Inflammatory bowel disease signaling (Homo sapiens)

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12, 4221, 31111Inhibition of activated Th1 cellAntigen processing and presentationDNADNADNAInhibition of IBDDNATh17 cell differentiationBacterial invasionCytokine-cytokine receptor interactionTH0 cellMacrophageTh2 lymphocyteCrohn's diseaseTh1 lymphocyteTreg cellINFLAMMATORY BOWEL DISEASELuminal bacteria (e.g. Enscherichia coli, Mycobacterium avium paratuberculosis)?NKT cellInhibition of activated Th2 cellIntestinal wall Th17 lymphocyteAPCInflammation Ulcerative colitisAntigenAntigenTLR2IL-1NOD2IL-13TGFBIFNGR1IL-4IFNGToll-like receptor signalingSTAT3IL-4RASTAT3JAK/STAT signalingTGFB1T-cell receptor signalingIL12RB1TLR2IL6IL-2RGIFNGSMAD2STAT6IL12RB2TLR2NOD2IL-18FOXP3FOXP3Nod-like receptor signalingIL21IL23RIL-18R-betaIL-6TLR4STAT3TLR5NF-kBIL-10TNFAIL-4AP1IL21RIL-2IL-12IL-4T-betc-MAFRORytSTAT4IL23AIL22MHC class 2GATA3TNFIL-5TGFB1IL-13NF-kBRORAPeptidoglycanIL12RB1IL-5IFNGIL-10NFATC1IL17STAT1FlagellinPeptidoglycans LipopolysaccaridesMDP4Increase frequency of Th17 cellsTCRDNADNADNADNADNADNADNADNADNANF-kBJAK/STAT signalingTissue injury


Description

Pathway representing the inflammatory bowel disease showing steps leading to Crohn's disease and ulcerative colitis.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Schmitt H, Neurath MF, Atreya R; ''Role of the IL23/IL17 Pathway in Crohn's Disease.''; Front Immunol, 2021 PubMed Europe PMC Scholia
  2. Strober W, Fuss I, Mannon P; ''The fundamental basis of inflammatory bowel disease.''; J Clin Invest, 2007 PubMed Europe PMC Scholia
  3. Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe K, Hibi T; ''IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease.''; Gut, 2008 PubMed Europe PMC Scholia
  4. Guan Q; ''A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease.''; J Immunol Res, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129326view14:04, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
128431view17:56, 4 February 2024EweitzOntology Term : 'T-helper 2 cell' added !
128430view17:55, 4 February 2024EweitzOntology Term : 'T-helper 1 cell' added !
128429view17:55, 4 February 2024EweitzOntology Term : 'T-helper 17 cell' added !
128428view17:52, 4 February 2024EweitzOntology Term : 'macrophage' added !
128427view17:52, 4 February 2024EweitzOntology Term : 'colon macrophage' added !
128426view17:51, 4 February 2024EweitzOntology Term : 'naive thymus-derived CD4-positive, alpha-beta T cell' added !
128425view17:51, 4 February 2024EweitzOntology Term : 'lymphocyte' added !
128424view17:50, 4 February 2024EweitzOntology Term : 'professional antigen presenting cell' added !
128388view02:51, 4 February 2024EweitzRefine cell label placement
128387view02:48, 4 February 2024EweitzEconomize layout
128386view01:53, 4 February 2024EweitzOntology Term : 'ulcerative colitis' added !
128385view01:50, 4 February 2024EweitzEconomize layout
128384view01:37, 4 February 2024EweitzEconomize layout
128383view01:29, 4 February 2024EweitzEconomize layout
128382view01:11, 4 February 2024EweitzEconomize layout
128381view00:48, 4 February 2024EweitzEconomize layout
128380view00:33, 4 February 2024EweitzUpgrade two pathway nodes
128370view12:44, 3 February 2024EweitzUpgrade disease nodes: link, color
128369view12:36, 3 February 2024EweitzStandardize case
123858view06:13, 19 August 2022EgonwTyped two datanodes with an Ensembl identifier as Type="GeneProduct"
121825view07:26, 7 March 2022EgonwMade a pathway clickable
121626view10:45, 22 February 2022ImkeGruttersOntology Term : 'Toll-like receptor signaling pathway' added !
121625view10:45, 22 February 2022ImkeGruttersOntology Term : 'interleukin-2 signaling pathway' added !
121624view10:44, 22 February 2022ImkeGruttersOntology Term : 'interleukin-12 family mediated signaling pathway' added !
121623view10:44, 22 February 2022ImkeGruttersOntology Term : 'altered cytokine mediated signaling pathway' added !
121622view10:43, 22 February 2022ImkeGruttersOntology Term : 'signaling pathway involving second messengers' added !
121621view10:36, 22 February 2022ImkeGruttersOntology Term : 'immune system disease' added !
121620view10:34, 22 February 2022ImkeGruttersOntology Term : 'inflammatory bowel disease' added !
121614view09:31, 22 February 2022SusanModified description
121613view09:29, 22 February 2022SusanModified title
121612view09:29, 22 February 2022SusanOntology Term : 'inflammatory bowel disease' added !
121592view17:48, 21 February 2022AndraOntology Term : 'colitis' added !
121591view17:48, 21 February 2022AndraOntology Term : 'Crohn's disease' added !
121590view17:47, 21 February 2022AndraOntology Term : 'colonic disease' added !
121583view15:31, 21 February 2022ZDLechTitle correction
121554view11:02, 21 February 2022JPippiFixed interactions
121553view10:58, 21 February 2022JPippiAddition of literature
121515view16:06, 20 February 2022JPippiAddition of literature, addition/change of some gene product ID's
121512view11:24, 20 February 2022ZDLechNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AP1GeneProductENSG00000177606 (Ensembl)
FOXP3GeneProductENSG00000049768 (Ensembl)
GATA3GeneProductENSG00000107485 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNGR1GeneProductENSG00000027697 (Ensembl)
IL-10GeneProductENSG00000136634 (Ensembl)
IL-12GeneProductENSG00000168811 (Ensembl)
IL-13GeneProductENSG00000169194 (Ensembl)
IL-18GeneProductENSG00000150782 (Ensembl)
IL-18R-betaGeneProductENSG00000115607 (Ensembl)
IL-1GeneProductENSG00000115008 (Ensembl)
IL-2GeneProductENSG00000109471 (Ensembl)
IL-2RGGeneProductENSG00000147168 (Ensembl)
IL-4GeneProductENSG00000113520 (Ensembl)
IL-4RAGeneProductENSG00000077238 (Ensembl)
IL-5GeneProductENSG00000113525 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
IL12RB1GeneProductENSG00000096996 (Ensembl)
IL12RB2GeneProductENSG00000081985 (Ensembl)
IL17GeneProductENSG00000112116 (Ensembl)
IL21GeneProductENSG00000138684 (Ensembl)
IL21RGeneProductENSG00000103522 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL23AGeneProductENSG00000110944 (Ensembl)
IL23RGeneProductENSG00000162594 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
JAK/STAT signalingPathwayWP2593 (WikiPathways)
MDPMetaboliteCHEBI:183049 (ChEBI)
MHC class 2ProteinENSG00000204257 (Ensembl)
NF-kBGeneProductENSG00000109320 (Ensembl)
NFATC1GeneProductENSG00000131196 (Ensembl)
NOD2GeneProductENSG00000167207 (Ensembl)
Nod-like receptor signalingPathwayWP288 (WikiPathways)
PeptidoglycanMetaboliteCHEBI:8005 (ChEBI)
RORAGeneProductENSG00000069667 (Ensembl)
RORytGeneProductENSG00000143365 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT4GeneProductENSG00000138378 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)
T-betGeneProductENSG00000073861 (Ensembl)
T-cell receptor signalingPathwayWP69 (WikiPathways)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBGeneProductENSG00000105329 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR5GeneProductENSG00000187554 (Ensembl)
TNFAGeneProductENSG00000232810 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
Toll-like receptor signalingPathwayWP75 (WikiPathways)
c-MAFGeneProductENSG00000178573 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5198"
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