00000171855 (Ensembl)
IRF3	GeneProduct	ENSG00000126456 (Ensembl)
MAVS	GeneProduct	ENSG00000088888 (Ensembl)
N sgRNA	Rna
N	Protein	Q89457519 (Wikidata)	PDB structure for SARS-CoV strain: 6JYT
ORF9b	Protein	P0DTD2 (Uniprot-TrEMBL)	promotes mitochondrial fusion
Orf6 sgRNA	Rna
Orf9b sgRNA	Rna
TBK1	GeneProduct	ENSG00000183735 (Ensembl)
TOMM70	Protein	ENSG00000154174 (Ensembl)
TRAF3	GeneProduct	ENSG00000131323 (Ensembl)
TRAF6	GeneProduct	ENSG00000175104 (Ensembl)
orf6	GeneProduct	P0DTC6 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions