ROS in COVID-19 endothelial dysfunction (Homo sapiens)
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(Difference between revisions)
(Modified title) |
Current revision (12:05, 3 May 2024) (view source) (alignment of 'increased permeability' updated.) |
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Description modified from [https://europepmc.org/article/MED/34838588 Ma et. al.].</Comment> | Description modified from [https://europepmc.org/article/MED/34838588 Ma et. al.].</Comment> | ||
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| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH Oxidase/ROS-Dependent VCAM-1 Induction on TNF-α-Challenged Human Cardiac Fibroblasts Enhances Monocyte Adhesion.</bp:TITLE> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Front Pharmacol</bp:SOURCE> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lin CC</bp:AUTHORS> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yang CC</bp:AUTHORS> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang CY</bp:AUTHORS> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tseng HC</bp:AUTHORS> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pan CS</bp:AUTHORS> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hsiao LD</bp:AUTHORS> |
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<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f47"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f47"> | ||
| Line 268: | Line 269: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Park A</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Park A</bp:AUTHORS> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iwasaki A</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iwasaki A</bp:AUTHORS> | ||
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<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f74"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f74"> | ||
| Line 304: | Line 285: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wack A</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wack A</bp:AUTHORS> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kassiotis G</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kassiotis G</bp:AUTHORS> | ||
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</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cee"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cee"> | ||
| Line 319: | Line 293: | ||
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR> | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roebuck KA</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roebuck KA</bp:AUTHORS> | ||
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<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a02"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a02"> | ||
| Line 353: | Line 311: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oudit GY</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oudit GY</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
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<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications.</bp:TITLE> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Mol Cell Cardiol</bp:SOURCE> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2022</bp:YEAR> |
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| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang Y</bp:AUTHORS> | ||
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| Line 365: | Line 327: | ||
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</bp:openControlledVocabulary> | </bp:openControlledVocabulary> | ||
| + | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f27"> | ||
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| + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.</bp:TITLE> | ||
| + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vascul Pharmacol</bp:SOURCE> | ||
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| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Incalza MA</bp:AUTHORS> | ||
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| Line 370: | Line 345: | ||
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</Pathway> | </Pathway> | ||
Current revision
Description
Proposed mechanism for COVID-19 induced endothelial dysfunction via ROS, as described by Ma et Al. (2022).
TNF-α stimulation of NADPH oxidase leads to accumulation of reactive oxygen species (ROS). Increased levels of IFN reduces the expression of functional ACE2, which leads to increased ROS via imbalanced RAS signaling. Excessive ROS disturbs vascular tone and increases endothelial permeability.
Description modified from Ma et. al..Quality Tags
Ontology Terms
Saving...Bibliography
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- ''''; , PubMed Europe PMC Scholia
- ''''; , PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| ACE2 (truncated) | GeneProduct | ENSG00000130234 (Ensembl)  | |
| ACE2 | GeneProduct | ENSG00000130234 (Ensembl) | |
| Angiotensin II | Metabolite | HMDB01035 (HMDB) | |
| ICAM1 | GeneProduct | ENSG00000090339 (Ensembl) | |
| IFN signaling | Pathway | ||
| IFNA1 | GeneProduct | ENSG00000197919 (Ensembl) | |
| IFNAR1 | GeneProduct | ENSG00000142166 (Ensembl) | |
| NFKB1 | GeneProduct | ENSG00000109320 (Ensembl) | |
| NOX1 | GeneProduct | NOX1 (HGNC) | |
| RAS signaling | Pathway | ||
| Reactive oxygen species | Metabolite | CHEBI:26523 (ChEBI) | |
| TNF | GeneProduct | ENSG00000232810 (Ensembl) | |
| TNFRSF1A | GeneProduct | ENSG00000067182 (Ensembl) | |
| nitric oxide | Metabolite | CHEBI:16480 (ChEBI) |
Annotated Interactions
No annotated interactions
