Macrophage-stimulating protein (MSP) signaling (Homo sapiens)

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Description

A network map of macrophage-stimulating protein (MSP) signaling

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Ontology Terms

Bibliography

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Thobe MN, Gurusamy D, Pathrose P, Waltz SE; ''The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells.''; Oncogene, 2010 PubMed Europe PMC Scholia
Wei X, Hao L, Ni S, Liu Q, Xu J, Correll PH; ''Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
Santoro MM, Gaudino G, Villa-Moruzzi E; ''Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor.''; Biochem J, 2003 PubMed Europe PMC Scholia
Moxley KM, Wang L, Welm AL, Bieniasz M; ''Short-form Ron is a novel determinant of ovarian cancer initiation and progression.''; Genes Cancer, 2016 PubMed Europe PMC Scholia
Yu Q, Wang J, Li T, Xu X, Guo X, Ding S, Zhu L, Zou G, Chen Y, Zhang X; ''RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma.''; Biomed Res Int, 2021 PubMed Europe PMC Scholia
Wang Z, Yang Y, Hu S, He J, Wu Z, Qi Z, Huang M, Liu R, Lin Y, Tan C, Xu M, Zhang Z; ''Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating Î²-catenin/SIX1 signaling pathway in gastric cancer.''; Cell Biol Toxicol, 2021 PubMed Europe PMC Scholia
Zhang J, Sun L, Li W, Wang Y, Li X, Liu Y; ''Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy.''; Biomed Pharmacother, 2019 PubMed Europe PMC Scholia
Danilkovitch A, Skeel A, Leonard EJ; ''Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism.''; Exp Cell Res, 1999 PubMed Europe PMC Scholia
Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SI; ''The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.''; Oncogene, 2015 PubMed Europe PMC Scholia
Chanda D, Li T, Song KH, Kim YH, Sim J, Lee CH, Chiang JY, Choi HS; ''Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
Baird AM, Easty D, Jarzabek M, Shiels L, Soltermann A, Klebe S, Raeppel S, MacDonagh L, Wu C, Griggs K, Kirschner MB, Stanfill B, Nonaka D, Goparaju CM, Murer B, Fennell DA, O'Donnell DM, Barr MP, Mutti L, Reid G, Finn S, Cuffe S, Pass HI, Opitz I, Byrne AT, O'Byrne KJ, Gray SG; ''When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All?''; Front Endocrinol (Lausanne), 2019 PubMed Europe PMC Scholia
Lu T, Wang Z, Prativa S, Xu Y, Wang T, Zhang Y, Yu L, Xu N, Tang J, You W, Chen G, Zhang JH; ''Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d'origine nantais dependent GAB1/Src/Î²-catenin pathway activation in a mouse model.''; J Neurochem, 2019 PubMed Europe PMC Scholia
CÃ´tÃ© M, Miller AD, Liu SL; ''Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
Chanda D, Li J, Oligschlaeger Y, Jeurissen ML, Houben T, Walenbergh SM, Shiri-Sverdlov R, Neumann D; ''MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.''; Exp Mol Med, 2016 PubMed Europe PMC Scholia
Kauder SE, Santell L, Mai E, Wright LY, Luis E, N'Diaye EN, Lutman J, Ratti N, Sa SM, Maun HR, Stefanich E, Gonzalez LC, Graham RR, Diehl L, Faubion WA Jr, Keir ME, Young J, Chaudhuri A, Lazarus RA, Egen JG; ''Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.''; PLoS One, 2013 PubMed Europe PMC Scholia
Iwama A, Yamaguchi N, Suda T; ''STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.''; EMBO J, 1996 PubMed Europe PMC Scholia
Zhao H, Chen MS, Lo YH, Waltz SE, Wang J, Ho PC, Vasiliauskas J, Plattner R, Wang YL, Wang SC; ''The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer.''; Oncogene, 2014 PubMed Europe PMC Scholia
Ma Q, Guin S, Padhye SS, Zhou YQ, Zhang RW, Wang MH; ''Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein.''; Mol Cancer, 2011 PubMed Europe PMC Scholia
Danilkovitch A, Donley S, Skeel A, Leonard EJ; ''Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
Wilson CB, Ray M, Lutz M, Sharda D, Xu J, Hankey PA; ''The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity.''; J Immunol, 2008 PubMed Europe PMC Scholia
Gunella G, Bardelli C, Amoruso A, Viano I, Balbo P, Brunelleschi S; ''Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release andNF-kappaB pathway.''; Br J Pharmacol, 2006 PubMed Europe PMC Scholia
Jeong BC, Oh SH, Lee MN, Koh JT; ''Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway.''; J Bone Metab, 2020 PubMed Europe PMC Scholia
Park JS, Choi HI, Kim DH, Kim CS, Bae EH, Ma SK, Kim SW; ''RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells.''; Int J Mol Sci, 2019 PubMed Europe PMC Scholia
Chaudhuri A, Wilson NS, Yang B, Paler Martinez A, Liu J, Zhu C, Bricker N, Couto S, Modrusan Z, French D, Cupp J, Ashkenazi A; ''Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages.''; Immunol Cell Biol, 2013 PubMed Europe PMC Scholia
Ling Y, Kuang Y, Chen LL, Lao WF, Zhu YR, Wang LQ, Wang D; ''A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells.''; Oncotarget, 2017 PubMed Europe PMC Scholia
Tsutsui S, Noorbakhsh F, Sullivan A, Henderson AJ, Warren K, Toney-Earley K, Waltz SE, Power C; ''RON-regulated innate immunity is protective in an animal model of multiple sclerosis.''; Ann Neurol, 2005 PubMed Europe PMC Scholia
Faham N, Zhao L, Welm AL; ''mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential.''; NPJ Breast Cancer, 2018 PubMed Europe PMC Scholia
Zhang K, Yao HP, Wang MH; ''Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility.''; Carcinogenesis, 2008 PubMed Europe PMC Scholia
Cunha S, Lin YC, Goossen EA, DeVette CI, Albertella MR, Thomson S, Mulvihill MJ, Welm AL; ''The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming.''; Cell Rep, 2014 PubMed Europe PMC Scholia
Ganesan R, Kolumam GA, Lin SJ, Xie MH, Santell L, Wu TD, Lazarus RA, Chaudhuri A, Kirchhofer D; ''Proteolytic activation of pro-macrophage-stimulating protein by hepsin.''; Mol Cancer Res, 2011 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
129512	view	15:21, 3 May 2024	Ash iyer	Data nodes annotated - improper annotation ids
129458	view	01:01, 23 April 2024	Eweitz	Modified title
128417	view	13:53, 4 February 2024	Eweitz	Modified description
128416	view	13:29, 4 February 2024	Eweitz	Fix typo, tailor node dimensions to fit text, standardize case
128415	view	13:17, 4 February 2024	Eweitz	Modified title
127177	view	08:44, 9 August 2023	Egonw	Marked diseases as @Type="Other"
126207	view	10:20, 15 April 2023	Egonw	Not a mim-conversion
126206	view	23:35, 14 April 2023	AlexanderPico	removed xrefs with id="0"
126160	view	15:44, 11 April 2023	Ash iyer	Ontology Term : 'ovarian disease' added !
126158	view	15:11, 11 April 2023	Ash iyer	Ontology Term : 'cancer pathway' added !
126157	view	15:09, 11 April 2023	Ash iyer	Ontology Term : 'breast cancer pathway' added !
126156	view	15:08, 11 April 2023	Ash iyer	Conversion of datanodes to graphical elements
126155	view	15:02, 11 April 2023	Ash iyer	Conversion of datanodes to grpahical elements
126151	view	14:49, 11 April 2023	Ash iyer	Re-annotation of nodes for missing cross-reference
126087	view	09:01, 4 April 2023	Rex D A B	New pathway

External references

DataNodes

View all...

Name	Type	Database reference
HSPB1	Protein	3315 (Entrez Gene)
IFNB1	GeneProduct	3456 (Entrez Gene)
MST1 p.R703C	Protein	NP_066278 (RefSeq)
MST1R	Protein	4486 (Entrez Gene)
ABL1	Protein	25 (Entrez Gene)
ACACA	Protein	31 (Entrez Gene)
ACO	GeneProduct	50681 (Entrez Gene)
ACTA2	Protein	59 (Entrez Gene)
AKT1	Protein	207 (Entrez Gene)
ALP	GeneProduct	11691 (Entrez Gene)
BGLAP	GeneProduct	12096 (Entrez Gene)
BSP	GeneProduct	103993 (Entrez Gene)
CCL2	Protein	20296 (Entrez Gene)
CDH1	Protein	999 (Entrez Gene)
CDH2	Protein	1000 (Entrez Gene)
CLDN1	Protein	9076 (Entrez Gene)
CLDN5	Protein	12741 (Entrez Gene)
COL4A1	Protein	1282 (Entrez Gene)
CPT1A	GeneProduct	12894 (Entrez Gene)
CRKL	Protein	1399 (Entrez Gene)
CSF2	Protein	12981 (Entrez Gene)
CSF3	Protein	12985 (Entrez Gene)
CTNNB1	Protein	12387 (Entrez Gene)
CTNNB1	Protein	1499 (Entrez Gene)
CXCL10	Protein	15945 (Entrez Gene)
CXCL1	Protein	2919 (Entrez Gene)
CXCL2	Protein	20310 (Entrez Gene)
CXCL5	Protein	6374 (Entrez Gene)
CXCL8	Protein	3576 (Entrez Gene)
DEK	Protein	110052 (Entrez Gene)
DUSP1	Protein	19252 (Entrez Gene)
DUSP4	Protein	1846 (Entrez Gene)
DUSP6	Protein	67603 (Entrez Gene)
EGR1	Protein	13653 (Entrez Gene)
ELK1	Protein	2002 (Entrez Gene)
Endometrial cancer	Other
FGFR1	Protein	2260 (Entrez Gene)
FN1	Protein	2335 (Entrez Gene)
FOS	Protein	14281 (Entrez Gene)
FZD1	Protein	8321 (Entrez Gene)
GAB1	Protein	2549 (Entrez Gene)
GLUT1	Protein	6513 (Entrez Gene)
GRB2	Protein	2885 (Entrez Gene)
GSK3B	Protein	2932 (Entrez Gene)
Gastric cancer	Other
HK2	Protein	3099 (Entrez Gene)
IGF1R	Protein	3480 (Entrez Gene)
IL10	Protein	16153 (Entrez Gene)
IL10	Protein	3586 (Entrez Gene)
IL1B	Protein	3553 (Entrez Gene)
IL6	Protein	16193 (Entrez Gene)
ITGB1	Protein	3688 (Entrez Gene)
JUN	Protein	3725 (Entrez Gene)
LDHA	Protein	3939 (Entrez Gene)
Ligand	Protein
Ligand other than MST1	Protein	7480 (Entrez Gene)
MAP2K1	Protein	5604 (Entrez Gene)
MAP2K2	Protein	5605 (Entrez Gene)
MAPK14	Protein	1432 (Entrez Gene)
MAPK1	Protein	5594 (Entrez Gene)
MAPK3	Protein	5595 (Entrez Gene)
MAPK8	Protein	5599 (Entrez Gene)
MAPK9	Protein	5601 (Entrez Gene)
MBD4	Protein	4486 (Entrez Gene)
MMP9	GeneProduct	4318 (Entrez Gene)
MST1	Protein	4485 (Entrez Gene)
MST1R Î” 165	Protein	4486 (Entrez Gene)
MST1R	Protein	4486 (Entrez Gene)
MTOR	Protein	2475 (Entrez Gene)
Mesothelioma	Other
NDRG1	Protein	10397 (Entrez Gene)
NFKB1	Protein	4790 (Entrez Gene)
NR0B2	Protein	23957 (Entrez Gene)
NR4A1	Protein	15370 (Entrez Gene)
OCLN	Protein	18260 (Entrez Gene)
PARP1	Protein	142 (Entrez Gene)
PCNA	Protein	5111 (Entrez Gene)
PDCD4	Protein	27250 (Entrez Gene)
PDGFRA	Protein	5156 (Entrez Gene)
PDGFRB	Protein	5159 (Entrez Gene)
PDPK1	Protein	5170 (Entrez Gene)
PIK3CA	Protein	207 (Entrez Gene)
PIK3R1	Protein	5295 (Entrez Gene)
PLCG1	Protein	5335 (Entrez Gene)
PPARGC1A	GeneProduct	19017 (Entrez Gene)
PRKAA2	Protein	5563 (Entrez Gene)
PRKCB	Protein	5579 (Entrez Gene)
PTEN	Protein	5728 (Entrez Gene)
PTK2	Protein	5747 (Entrez Gene)
Pancreatic cancer	Other
Prostate cancer	Other
Protein	Protein
Protein/ Gene	Protein
RAF1	Protein	5894 (Entrez Gene)
RELA	Protein	5970 (Entrez Gene)
RPS6	Protein	6194 (Entrez Gene)
RPS6KA1	Protein	6195 (Entrez Gene)
RPS6KA3	Protein	6197 (Entrez Gene)
RPS6KA4	Protein	8986 (Entrez Gene)
RPS6KA5	Protein	9252 (Entrez Gene)
RPS6KB1	Protein	6198 (Entrez Gene)
Receptor	Other
SHC1	Protein	6464 (Entrez Gene)
SIP1	GeneProduct	9839 (Entrez Gene)
SIX1	Protein	6495 (Entrez Gene)
SLUG	GeneProduct	20583 (Entrez Gene)
SMAD1	Protein	17125 (Entrez Gene)
SMAD1	Protein	4086 (Entrez Gene)
SMAD2	Protein	4087 (Entrez Gene)
SMAD3	Protein	4088 (Entrez Gene)
SMAD4	Protein	4091 (Entrez Gene)
SMAD5	Protein	17129 (Entrez Gene)
SMAD5	Protein	4090 (Entrez Gene)
SMAD9	Protein	4093 (Entrez Gene)
SMAD9	Protein	55994 (Entrez Gene)
SOCS1	Protein	12703 (Entrez Gene)
SOCS3	Protein	12702 (Entrez Gene)
SP7	GeneProduct	170574 (Entrez Gene)
SRC	Protein	6714 (Entrez Gene)
STAT1	Protein	17125 (Entrez Gene)
STAT3	Protein	20848 (Entrez Gene)
STAT3	Protein	4088 (Entrez Gene)
TGFB1	Protein	7040 (Entrez Gene)
TJP1	Protein	21872 (Entrez Gene)
TNF	Protein	7124 (Entrez Gene)
TP53	Protein	7157 (Entrez Gene)
VEGFA	GeneProduct	7422 (Entrez Gene)
VEGFR1	Protein	2321 (Entrez Gene)
VEGFR2	Protein	3791 (Entrez Gene)
VIM	Protein	7431 (Entrez Gene)
WNT10B	Protein	7480 (Entrez Gene)
ZEB1	GeneProduct	21417 (Entrez Gene)
ZEB2	Protein	9839 (Entrez Gene)
mRNA	Rna
rh-MST1	GeneProduct	4485 (Entrez Gene)
sf-MST1R	Protein	4486 (Entrez Gene)

Annotated Interactions

No annotated interactions

Macrophage-stimulating protein (MSP) signaling (Homo sapiens)

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Description

Try the New WikiPathways

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Ontology Terms

Bibliography

History

External references

DataNodes

Annotated Interactions

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@@ Line 2: / Line 2: @@
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    <DataNode TextLabel="AKT1" GraphId="ff2f5" Type="Protein">
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      </bp:openControlledVocabulary>
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-      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d'origine nantais dependent GAB1/Src/Î²-catenin pathway activation in a mouse model.</bp:TITLE>
-      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Neurochem</bp:SOURCE>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lu T</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang T</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang Y</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yu L</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xu N</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang J</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">You W</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen G</bp:AUTHORS>
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-    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d56">
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-      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages.</bp:TITLE>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chaudhuri A</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bricker N</bp:AUTHORS>
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-      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer.</bp:TITLE>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang J</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ho PC</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vasiliauskas J</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Plattner R</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang YL</bp:AUTHORS>
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-    </bp:PublicationXref>
-    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d84">
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-      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity.</bp:TITLE>
-      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Immunol</bp:SOURCE>
-      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wilson CB</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ray M</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lutz M</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xu J</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hankey PA</bp:AUTHORS>
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@@ Line 3,979: / Line 3,829: @@
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+     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ff5">
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy.</bp:TITLE>
+       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma.</bp:TITLE>
-       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biomed Pharmacother</bp:SOURCE>
+       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biomed Res Int</bp:SOURCE>
-       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang J</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yu Q</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sun L</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang J</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li W</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li T</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang Y</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xu X</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li X</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guo X</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu Y</bp:AUTHORS>
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+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhu L</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zou G</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen Y</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang X</bp:AUTHORS>
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@@ Line 4,016: / Line 3,865: @@
        <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang Z</bp:AUTHORS>
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells.</bp:TITLE>
+       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy.</bp:TITLE>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Choi HI</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim CS</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bae EH</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ma SK</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu Y</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim SW</bp:AUTHORS>
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells.</bp:TITLE>
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d&amp;apos;Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway.</bp:TITLE>
+       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.</bp:TITLE>
-       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Bone Metab</bp:SOURCE>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee MN</bp:AUTHORS>
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming.</bp:TITLE>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lin YC</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang Z</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goossen EA</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prativa S</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DeVette CI</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Albertella MR</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thomson S</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mulvihill MJ</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Welm AL</bp:AUTHORS>
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells.</bp:TITLE>
+       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence.</bp:TITLE>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ling Y</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kuang Y</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen LL</bp:AUTHORS>
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.</bp:TITLE>
+       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.</bp:TITLE>
-       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
+       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Exp Mol Med</bp:SOURCE>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li T</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song KH</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim YH</bp:AUTHORS>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sim J</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee CH</bp:AUTHORS>
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-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chiang JY</bp:AUTHORS>
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-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity.</bp:TITLE>
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-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ni S</bp:AUTHORS>
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