IL-26 signaling pathways (Homo sapiens)

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AsthmaSuppression of EGFR-TKI-induced endoplasmic reticulum (ER) stressInhibitionMacrophage differentiationin RAW264.7 cells LEGENDIL-26 exacerbates liver fibrosis by promoting the proliferation and activation of hepatic stellate cellsNUIL10R2IL20R1JAK213PNos28Cd80Tnf8TGFB185SMAD2CASP355cleaved CASP35BAXIL655IL10TNF55MMP9ACTA255Supresses apoptosis and promotes liver fibrosis of hepatic stellate cells (HSCs) MAPK3T1833, 4, 6, 10, 12MAPK1T202Y2043, 4, 6, 10Y185MAPK8T1833, 4, 6, 10, 11Y185MAPK14Y182T1803, 6, 10STAT13, 4, 6, 7, 10...Y701S727Y705COX210MMP110IL6Induces proinflammatory effects in human articularchondrocytes (HACs), keratinocytes and colonic subepithelial myofibroblasts/adenocarcinoma 3, 10NFKBIAP6STAT3Y7053, 4, 6, 7, 12...S727TNFSF11 TRAP6OCSTAMP6ATP6V0D26CTSK6 NFATC16DCSTAMP6Involved in osteoclastogenesis in RA (rheumatoid arthritis) fibroblast-like synoviocytes (FLSs) 6IL26EPHA3 11AKT111S4733, 11DDIT3 11IL1B2IL62TNFIL17A22RORCIL-26 overexpressioninduces proinflammation in asthmatic patients 2RELACXCL8P3, 83, 4, 7MAPK93, 4T183Y185TNF4Ccl31Mpo1Mmp91Mmp21Tnf1Ccl20Cxcl211Csf1Facilitates innate immune response in bronchoalveolar space of miceJAK113PTYK213PIL813IL1BCCL201313IL3313DEFB413Il413Il1313Il3313Il17aCcl201313Involved in human epidermal keratinocytes Atopic dermatitisIL8 SOCS344CXCL8IL1B9TNF9STAT199STAT3CSF29MPO9Involved in antibacterial host defense9IL107ICAM17LigandProteinmRNARegulation of protein/gene expressionLeads to multple reactionsProteinPPhosphorylation site modificationGene/ProteinUpregulationDownregulationInduces antiapoptosis and tumor growth in murine and human TNBC cellsPIK3CAP3RELAP3, 8Il68Il108IL26Gene/ProteinLeads to EPHA3 mediated signalingReceptor 1Receptor 2Liver fibrosisRheumatoid arthritisJUNS733, 10CYNUCYTranslocationCytoplasmCytoplasm


Description

A comprehensive network map of IL-26 signaling pathway

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Bibliography

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  1. Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, Peng YJ; ''Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway.''; Cells, 2021 PubMed Europe PMC Scholia
  2. Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S; ''The role of the novel Th17 cytokine IL-26 in intestinal inflammation.''; Gut, 2009 PubMed Europe PMC Scholia
  3. Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A; ''Expression of Interleukin-26 is upregulated in inflammatory bowel disease.''; World J Gastroenterol, 2017 PubMed Europe PMC Scholia
  4. Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Georen SK, Adner M, Cardell LO, Linden A; ''Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.''; PLoS One, 2017 PubMed Europe PMC Scholia
  5. Zhang X, Xie X, Wang Y, Li W, Lin Z; ''Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-B1/Smad2 signaling pathway.''; Int J Clin Exp Pathol, 2019 PubMed Europe PMC Scholia
  6. Louhaichi S, Mlika M, Hamdi B, Hamzaoui K, Hamzaoui A; ''Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women.''; J Asthma Allergy, 2020 PubMed Europe PMC Scholia
  7. Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, Klauss M, Poth T, Gaida MM; ''The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  8. Lee KA, Kim KW, Kim BM, Won JY, Min HK, Lee DW, Kim HR, Lee SH; ''Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis.''; Arthritis Res Ther, 2019 PubMed Europe PMC Scholia
  9. Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP; ''Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-kB Pathway.''; Cells, 2020 PubMed Europe PMC Scholia
  10. Che KF, Tengvall S, Levanen B, Silverpil E, Smith ME, Awad M, Vikstrom M, Palmberg L, Qvarfordt I, Skold M, Linden A; ''Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization.''; Am J Respir Crit Care Med, 2014 PubMed Europe PMC Scholia
  11. Hor S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H; ''The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  12. Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, Shirakawa Y, Mastuoka S, Iwao N, Aune TM, Dang NH, Kaneko Y, Okumura K, Morimoto C, Ohnuma K; ''IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells.''; Cell Death Dis, 2021 PubMed Europe PMC Scholia
  13. Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, Shishido-Takahashi N, Suga H, Sugaya M, Sato S; ''Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis.''; J Invest Dermatol, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126468view05:51, 2 May 2023EgonwNot mim-conversions
126466view04:46, 2 May 2023EgonwBinding instead?
126456view20:24, 30 April 2023AlexanderPicoremoved more data-coded color
126455view20:21, 30 April 2023AlexanderPicoremoved data-coded color; replaced datanodes in legend
126454view20:05, 30 April 2023AlexanderPicofixed citations
126072view22:35, 31 March 2023KhanspersOntology Term : 'interleukin-6 signaling pathway' added !
126071view22:35, 31 March 2023KhanspersOntology Term : 'signaling pathway' added !
126019view07:49, 27 March 2023Rex D A B
126018view07:48, 27 March 2023Rex D A B
126017view07:43, 27 March 2023Rex D A B
126016view07:25, 27 March 2023Rex D A B
126015view05:31, 27 March 2023Rex D A B
126014view05:25, 27 March 2023Rex D A B
126013view05:19, 27 March 2023Rex D A B
126010view10:29, 26 March 2023EgonwUpdated the UniProt data sources
126009view13:48, 25 March 2023Rex D A B
126008view13:41, 25 March 2023Rex D A B
126007view11:39, 25 March 2023Rex D A BMolecule rearrangement
126006view11:01, 25 March 2023Rex D A BPathway arrangement
126003view07:32, 25 March 2023Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
NFATC1GeneProduct4772 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
ATP6V0D2GeneProduct245972 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CCL20GeneProduct6364 (Entrez Gene)
COX2ProteinP00403 (Uniprot-SwissProt)
CSF2GeneProduct1437 (Entrez Gene)
CTSKGeneProduct1513 (Entrez Gene)
CXCL8GeneProduct3576 (Entrez Gene)
Ccl20GeneProduct20297 (Entrez Gene)
Ccl3ProteinP10855 (Uniprot-SwissProt)
Cd80GeneProduct12519 (Entrez Gene)
CsfGeneProduct12977 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
DCSTAMPGeneProduct81501 (Entrez Gene)
DDIT3 ProteinP35638 (Uniprot-SwissProt)
DEFB4GeneProduct1673 (Entrez Gene)
EPHA3 ProteinP29320 (Uniprot-SwissProt)
Gene/ProteinRna
ICAM1GeneProduct3383 (Entrez Gene)
IL10GeneProduct3586 (Entrez Gene)
IL10R2ProteinQ08334 (Uniprot-SwissProt)
IL17AGeneProduct3605 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1BProteinP01584 (Uniprot-SwissProt)
IL20R1ProteinQ9UHF4 (Uniprot-SwissProt)
IL26ProteinQ9NPH9 (Uniprot-SwissProt)
IL33GeneProduct90865 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6ProteinP05231 (Uniprot-SwissProt)
IL8GeneProduct3576 (Entrez Gene)
IL8ProteinP10145 (Uniprot-SwissProt)
Il10Protein16153 (Entrez Gene)
Il13GeneProduct16163 (Entrez Gene)
Il17aGeneProduct16171 (Entrez Gene)
Il33GeneProduct77125 (Entrez Gene)
Il4GeneProduct16189 (Entrez Gene)
Il6Protein16193 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LigandProtein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP1ProteinP03956 (Uniprot-SwissProt)
MMP9GeneProduct4318 (Entrez Gene)
MPOProteinP05164 (Uniprot-SwissProt)
Mmp2ProteinP33434 (Uniprot-SwissProt)
Mmp9ProteinP41245 (Uniprot-SwissProt)
MpoProteinP11247 (Uniprot-SwissProt)
NFKBIAProtein4792 (Entrez Gene)
Nos2GeneProduct18126 (Entrez Gene)
OCSTAMPGeneProduct74614 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
ProteinProtein
RELAProtein5970 (Entrez Gene)
RELAProteinQ04206 (Uniprot-SwissProt)
RORCGeneProduct6097 (Entrez Gene)
Receptor 1w (WikiPathways)
Receptor 2ProteinQ9UHF4 (Uniprot-SwissProt)
SMAD2ProteinQ15796 (Uniprot-SwissProt)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TGFB1ProteinP01137 (Uniprot-SwissProt)
TNFGeneProduct7124 (Entrez Gene)
TNFProteinP01375 (Uniprot-SwissProt)
TNFSF11 GeneProduct8600 (Entrez Gene)
TRAPGeneProduct100187907 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
cleaved CASP3GeneProduct836 (Entrez Gene)
mRNARna

Annotated Interactions

No annotated interactions

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