ROS in COVID-19 endothelial dysfunction (Homo sapiens)
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Description
Proposed mechanism for COVID-19 induced endothelial dysfunction via ROS, as described by Ma et Al. (2022)
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- Lin CC, Yang CC, Wang CY, Tseng HC, Pan CS, Hsiao LD, Yang CM; ''NADPH Oxidase/ROS-Dependent VCAM-1 Induction on TNF-α-Challenged Human Cardiac Fibroblasts Enhances Monocyte Adhesion.''; Front Pharmacol, 2015 PubMed Europe PMC Scholia
- Park A, Iwasaki A; ''Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19.''; Cell Host Microbe, 2020 PubMed Europe PMC Scholia
- Ng KW, Attig J, Bolland W, Young GR, Major J, Wrobel AG, Gamblin S, Wack A, Kassiotis G; ''Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option.''; Nat Genet, 2020 PubMed Europe PMC Scholia
- Roebuck KA; ''Oxidant stress regulation of IL-8 and ICAM-1gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review).''; Int J Mol Med, 1999 PubMed Europe PMC Scholia
- Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY; ''Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.''; Hypertension, 2011 PubMed Europe PMC Scholia
- Ma Z, Yang KY, Huang Y, Lui KO; ''Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications.''; J Mol Cell Cardiol, 2022 PubMed Europe PMC Scholia
- Incalza MA, D'Oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F; ''Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.''; Vascul Pharmacol, 2018 PubMed Europe PMC Scholia
- Verdecchia P, Cavallini C, Spanevello A, Angeli F; ''''; , PubMed Europe PMC Scholia
- Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B; ''Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.''; Lancet, 2020 PubMed Europe PMC Scholia
- Ding J, Yu M, Jiang J, Luo Y, Zhang Q, Wang S, Yang F, Wang A, Wang L, Zhuang M, Wu S, Xia Y, Lu D; ''Angiotensin II Decreases Endothelial Nitric Oxide Synthase PhosphorylationviaAT1R Nox/ROS/PP2A Pathway.''; Front Physiol, 2020 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ACE2 (truncated) | GeneProduct | ENSG00000130234 (Ensembl)  | |
| ACE2 | GeneProduct | ENSG00000130234 (Ensembl) | |
| ACE2 | GeneProduct | ENSG00000130234 (Ensembl) | |
| Angiotensin II | Metabolite | HMDB01035 (HMDB) | |
| ICAM1 | GeneProduct | ENSG00000090339 (Ensembl) | |
| IFN signaling | Pathway | ||
| IFNA1 | GeneProduct | ENSG00000197919 (Ensembl) | |
| IFNAR1 | GeneProduct | ENSG00000142166 (Ensembl) | |
| NFKB1 | GeneProduct | ENSG00000109320 (Ensembl) | |
| NOX1 | GeneProduct | NOX1 (HGNC) | |
| RAS signaling | Pathway | ||
| Reactive oxygen species | Metabolite | ||
| TNF | GeneProduct | ENSG00000232810 (Ensembl) | |
| TNFRSF1A | GeneProduct | ENSG00000067182 (Ensembl) | |
| nitric oxide | Metabolite | CHEBI:16480 (ChEBI) |
Annotated Interactions
No annotated interactions
