Comprehensive IL-17A signaling (Mus musculus)

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Inflammation, apoptosis, and migration Chemokine ligands IL-17A mediated pulmonary SMAD- dependent and non-dependent mechanism during acute lung injury in vivoAlveolar basal epithelial A549 cells Transforming growth factor beta signalingHuman bronchial epithelial (HBE) cellsDissociationInterleukinsγδT and Th17 cells Bleomycin-induced pulmonary fibrotic mice modelPulmonary inflammation and fibrosis Minichromosome maintenance (MCM) proteins invovled in DNA replicationActa1Rac1IL-11PcnaTGFB1NaspCdc42Orc2IL-10Pole3HSPG2Parp1AtrxPlaurCcl3Casp3Zmpste24LIFTNFFn1Cdc42Cxcl1PlauCOL3A1Nucks1Serpine1CXCL1EgfrVCANDhx9Cxcl5CrebbpCCL2 COL5A2Cxcl12CXCL8CSF3IL-6CacybpPuraOrc1ACTA2MUC5ACSamhd1Ccl4Npm1Upf1Ccl5Rbbp4Srpk2CXCL2Sqstm1Acta2Igf1Acta2Map1lc3bBaffFbn1Bcl2IL1BHspa1bSnai1Mki67Mcm7Adh1Hmgb1Smad6Col1a1PdgfbHbb-bh1Sod2Stat1Y701RelaPlch1mTORS2448CXCL5Smad2S465S467P53IL17RAPrkacb MAPK1PRKAA1PMAPK3Anxa6PPlauIl1bPtgs2CXCL6Mmp3PI3KCABecn1Y458Y199Akt1IL17AStat1S473Ccn2IL17RARac1MAPK14MtorMylkGng12Uggt1Stat3Y705Il6Mcm5RELAS536Casp3PdgfaRab10Serpine1RELAS536Cpne1NFKB1Map1lc3aNFKBIAC3Arpc2Smad7 CXCL1RELAEgfrNFKB1Y1068BECN1 NFKBIAPik3c3CFBActa2Cxcl1Hbb-b2Col1a1BCL2Psmc6PlaurRelaMcm4Mcm6GSK3BS9Particulate matter (PM2.5)CXCL3Bleomycin induced IL-17A activationMcm2Tgfb1Ppp1r14bActa2BlmhSnai2IL8Experimental silica treatment in miceP53RhoaAutophagyPak3GRK5Il1bIL6C7 Mmp14Arpc3Gap43Mcm3Smad3Degrease kinase activity GSK3BS423S425mTORInhibit autophagy in pulmonary fibrosis IL17AS2448PIK3CAPActa2Inflammatory neutrophils in the bronchoalveolar space Rras2Arpc5Atox1Hyou1 FibrosisPon3IL-17A stimulationNgpIL-17ACxcl12 IL17RAMmp9Cxcl2Hbb-b1Tgfb1Smad2S467S465Smad3S425S423Jak2Y1008Y1007Jak1Y1034Y1035Stat3Y705Acute lung injurySTAT1/3 mediated transcriptionalregulationMAPK1MAPK3PmTORPStat3IL-17AIL17RAJak2Jak1Y1007Y1008Y1035Y1034P53PAkt1PMAPK14T183Y185Bleomycin induced IL-17A activationUnilateral Ureteral Obstruction (UUO) injuryIL-17A stimulationIL-17AIL17RANFKB1NFKBIAPChronic airway diseasesIL-17A stimulationReceptorProteinmRNALigand Inhibition Leads to through multiple reactionsLEGEND IL-17A stimulation Bleomycin induced IL-17A activationSmad3S425S423DissociationStat3Y705Stat1Y701Stat3Y705 Translocation Nucleus Cytoplasm Plasma membraneCYPMNU ExtracellularECGene/ProteinGene/Protein Upregulation DownregulationProteinP PhosphorylationDissociationNUCYNUCYNUCYNUCYActivationGram-negative bacterial pneumonia infection Airway epithelial cells Proliferation of asthmatic fibrocytes AsthmaIL-10ACTA2Extracellular matrix deposition and neovascularization Apoptosis and injury Bleomycin induced miceDegradation of BCL-2Human lung epithelial cellsBCL2S70Renal fibrosisSilicosis lung inflammation in miceSnai1Col1a1Snai2Tjp1Cdh1Epithelial-mesenchymal transition (EMT) markersHuman primary small airway epithelial cellsMouse alveolar epithelial (MLE-12) cells Jak2PJak1PParticulate matter (PM2.5) stimulationExperimental silica treatment in mice


Description

Schematic representation of IL-17A signaling pathway

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Bibliography

  1. Rex DAB, Dagamajalu S, Gouda MM, Suchitha GP, Chanderasekaran J, Raju R, Prasad TSK, Bhandary YP; ''A comprehensive network map of IL-17A signaling pathway.''; J Cell Commun Signal, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126495view21:40, 9 May 2023Khanspersadded missing groups, fixed interactions, converted interactions in legend to graphical lines
126212view09:41, 16 April 2023EgonwLicense is CCZero
124849view21:41, 14 December 2022EweitzModified title
124477view21:23, 30 October 2022AlexanderPicoModified description
124476view21:22, 30 October 2022AlexanderPicomore xrefs
124475view21:15, 30 October 2022AlexanderPicoremoved off-map nodes; added ref
124474view21:13, 30 October 2022AlexanderPicocompleted xrefs; fixed legend to use labels
123976view10:33, 9 September 2022EweitzModified title
123802view18:04, 15 August 2022KhanspersOntology Term : 'interleukin-17 family mediated signaling pathway' added !
123801view18:04, 15 August 2022KhanspersOntology Term : 'signaling pathway' added !
123125view04:40, 5 July 2022EgonwWorked on the data sources
123092view08:08, 29 June 2022Rex D A BAnnotations
123091view07:35, 29 June 2022Rex D A BAlignment
123090view06:32, 28 June 2022Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2GeneProduct59 (Entrez Gene)
Acta1GeneProduct11459 (Entrez Gene)
Acta2GeneProduct11475 (Entrez Gene)
Acta2GeneProductActa2
Acta2ProteinP62737 (Uniprot-SwissProt)
Adh1GeneProductAdh1
Akt1GeneProduct207 (Entrez Gene)
Akt1ProteinP31750 (Uniprot-SwissProt)
Anxa6GeneProductAnxa6
Arpc2GeneProductArpc2
Arpc3GeneProductArpc3
Arpc5GeneProductArpc5
Atox1GeneProductAtox1
AtrxProteinQ61687 (Uniprot-SwissProt)
BCL2ProteinP10415.2 (Uniprot-SwissProt)
BECN1 ProteinQ14457.2 (Uniprot-SwissProt)
BaffGeneProduct24099 (Entrez Gene)
Bcl2ProteinP10417 (Uniprot-SwissProt)
Becn1ProteinO88597 (Uniprot-SwissProt)
BlmhGeneProductBlmh
C3GeneProduct12266 (Entrez Gene)
C7 GeneProductC7
CCL2 ProteinP13500 (Uniprot-SwissProt)
CFBGeneProduct629 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
CSF3ProteinP09919 (Uniprot-SwissProt)
CXCL1GeneProduct2919 (Entrez Gene)
CXCL1ProteinP09341 (Uniprot-SwissProt)
CXCL2GeneProduct2920 (Entrez Gene)
CXCL3GeneProduct2921 (Entrez Gene)
CXCL5GeneProduct20311 (Entrez Gene)
CXCL6GeneProductCXCL6
CXCL8ProteinP10145 (Uniprot-TrEMBL)
CacybpProteinQ9CXW3 (Uniprot-SwissProt)
Casp3GeneProduct12367 (Entrez Gene)
Casp3ProteinP05122 (Uniprot-SwissProt)
Ccl3GeneProduct20302 (Entrez Gene)
Ccl4GeneProduct20303 (Entrez Gene)
Ccl5GeneProduct20304 (Entrez Gene)
Ccn2GeneProduct14219 (Entrez Gene)
Cdc42GeneProductCdc42
Cdc42ProteinP60766 (Uniprot-SwissProt)
Cdh1ProteinP09803 (Uniprot-SwissProt)
Col1a1GeneProduct12842 (Entrez Gene)
Col1a1ProteinP02452 (Uniprot-SwissProt)
Cpne1GeneProductCpne1
CrebbpGeneProductP45481 (Uniprot-SwissProt)
Cxcl1GeneProduct14825 (Entrez Gene)
Cxcl12 ProteinP40224 (Uniprot-SwissProt)
Cxcl12GeneProduct20315 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
Cxcl5GeneProduct20311 (Entrez Gene)
Dhx9ProteinO70133 (Uniprot-SwissProt)
EgfrProteinQ01279 (Uniprot-SwissProt)
Fbn1GeneProduct14118 (Entrez Gene)
Fn1GeneProduct14268 (Entrez Gene)
GRK5GeneProduct2869 (Entrez Gene)
GSK3BProteinP49841 (Uniprot-SwissProt)
Gap43GeneProductGap43
Gng12GeneProductGng12
HSPG2GeneProduct3339 (Entrez Gene)
Hbb-b1GeneProductHbb-b1
Hbb-b2GeneProductHbb-b2
Hbb-bh1GeneProductHbb-bh1
Hmgb1GeneProductHmgb1
Hspa1bGeneProductHspa1b
Hyou1 GeneProductHyou1
IL-10ProteinP22301 (Uniprot-SwissProt)
IL-11ProteinP20809 (Uniprot-SwissProt)
IL-17AGeneProduct3605 (Entrez Gene)
IL-6ProteinP05231 (Uniprot-SwissProt)
IL17AGeneProduct3605 (Entrez Gene)
IL17RAGeneProduct23765 (Entrez Gene)
IL1BGeneProductP01584.2 (Uniprot-SwissProt)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct20309 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Il1bGeneProduct16176 (Entrez Gene)
Il1bProteinP10749 (Uniprot-SwissProt)
Il6GeneProduct16193 (Entrez Gene)
Jak1ProteinP23458 (Uniprot-SwissProt)
Jak1ProteinP52332 (Uniprot-SwissProt)
Jak2ProteinO60674 (Uniprot-SwissProt)
Jak2ProteinQ62120 (Uniprot-SwissProt)
LIFProteinP15018 (Uniprot-SwissProt)
MAPK14GeneProduct1432 (Entrez Gene) p38
MAPK14ProteinQ16539 (Uniprot-SwissProt) p38
MAPK1GeneProduct5594 (Entrez Gene) p38
MAPK1ProteinP28482 (Uniprot-SwissProt) p38
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3ProteinP27361 (Uniprot-SwissProt)
MUC5ACGeneProduct4586 (Entrez Gene)
Map1lc3aProteinQ91VR7 (Uniprot-SwissProt)
Map1lc3bProteinQ9CQV6 (Uniprot-SwissProt)
Mcm2ProteinP97310 (Uniprot-SwissProt)
Mcm3ProteinP25206 (Uniprot-SwissProt)
Mcm4Protein17217 (Entrez Gene)
Mcm5GeneProduct17218 (Uniprot-SwissProt)
Mcm6ProteinP97311 (Uniprot-SwissProt)
Mcm7GeneProductQ61881 (Uniprot-SwissProt)
Mki67GeneProduct17345 (Entrez Gene)
Mmp14GeneProduct17387 (Entrez Gene)
Mmp3GeneProduct17392 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
MylkGeneProductMylk
NFKB1GeneProduct4790 (Entrez Gene)
NFKB1ProteinP19838 (Uniprot-SwissProt)
NFKBIAGeneProduct4792 (Entrez Gene)
NaspProteinQ99MD9 (Uniprot-SwissProt)
NgpGeneProductNgp
Npm1ProteinQ61937 (Uniprot-SwissProt)
Nucks1ProteinQ80XU3 (Uniprot-SwissProt)
Orc1ProteinQ9Z1N2 (Uniprot-SwissProt)
Orc2ProteinQ60862 (Uniprot-SwissProt)
P53GeneProduct22059 (Entrez Gene)
P53ProteinP04637 (Entrez Gene)
P53ProteinP04637 (Uniprot-SwissProt)
PI3KCAProtein5290 (Entrez Gene)
PIK3CAGeneProductPIK3CA
PRKAA1ProteinQ13131 (Uniprot-SwissProt)
Pak3GeneProductPak3
Parp1ProteinP11103 (Uniprot-SwissProt)
PcnaProteinP17918 (Entrez Gene)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
Pik3c3ProteinQ6PF93 (Uniprot-SwissProt)
PlauGeneProduct18792 (Entrez Gene)
PlauProteinP06869 (Uniprot-SwissProt)
PlaurGeneProduct18793 (Entrez Gene)
PlaurProteinP35456 (Uniprot-SwissProt)
Plch1GeneProductPlch1
Pole3ProteinQ9JKP7 (Uniprot-SwissProt)
Pon3GeneProductPon3
Ppp1r14bGeneProductPpp1r14b
Prkacb GeneProductPrkacb
ProteinGeneProductTNFB1 (Ensembl)
Psmc6GeneProductPsmc6
Ptgs2GeneProduct19225 (Entrez Gene)
PuraProteinP42669 (Uniprot-SwissProt)
RELAProteinQ04206 (Entrez Gene)
RELAProteinQ04206 (Uniprot-SwissProt)
Rab10GeneProductRab10
Rac1ProteinP63001 (Uniprot-SwissProt)
Rac1GeneProductRac1
Rbbp4ProteinQ60972 (Uniprot-SwissProt)
RelaGeneProductRela
RhoaGeneProductRhoa
Rras2GeneProductRras2
Samhd1ProteinQ60710 (Uniprot-SwissProt)
Serpine1GeneProduct66870 (Entrez Gene)
Serpine1ProteinP05121 (Uniprot-SwissProt)
Smad2Protein17126 (Uniprot-SwissProt)
Smad2ProteinQ62432 (Uniprot-SwissProt)
Smad3Protein17127 (Uniprot-SwissProt)
Smad3ProteinQ8BUN5 (Uniprot-SwissProt)
Smad6ProteinO35182 (Uniprot-SwissProt)
Smad7 ProteinO35253 (Uniprot-SwissProt)
Snai1ProteinQ02085 (Uniprot-SwissProt)
Snai2ProteinP97469 (Uniprot-SwissProt)
Sod2GeneProductSod2
Sqstm1ProteinQ64337 (Uniprot-SwissProt)
Srpk2ProteinO54781 (Uniprot-SwissProt)
Stat1ProteinP42225 (Uniprot-SwissProt)
Stat1GeneProductStat1
Stat3ProteinP42227 (Uniprot-SwissProt)
TGFB1GeneProductTGFB1
TNFProteinP01375 (Uniprot-SwissProt)
Tgfb1ProteinP04202 (Uniprot-SwissProt)
Tjp1ProteinP39447 (Uniprot-SwissProt)
Uggt1GeneProductUggt1
Upf1ProteinQ9EPU0 (Uniprot-SwissProt)
VCANGeneProduct1462 (Entrez Gene)
Zmpste24ProteinQ80W54 (Uniprot-SwissProt)
mTORProteinP42345.1 (Uniprot-SwissProt)
mTORProteinQ9JLN9 (Uniprot-SwissProt)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5242"
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