IL-26 signaling pathways (Homo sapiens)

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InhibitionAsthmaDegradationLEGENDMacrophage differentiationin RAW264.7 cells Suppression of EGFR-TKI-induced endoplasmic reticulum (ER) stressIL-10R2IL-20R1JAK210PNos2Cd8013Tnf1313TGFB1SMAD21212CASP312cleaved CASP3BAX1212IL6IL1012TNF12MMP912ACTA212Supresses apoptosis and promotes liver fibrosis of hepatic stellate cells (HSCs) 12MAPK3T1833-5, 7, 8T202MAPK13, 5, 7, 8Y204Y185MAPK8T1833, 5, 7, 8, 11Y185MAPK14T180Y1823, 7, 8STAT1Y701Y7053, 5-8, 10S727COX2MMP133IL6Induces proinflammatory effects in human articularchondrocytes (HACs), keratinocytes and colonic subepithelial myofibroblasts/adenocarcinoma 3, 8NFKBIAP7STAT34-8, 10Y705S727TNFSF117PTPN67TNFSF11 7TRAP7OCSTAMP7ATP6V0D27CTSK7 NFATC1DCSTAMP77Involved in osteoclastogenesis in RA (rheumatoid arthritis) fibroblast-like synoviocytes (FLSs) IL-2611EPHA3 AKT1118, 11S473DDIT3 11IL1BIL611TNF1IL17A1RORC1IL-26 overexpressioninduces proinflammation in asthmatic patients RELAP8, 13CXCL85, 6, 8MAPK9T1835, 8Y185TNF5Ccl3Mpo9Mmp99Mmp29Tnf99Ccl209Cxcl29CsfFacilitates innate immune response in bronchoalveolar space of mice9JAK1P10TYK210PIL810IL1BCCL201010IL3310DEFB4Il410Il131010Il3310Il17aCcl2010Involved in human epidermal keratinocytes 10Atopic dermatitisIL85 SOCS35CXCL82IL1B2TNF2STAT12STAT32CSF2MPO22Involved in antibacterial host defenseIL10ICAM166LigandProteinmRNARegulation of protein/gene expressionLeads to multple reactionsProteinPPhosphorylationGene/ProteinUpregulationDownregulationInduces antiapoptosis and tumor growth in murine and human TNBC cellsPIK3CA8PRELAP8, 13Il613Il1013IL-26Gene/ProteinLeads to EPHA3 mediated signalingReceptor 1Receptor 2Liver fibrosisRheumatoid arthritisJUNS733, 8


Description

A comprehensive network map of IL-26 signaling pathway

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Bibliography

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  1. Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, Peng YJ; ''Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway.''; Cells, 2021 PubMed Europe PMC Scholia
  2. Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S; ''The role of the novel Th17 cytokine IL-26 in intestinal inflammation.''; Gut, 2009 PubMed Europe PMC Scholia
  3. Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A; ''Expression of Interleukin-26 is upregulated in inflammatory bowel disease.''; World J Gastroenterol, 2017 PubMed Europe PMC Scholia
  4. Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Georen SK, Adner M, Cardell LO, Linden A; ''Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.''; PLoS One, 2017 PubMed Europe PMC Scholia
  5. Zhang X, Xie X, Wang Y, Li W, Lin Z; ''Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-B1/Smad2 signaling pathway.''; Int J Clin Exp Pathol, 2019 PubMed Europe PMC Scholia
  6. Louhaichi S, Mlika M, Hamdi B, Hamzaoui K, Hamzaoui A; ''Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women.''; J Asthma Allergy, 2020 PubMed Europe PMC Scholia
  7. Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, Klauss M, Poth T, Gaida MM; ''The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  8. Lee KA, Kim KW, Kim BM, Won JY, Min HK, Lee DW, Kim HR, Lee SH; ''Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis.''; Arthritis Res Ther, 2019 PubMed Europe PMC Scholia
  9. Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP; ''Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-kB Pathway.''; Cells, 2020 PubMed Europe PMC Scholia
  10. Che KF, Tengvall S, Levanen B, Silverpil E, Smith ME, Awad M, Vikstrom M, Palmberg L, Qvarfordt I, Skold M, Linden A; ''Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization.''; Am J Respir Crit Care Med, 2014 PubMed Europe PMC Scholia
  11. Hor S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H; ''The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  12. Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, Shirakawa Y, Mastuoka S, Iwao N, Aune TM, Dang NH, Kaneko Y, Okumura K, Morimoto C, Ohnuma K; ''IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells.''; Cell Death Dis, 2021 PubMed Europe PMC Scholia
  13. Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, Shishido-Takahashi N, Suga H, Sugaya M, Sato S; ''Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis.''; J Invest Dermatol, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126468view05:51, 2 May 2023EgonwNot mim-conversions
126466view04:46, 2 May 2023EgonwBinding instead?
126456view20:24, 30 April 2023AlexanderPicoremoved more data-coded color
126455view20:21, 30 April 2023AlexanderPicoremoved data-coded color; replaced datanodes in legend
126454view20:05, 30 April 2023AlexanderPicofixed citations
126072view22:35, 31 March 2023KhanspersOntology Term : 'interleukin-6 signaling pathway' added !
126071view22:35, 31 March 2023KhanspersOntology Term : 'signaling pathway' added !
126019view07:49, 27 March 2023Rex D A B
126018view07:48, 27 March 2023Rex D A B
126017view07:43, 27 March 2023Rex D A B
126016view07:25, 27 March 2023Rex D A B
126015view05:31, 27 March 2023Rex D A B
126014view05:25, 27 March 2023Rex D A B
126013view05:19, 27 March 2023Rex D A B
126010view10:29, 26 March 2023EgonwUpdated the UniProt data sources
126009view13:48, 25 March 2023Rex D A B
126008view13:41, 25 March 2023Rex D A B
126007view11:39, 25 March 2023Rex D A BMolecule rearrangement
126006view11:01, 25 March 2023Rex D A BPathway arrangement
126003view07:32, 25 March 2023Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
NFATC1GeneProduct4772 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
ATP6V0D2GeneProduct245972 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CCL20GeneProduct6364 (Entrez Gene)
COX2ProteinP00403 (Uniprot-SwissProt)
CSF2GeneProduct1437 (Entrez Gene)
CTSKGeneProduct1513 (Entrez Gene)
CXCL8GeneProduct3576 (Entrez Gene)
Ccl20GeneProduct20297 (Entrez Gene)
Ccl3ProteinP10855 (Uniprot-SwissProt)
Cd80GeneProduct12519 (Entrez Gene)
CsfGeneProduct12977 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
DCSTAMPGeneProduct81501 (Entrez Gene)
DDIT3 ProteinP35638 (Uniprot-SwissProt)
DEFB4GeneProduct1673 (Entrez Gene)
EPHA3 ProteinP29320 (Uniprot-SwissProt)
Gene/ProteinRna
ICAM1GeneProduct3383 (Entrez Gene)
IL-10R2ProteinQ08334 (Uniprot-SwissProt)
IL-20R1ProteinQ9UHF4 (Uniprot-SwissProt)
IL-26ProteinQ9NPH9 (Uniprot-SwissProt)
IL10GeneProduct3586 (Entrez Gene)
IL17AGeneProduct3605 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1BProteinP01584 (Uniprot-SwissProt)
IL33GeneProduct90865 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6ProteinP05231 (Uniprot-SwissProt)
IL8GeneProduct3576 (Entrez Gene)
IL8ProteinP10145 (Uniprot-SwissProt)
Il10Protein16153 (Entrez Gene)
Il13GeneProduct16163 (Entrez Gene)
Il17aGeneProduct16171 (Entrez Gene)
Il33GeneProduct77125 (Entrez Gene)
Il4GeneProduct16189 (Entrez Gene)
Il6Protein16193 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LigandProtein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP1ProteinP03956 (Uniprot-SwissProt)
MMP9GeneProduct4318 (Entrez Gene)
MPOProteinP05164 (Uniprot-SwissProt)
Mmp2ProteinP33434 (Uniprot-SwissProt)
Mmp9ProteinP41245 (Uniprot-SwissProt)
MpoProteinP11247 (Uniprot-SwissProt)
NFKBIAProtein4792 (Entrez Gene)
Nos2GeneProduct18126 (Entrez Gene)
OCSTAMPGeneProduct74614 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
PTPN6Protein5777 (Entrez Gene)
ProteinProtein
RELAProtein5970 (Entrez Gene)
RELAProteinQ04206 (Uniprot-SwissProt)
RORCGeneProduct6097 (Entrez Gene)
Receptor 1w (WikiPathways)
Receptor 2ProteinQ9UHF4 (Uniprot-SwissProt)
SMAD2ProteinQ15796 (Uniprot-SwissProt)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TGFB1ProteinP01137 (Uniprot-SwissProt)
TNFGeneProduct7124 (Entrez Gene)
TNFProteinP01375 (Uniprot-SwissProt)
TNFSF11 GeneProduct8600 (Entrez Gene)
TNFSF11Protein8600 (Entrez Gene)
TRAPGeneProduct100187907 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
cleaved CASP3GeneProduct836 (Entrez Gene)
mRNARna

Annotated Interactions

No annotated interactions

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