Androgen biosynthesis (Homo sapiens)

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12111Fetal adrenal glands, placenta and peripheral metabolism in pregnancy17alpha-hydroxy-alloprogesteroneSRD5A211-keto-testosteroneSRD5A15alpha-Androstane-3,11,17-trioneHSD3B117alpha-hydroxyprogesterone11beta-hydroxyandrosterone11beta-hydroxytestosterone11beta-Hydroxyandrostenedione5alpha-Androstan-3alpha,16alpha,17beta-triol 5beta-DihydrotestosteroneAllopregnanolone5alpha-dihydrotesosterone16alpha-hydroxyprogesterone11beta-hydroxyandrostan-3,17-dione AdrenosteroneHSD17B2Androstenedione5alpha-androstane-3alpha,17beta-diolSULT2A111-KetodihydrotestosteroneDehydroepiandrosterone5-AndrostenediolCYP3A711-Keto-5beta-dihydrotestosterone5beta-androstanedione5beta-androstan-16alpha-ol-3,17-dione POR5alpha-androstan-16alpha-ol-3,17-dione5alpha-androstanedione5beta-androstane-3alpha,17beta-diol6beta-hydroxytestosteroneSRD5A25beta-androstan-16alpha,17beta-diol-3one Other5alpha-Pregnan-17alpha-ol-3,20-dionePregnenolone5alpha-dihydroprogesteroneEtiocholanoloneAKR1D1HSD11B2Androsterone5beta-Androstane-3,11,17-trioneProgesterone17alpha-hydroxypregnenoloneTestosteroneCYP3A45alpha-androstan-16alpha,17beta-diol-3one5alpha-androstan-11beta,17beta-diol-3oneSTS16alpha-HydroxytestosteroneDHEAS16alpha-HydroxydehydroepiandrosteroneEstriol16alpha-hydroxyestrone3beta,16alpha-Dihydroxy-androstenone sulfate16alpha-hydroxyandrost-4-ene-3,17-dione5beta-Androstan-3alpha,16alpha,17beta-triol 16alpha-Hydroxyetiocholanolone 16alpha-hydroxyandrosterone5beta-Androstan-3alpha,17beta-diol-11-one 11-Ketoetiocholanolone5alpha-Androstan-3alpha,17beta-diol-11-one 11-KetoandrosteroneAKR1D1SRD5A2AKR1C4AKR1C3AKR1C1AKR1C2AKR1C4AKR1C3AKR1C1AKR1C2AKR1C4AKR1C3AKR1C1AKR1C2AKR1C4AKR1C3AKR1C1AKR1C2AKR1C4AKR1C3AKR1C1AKR1C2AKR1C3OtherAKR1C3HSD17B2HSD17B2AKR1C3HSD11B2SRD5A2SRD5A1HSD17B2PORCYP3A4PORCYP17A1PORCYP17A1PORCYP17A1PORCYP17A1STSSRD5A2SRD5A1SRD5A2SRD5A1AKR1D1AKR1D1HSD17B1OtherPORCYP17A1


Description

Androgen metabolism from L Schiffer

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Quality Tags

Ontology Terms

 

Bibliography

  1. Storbeck KH, Bloem LM, Africander D, Schloms L, Swart P, Swart AC; ''11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?''; Mol Cell Endocrinol, 2013 PubMed Europe PMC Scholia
  2. Barnard L, Nikolaou N, Louw C, Schiffer L, Gibson H, Gilligan LC, Gangitano E, Snoep J, Arlt W, Tomlinson JW, Storbeck KH; ''The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1.''; J Steroid Biochem Mol Biol, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127449view17:24, 3 October 2023Khanspersadjusted size of metabolite nodes, adjusted layout, connected interactions
126925view14:24, 6 July 2023EgonwReplaced SwissProt with TrEMBL
126874view11:27, 29 June 2023Conroy lipids
126871view13:25, 28 June 2023Conroy lipidsadd enzymes
126870view12:53, 28 June 2023Conroy lipidsadd enzymes
126869view12:35, 28 June 2023Conroy lipidsmore enzymes
126868view11:51, 28 June 2023Conroy lipidsadd enzymes
126864view08:17, 28 June 2023Conroy lipidsadd enzymes
126863view07:39, 28 June 2023Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
126862view07:38, 28 June 2023Conroy lipidsOntology Term : 'steroid biosynthetic pathway' added !
126853view13:21, 27 June 2023Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
16alpha-hydroxyandrosteroneMetaboliteLMST02020133 (LIPID MAPS)
11-Keto-5beta-dihydrotestosteroneMetaboliteLMST02020127 (LIPID MAPS)
11-KetoandrosteroneMetaboliteLMST02020087 (LIPID MAPS)
11-KetodihydrotestosteroneMetaboliteLMST02020122 (LIPID MAPS)
11-KetoetiocholanoloneMetaboliteLMST02020123 (LIPID MAPS)
11-keto-testosteroneMetaboliteLMST02020120 (LIPID MAPS)
11beta-HydroxyandrostenedioneMetaboliteLMST02020066 (LIPID MAPS)
11beta-hydroxy testosteroneMetaboliteLMST02020124 (LIPID MAPS)
11beta-hydroxyandrostan-3,17-dione MetaboliteLMST02020121 (LIPID MAPS)
11beta-hydroxyandrosteroneMetaboliteLMST02020086 (LIPID MAPS)
16alpha- hydroxyprogesteroneMetaboliteLMST02030182 (LIPID MAPS)
16alpha-HydroxydehydroepiandrosteroneMetaboliteLMST02020064 (LIPID MAPS)
16alpha-HydroxyetiocholanoloneMetaboliteLMST02020132 (LIPID MAPS)
16alpha-HydroxytestosteroneMetaboliteLMST02020125 (LIPID MAPS)
16alpha-hydroxy androst-4-ene-3,17-dioneMetabolite
16alpha-hydroxyestroneMetaboliteLMST02010041 (LIPID MAPS)
17alpha- hydroxypregnenoloneMetaboliteLMST02030089 (LIPID MAPS)
17alpha- hydroxyprogesteroneMetaboliteLMST02030161 (LIPID MAPS)
17alpha-hydroxy- alloprogesteroneMetaboliteLMST02030305 (LIPID MAPS)
3beta,16alpha-Dihydroxy- androstenone sulfateMetaboliteLMST05020022 (LIPID MAPS)
5-AndrostenediolMetaboliteLMST02020005 (LIPID MAPS)
5alpha- androstanedioneMetaboliteLMST02020085 (LIPID MAPS)
5alpha- dihydrotesosteroneMetaboliteLMST02020042 (LIPID MAPS)
5alpha-Androstan- 3alpha,16alpha,17beta-triol MetaboliteLMST02020134 (LIPID MAPS)
5alpha-Androstan- 3alpha,17beta-diol-11-one MetaboliteLMST02020129 (LIPID MAPS)
5alpha-Androstane-3,11,17-trioneMetaboliteLMST02020130 (LIPID MAPS)
5alpha-Pregnan-17alpha-ol-3,20-dioneMetaboliteLMST02030304 (LIPID MAPS)
5alpha-androstan- 11beta,17beta-diol-3oneMetaboliteLMST02020136 (LIPID MAPS)
5alpha-androstan- 16alpha,17beta-diol-3oneMetaboliteLMST02020138 (LIPID MAPS)
5alpha-androstan- 16alpha-ol-3,17-dioneMetaboliteLMST02020141 (LIPID MAPS)
5alpha-androstane- 3alpha,17beta-diolMetaboliteLMST02020052 (LIPID MAPS)
5alpha-dihydroprogesteroneMetaboliteLMST02030170 (LIPID MAPS)
5beta- DihydrotestosteroneMetaboliteLMST02020069 (LIPID MAPS)
5beta- androstanedioneMetaboliteLMST02020058 (LIPID MAPS)
5beta-Androstan- 3alpha,16alpha,17beta-triol MetaboliteLMST02020135 (LIPID MAPS)
5beta-Androstan- 3alpha,17beta-diol-11-one MetaboliteLMST02020128 (LIPID MAPS)
5beta-Androstane-3,11,17-trioneMetaboliteLMST02020131 (LIPID MAPS)
5beta-androstan- 16alpha,17beta-diol-3one MetaboliteLMST02020139 (LIPID MAPS)
5beta-androstan- 16alpha-ol-3,17-dione MetaboliteLMST02020140 (LIPID MAPS)
5beta-androstane- 3alpha,17beta-diolMetaboliteLMST02020077 (LIPID MAPS)
6beta-hydroxytestosteroneMetaboliteLMST02020054 (LIPID MAPS)
AKR1C1GeneProductQ04828 (Uniprot-TrEMBL)
AKR1C2GeneProductP52895 (Uniprot-TrEMBL)
AKR1C3GeneProductP42330 (Uniprot-TrEMBL)
AKR1C4GeneProductP17516 (Uniprot-TrEMBL)
AKR1D1GeneProductP51857 (Uniprot-TrEMBL)
AdrenosteroneMetaboliteLMST02020126 (LIPID MAPS)
AllopregnanoloneMetaboliteLMST02030130 (LIPID MAPS)
AndrostenedioneMetaboliteLMST02020007 (LIPID MAPS)
AndrosteroneMetaboliteLMST02020001 (LIPID MAPS)
CYP17A1GeneProductP05093 (Uniprot-TrEMBL)
CYP3A4GeneProductP08684 (Uniprot-TrEMBL)
CYP3A7GeneProductP24462 (Uniprot-TrEMBL)
DHEASMetaboliteLMST05020010 (LIPID MAPS)
DehydroepiandrosteroneMetaboliteLMST02020021 (LIPID MAPS)
EstriolMetaboliteLMST02010003 (LIPID MAPS)
EtiocholanoloneMetaboliteLMST02020059 (LIPID MAPS)
HSD11B2GeneProductP80365 (Uniprot-TrEMBL)
HSD17B1GeneProductP14061 (Uniprot-TrEMBL)
HSD17B2GeneProductP37059 (Uniprot-TrEMBL)
HSD3B1GeneProductP14060 (Uniprot-TrEMBL)
OtherGeneProduct
PORGeneProductP16435 (Uniprot-TrEMBL)
PregnenoloneMetaboliteLMST02030088 (LIPID MAPS)
ProgesteroneMetaboliteLMST02030159 (LIPID MAPS)
SRD5A1GeneProductP18405 (Uniprot-TrEMBL)
SRD5A2GeneProductP31213 (Uniprot-TrEMBL)
STSGeneProductP08842 (Uniprot-TrEMBL)
SULT2A1GeneProductQ06520 (Uniprot-TrEMBL)
TestosteroneMetaboliteLMST02020002 (LIPID MAPS)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
11beta-HydroxyandrostenedioneAdrenosteronemim-conversion69409 (Rhea)
Adrenosterone11-keto-testosteronemim-conversion53485 (Rhea)
DHEAS3beta,16alpha-Dihydroxy- androstenone sulfatemim-conversion47225 (Rhea)
Dehydroepiandrosterone16alpha-Hydroxydehydroepiandrosteronemim-conversion47221 (Rhea)
DehydroepiandrosteroneDHEASmim-conversion51217 (Rhea) EC:2.8.2.2
Pregnenolone17alpha- hydroxypregnenolonemim-conversion50237 (Rhea) EC:1.14.14.19
Progesterone17alpha- hydroxyprogesteronemim-conversion46309 (Rhea) EC:1.14.14.19
Testosterone6beta-hydroxytestosteronemim-conversion46297 (Rhea) EC:1.14.14.1
mim-conversion19874 (Rhea) EC:3.1.6.2
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