Cardiomyocyte signaling pathways converging on titin (Homo sapiens)

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ACTC1TTNPPP2N2BN2ATKZ-discM-bandPEVKHypertrophic signallingNPR1Ca2+Protein Quality ControlObscurinPRKAR1ANFATGTPPKC:PRKCGAnkrd23pGCFHL-1NOSRFAnkrd1TTNsGCET-1(EDN1)T-CapPRKACBERK2PRKACAMYPNPKCaRASMLPN2BPKA:PRKAR2BCaMK21PRKACGN2BAAnkrd2PKGPKA:PRKAR1BcGMPMURF2MyBP-CNbr1cAMPCalpain-1CRYABp62ATPMDM2MURF1PKC:PRKCBFHL-2PKA:PRKAR2AMDM2AngII(AGTR2)FHL-2MEK11MEK2RAF1ACTC1GPCRPLCbetaAR2betaAR1adenylyl cyclase


Description

Cardiac titin phosphorylation and its involvement in Protein Quality Control pathways as well as Hypertrophic Signalling.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Linke WA, Hamdani N; ''Gigantic business: titin properties and function through thick and thin.''; Circ Res, 2014 PubMed Europe PMC Scholia
  2. Linke, WA, Krüger, Martina; ''The giant protein titin: a regulatory node that integrates myocyte signaling pathways.''; J Biol Chem, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128794view01:41, 22 February 2024EweitzModified description
128793view01:41, 22 February 2024EweitzOntology Term : 'cardiac muscle cell' added !
128792view01:40, 22 February 2024EweitzModified title
128787view00:22, 22 February 2024EweitzStandardize nomenclature, case
125919view05:55, 20 March 2023EgonwUpdated two UniProt data sources
125904view14:13, 17 March 2023JmillanacostaFixed citation (encoded characters)
125901view11:17, 17 March 2023SnnrrdcOntology Term : 'signaling pathway' added !
125900view11:17, 17 March 2023SnnrrdcOntology Term : 'Ras superfamily mediated signaling pathway' added !
125899view11:13, 17 March 2023Isa LeendersModified description
125898view11:09, 17 March 2023Isa LeendersModified title
125897view11:05, 17 March 2023Bep3.14eIncorrect TTN node was removed.
125896view11:04, 17 March 2023Bep3.14eTitle was changed to a more descriptive one. Gene names and Node labels were corrected. Layout was changed for visual clarification. Arrow/line types and styles were updated.
125866view14:16, 14 March 2023Bep3.14eUnused data nodes were removed and a pathway title was added.
125865view14:13, 14 March 2023Bep3.14eNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTC1GeneProductENSG00000159251 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
AngII(AGTR2)GeneProductP50052 (Uniprot-TrEMBL)
Ankrd1GeneProductENSG00000148677 (Ensembl)
Ankrd23GeneProductENSG00000163126 (Ensembl)
Ankrd2GeneProductENSG00000165887 (Ensembl)
CRYABGeneProductP02511 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CaMK2GeneProductENSG00000070808 (Ensembl)
Calpain-1GeneProductQ3TB79 (Uniprot-SwissProt)
ERK2GeneProductENSG00000100030 (Ensembl)
ET-1(EDN1)GeneProductP05305 (Uniprot-TrEMBL)
FHL-1GeneProductQ13642 (Uniprot-TrEMBL)
FHL-2GeneProductQ14192 (Uniprot-TrEMBL)
GPCRGeneProductQ8TDU1 (Uniprot-TrEMBL)
GTPMetaboliteCHEBI:37565 (ChEBI)
Hypertrophic signallingPathway
MDM2GeneProductENSG00000135679 (Ensembl)
MDM2GeneProductQ00987 (Uniprot-TrEMBL)
MEK1GeneProductQ02750 (Uniprot-TrEMBL)
MEK2GeneProductP36507 (Uniprot-TrEMBL)
MLPGeneProductENSG00000129170 (Ensembl)
MURF1GeneProductQ969Q1 (Uniprot-TrEMBL)
MURF2GeneProductQ9BYV6 (Uniprot-TrEMBL)
MYPNGeneProductENSG00000138347 (Ensembl)
MyBP-CGeneProductQ14896 (Uniprot-SwissProt)
N2BAGeneProductP20929 (Uniprot-SwissProt)
N2BGeneProductP20933 (Uniprot-SwissProt)
NFATGeneProductO94916 (Uniprot-TrEMBL)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR1GeneProductP16066 (Uniprot-SwissProt)
Nbr1GeneProductQ14596 (Uniprot-TrEMBL)
ObscurinGeneProductH3BQA7 (Uniprot-SwissProt)
PKA:PRKAR1BGeneProductENSG00000188191 (Ensembl)
PKA:PRKAR2AGeneProductENSG00000114302 (Ensembl)
PKA:PRKAR2BGeneProductENSG00000005249 (Ensembl)
PKC:PRKCBGeneProductENSG00000166501 (Ensembl)
PKC:PRKCGGeneProductENSG00000126583 (Ensembl)
PKCaGeneProductENSG00000154229 (Ensembl)
PKGGeneProductQ13237 (Uniprot-TrEMBL)
PLCGeneProductENSG00000139151 (Ensembl)
PRKACAGeneProductP17612 (Uniprot-TrEMBL)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
Protein Quality ControlPathway
RAF1GeneProductP04049 (Uniprot-TrEMBL)
RASGeneProductP01114 (Uniprot-TrEMBL)
SRFGeneProductP11831 (Uniprot-TrEMBL)
T-CapGeneProductENSG00000173991 (Ensembl)
TTNGeneProductENSG00000155657 (Ensembl)
adenylyl cyclaseGeneProductQ59FG4 (Uniprot-TrEMBL)
betaAR1GeneProductP08588 (Uniprot-TrEMBL)
betaAR2GeneProductP07550 (Uniprot-TrEMBL)
cAMPMetaboliteCHEBI:17489 (ChEBI)
cGMPMetaboliteCHEBI:16356 (ChEBI)
p62GeneProductP37198 (Uniprot-TrEMBL)
pGCGeneProductENSG00000138867 (Ensembl)
sGCGeneProductENSG00000061918 (Ensembl)

Annotated Interactions

No annotated interactions

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