TAR syndrome (Homo sapiens)

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2612, 33143, 95, 13128, 10121, 20, 24, 257, 238, 103, 9333, 92719, 201, 21, 24, 25, 298, 1011417228, 103, 9317, 2317113048, 10283, 92728, 101, 24, 25153118, 32416615Maintaining normal cholesterol levelsOn CD8+ T-cellsE2 dependentNucleoside diphosphate derivativesFormation of proapoptotic isoformsAngiogenesisStabilizingIn activated T-cellsLys-48 and/or Lys-63 linkedMulti drug resistanceHydrolysisDuring bacterial infectionAntigenIn activated NK cellsReceptor for collagenIn immune privileged sitesOn activated CD4+ T-cellsDNATraps EJC onto spliced mRNARequired for pre-mRNA as component of the splicosomeNK cell cytotoxic activityVoltage dependent anion channel required foracidification and functions of the Golgi apparatusthat may function in counter-ion conductance SubstratesProgressivelyMost probably non-functionalIn response to sensing of non-self RNARNA polymeraseCostimulatory signals toactivated/memory CD8+ T-cellsSplicing modulationType I IFNsNF-κBOn NK cellsEJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNADuring viral infectionSensesReceptor for classical andnon-classical MHCI moleculesCluster proteins, modulate theirtrafficking and activityT-cell exhaustionPersistentBidirectional signallingMembrane protrusion and elongationon the peroxisomal surfacechr1:145,394,955In the brush border of the proximal tubule of the kidneyIn HSCsFunction unknownTXNIPDNM1LHLA-GPeroxisome divisionGNRHR2Proteasomal degradation of DDIT4DNAMAGOHFLT3MTA1ANKRD35HLA-CNHERF1Lymphocyte developmentPIAS3LIX1LBRF1CD160SubstrateCOPS5HFE2EGFRANKRD34ABMPRABL3METCFTRSLC26A6STAT3DNAGnRH-IICD247JAK/STAT pathwayCD3NUDT17LCKnon-self RNAIron homeostasisProduction of anti-microbial proteinsand inflammatory cytokinesIFNGPOLR3FTCR signallingCDKN1BPDZK1IP1RNAPDZK1Tumour cell growthPEX11BCollagenHepcidinnon-self dsDNAPI3KRBM8ASteroid hormone signalling pathwayCD28 costimulatory signalingGPR89AHLA-ATXNViral peptideRNF115TBPRIG-I pathwayCCAR2POLR3GCXCR4POLR3GLPOLR3CBCL2L13PDZK1EIF4A3SCARB1SIRT1ITGA10ZFHX3UBE2IRNATNFRSF14POLR3CABCC2Signalling pathwaysMaturation of NK cellsmTORC1PYM1Nonsense mediated decay pathwayPeroxisomal proliferationSUMO1RBM8AMTA1SCCAR2SZFHX3SubstrateUCXCR4METFLT3EGFRUUUUSignalling pathwaysDuring viral infectionHLA-AIn immune privileged sitesFunction unknownFunction unknownCatalysisBindingUbiquitinatedLEGENDInhibitionSumoylatedConversionStimulationUS


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Bibliography

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History

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CompareRevisionActionTimeUserComment
127046view09:38, 26 July 2023FehrhartOntology Term : 'Disease' added !
127045view09:38, 26 July 2023FehrhartOntology Term : 'disease pathway' added !
127044view09:37, 26 July 2023FehrhartModified description
127043view09:30, 26 July 2023Fehrhartcorrections and updates (done)
127042view07:47, 26 July 2023Fehrhartupdate in progress
127041view06:54, 26 July 2023Fehrhartupdate in progress
127029view13:11, 24 July 2023Fehrhartupdate
127028view12:36, 24 July 2023Fehrhartupgrade
127027view12:00, 24 July 2023Fehrhartupgrade
126901view14:14, 30 June 2023JmillanacostaChanged legend interactions and nodes to graphical objects
126849view09:37, 27 June 2023Ewoud
126578view15:20, 4 June 2023Ewoudfiller
126517view15:21, 23 May 2023EwoudNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProductENSG00000023839 (Ensembl)
ANKRD34AGeneProductENSG00000181039 (Ensembl)
ANKRD35GeneProductENSG00000198483 (Ensembl)
BCL2L13GeneProductENSG00000099968 (Ensembl)
BMPMetaboliteCHEBI:60815 (ChEBI)
BRF1GeneProductENSG00000185024 (Ensembl)
CCAR2GeneProductENSG00000158941 (Ensembl)
CD160GeneProductENSG00000117281 (Ensembl)
CD247GeneProductENSG00000198821 (Ensembl)
CD28 costimulatory signalingPathway
CD3GeneProductENSG00000167286 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CFTRGeneProductENSG00000001626 (Ensembl)
COPS5GeneProductENSG00000121022 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
CollagenMetaboliteCHEBI:3815 (ChEBI)
DNAGeneProduct
DNM1LGeneProductENSG00000087470 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4A3GeneProductENSG00000141543 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
GNRHR2GeneProductENSG00000211451 (Ensembl)
GPR89AGeneProductENSG00000117262 (Ensembl)
GnRH-IIMetaboliteCHEBI:80298 (ChEBI)
HFE2GeneProductENSG00000168509 (Ensembl)
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
HepcidinMetaboliteHMDB0259694 (HMDB)
IFNGGeneProductENSG00000111537 (Ensembl)
ITGA10GeneProductENSG00000143127 (Ensembl)
Iron homeostasisPathway
JAK/STAT pathwayPathwaymap04630 (KEGG Pathway)
LCKGeneProductENSG00000182866 (Ensembl)
LIX1LGeneProductENSG00000152022 (Ensembl)
Lymphocyte developmentPathway
MAGOHGeneProductENSG00000162385 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
Maturation of NK cellsPathway
NHERF1GeneProductENSG00000109062 (Ensembl)
NUDT17GeneProductENSG00000186364 (Ensembl)
Nonsense mediated decay pathwayPathway
PDZK1GeneProductENSG00000174827 (Ensembl)
PDZK1IP1GeneProductENSG00000162366 (Ensembl)
PEX11BGeneProductENSG00000131779 (Ensembl)
PI3KMetaboliteCHEBI:89296 (ChEBI)
PIAS3GeneProductENSG00000131788 (Ensembl)
POLR3CGeneProductENSG00000186141 (Ensembl)
POLR3FGeneProductENSG00000132664 (Ensembl)
POLR3GGeneProductENSG00000113356 (Ensembl)
POLR3GLGeneProductENSG00000121851 (Ensembl)
PYM1GeneProductENSG00000170473 (Ensembl)
Peroxisomal proliferationPathway
Peroxisome divisionPathway
Production of anti-microbial proteins and inflammatory cytokinesPathway
Proteasomal degradation of DDIT4Pathway
RABL3GeneProductENSG00000144840 (Ensembl)
RBM8AGeneProductENSG00000131795 (Ensembl)
RIG-I pathwayPathway
RNARna
RNF115GeneProductENSG00000121848 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SLC26A6GeneProductENSG00000225697 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
SUMO1GeneProductENSG00000116030 (Ensembl)
Signalling pathwaysPathway
Steroid hormone signalling pathwayPathway
SubstrateMetabolite
TBPMetaboliteCHEBI:35019 (ChEBI)
TCR signallingPathway
TNFRSF14GeneProductENSG00000157873 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNIPGeneProductENSG00000117289 (Ensembl)
Tumour cell growthPathway
UBE2IGeneProductENSG00000103275 (Ensembl)
Viral peptideMetabolite
ZFHX3GeneProductENSG00000140836 (Ensembl)
mTORC1ProteinF5H479 (Uniprot-TrEMBL)
non-self RNARna
non-self dsDNAGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5362"
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