Thyroid hormone imbalance leading to neurodevelopmental abnormalities (Homo sapiens)

Revision as of 07:59, 29 April 2022 by CMalyar (Talk | contribs)

Description

Adverse Outcome Pathway for the effect of thyroid hormone disruption

View approved pathways at the new wikipathways.org.

Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, Marty S, Melching-Kollmuss S, Palha JA, Strauss V, van Ravenzwaay B, Swaen G; ''Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?''; Crit Rev Toxicol, 2020 PubMed Europe PMC Scholia
Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, Melching-Kollmuss S, Sauer UG, Sheets LP, Strauss V, Urbisch D, Botham PA, van Ravenzwaay B; ''Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?''; Crit Rev Toxicol, 2021 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
128159	view	17:07, 28 January 2024	Eweitz	Modified description
128158	view	17:06, 28 January 2024	Eweitz	Refine node padding, add space after colons, standardize case
128157	view	17:02, 28 January 2024	Eweitz	Modified title
127806	view	21:23, 17 December 2023	Marvin M2	Modified description
127805	view	21:22, 17 December 2023	Marvin M2
127804	view	21:18, 17 December 2023	Marvin M2	graphical updates
127291	view	14:34, 4 September 2023	Marvin M2	Updated layout, added chain of KEs
126475	view	17:27, 4 May 2023	CMalyar	Modified title
125574	view	13:23, 28 February 2023	Marvin M2	Added references
125573	view	13:19, 28 February 2023	Marvin M2	Ontology Term : 'thyroid hormone signaling pathway' added !
124846	view	21:03, 14 December 2022	Eweitz	Modified title
124834	view	19:38, 13 December 2022	Marvin M2
124833	view	19:36, 13 December 2022	Marvin M2	alignment changes
122991	view	13:39, 10 June 2022	CMalyar	Fixed interactions
122990	view	14:06, 9 June 2022	CMalyar	Pathway interactions fixed
122989	view	14:04, 9 June 2022	CMalyar	Fixed interaction arrows
122983	view	08:01, 9 June 2022	CMalyar	Manual identifiers of key events from AOP-Wiki
122980	view	20:03, 8 June 2022	CMalyar	Fixed pathway identifiers
122979	view	19:57, 8 June 2022	CMalyar	Structural changes
122671	view	07:59, 29 April 2022	CMalyar
122655	view	12:58, 26 April 2022	CMalyar
122654	view	11:03, 26 April 2022	CMalyar	New pathway

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Name	Type	Database reference	Comment
CaMKK2 signaling pathway	Pathway
GABA receptor signaling pathway	Pathway
KE277: Decrease thyroid hormone synthesis
KE279: Thyroperoxidase inhibition
KE280:Decreased T4 in neuronal tissue
KE281:Decreased T4 in serum
KE319: loss of cochlear function
KE341: Learning and memory impairment
KE381:Reduced levels of BDNF
KE385: Decreased synaptogenesis
KE386: Decreased neuronal network function
KE424: NIS inhibition
KE425: Decrease of Thyroidal Iodide
KE42: Decreased cognitive function
KE756:Altered hippocampal gene expression
KE757: Altered hippocampal anatomy
KE758: Altered hippocampal physiology
KE851: Decreased GABAergic interneurons
Pathway	Pathway
Thyroid hormone biosynthesis pathway	Pathway

No annotated interactions