Male steroid hormones in cardiomyocyte energy metabolism (Homo sapiens)

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41, 44NucleusCardiomyocyte1, 313β-HSD23α-HSDCholesterolCYP17A1(C17,20-lyase)Testosterone-sulfateHSD17B217α-HydroxypregnenoloneAndrogen Receptor (AR)PregnenoloneAndrosteroneAromatase3α-Etiocholane-diolEpietio-cholanoloneEstradiolAndrostenediolAKR1C317β-HSDHSD3B1CYP17A1(17α-hydroxylase)SRD5A23α-Androstane-diol17β-HSDSRD5A2/5β-reductaseHSD17B33β-Androstane-diolHSD3B2HSD17B317β-HSD5α-Dihydro-testosteroneHSD3B1AKR1C3 Testosterone3β-HSDCYP11A1AndrostanedioneAndrostenedioneEpiandrosteroneEtiocholanoloneSRD5A1/5α-reductaseEstroneSulfotransferaseHSD3B25β-Dihydro-testosteroneProgesteroneDehydroepiandrosterone (DHEA)3β-HSD17β-HSDSRD5A1HSD17B2AKR1C317β-HSD3α-HSDAromataseTestosteroneGlucuronideHSD17B3Glucuronosyl-transferase3β-Eticholane-diol1, 21, 21, 2, 41, 21, 2, 4431, 421, 2, 441, 41, 241, 2141, 41, 2, 4411, 241, 2


Description

The effect of androgens on cardiomyocytes

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Quality Tags

Ontology Terms

 

Bibliography

  1. Carbajal-García A, Reyes-García J, Montaño LM; ''Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.''; Int J Endocrinol, 2020 PubMed Europe PMC Scholia
  2. Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, Naito M, Takahashi K; ''Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.''; Sci Rep, 2013 PubMed Europe PMC Scholia
  3. Davey RA, Grossmann M; ''Androgen Receptor Structure, Function and Biology: From Bench to Bedside.''; Clin Biochem Rev, 2016 PubMed Europe PMC Scholia
  4. McEwan IJ, Brinkmann AO; ''Androgen Physiology: Receptor and Metabolic Disorders.''; , 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125916view22:07, 17 March 2023EgonwMore fixed HMDB identifiers
125914view19:12, 17 March 2023EgonwNew HMDB format
125912view18:45, 17 March 2023EgonwUpdated the UniProt data sources
125903view13:59, 17 March 2023JmillanacostaAdded identifier
125868view17:27, 14 March 2023Bhavanakapalliidentifiers added
125623view20:02, 5 March 2023AlexanderPicoModified description
125617view11:38, 5 March 2023EgonwCorrect PubChem identifier (was for a silicon derivative)
125616view11:34, 5 March 2023EgonwRemoved duplicate reference info
125552view21:42, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125254view20:56, 30 January 2023Bhavanakapalliidentifiers
125253view20:53, 30 January 2023Bhavanakapalliidentifiers
125220view10:07, 30 January 2023BhavanakapalliReverted to version '10:05, 30 January 2023' by Bhavanakapalli
125219view10:06, 30 January 2023BhavanakapalliReverted to version '16:44, 29 January 2023' by Bhavanakapalli
125218view10:05, 30 January 2023Bhavanakapalli
125210view16:44, 29 January 2023Isissampermans
125209view16:42, 29 January 2023Isissampermans
125208view16:41, 29 January 2023Isissampermans
125207view16:39, 29 January 2023IsissampermansAddition of nucleus and cell structures
125205view15:53, 29 January 2023Isissampermans
125204view15:50, 29 January 2023IsissampermansNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
17α-HydroxypregnenoloneMetabolite
17β-HSDProteinCHEMBL4234 (EMBL)
3α-Androstane-diolMetabolite5879 (PubChem-compound)
3α-Etiocholane-diolMetabolite5880 (PubChem-compound)
3α-HSDProteinPF01073 (InterPro)
3β-Androstane-diolMetabolite441302 (PubChem-compound)
3β-Eticholane-diolMetabolite247732 (PubChem-compound)
3β-HSD2GeneProduct
3β-HSDProteinPF01073 (InterPro)
5α-Dihydro-testosteroneMetabolite91696576 (PubChem-compound)
5β-Dihydro-testosteroneMetabolite11302 (PubChem-compound)
AKR1C3GeneProduct
AKR1C3 ProteinAKR1C3 (Ensembl)
AKR1C3GeneProductENSG00000196139.14 (Ensembl)
Androgen Receptor (AR)Metabolite
AndrostanedioneMetabolite
AndrostenediolMetabolite
Androstenedione Metabolite
AndrosteroneMetabolite5879 (PubChem-compound)
AromataseProteinCHEMBL1978 (EMBL)
CYP11A1ProteinENSG00000140459.18 (Ensembl)
CYP17A1 (17α-hydroxylase)ProteinENSG00000148795.7 (Ensembl)
CYP17A1 (C17,20-lyase)ProteinENSG00000148795.7 (Ensembl)
CholesterolMetabolite
Dehydroepiandrosterone (DHEA)Metabolite
EpiandrosteroneMetabolite441302 (PubChem-compound)
Epietio- cholanoloneMetabolite247732 (PubChem-compound)
EstradiolMetabolite5757 (PubChem-compound)
EstroneMetabolite5870 (PubChem-compound)
EtiocholanoloneMetabolite5880 (PubChem-compound)
Glucuronosyl- transferaseProteinENST00000305231 (Ensembl)
HSD17B2GeneProduct
HSD17B2ProteinENSG00000086696.11 (Ensembl)
HSD17B3GeneProduct
HSD17B3GeneProductENSG00000130948.10 (Ensembl)
HSD3B1GeneProductENSG00000073737.17 (Ensembl)
HSD3B1GeneProductENSG00000203857.10 (Ensembl)
HSD3B2GeneProductENSG00000203859.10 (Ensembl)
PregnenoloneMetabolite
ProgesteroneMetabolite
SRD5A1/5α-reductaseGeneProduct
SRD5A1GeneProductENSG00000145545.12 (Ensembl)
SRD5A2/5β-reductaseGeneProduct
SRD5A2GeneProductENSG00000277893.2 (Ensembl)
SulfotransferaseProteinENST00000192314 (Ensembl)
Testosterone GlucuronideMetabolite108192 (PubChem-compound)
Testosterone-sulfateMetabolite119207 (PubChem-compound)
TestosteroneMetabolite236666 (PubChem-compound)

Annotated Interactions

No annotated interactions

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