Cholesterol metabolism (Homo sapiens)
From WikiPathways
(Difference between revisions)
(Ontology Term : 'hepatocyte' added !) |
Current revision (01:46, 9 May 2024) (view source) (Standardize case, align label with ChEBI) |
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<Comment Source="WikiPathways-description">This pathway includes the following processes regarding cholesterol metabolism: I) Absorption of cholesterol in the enterocyte, II) Forming of chylomicrons and other lipid droplets, III) Distinction between Bloch and Kandutsch-Russell cholesterol biosynthesis, IV) Absorption of cholesterol in the hepatocyte and V) Transintestinal cholesterol excretion (TICE).</Comment> | <Comment Source="WikiPathways-description">This pathway includes the following processes regarding cholesterol metabolism: I) Absorption of cholesterol in the enterocyte, II) Forming of chylomicrons and other lipid droplets, III) Distinction between Bloch and Kandutsch-Russell cholesterol biosynthesis, IV) Absorption of cholesterol in the hepatocyte and V) Transintestinal cholesterol excretion (TICE).</Comment> | ||
<BiopaxRef>e32</BiopaxRef> | <BiopaxRef>e32</BiopaxRef> | ||
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| + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Metab</bp:SOURCE> | ||
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| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song BL</bp:AUTHORS> | ||
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| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of intestinal lipid metabolism: current concepts and relevance to disease.</bp:TITLE> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Rev Gastroenterol Hepatol</bp:SOURCE> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2020</bp:YEAR> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ko CW</bp:AUTHORS> |
| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Qu J</bp:AUTHORS> | ||
| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Black DD</bp:AUTHORS> | ||
| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tso P</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d63"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d63"> | ||
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<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cohen JC</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cohen JC</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
| - | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id=" | + | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e73"> |
| - | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12235098</bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Malformation syndromes due to inborn errors of cholesterol synthesis.</bp:TITLE> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Invest</bp:SOURCE> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Porter FD</bp:AUTHORS> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | </bp:PublicationXref> |
| - | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> |
| + | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cholesterol transport pathway</bp:TERM> | ||
| + | <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001346</bp:ID> | ||
| + | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> | ||
| + | </bp:openControlledVocabulary> | ||
| + | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | ||
| + | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cholesterol biosynthetic pathway</bp:TERM> | ||
| + | <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000454</bp:ID> | ||
| + | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> | ||
| + | </bp:openControlledVocabulary> | ||
| + | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e32"> | ||
| + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30354248</bp:ID> | ||
| + | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
| + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity.</bp:TITLE> | ||
| + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arterioscler Thromb Vasc Biol</bp:SOURCE> | ||
| + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR> | ||
| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gonias SL</bp:AUTHORS> | ||
| + | </bp:PublicationXref> | ||
| + | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="de3"> | ||
| + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8751718</bp:ID> | ||
| + | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
| + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Phospholipases: structural and functional motifs for working at an interface.</bp:TITLE> | ||
| + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FASEB J</bp:SOURCE> | ||
| + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR> | ||
| + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roberts MF</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f4d"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f4d"> | ||
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<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verkade HJ</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verkade HJ</bp:AUTHORS> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Groen AK</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Groen AK</bp:AUTHORS> | ||
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<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fb0"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fb0"> | ||
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<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Catapano AL</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Catapano AL</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
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<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d35"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d35"> | ||
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">34981790</bp:ID> | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">34981790</bp:ID> | ||
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<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gonzalez-Cabodevilla AG</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gonzalez-Cabodevilla AG</bp:AUTHORS> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goldberg IJ</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goldberg IJ</bp:AUTHORS> | ||
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</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | ||
| - | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hepatocyte</bp:TERM> |
| - | <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000182</bp:ID> |
| - | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology> |
</bp:openControlledVocabulary> | </bp:openControlledVocabulary> | ||
| - | + | </Biopax> | |
</Pathway> | </Pathway> | ||
Current revision
Description
This pathway includes the following processes regarding cholesterol metabolism: I) Absorption of cholesterol in the enterocyte, II) Forming of chylomicrons and other lipid droplets, III) Distinction between Bloch and Kandutsch-Russell cholesterol biosynthesis, IV) Absorption of cholesterol in the hepatocyte and V) Transintestinal cholesterol excretion (TICE).
Quality Tags
Ontology Terms
Saving...Bibliography
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- Ponz de Leon M, Carubbi F, Di Donato P, Carulli N; ''Cholesterol esterase activity of human intestinal mucosa.''; Dig Dis Sci, 1985 PubMed Europe PMC Scholia
- Huang B, Song BL, Xu C; ''Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities.''; Nat Metab, 2020 PubMed Europe PMC Scholia
- Rousset X, Vaisman B, Amar M, Sethi AA, Remaley AT; ''Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease.''; Curr Opin Endocrinol Diabetes Obes, 2009 PubMed Europe PMC Scholia
- Ko CW, Qu J, Black DD, Tso P; ''Regulation of intestinal lipid metabolism: current concepts and relevance to disease.''; Nat Rev Gastroenterol Hepatol, 2020 PubMed Europe PMC Scholia
- Mitsche MA, McDonald JG, Hobbs HH, Cohen JC; ''Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways.''; Elife, 2015 PubMed Europe PMC Scholia
- Porter FD; ''Malformation syndromes due to inborn errors of cholesterol synthesis.''; J Clin Invest, 2002 PubMed Europe PMC Scholia
- Gonias SL; ''Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity.''; Arterioscler Thromb Vasc Biol, 2018 PubMed Europe PMC Scholia
- Roberts MF; ''Phospholipases: structural and functional motifs for working at an interface.''; FASEB J, 1996 PubMed Europe PMC Scholia
- Grefhorst A, Verkade HJ, Groen AK; ''The TICE Pathway: Mechanisms and Lipid-Lowering Therapies.''; Methodist Debakey Cardiovasc J, 2019 PubMed Europe PMC Scholia
- Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, Calabresi L, Chapman MJ, Cuchel M, von Eckardstein A, Frikke-Schmidt R, Gaudet D, Hovingh GK, Kronenberg F, Lütjohann D, Parhofer KG, Raal FJ, Ray KK, Remaley AT, Stock JK, Stroes ES, Tokgözoğlu L, Catapano AL; ''Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement.''; Lancet Diabetes Endocrinol, 2020 PubMed Europe PMC Scholia
- Tall AR, Thomas DG, Gonzalez-Cabodevilla AG, Goldberg IJ; ''Addressing dyslipidemic risk beyond LDL-cholesterol.''; J Clin Invest, 2022 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Annotated Interactions
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