ROS in COVID-19 endothelial dysfunction (Homo sapiens)
From WikiPathways
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(Ontology Term : 'infectious disease pathway' added !) |
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<?xml version="1.0" encoding="UTF-8"?> | <?xml version="1.0" encoding="UTF-8"?> | ||
| - | <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name=" | + | <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="ROS in COVID-19 endothelial dysfunction" Version="20220705" Organism="Homo sapiens"> |
<Comment Source="WikiPathways-description">Proposed mechanism for COVID-19 induced endothelial dysfunction via ROS, as described by Ma et Al. (2022). | <Comment Source="WikiPathways-description">Proposed mechanism for COVID-19 induced endothelial dysfunction via ROS, as described by Ma et Al. (2022). | ||
TNF-α stimulation of NADPH oxidase leads to accumulation of reactive oxygen species (ROS). Increased levels of IFN reduces the expression of functional ACE2, which leads to increased ROS via imbalanced RAS signaling. Excessive ROS disturbs vascular tone and increases endothelial permeability. | TNF-α stimulation of NADPH oxidase leads to accumulation of reactive oxygen species (ROS). Increased levels of IFN reduces the expression of functional ACE2, which leads to increased ROS via imbalanced RAS signaling. Excessive ROS disturbs vascular tone and increases endothelial permeability. | ||
Revision as of 03:25, 24 April 2024
Error rendering pathway page
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Error details
exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/4/4d/WP5258_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
at org.pathvisio.core.Engine.importPathway(Unknown Source)
at org.pathvisio.core.util.Converter.main(Unknown Source)
<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/4/4d/WP5258_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 129476)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
