ADHD and autism (ASD) pathways (Homo sapiens)
From WikiPathways
(Difference between revisions)
(Fixed two datasources) |
Current revision (23:43, 22 April 2024) (view source) (Modified title) |
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<?xml version="1.0" encoding="UTF-8"?> | <?xml version="1.0" encoding="UTF-8"?> | ||
| - | <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="ADHD and autism (ASD) | + | <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="ADHD and autism (ASD) pathways" Version="20160803" Organism="Homo sapiens"> |
<Comment Source="WikiPathways-description">Pathways associated with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Neurodivergent conditions linked in studies to these pathways include ADHD, autism, dyspraxia, dyslexia, dyscalculia, bipolar disorder, obsessive-compulsive disorder, sensory processing disorders, and Tourette syndrome. This aims to be a highly detailed, comprehensive map of the metabolic pathways associated with these disorders, from indicated input vitamins through synthesis to signaling across the synaptic gap, re-uptake, and catabolism receptors. This pathway is constructed with computational analysis and machine learning in mind. In cases where there is a trade-off between readability and parametric accuracy, parametric accuracy is prioritized. This pathway is inspired by Kimberly Kitzerow and her meta-analysis research on the biomechanisms and pathways behind invisible illnesses. | <Comment Source="WikiPathways-description">Pathways associated with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Neurodivergent conditions linked in studies to these pathways include ADHD, autism, dyspraxia, dyslexia, dyscalculia, bipolar disorder, obsessive-compulsive disorder, sensory processing disorders, and Tourette syndrome. This aims to be a highly detailed, comprehensive map of the metabolic pathways associated with these disorders, from indicated input vitamins through synthesis to signaling across the synaptic gap, re-uptake, and catabolism receptors. This pathway is constructed with computational analysis and machine learning in mind. In cases where there is a trade-off between readability and parametric accuracy, parametric accuracy is prioritized. This pathway is inspired by Kimberly Kitzerow and her meta-analysis research on the biomechanisms and pathways behind invisible illnesses. | ||
https://kimberly102347.com/the-chart/ | https://kimberly102347.com/the-chart/ | ||
| Line 14: | Line 14: | ||
Neuroreceptor Dynamics in the Synaptic Cleft, | Neuroreceptor Dynamics in the Synaptic Cleft, | ||
ROS Reactive Oxygen Stress.</Comment> | ROS Reactive Oxygen Stress.</Comment> | ||
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<Comment>Mo-molybdopterin</Comment> | <Comment>Mo-molybdopterin</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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<Comment>PNG hydrolase, PNGH</Comment> | <Comment>PNG hydrolase, PNGH</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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<Comment>Intestinal-type alkaline phosphatase</Comment> | <Comment>Intestinal-type alkaline phosphatase</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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<Comment>Aldehyde oxidase</Comment> | <Comment>Aldehyde oxidase</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:77657" /> | + | <Xref Database="ChEBI" ID="CHEBI:77657"/> |
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<DataNode TextLabel="TBCD7" GraphId="e0a80" Type="Protein"> | <DataNode TextLabel="TBCD7" GraphId="e0a80" Type="Protein"> | ||
<Comment>Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex</Comment> | <Comment>Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex</Comment> | ||
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<DataNode TextLabel="PDGFRA" GraphId="e73c0" Type="Protein" GroupRef="f510b"> | <DataNode TextLabel="PDGFRA" GraphId="e73c0" Type="Protein" GroupRef="f510b"> | ||
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<DataNode TextLabel="rs701848" GraphId="e73fe" Type="Rna" GroupRef="ce3ec"> | <DataNode TextLabel="rs701848" GraphId="e73fe" Type="Rna" GroupRef="ce3ec"> | ||
<BiopaxRef>bdc</BiopaxRef> | <BiopaxRef>bdc</BiopaxRef> | ||
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<DataNode TextLabel="PLCG1" GraphId="e8eb3" Type="GeneProduct" GroupRef="dbf6d"> | <DataNode TextLabel="PLCG1" GraphId="e8eb3" Type="GeneProduct" GroupRef="dbf6d"> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PA" GraphId="e98ec" Type="Metabolite"> | <DataNode TextLabel="PA" GraphId="e98ec" Type="Metabolite"> | ||
<Comment>4-pyridoxic acid</Comment> | <Comment>4-pyridoxic acid</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="DRD4 VNTR exon III-7r" GraphId="ebf1a" Type="Rna" GroupRef="d6255"> | <DataNode TextLabel="DRD4 VNTR exon III-7r" GraphId="ebf1a" Type="Rna" GroupRef="d6255"> | ||
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<BiopaxRef>a56</BiopaxRef> | <BiopaxRef>a56</BiopaxRef> | ||
<BiopaxRef>ec3</BiopaxRef> | <BiopaxRef>ec3</BiopaxRef> | ||
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<DataNode TextLabel="SESN1" GraphId="edd79" Type="GeneProduct" GroupRef="e3c1c"> | <DataNode TextLabel="SESN1" GraphId="edd79" Type="GeneProduct" GroupRef="e3c1c"> | ||
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<DataNode TextLabel="DAG" GraphId="ef3a2" Type="Metabolite"> | <DataNode TextLabel="DAG" GraphId="ef3a2" Type="Metabolite"> | ||
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<DataNode TextLabel="glycine" GraphId="f1ce4" Type="Metabolite"> | <DataNode TextLabel="glycine" GraphId="f1ce4" Type="Metabolite"> | ||
<BiopaxRef>e30</BiopaxRef> | <BiopaxRef>e30</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57305" /> | + | <Xref Database="ChEBI" ID="CHEBI:57305"/> |
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<DataNode TextLabel="EGFR" GraphId="f2d42" Type="Protein" GroupRef="f510b"> | <DataNode TextLabel="EGFR" GraphId="f2d42" Type="Protein" GroupRef="f510b"> | ||
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<DataNode TextLabel="KIT" GraphId="f3798" Type="Protein" GroupRef="f510b"> | <DataNode TextLabel="KIT" GraphId="f3798" Type="Protein" GroupRef="f510b"> | ||
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<DataNode TextLabel="MAPK1" GraphId="f5614" Type="Protein" GroupRef="f0d56"> | <DataNode TextLabel="MAPK1" GraphId="f5614" Type="Protein" GroupRef="f0d56"> | ||
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<DataNode TextLabel="creatine" GraphId="fd8e0" Type="Metabolite"> | <DataNode TextLabel="creatine" GraphId="fd8e0" Type="Metabolite"> | ||
<BiopaxRef>e30</BiopaxRef> | <BiopaxRef>e30</BiopaxRef> | ||
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<DataNode TextLabel="rs6189" GraphId="cd049" Type="Rna" GroupRef="a3848"> | <DataNode TextLabel="rs6189" GraphId="cd049" Type="Rna" GroupRef="a3848"> | ||
<BiopaxRef>a94</BiopaxRef> | <BiopaxRef>a94</BiopaxRef> | ||
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<DataNode TextLabel="MN2+" GraphId="a5974" Type="Metabolite" GroupRef="a4d6d"> | <DataNode TextLabel="MN2+" GraphId="a5974" Type="Metabolite" GroupRef="a4d6d"> | ||
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<DataNode TextLabel="CNTN6" GraphId="a99ad" Type="GeneProduct" GroupRef="c2301"> | <DataNode TextLabel="CNTN6" GraphId="a99ad" Type="GeneProduct" GroupRef="c2301"> | ||
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<BiopaxRef>c8e</BiopaxRef> | <BiopaxRef>c8e</BiopaxRef> | ||
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<DataNode TextLabel="NA Aldehyde" GraphId="d616e" Type="Metabolite"> | <DataNode TextLabel="NA Aldehyde" GraphId="d616e" Type="Metabolite"> | ||
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<DataNode TextLabel="THF-polyglutamate" GraphId="f9e28" Type="Metabolite"> | <DataNode TextLabel="THF-polyglutamate" GraphId="f9e28" Type="Metabolite"> | ||
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<DataNode TextLabel="3-MT SO" GraphId="ad2f6" Type="Metabolite"> | <DataNode TextLabel="3-MT SO" GraphId="ad2f6" Type="Metabolite"> | ||
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<DataNode TextLabel="Imidazole-4-acetate" GraphId="bd2da" Type="Metabolite"> | <DataNode TextLabel="Imidazole-4-acetate" GraphId="bd2da" Type="Metabolite"> | ||
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<DataNode TextLabel="a 1-(1-hydroxyalkyl)-sn-glycerol" GraphId="a5fac" Type="Metabolite"> | <DataNode TextLabel="a 1-(1-hydroxyalkyl)-sn-glycerol" GraphId="a5fac" Type="Metabolite"> | ||
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<DataNode TextLabel="FMN" GraphId="f3359" Type="Metabolite"> | <DataNode TextLabel="FMN" GraphId="f3359" Type="Metabolite"> | ||
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| Line 727: | Line 727: | ||
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<DataNode TextLabel="10-formyl-THF" GraphId="a2c2d" Type="Metabolite"> | <DataNode TextLabel="10-formyl-THF" GraphId="a2c2d" Type="Metabolite"> | ||
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<DataNode TextLabel="QPRT" GraphId="d2bb4" Type="Protein"> | <DataNode TextLabel="QPRT" GraphId="d2bb4" Type="Protein"> | ||
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<DataNode TextLabel="SOD2" GraphId="f8b32" Type="Protein"> | <DataNode TextLabel="SOD2" GraphId="f8b32" Type="Protein"> | ||
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| Line 1,120: | Line 1,120: | ||
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<DataNode TextLabel="rs6269" Type="Rna" GroupRef="ed7b2"> | <DataNode TextLabel="rs6269" Type="Rna" GroupRef="ed7b2"> | ||
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<DataNode TextLabel="AGMO" GraphId="ca99c" Type="Protein"> | <DataNode TextLabel="AGMO" GraphId="ca99c" Type="Protein"> | ||
<BiopaxRef>fcc</BiopaxRef> | <BiopaxRef>fcc</BiopaxRef> | ||
<BiopaxRef>d02</BiopaxRef> | <BiopaxRef>d02</BiopaxRef> | ||
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<DataNode TextLabel="MoCo" GraphId="e0d50" Type="Metabolite"> | <DataNode TextLabel="MoCo" GraphId="e0d50" Type="Metabolite"> | ||
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<DataNode TextLabel="L-glutamine" GraphId="d49de" Type="Metabolite"> | <DataNode TextLabel="L-glutamine" GraphId="d49de" Type="Metabolite"> | ||
<BiopaxRef>fc8</BiopaxRef> | <BiopaxRef>fc8</BiopaxRef> | ||
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<DataNode TextLabel="rs151257822" GraphId="ac7b1" Type="GeneProduct" GroupRef="cf318"> | <DataNode TextLabel="rs151257822" GraphId="ac7b1" Type="GeneProduct" GroupRef="cf318"> | ||
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<BiopaxRef>a69</BiopaxRef> | <BiopaxRef>a69</BiopaxRef> | ||
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<DataNode TextLabel="(4aS,6R)-4a-hydroxy - BH4" GraphId="d3e64" Type="Metabolite"> | <DataNode TextLabel="(4aS,6R)-4a-hydroxy - BH4" GraphId="d3e64" Type="Metabolite"> | ||
<BiopaxRef>e77</BiopaxRef> | <BiopaxRef>e77</BiopaxRef> | ||
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<DataNode TextLabel="rs251915" GraphId="d68f6" Type="Rna"> | <DataNode TextLabel="rs251915" GraphId="d68f6" Type="Rna"> | ||
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<BiopaxRef>e73</BiopaxRef> | <BiopaxRef>e73</BiopaxRef> | ||
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<DataNode TextLabel="HVAL" GraphId="f7640" Type="Metabolite"> | <DataNode TextLabel="HVAL" GraphId="f7640" Type="Metabolite"> | ||
<Comment>HVAL = Homovanillyl = alcohol(4-Hydroxy-3-methoxyphenyl)ethanol</Comment> | <Comment>HVAL = Homovanillyl = alcohol(4-Hydroxy-3-methoxyphenyl)ethanol</Comment> | ||
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<DataNode TextLabel="SOD1" GraphId="aa6a6" Type="Protein" GroupRef="ba367"> | <DataNode TextLabel="SOD1" GraphId="aa6a6" Type="Protein" GroupRef="ba367"> | ||
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<BiopaxRef>f9b</BiopaxRef> | <BiopaxRef>f9b</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="TPH2" GraphId="e0a6b" Type="Protein" GroupRef="c3629"> | <DataNode TextLabel="TPH2" GraphId="e0a6b" Type="Protein" GroupRef="c3629"> | ||
<BiopaxRef>e77</BiopaxRef> | <BiopaxRef>e77</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTR" GraphId="e4bcd" Type="Protein" GroupRef="c2d21"> | <DataNode TextLabel="MTR" GraphId="e4bcd" Type="Protein" GroupRef="c2d21"> | ||
<BiopaxRef>f83</BiopaxRef> | <BiopaxRef>f83</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="SLC52A3" GraphId="befa3" Type="GeneProduct"> | <DataNode TextLabel="SLC52A3" GraphId="befa3" Type="GeneProduct"> | ||
<BiopaxRef>e60</BiopaxRef> | <BiopaxRef>e60</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs4570625" GraphId="a7959" Type="Rna" GroupRef="c959d"> | <DataNode TextLabel="rs4570625" GraphId="a7959" Type="Rna" GroupRef="c959d"> | ||
<BiopaxRef>a94</BiopaxRef> | <BiopaxRef>a94</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
| - | <DataNode TextLabel="Pharmacological &# | + | <DataNode TextLabel="Pharmacological Intervention (drug)" GraphId="a4195"> |
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| - | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Angiotensinogen" GraphId="ad89d" Type="Metabolite"> | <DataNode TextLabel="Angiotensinogen" GraphId="ad89d" Type="Metabolite"> | ||
<BiopaxRef>b9b</BiopaxRef> | <BiopaxRef>b9b</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="CNTN4" Type="GeneProduct" GroupRef="c2301"> | <DataNode TextLabel="CNTN4" Type="GeneProduct" GroupRef="c2301"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9P232" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9P232"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFR" GraphId="e4bfc" Type="Protein"> | <DataNode TextLabel="MTHFR" GraphId="e4bfc" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P42898" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P42898"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs6318" GraphId="bfee0" Type="Rna"> | <DataNode TextLabel="rs6318" GraphId="bfee0" Type="Rna"> | ||
<BiopaxRef>a69</BiopaxRef> | <BiopaxRef>a69</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs6318" /> | + | <Xref Database="dbSNP" ID="rs6318"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="hypotaurine" GraphId="aa6f4" Type="Metabolite"> | <DataNode TextLabel="hypotaurine" GraphId="aa6f4" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57853" /> | + | <Xref Database="ChEBI" ID="CHEBI:57853"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="NMNAT1" GraphId="aed2d" Type="Protein"> | <DataNode TextLabel="NMNAT1" GraphId="aed2d" Type="Protein"> | ||
<BiopaxRef>fe5</BiopaxRef> | <BiopaxRef>fe5</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9HAN9" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9HAN9"/> |
</DataNode> | </DataNode> | ||
| - | <DataNode TextLabel="DOPGAL&# | + | <DataNode TextLabel="DOPGAL " GraphId="c7552" Type="Metabolite"> |
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| - | <Xref Database="ChEBI" ID="CHEBI:180943" /> | + | <Xref Database="ChEBI" ID="CHEBI:180943"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SCN11A" Type="Protein" GroupRef="b3ab0"> | <DataNode TextLabel="SCN11A" Type="Protein" GroupRef="b3ab0"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9UI33" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9UI33"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SLC25A13" GraphId="c7e76" Type="Protein" GroupRef="ba2f2"> | <DataNode TextLabel="SLC25A13" GraphId="c7e76" Type="Protein" GroupRef="ba2f2"> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="ALDH1L1" GraphId="ffe0d" Type="Protein"> | <DataNode TextLabel="ALDH1L1" GraphId="ffe0d" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="O75891" /> | + | <Xref Database="Uniprot-TrEMBL" ID="O75891"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs237887" Type="GeneProduct" GroupRef="cf318"> | <DataNode TextLabel="rs237887" Type="GeneProduct" GroupRef="cf318"> | ||
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| - | <Xref Database="dbSNP" ID="rs237887" /> | + | <Xref Database="dbSNP" ID="rs237887"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="B2" GraphId="ba917" Type="Metabolite"> | <DataNode TextLabel="B2" GraphId="ba917" Type="Metabolite"> | ||
| Line 1,668: | Line 1,668: | ||
<BiopaxRef>dae</BiopaxRef> | <BiopaxRef>dae</BiopaxRef> | ||
<BiopaxRef>e60</BiopaxRef> | <BiopaxRef>e60</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17015" /> | + | <Xref Database="ChEBI" ID="CHEBI:17015"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs4532" GraphId="a48a1" Type="Rna" GroupRef="fafa5"> | <DataNode TextLabel="rs4532" GraphId="a48a1" Type="Rna" GroupRef="fafa5"> | ||
<BiopaxRef>a69</BiopaxRef> | <BiopaxRef>a69</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs4532" /> | + | <Xref Database="dbSNP" ID="rs4532"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SCN3A" Type="Protein" GroupRef="b3ab0"> | <DataNode TextLabel="SCN3A" Type="Protein" GroupRef="b3ab0"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9NY46" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9NY46"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs1352250" GraphId="d3675" Type="Rna" GroupRef="c959d"> | <DataNode TextLabel="rs1352250" GraphId="d3675" Type="Rna" GroupRef="c959d"> | ||
<BiopaxRef>f35</BiopaxRef> | <BiopaxRef>f35</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs1352250" /> | + | <Xref Database="dbSNP" ID="rs1352250"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs4570625" GraphId="cd54c" Type="Rna" GroupRef="c959d"> | <DataNode TextLabel="rs4570625" GraphId="cd54c" Type="Rna" GroupRef="c959d"> | ||
<BiopaxRef>a94</BiopaxRef> | <BiopaxRef>a94</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs4570625" /> | + | <Xref Database="dbSNP" ID="rs4570625"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="GPHN" GraphId="f0b68" Type="Protein"> | <DataNode TextLabel="GPHN" GraphId="f0b68" Type="Protein"> | ||
<BiopaxRef>d44</BiopaxRef> | <BiopaxRef>d44</BiopaxRef> | ||
<BiopaxRef>bb7</BiopaxRef> | <BiopaxRef>bb7</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9NQX3" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9NQX3"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="OH-" GraphId="bffad" Type="Metabolite"> | <DataNode TextLabel="OH-" GraphId="bffad" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16234" /> | + | <Xref Database="ChEBI" ID="CHEBI:16234"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="NOX5" GraphId="dfd3f" Type="Protein" GroupRef="d0504"> | <DataNode TextLabel="NOX5" GraphId="dfd3f" Type="Protein" GroupRef="d0504"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q96PH1" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q96PH1"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs3027400" GraphId="c6f72" Type="Rna" GroupRef="c4fef"> | <DataNode TextLabel="rs3027400" GraphId="c6f72" Type="Rna" GroupRef="c4fef"> | ||
<BiopaxRef>bc6</BiopaxRef> | <BiopaxRef>bc6</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs3027400" /> | + | <Xref Database="dbSNP" ID="rs3027400"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs2129575" GraphId="bbfc5" Type="Rna" GroupRef="c959d"> | <DataNode TextLabel="rs2129575" GraphId="bbfc5" Type="Rna" GroupRef="c959d"> | ||
<Comment>rs2129575</Comment> | <Comment>rs2129575</Comment> | ||
<BiopaxRef>b7b</BiopaxRef> | <BiopaxRef>b7b</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs2129575" /> | + | <Xref Database="dbSNP" ID="rs2129575"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CDO1" GraphId="db337" Type="GeneProduct"> | <DataNode TextLabel="CDO1" GraphId="db337" Type="GeneProduct"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q16878" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q16878"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SLC17A7" GraphId="e17c5" Type="Protein" GroupRef="b463f"> | <DataNode TextLabel="SLC17A7" GraphId="e17c5" Type="Protein" GroupRef="b463f"> | ||
<Comment>Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). | <Comment>Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). | ||
At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).</Comment> | At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).</Comment> | ||
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<DataNode TextLabel="KYAT3" GraphId="abce4" Type="Protein" GroupRef="c734a"> | <DataNode TextLabel="KYAT3" GraphId="abce4" Type="Protein" GroupRef="c734a"> | ||
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<DataNode TextLabel="ALDH1L2" GraphId="a09b1" Type="Protein"> | <DataNode TextLabel="ALDH1L2" GraphId="a09b1" Type="Protein"> | ||
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<DataNode TextLabel="GK" GraphId="becf8" Type="Protein"> | <DataNode TextLabel="GK" GraphId="becf8" Type="Protein"> | ||
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<DataNode TextLabel="SYP" GraphId="ebffb" Type="Protein" GroupRef="ec3f5"> | <DataNode TextLabel="SYP" GraphId="ebffb" Type="Protein" GroupRef="ec3f5"> | ||
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<DataNode TextLabel="FMO1" GraphId="a9800" Type="GeneProduct" GroupRef="b2149"> | <DataNode TextLabel="FMO1" GraphId="a9800" Type="GeneProduct" GroupRef="b2149"> | ||
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<DataNode TextLabel="REN" GraphId="ea0b2" Type="Protein"> | <DataNode TextLabel="REN" GraphId="ea0b2" Type="Protein"> | ||
<BiopaxRef>b9b</BiopaxRef> | <BiopaxRef>b9b</BiopaxRef> | ||
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<DataNode TextLabel="rs2710102" GraphId="c4e22" Type="Rna" GroupRef="b9f78"> | <DataNode TextLabel="rs2710102" GraphId="c4e22" Type="Rna" GroupRef="b9f78"> | ||
<BiopaxRef>a69</BiopaxRef> | <BiopaxRef>a69</BiopaxRef> | ||
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<DataNode TextLabel="CTH" GraphId="db72c" Type="Protein" GroupRef="d0530"> | <DataNode TextLabel="CTH" GraphId="db72c" Type="Protein" GroupRef="d0530"> | ||
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<BiopaxRef>fcc</BiopaxRef> | <BiopaxRef>fcc</BiopaxRef> | ||
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<DataNode TextLabel="adrenaline" GraphId="ea073" Type="Metabolite"> | <DataNode TextLabel="adrenaline" GraphId="ea073" Type="Metabolite"> | ||
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<DataNode TextLabel="AKR" GraphId="e34d5" Type="Protein"> | <DataNode TextLabel="AKR" GraphId="e34d5" Type="Protein"> | ||
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<DataNode TextLabel="AHCY" GraphId="d58fd" Type="Protein"> | <DataNode TextLabel="AHCY" GraphId="d58fd" Type="Protein"> | ||
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<DataNode TextLabel="arachidonic acid" GraphId="abe84" Type="Metabolite"> | <DataNode TextLabel="arachidonic acid" GraphId="abe84" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:15843" /> | + | <Xref Database="ChEBI" ID="CHEBI:15843"/> |
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<DataNode TextLabel="cystathionine" GraphId="e3468" Type="Metabolite"> | <DataNode TextLabel="cystathionine" GraphId="e3468" Type="Metabolite"> | ||
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<DataNode TextLabel="DOPEG" GraphId="e99ba" Type="Metabolite"> | <DataNode TextLabel="DOPEG" GraphId="e99ba" Type="Metabolite"> | ||
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<DataNode TextLabel="SPR" GraphId="d3452" Type="Protein" GroupRef="b889a"> | <DataNode TextLabel="SPR" GraphId="d3452" Type="Protein" GroupRef="b889a"> | ||
<BiopaxRef>ea0</BiopaxRef> | <BiopaxRef>ea0</BiopaxRef> | ||
<BiopaxRef>c84</BiopaxRef> | <BiopaxRef>c84</BiopaxRef> | ||
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<DataNode TextLabel="5-hydroxy-L-tryptophan" GraphId="e1aa3" Type="Metabolite"> | <DataNode TextLabel="5-hydroxy-L-tryptophan" GraphId="e1aa3" Type="Metabolite"> | ||
<BiopaxRef>eb6</BiopaxRef> | <BiopaxRef>eb6</BiopaxRef> | ||
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<DataNode TextLabel="CNTNAP3" Type="GeneProduct" GroupRef="d7b0b"> | <DataNode TextLabel="CNTNAP3" Type="GeneProduct" GroupRef="d7b0b"> | ||
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<DataNode TextLabel="rs7794745" GraphId="bb54e" Type="Rna" GroupRef="b9f78"> | <DataNode TextLabel="rs7794745" GraphId="bb54e" Type="Rna" GroupRef="b9f78"> | ||
<BiopaxRef>a69</BiopaxRef> | <BiopaxRef>a69</BiopaxRef> | ||
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<DataNode TextLabel="rs1799971" GraphId="d5e99" Type="Rna"> | <DataNode TextLabel="rs1799971" GraphId="d5e99" Type="Rna"> | ||
| Line 1,816: | Line 1,816: | ||
<BiopaxRef>bcf</BiopaxRef> | <BiopaxRef>bcf</BiopaxRef> | ||
<BiopaxRef>cc9</BiopaxRef> | <BiopaxRef>cc9</BiopaxRef> | ||
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<DataNode TextLabel="L-arginine" GraphId="c4f12" Type="Metabolite"> | <DataNode TextLabel="L-arginine" GraphId="c4f12" Type="Metabolite"> | ||
<BiopaxRef>e30</BiopaxRef> | <BiopaxRef>e30</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:32682" /> | + | <Xref Database="ChEBI" ID="CHEBI:32682"/> |
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<DataNode TextLabel="TPH1" GraphId="c83c7" Type="Protein" GroupRef="c3629"> | <DataNode TextLabel="TPH1" GraphId="c83c7" Type="Protein" GroupRef="c3629"> | ||
<BiopaxRef>e77</BiopaxRef> | <BiopaxRef>e77</BiopaxRef> | ||
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<DataNode TextLabel="GLUL" GraphId="c6690" Type="GeneProduct"> | <DataNode TextLabel="GLUL" GraphId="c6690" Type="GeneProduct"> | ||
<BiopaxRef>f51</BiopaxRef> | <BiopaxRef>f51</BiopaxRef> | ||
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<DataNode TextLabel="rs2254298" Type="GeneProduct" GroupRef="cf318"> | <DataNode TextLabel="rs2254298" Type="GeneProduct" GroupRef="cf318"> | ||
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<DataNode TextLabel="ADH" GraphId="c5068" Type="Protein"> | <DataNode TextLabel="ADH" GraphId="c5068" Type="Protein"> | ||
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<DataNode TextLabel="L-cysteine" GraphId="fdd3f" Type="Metabolite"> | <DataNode TextLabel="L-cysteine" GraphId="fdd3f" Type="Metabolite"> | ||
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<DataNode TextLabel="rs4446909" GraphId="e2582" Type="Rna" GroupRef="f7a1c"> | <DataNode TextLabel="rs4446909" GraphId="e2582" Type="Rna" GroupRef="f7a1c"> | ||
<BiopaxRef>fe1</BiopaxRef> | <BiopaxRef>fe1</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="L-phenylalanine" GraphId="b9323" Type="Metabolite"> | <DataNode TextLabel="L-phenylalanine" GraphId="b9323" Type="Metabolite"> | ||
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<DataNode TextLabel="2′-OXPH4" GraphId="c9382" Type="Metabolite"> | <DataNode TextLabel="2′-OXPH4" GraphId="c9382" Type="Metabolite"> | ||
| Line 1,859: | Line 1,859: | ||
<BiopaxRef>ea0</BiopaxRef> | <BiopaxRef>ea0</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs70991108" /> | + | <Xref Database="dbSNP" ID="rs70991108"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="norepinephrine" GraphId="a8831" Type="Metabolite"> | <DataNode TextLabel="norepinephrine" GraphId="a8831" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:72587" /> | + | <Xref Database="ChEBI" ID="CHEBI:72587"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs167771" GraphId="f2eca" Type="Rna" GroupRef="ded1d"> | <DataNode TextLabel="rs167771" GraphId="f2eca" Type="Rna" GroupRef="ded1d"> | ||
<BiopaxRef>b35</BiopaxRef> | <BiopaxRef>b35</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs167771" /> | + | <Xref Database="dbSNP" ID="rs167771"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="dopamine" GraphId="a881f" Type="Metabolite"> | <DataNode TextLabel="dopamine" GraphId="a881f" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:59905" /> | + | <Xref Database="ChEBI" ID="CHEBI:59905"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="serotonin" GraphId="bdee0" Type="Metabolite"> | <DataNode TextLabel="serotonin" GraphId="bdee0" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:350546" /> | + | <Xref Database="ChEBI" ID="CHEBI:350546"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="dopamine" GraphId="b4b9a" Type="Metabolite"> | <DataNode TextLabel="dopamine" GraphId="b4b9a" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:59905" /> | + | <Xref Database="ChEBI" ID="CHEBI:59905"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="VMA" GraphId="bd50d" Type="Metabolite"> | <DataNode TextLabel="VMA" GraphId="bd50d" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:27622" /> | + | <Xref Database="ChEBI" ID="CHEBI:27622"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="HVA" GraphId="bb668" Type="Metabolite"> | <DataNode TextLabel="HVA" GraphId="bb668" Type="Metabolite"> | ||
| Line 2,165: | Line 2,165: | ||
<BiopaxRef>da2</BiopaxRef> | <BiopaxRef>da2</BiopaxRef> | ||
<BiopaxRef>d63</BiopaxRef> | <BiopaxRef>d63</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:545959" /> | + | <Xref Database="ChEBI" ID="CHEBI:545959"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="COMT" GraphId="b715a" Type="Protein"> | <DataNode TextLabel="COMT" GraphId="b715a" Type="Protein"> | ||
<Comment>AKA Catechol-O- metyltransferase</Comment> | <Comment>AKA Catechol-O- metyltransferase</Comment> | ||
<BiopaxRef>da2</BiopaxRef> | <BiopaxRef>da2</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P21964" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P21964"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="5-HIAA" GraphId="f739c" Type="Metabolite"> | <DataNode TextLabel="5-HIAA" GraphId="f739c" Type="Metabolite"> | ||
<Comment>AKA 5-HIAA</Comment> | <Comment>AKA 5-HIAA</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:27823" /> | + | <Xref Database="ChEBI" ID="CHEBI:27823"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="norepinephrine" GraphId="ff15d" Type="Metabolite"> | <DataNode TextLabel="norepinephrine" GraphId="ff15d" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:72587" /> | + | <Xref Database="ChEBI" ID="CHEBI:72587"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="adrenaline" GraphId="fd05f" Type="Metabolite"> | <DataNode TextLabel="adrenaline" GraphId="fd05f" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:28918" /> | + | <Xref Database="ChEBI" ID="CHEBI:28918"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Clonidine" GraphId="c1050" Type="Metabolite"> | <DataNode TextLabel="Clonidine" GraphId="c1050" Type="Metabolite"> | ||
<BiopaxRef>b6c</BiopaxRef> | <BiopaxRef>b6c</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:46631" /> | + | <Xref Database="ChEBI" ID="CHEBI:46631"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Guanfacine" GraphId="f3005" Type="Metabolite"> | <DataNode TextLabel="Guanfacine" GraphId="f3005" Type="Metabolite"> | ||
<BiopaxRef>b6c</BiopaxRef> | <BiopaxRef>b6c</BiopaxRef> | ||
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| - | <Xref Database="HMDB" ID="HMDB15153" /> | + | <Xref Database="HMDB" ID="HMDB15153"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Prazosin" GraphId="dfb58" Type="Metabolite"> | <DataNode TextLabel="Prazosin" GraphId="dfb58" Type="Metabolite"> | ||
<BiopaxRef>bd4</BiopaxRef> | <BiopaxRef>bd4</BiopaxRef> | ||
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| - | <Xref Database="HMDB" ID="HMDB14600" /> | + | <Xref Database="HMDB" ID="HMDB14600"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="L-glutamate" GraphId="ac2aa" Type="Metabolite"> | <DataNode TextLabel="L-glutamate" GraphId="ac2aa" Type="Metabolite"> | ||
| - | <Attribute Key="cellular_location" Value="mitochondrial matrix" /> | + | <Attribute Key="cellular_location" Value="mitochondrial matrix"/> |
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| - | <Xref Database="ChEBI" ID="CHEBI:29985" /> | + | <Xref Database="ChEBI" ID="CHEBI:29985"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="L-Asp" GraphId="c3e7c" Type="Metabolite"> | <DataNode TextLabel="L-Asp" GraphId="c3e7c" Type="Metabolite"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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| - | <Xref Database="ChEBI" ID="CHEBI:29991" /> | + | <Xref Database="ChEBI" ID="CHEBI:29991"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="L-Asp" GraphId="ad523" Type="Metabolite"> | <DataNode TextLabel="L-Asp" GraphId="ad523" Type="Metabolite"> | ||
| - | <Attribute Key="cellular_location" Value="mitochondrial matrix" /> | + | <Attribute Key="cellular_location" Value="mitochondrial matrix"/> |
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| - | <Xref Database="ChEBI" ID="CHEBI:29991" /> | + | <Xref Database="ChEBI" ID="CHEBI:29991"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="rs908670" GraphId="e49ca" Type="Rna" GroupRef="d84b1"> | <DataNode TextLabel="rs908670" GraphId="e49ca" Type="Rna" GroupRef="d84b1"> | ||
<BiopaxRef>ea8</BiopaxRef> | <BiopaxRef>ea8</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs908670" /> | + | <Xref Database="dbSNP" ID="rs908670"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Ca2+" GraphId="ac46c" Type="Metabolite"> | <DataNode TextLabel="Ca2+" GraphId="ac46c" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:29108" /> | + | <Xref Database="ChEBI" ID="CHEBI:29108"/> |
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<DataNode TextLabel="SNAP25" GraphId="d4e32" Type="Protein" GroupRef="ec3f5"> | <DataNode TextLabel="SNAP25" GraphId="d4e32" Type="Protein" GroupRef="ec3f5"> | ||
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<DataNode TextLabel="VAMP2" GraphId="fada6" Type="Protein" GroupRef="ec3f5"> | <DataNode TextLabel="VAMP2" GraphId="fada6" Type="Protein" GroupRef="ec3f5"> | ||
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<DataNode TextLabel="SYT1" GraphId="afcc1" Type="Protein" GroupRef="ec3f5"> | <DataNode TextLabel="SYT1" GraphId="afcc1" Type="Protein" GroupRef="ec3f5"> | ||
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<DataNode TextLabel="STX1A" GraphId="bffe2" Type="Protein" GroupRef="ec3f5"> | <DataNode TextLabel="STX1A" GraphId="bffe2" Type="Protein" GroupRef="ec3f5"> | ||
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<DataNode TextLabel="Ca2+" GraphId="de95f" Type="Metabolite"> | <DataNode TextLabel="Ca2+" GraphId="de95f" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:29108" /> | + | <Xref Database="ChEBI" ID="CHEBI:29108"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="GRM8" Type="Protein" GroupRef="cab95"> | <DataNode TextLabel="GRM8" Type="Protein" GroupRef="cab95"> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="KCNA2" Type="Protein" GroupRef="bb1d9"> | <DataNode TextLabel="KCNA2" Type="Protein" GroupRef="bb1d9"> | ||
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<DataNode TextLabel="KCNA1" GraphId="d8b53" Type="Protein" GroupRef="bb1d9"> | <DataNode TextLabel="KCNA1" GraphId="d8b53" Type="Protein" GroupRef="bb1d9"> | ||
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<DataNode TextLabel="DLG3" Type="Protein" GroupRef="ffb8e"> | <DataNode TextLabel="DLG3" Type="Protein" GroupRef="ffb8e"> | ||
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<DataNode TextLabel="GRM6" GraphId="efd32" Type="Protein" GroupRef="cab95"> | <DataNode TextLabel="GRM6" GraphId="efd32" Type="Protein" GroupRef="cab95"> | ||
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| Line 2,841: | Line 2,841: | ||
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<BiopaxRef>b65</BiopaxRef> | <BiopaxRef>b65</BiopaxRef> | ||
<BiopaxRef>fe5</BiopaxRef> | <BiopaxRef>fe5</BiopaxRef> | ||
<BiopaxRef>add</BiopaxRef> | <BiopaxRef>add</BiopaxRef> | ||
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<DataNode TextLabel="Anthranilic Acid" GraphId="b363c" Type="Metabolite"> | <DataNode TextLabel="Anthranilic Acid" GraphId="b363c" Type="Metabolite"> | ||
<BiopaxRef>c14</BiopaxRef> | <BiopaxRef>c14</BiopaxRef> | ||
<BiopaxRef>add</BiopaxRef> | <BiopaxRef>add</BiopaxRef> | ||
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<DataNode TextLabel="Kynurenine" GraphId="c521d" Type="Metabolite"> | <DataNode TextLabel="Kynurenine" GraphId="c521d" Type="Metabolite"> | ||
| Line 2,866: | Line 2,866: | ||
<BiopaxRef>b65</BiopaxRef> | <BiopaxRef>b65</BiopaxRef> | ||
<BiopaxRef>add</BiopaxRef> | <BiopaxRef>add</BiopaxRef> | ||
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<DataNode TextLabel="NAD+" GraphId="a9d0e" Type="Metabolite"> | <DataNode TextLabel="NAD+" GraphId="a9d0e" Type="Metabolite"> | ||
<BiopaxRef>fe5</BiopaxRef> | <BiopaxRef>fe5</BiopaxRef> | ||
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<DataNode TextLabel="INFA" GraphId="fff7f" Type="Protein" GroupRef="ffdf1"> | <DataNode TextLabel="INFA" GraphId="fff7f" Type="Protein" GroupRef="ffdf1"> | ||
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<DataNode TextLabel="KMO" GraphId="b8138" Type="Protein"> | <DataNode TextLabel="KMO" GraphId="b8138" Type="Protein"> | ||
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<DataNode TextLabel="IDO1" GraphId="f2f96" Type="Protein" GroupRef="ef8de"> | <DataNode TextLabel="IDO1" GraphId="f2f96" Type="Protein" GroupRef="ef8de"> | ||
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<DataNode TextLabel="IDO2" GraphId="b3301" Type="Protein" GroupRef="ef8de"> | <DataNode TextLabel="IDO2" GraphId="b3301" Type="Protein" GroupRef="ef8de"> | ||
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<DataNode TextLabel="T23O" GraphId="ce8bf" Type="Protein" GroupRef="ef8de"> | <DataNode TextLabel="T23O" GraphId="ce8bf" Type="Protein" GroupRef="ef8de"> | ||
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<DataNode TextLabel="KAT3" GraphId="fdb17" Type="Protein" GroupRef="d12e1"> | <DataNode TextLabel="KAT3" GraphId="fdb17" Type="Protein" GroupRef="d12e1"> | ||
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<DataNode TextLabel="AADAT" GraphId="a3af4" Type="Protein" GroupRef="a2ffb"> | <DataNode TextLabel="AADAT" GraphId="a3af4" Type="Protein" GroupRef="a2ffb"> | ||
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<DataNode TextLabel="AATM" GraphId="d9d31" Type="Protein" GroupRef="a2ffb"> | <DataNode TextLabel="AATM" GraphId="d9d31" Type="Protein" GroupRef="a2ffb"> | ||
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<DataNode TextLabel="TNFA" GraphId="a284d" Type="Protein" GroupRef="ffdf1"> | <DataNode TextLabel="TNFA" GraphId="a284d" Type="Protein" GroupRef="ffdf1"> | ||
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<DataNode TextLabel="QUIN" GraphId="fd1bb" Type="Metabolite" GroupRef="ca316"> | <DataNode TextLabel="QUIN" GraphId="fd1bb" Type="Metabolite" GroupRef="ca316"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16675" /> | + | <Xref Database="ChEBI" ID="CHEBI:16675"/> |
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<DataNode TextLabel="adrenaline" GraphId="e6a87" Type="Metabolite"> | <DataNode TextLabel="adrenaline" GraphId="e6a87" Type="Metabolite"> | ||
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</DataNode> | </DataNode> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:72587" /> | + | <Xref Database="ChEBI" ID="CHEBI:72587"/> |
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<DataNode TextLabel="adrenaline" GraphId="b3bb8" Type="Metabolite"> | <DataNode TextLabel="adrenaline" GraphId="b3bb8" Type="Metabolite"> | ||
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<DataNode TextLabel="gamma-hydroxybutyrate " GraphId="e89b6" Type="Metabolite"> | <DataNode TextLabel="gamma-hydroxybutyrate " GraphId="e89b6" Type="Metabolite"> | ||
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<DataNode TextLabel="L-glutamate" GraphId="ea3ef" Type="Metabolite"> | <DataNode TextLabel="L-glutamate" GraphId="ea3ef" Type="Metabolite"> | ||
<BiopaxRef>fc8</BiopaxRef> | <BiopaxRef>fc8</BiopaxRef> | ||
<BiopaxRef>ab8</BiopaxRef> | <BiopaxRef>ab8</BiopaxRef> | ||
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<DataNode TextLabel="GABA" GraphId="ac224" Type="Metabolite"> | <DataNode TextLabel="GABA" GraphId="ac224" Type="Metabolite"> | ||
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<DataNode TextLabel="GABBR1" GraphId="c754a" Type="Protein"> | <DataNode TextLabel="GABBR1" GraphId="c754a" Type="Protein"> | ||
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<DataNode TextLabel="SLC32A1" GraphId="d8025" Type="Protein"> | <DataNode TextLabel="SLC32A1" GraphId="d8025" Type="Protein"> | ||
<Comment>Vesicular inhibitory amino acid transporter</Comment> | <Comment>Vesicular inhibitory amino acid transporter</Comment> | ||
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<DataNode TextLabel="succinate " GraphId="bbd9c" Type="Metabolite"> | <DataNode TextLabel="succinate " GraphId="bbd9c" Type="Metabolite"> | ||
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<DataNode TextLabel="citrate cycle" GraphId="feb95" Type="Pathway"> | <DataNode TextLabel="citrate cycle" GraphId="feb95" Type="Pathway"> | ||
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<DataNode TextLabel="GAD2" GraphId="b648d" Type="GeneProduct" GroupRef="dc127"> | <DataNode TextLabel="GAD2" GraphId="b648d" Type="GeneProduct" GroupRef="dc127"> | ||
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<DataNode TextLabel="succinic semialdehyde" GraphId="d565a" Type="Metabolite"> | <DataNode TextLabel="succinic semialdehyde" GraphId="d565a" Type="Metabolite"> | ||
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<DataNode TextLabel="ALDH9A1" GraphId="b052e" Type="Protein"> | <DataNode TextLabel="ALDH9A1" GraphId="b052e" Type="Protein"> | ||
<Comment>4-trimethylaminobutyraldehyde dehydrogenase</Comment> | <Comment>4-trimethylaminobutyraldehyde dehydrogenase</Comment> | ||
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<DataNode TextLabel="ABAT" GraphId="bb519" Type="Protein"> | <DataNode TextLabel="ABAT" GraphId="bb519" Type="Protein"> | ||
<Comment>4-Aminobutyrate aminotransferase</Comment> | <Comment>4-Aminobutyrate aminotransferase</Comment> | ||
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<DataNode TextLabel="GAD1" GraphId="c0288" Type="GeneProduct" GroupRef="e42dc"> | <DataNode TextLabel="GAD1" GraphId="c0288" Type="GeneProduct" GroupRef="e42dc"> | ||
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<DataNode TextLabel="GABA" GraphId="b97e5" Type="Metabolite"> | <DataNode TextLabel="GABA" GraphId="b97e5" Type="Metabolite"> | ||
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<DataNode TextLabel="SLC6A1" GraphId="a5c45" Type="GeneProduct"> | <DataNode TextLabel="SLC6A1" GraphId="a5c45" Type="GeneProduct"> | ||
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<DataNode TextLabel="GABA" GraphId="e5570" Type="Metabolite"> | <DataNode TextLabel="GABA" GraphId="e5570" Type="Metabolite"> | ||
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<DataNode TextLabel="GLS2" GraphId="e298b" Type="Protein" GroupRef="b7a07"> | <DataNode TextLabel="GLS2" GraphId="e298b" Type="Protein" GroupRef="b7a07"> | ||
<BiopaxRef>fc8</BiopaxRef> | <BiopaxRef>fc8</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9UI32" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9UI32"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="2A-3OBU" GraphId="d3b20" Type="Metabolite"> | <DataNode TextLabel="2A-3OBU" GraphId="d3b20" Type="Metabolite"> | ||
| - | <Attribute Key="cellular_location" Value="mitochondrial matrix" /> | + | <Attribute Key="cellular_location" Value="mitochondrial matrix"/> |
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| - | <Xref Database="ChEBI" ID="CHEBI:78948" /> | + | <Xref Database="ChEBI" ID="CHEBI:78948"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="L-threonine" GraphId="bb572" Type="Metabolite"> | <DataNode TextLabel="L-threonine" GraphId="bb572" Type="Metabolite"> | ||
| - | <Attribute Key="cellular_location" Value="mitochondrial matrix" /> | + | <Attribute Key="cellular_location" Value="mitochondrial matrix"/> |
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| - | <Xref Database="ChEBI" ID="CHEBI:57926" /> | + | <Xref Database="ChEBI" ID="CHEBI:57926"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FMO3" GraphId="aacae" Type="GeneProduct" GroupRef="b2149"> | <DataNode TextLabel="FMO3" GraphId="aacae" Type="GeneProduct" GroupRef="b2149"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q01740" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q01740"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FAD" GraphId="e6b2a" Type="Metabolite"> | <DataNode TextLabel="FAD" GraphId="e6b2a" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57692" /> | + | <Xref Database="ChEBI" ID="CHEBI:57692"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="B2" GraphId="cc73a" Type="Metabolite"> | <DataNode TextLabel="B2" GraphId="cc73a" Type="Metabolite"> | ||
| Line 3,018: | Line 3,018: | ||
<BiopaxRef>dae</BiopaxRef> | <BiopaxRef>dae</BiopaxRef> | ||
<BiopaxRef>e60</BiopaxRef> | <BiopaxRef>e60</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17015" /> | + | <Xref Database="ChEBI" ID="CHEBI:17015"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="f019f" Type="Metabolite"> | <DataNode TextLabel="PLP" GraphId="f019f" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="dd2b1" Type="Metabolite" GroupRef="ce20c"> | <DataNode TextLabel="PLP" GraphId="dd2b1" Type="Metabolite" GroupRef="ce20c"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="f17a7" Type="Metabolite" GroupRef="d12e1"> | <DataNode TextLabel="PLP" GraphId="f17a7" Type="Metabolite" GroupRef="d12e1"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FMN" GraphId="b0de0" Type="Metabolite" GroupRef="c2d21"> | <DataNode TextLabel="FMN" GraphId="b0de0" Type="Metabolite" GroupRef="c2d21"> | ||
<BiopaxRef>dae</BiopaxRef> | <BiopaxRef>dae</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="cHEBI:58210" /> | + | <Xref Database="ChEBI" ID="cHEBI:58210"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ABCD4" GraphId="de71f" Type="Protein" GroupRef="beb7c"> | <DataNode TextLabel="ABCD4" GraphId="de71f" Type="Protein" GroupRef="beb7c"> | ||
| Line 3,042: | Line 3,042: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="O14678" /> | + | <Xref Database="Uniprot-TrEMBL" ID="O14678"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Succinyl-CoA" GraphId="e518d" Type="Metabolite"> | <DataNode TextLabel="Succinyl-CoA" GraphId="e518d" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:15380" /> | + | <Xref Database="ChEBI" ID="CHEBI:15380"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMUT" GraphId="e4dca" Type="Protein" GroupRef="c5c43"> | <DataNode TextLabel="MMUT" GraphId="e4dca" Type="Protein" GroupRef="c5c43"> | ||
<Comment>aka methylmalonyl-CoA mutase or MCM</Comment> | <Comment>aka methylmalonyl-CoA mutase or MCM</Comment> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P22033" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P22033"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CD320" GraphId="e3fb9" Type="Protein"> | <DataNode TextLabel="CD320" GraphId="e3fb9" Type="Protein"> | ||
<Comment>Aka CD320 receptor</Comment> | <Comment>Aka CD320 receptor</Comment> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9NPF0" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9NPF0"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="R-cob(III)alamin" GraphId="d1295" Type="Metabolite" GroupRef="beb7c"> | <DataNode TextLabel="R-cob(III)alamin" GraphId="d1295" Type="Metabolite" GroupRef="beb7c"> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:140785" /> | + | <Xref Database="ChEBI" ID="CHEBI:140785"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="cob(I)alamin" GraphId="cca50" Type="Metabolite" GroupRef="b31bb"> | <DataNode TextLabel="cob(I)alamin" GraphId="cca50" Type="Metabolite" GroupRef="b31bb"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:15982" /> | + | <Xref Database="ChEBI" ID="CHEBI:15982"/> |
</DataNode> | </DataNode> | ||
| - | <DataNode TextLabel="cbLA&# | + | <DataNode TextLabel="cbLA MMAA" GraphId="ba96a" Type="Protein" GroupRef="b31bb"> |
<Comment>Gene: MMAA</Comment> | <Comment>Gene: MMAA</Comment> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q8IVH4" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q8IVH4"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Methylmalonyl-CoA" GraphId="dedc0" Type="Metabolite"> | <DataNode TextLabel="Methylmalonyl-CoA" GraphId="dedc0" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16625" /> | + | <Xref Database="ChEBI" ID="CHEBI:16625"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="LMBRD1" GraphId="c3393" Type="Protein" GroupRef="beb7c"> | <DataNode TextLabel="LMBRD1" GraphId="c3393" Type="Protein" GroupRef="beb7c"> | ||
<Comment>cblF</Comment> | <Comment>cblF</Comment> | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9NUN5" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9NUN5"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMACHC" GraphId="a6e5a" Type="Protein" GroupRef="a6fa5"> | <DataNode TextLabel="MMACHC" GraphId="a6e5a" Type="Protein" GroupRef="a6fa5"> | ||
| Line 3,087: | Line 3,087: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FMN" GraphId="b8d35" Type="Metabolite" GroupRef="a6fa5"> | <DataNode TextLabel="FMN" GraphId="b8d35" Type="Metabolite" GroupRef="a6fa5"> | ||
<Comment>cofactor</Comment> | <Comment>cofactor</Comment> | ||
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| - | <Xref Database="ChEBI" ID="cHEBI:58210" /> | + | <Xref Database="ChEBI" ID="cHEBI:58210"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMAB" GraphId="a2f71" Type="Protein" GroupRef="c5c43"> | <DataNode TextLabel="MMAB" GraphId="a2f71" Type="Protein" GroupRef="c5c43"> | ||
| Line 3,099: | Line 3,099: | ||
</Comment> | </Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="c1c38" Type="Metabolite" GroupRef="d0530"> | <DataNode TextLabel="PLP" GraphId="c1c38" Type="Metabolite" GroupRef="d0530"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
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<DataNode TextLabel="PLP" GraphId="ade29" Type="Metabolite" GroupRef="c3678"> | <DataNode TextLabel="PLP" GraphId="ade29" Type="Metabolite" GroupRef="c3678"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="e12d0" Type="Metabolite" GroupRef="caf4b"> | <DataNode TextLabel="PLP" GraphId="e12d0" Type="Metabolite" GroupRef="caf4b"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="aa5b3" Type="Metabolite" GroupRef="b7a57"> | <DataNode TextLabel="PLP" GraphId="aa5b3" Type="Metabolite" GroupRef="b7a57"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="ff721" Type="Metabolite" GroupRef="c6c34"> | <DataNode TextLabel="PLP" GraphId="ff721" Type="Metabolite" GroupRef="c6c34"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="a3bcd" Type="Metabolite" GroupRef="c734a"> | <DataNode TextLabel="PLP" GraphId="a3bcd" Type="Metabolite" GroupRef="c734a"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMADHC" GraphId="bd7d2" Type="Protein" GroupRef="c2d21"> | <DataNode TextLabel="MMADHC" GraphId="bd7d2" Type="Protein" GroupRef="c2d21"> | ||
| Line 3,131: | Line 3,131: | ||
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In summary, THC acts as a partial agonist at both CB1 and CB2 receptors, stimulating these receptors to produce a variety of effects in the body, including psychoactive and potential therapeutic effects. Unlike CBD, THC does not act as an antagonist or inhibitor at these receptors, and its binding and activation of CB1 and CB2 receptors are central to its effects.</Comment> | In summary, THC acts as a partial agonist at both CB1 and CB2 receptors, stimulating these receptors to produce a variety of effects in the body, including psychoactive and potential therapeutic effects. Unlike CBD, THC does not act as an antagonist or inhibitor at these receptors, and its binding and activation of CB1 and CB2 receptors are central to its effects.</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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<Comment>2-arachidonoylglycerol</Comment> | <Comment>2-arachidonoylglycerol</Comment> | ||
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<Comment>CB2</Comment> | <Comment>CB2</Comment> | ||
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<Comment>anandamide</Comment> | <Comment>anandamide</Comment> | ||
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<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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<DataNode TextLabel="PIK3R1 " GraphId="a18bd" Type="Protein" GroupRef="bcbd1"> | <DataNode TextLabel="PIK3R1 " GraphId="a18bd" Type="Protein" GroupRef="bcbd1"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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<DataNode TextLabel="PIK3CD" GraphId="bcc3b" Type="Protein" GroupRef="bcbd1"> | <DataNode TextLabel="PIK3CD" GraphId="bcc3b" Type="Protein" GroupRef="bcbd1"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PIK3R3" GraphId="a3cd2" Type="Protein" GroupRef="bcbd1"> | <DataNode TextLabel="PIK3R3" GraphId="a3cd2" Type="Protein" GroupRef="bcbd1"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PDGFRB" GraphId="c97ba" Type="Protein" GroupRef="f510b"> | <DataNode TextLabel="PDGFRB" GraphId="c97ba" Type="Protein" GroupRef="f510b"> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRKCD " GraphId="f7298" Type="Protein" GroupRef="d3f76"> | <DataNode TextLabel="PRKCD " GraphId="f7298" Type="Protein" GroupRef="d3f76"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRKCZ " GraphId="e1bf7" Type="Protein"> | <DataNode TextLabel="PRKCZ " GraphId="e1bf7" Type="Protein"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRKCA " GraphId="cf9c3" Type="Protein" GroupRef="d3f76"> | <DataNode TextLabel="PRKCA " GraphId="cf9c3" Type="Protein" GroupRef="d3f76"> | ||
<BiopaxRef>ab3</BiopaxRef> | <BiopaxRef>ab3</BiopaxRef> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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| - | <Xref Database="Uniprot-TrEMBL" ID="P17252" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P17252"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRKCB " GraphId="c9866" Type="Protein" GroupRef="d3f76"> | <DataNode TextLabel="PRKCB " GraphId="c9866" Type="Protein" GroupRef="d3f76"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLCG2" GraphId="f4a01" Type="GeneProduct" GroupRef="dbf6d"> | <DataNode TextLabel="PLCG2" GraphId="f4a01" Type="GeneProduct" GroupRef="dbf6d"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P16885" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P16885"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRKCG " GraphId="e2210" Type="Protein" GroupRef="d3f76"> | <DataNode TextLabel="PRKCG " GraphId="e2210" Type="Protein" GroupRef="d3f76"> | ||
| - | <Attribute Key="cellular_location" Value="cytosol" /> | + | <Attribute Key="cellular_location" Value="cytosol"/> |
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| - | <Xref Database="Uniprot-TrEMBL" ID="P05129" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P05129"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="mTORC1 complex" GraphId="f59c8" Type="Complex" GroupRef="e9a60"> | <DataNode TextLabel="mTORC1 complex" GraphId="f59c8" Type="Complex" GroupRef="e9a60"> | ||
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| - | <Xref Database="Complex Portal" ID="CPX-503" /> | + | <Xref Database="Complex Portal" ID="CPX-503"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MLST8" GraphId="a0470" Type="GeneProduct" GroupRef="e9a60"> | <DataNode TextLabel="MLST8" GraphId="a0470" Type="GeneProduct" GroupRef="e9a60"> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="mTORC2 complex" GraphId="a200f" Type="Complex" GroupRef="a7d43"> | <DataNode TextLabel="mTORC2 complex" GraphId="a200f" Type="Complex" GroupRef="a7d43"> | ||
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| - | <Xref Database="Complex Portal" ID="CPX-4402" /> | + | <Xref Database="Complex Portal" ID="CPX-4402"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="AKT1S1" GraphId="db9f0" Type="GeneProduct" GroupRef="e9a60"> | <DataNode TextLabel="AKT1S1" GraphId="db9f0" Type="GeneProduct" GroupRef="e9a60"> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="RPTOR" GraphId="f3631" Type="GeneProduct" GroupRef="e9a60"> | <DataNode TextLabel="RPTOR" GraphId="f3631" Type="GeneProduct" GroupRef="e9a60"> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000141564" /> | + | <Xref Database="Ensembl" ID="ENSG00000141564"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DEPTOR" GraphId="d8e57" Type="GeneProduct" GroupRef="e9a60"> | <DataNode TextLabel="DEPTOR" GraphId="d8e57" Type="GeneProduct" GroupRef="e9a60"> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000155792" /> | + | <Xref Database="Ensembl" ID="ENSG00000155792"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTOR" GraphId="be0cc" Type="GeneProduct" GroupRef="e9a60"> | <DataNode TextLabel="MTOR" GraphId="be0cc" Type="GeneProduct" GroupRef="e9a60"> | ||
<Comment>effect of AKT on MTOR is indirect</Comment> | <Comment>effect of AKT on MTOR is indirect</Comment> | ||
<Comment>Part of two multiprotein complexes, TORC 1 and TORC 2</Comment> | <Comment>Part of two multiprotein complexes, TORC 1 and TORC 2</Comment> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000198793" /> | + | <Xref Database="Ensembl" ID="ENSG00000198793"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MLST8" GraphId="dd991" Type="GeneProduct" GroupRef="a7d43"> | <DataNode TextLabel="MLST8" GraphId="dd991" Type="GeneProduct" GroupRef="a7d43"> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000167965" /> | + | <Xref Database="Ensembl" ID="ENSG00000167965"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MAPKAP1" GraphId="ec790" Type="GeneProduct" GroupRef="a7d43"> | <DataNode TextLabel="MAPKAP1" GraphId="ec790" Type="GeneProduct" GroupRef="a7d43"> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000119487" /> | + | <Xref Database="Ensembl" ID="ENSG00000119487"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="RICTOR" GraphId="b8db9" Type="GeneProduct" GroupRef="a7d43"> | <DataNode TextLabel="RICTOR" GraphId="b8db9" Type="GeneProduct" GroupRef="a7d43"> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000164327" /> | + | <Xref Database="Ensembl" ID="ENSG00000164327"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTOR" GraphId="c0e75" Type="GeneProduct" GroupRef="a7d43"> | <DataNode TextLabel="MTOR" GraphId="c0e75" Type="GeneProduct" GroupRef="a7d43"> | ||
<Comment>effect of AKT on MTOR is indirect</Comment> | <Comment>effect of AKT on MTOR is indirect</Comment> | ||
<Comment>Part of two multiprotein complexes, TORC 1 and TORC 2</Comment> | <Comment>Part of two multiprotein complexes, TORC 1 and TORC 2</Comment> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="MAPK3" GraphId="c08e1" Type="Protein" GroupRef="f0d56"> | <DataNode TextLabel="MAPK3" GraphId="c08e1" Type="Protein" GroupRef="f0d56"> | ||
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| - | <Xref Database="dbSNP" ID="P27361" /> | + | <Xref Database="dbSNP" ID="P27361"/> |
</DataNode> | </DataNode> | ||
| - | <DataNode TextLabel="SAMe&# | + | <DataNode TextLabel="SAMe " GraphId="d839d" Type="Metabolite"> |
<BiopaxRef>f83</BiopaxRef> | <BiopaxRef>f83</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:59789" /> | + | <Xref Database="ChEBI" ID="CHEBI:59789"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SAH" GraphId="abc5c" Type="Metabolite"> | <DataNode TextLabel="SAH" GraphId="abc5c" Type="Metabolite"> | ||
<BiopaxRef>f83</BiopaxRef> | <BiopaxRef>f83</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16680" /> | + | <Xref Database="ChEBI" ID="CHEBI:16680"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="cob(II)alamin" GraphId="d4228" Type="Metabolite" GroupRef="c2d21"> | <DataNode TextLabel="cob(II)alamin" GraphId="d4228" Type="Metabolite" GroupRef="c2d21"> | ||
<Comment>Should be cob(II)alamin according to literature</Comment> | <Comment>Should be cob(II)alamin according to literature</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16304" /> | + | <Xref Database="ChEBI" ID="CHEBI:16304"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMACHC" GraphId="e6863" Type="Protein" GroupRef="c2d21"> | <DataNode TextLabel="MMACHC" GraphId="e6863" Type="Protein" GroupRef="c2d21"> | ||
| Line 3,735: | Line 3,735: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> |
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<DataNode TextLabel="WIPI1" GraphId="a8aaa" Type="GeneProduct"> | <DataNode TextLabel="WIPI1" GraphId="a8aaa" Type="GeneProduct"> | ||
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<DataNode TextLabel="ATG4" GraphId="c7e15" Type="GeneProduct" GroupRef="cdcac"> | <DataNode TextLabel="ATG4" GraphId="c7e15" Type="GeneProduct" GroupRef="cdcac"> | ||
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<DataNode TextLabel="WDR45" GraphId="d73a2" Type="GeneProduct" GroupRef="ade19"> | <DataNode TextLabel="WDR45" GraphId="d73a2" Type="GeneProduct" GroupRef="ade19"> | ||
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<DataNode TextLabel="PtdIns3P" GraphId="d5ebb" Type="Metabolite"> | <DataNode TextLabel="PtdIns3P" GraphId="d5ebb" Type="Metabolite"> | ||
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<DataNode TextLabel="ATG101" GraphId="d984a" Type="GeneProduct" GroupRef="d9e66"> | <DataNode TextLabel="ATG101" GraphId="d984a" Type="GeneProduct" GroupRef="d9e66"> | ||
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<DataNode TextLabel="ATG3" GraphId="f679e" Type="GeneProduct" GroupRef="a2a6a"> | <DataNode TextLabel="ATG3" GraphId="f679e" Type="GeneProduct" GroupRef="a2a6a"> | ||
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<DataNode TextLabel="ATG12" GraphId="cb18d" Type="GeneProduct" GroupRef="f4f6f"> | <DataNode TextLabel="ATG12" GraphId="cb18d" Type="GeneProduct" GroupRef="f4f6f"> | ||
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<DataNode TextLabel="ATG12" GraphId="b3aa6" Type="GeneProduct" GroupRef="f98ae"> | <DataNode TextLabel="ATG12" GraphId="b3aa6" Type="GeneProduct" GroupRef="f98ae"> | ||
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<DataNode TextLabel="ATG5" GraphId="cfaf5" Type="GeneProduct" GroupRef="f98ae"> | <DataNode TextLabel="ATG5" GraphId="cfaf5" Type="GeneProduct" GroupRef="f98ae"> | ||
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<DataNode TextLabel="LC3" GraphId="d01bf" Type="GeneProduct" GroupRef="a2a6a"> | <DataNode TextLabel="LC3" GraphId="d01bf" Type="GeneProduct" GroupRef="a2a6a"> | ||
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<DataNode TextLabel="LC3" GraphId="b8753" Type="GeneProduct" GroupRef="ba945"> | <DataNode TextLabel="LC3" GraphId="b8753" Type="GeneProduct" GroupRef="ba945"> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="LC3" GraphId="cc5cd" Type="GeneProduct" GroupRef="cdcac"> | <DataNode TextLabel="LC3" GraphId="cc5cd" Type="GeneProduct" GroupRef="cdcac"> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000101460" /> | + | <Xref Database="Ensembl" ID="ENSG00000101460"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ACACA" GraphId="b2ff6" Type="GeneProduct"> | <DataNode TextLabel="ACACA" GraphId="b2ff6" Type="GeneProduct"> | ||
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| - | <Xref Database="Ensembl" ID="ENSG00000278540" /> | + | <Xref Database="Ensembl" ID="ENSG00000278540"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="acetyl-CoA" GraphId="edb81" Type="Metabolite"> | <DataNode TextLabel="acetyl-CoA" GraphId="edb81" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57288" /> | + | <Xref Database="ChEBI" ID="CHEBI:57288"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="malonyl-CoA" GraphId="b7e9f" Type="Metabolite"> | <DataNode TextLabel="malonyl-CoA" GraphId="b7e9f" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57384" /> | + | <Xref Database="ChEBI" ID="CHEBI:57384"/> |
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<DataNode TextLabel="SESN2" GraphId="b50b8" Type="GeneProduct" GroupRef="e3c1c"> | <DataNode TextLabel="SESN2" GraphId="b50b8" Type="GeneProduct" GroupRef="e3c1c"> | ||
<BiopaxRef>af0</BiopaxRef> | <BiopaxRef>af0</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P58004" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P58004"/> |
</DataNode> | </DataNode> | ||
| - | <DataNode TextLabel="MAO Inhibitors&# | + | <DataNode TextLabel="MAO Inhibitors MAOIs" GraphId="c4afa" Type="Metabolite"> |
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| - | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="COMT Inhibitors" GraphId="cbfeb" Type="Metabolite"> | <DataNode TextLabel="COMT Inhibitors" GraphId="cbfeb" Type="Metabolite"> | ||
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| - | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</DataNode> | </DataNode> | ||
| - | <DataNode TextLabel="Derived From WP44577&# | + | <DataNode TextLabel="Derived From WP44577 Neurodegeneration w/ Fe" GraphId="a86f5" Type="Pathway"> |
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| - | <Xref Database="WikiPathways" ID="WP44577" /> | + | <Xref Database="WikiPathways" ID="WP44577"/> |
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<DataNode TextLabel="rs2735343" GraphId="ddc94" Type="Rna" GroupRef="ce3ec"> | <DataNode TextLabel="rs2735343" GraphId="ddc94" Type="Rna" GroupRef="ce3ec"> | ||
<BiopaxRef>bdc</BiopaxRef> | <BiopaxRef>bdc</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs2735343" /> | + | <Xref Database="dbSNP" ID="rs2735343"/> |
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<DataNode TextLabel="rs112025902" GraphId="c7c44" Type="Rna" GroupRef="ce3ec"> | <DataNode TextLabel="rs112025902" GraphId="c7c44" Type="Rna" GroupRef="ce3ec"> | ||
<BiopaxRef>bdc</BiopaxRef> | <BiopaxRef>bdc</BiopaxRef> | ||
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| - | <Xref Database="dbSNP" ID="rs112025902" /> | + | <Xref Database="dbSNP" ID="rs112025902"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMACHC" GraphId="e61f3" Type="Protein" GroupRef="ecc0c"> | <DataNode TextLabel="MMACHC" GraphId="e61f3" Type="Protein" GroupRef="ecc0c"> | ||
| Line 3,987: | Line 3,987: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FAD" GraphId="f0fb2" Type="Metabolite" GroupRef="ecc0c"> | <DataNode TextLabel="FAD" GraphId="f0fb2" Type="Metabolite" GroupRef="ecc0c"> | ||
<Comment>cofactor</Comment> | <Comment>cofactor</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57692" /> | + | <Xref Database="ChEBI" ID="CHEBI:57692"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="cob(II)alamin" GraphId="c188d" Type="Metabolite" GroupRef="db1ac"> | <DataNode TextLabel="cob(II)alamin" GraphId="c188d" Type="Metabolite" GroupRef="db1ac"> | ||
<Comment>Should be cob(II)alamin according to literature</Comment> | <Comment>Should be cob(II)alamin according to literature</Comment> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16304" /> | + | <Xref Database="ChEBI" ID="CHEBI:16304"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="cob(II)alamin" GraphId="d4524" Type="Metabolite"> | <DataNode TextLabel="cob(II)alamin" GraphId="d4524" Type="Metabolite"> | ||
<Comment>Should be cob(II)alamin according to literature</Comment> | <Comment>Should be cob(II)alamin according to literature</Comment> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16304" /> | + | <Xref Database="ChEBI" ID="CHEBI:16304"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMACHC" GraphId="f455f" Type="Protein" GroupRef="db1ac"> | <DataNode TextLabel="MMACHC" GraphId="f455f" Type="Protein" GroupRef="db1ac"> | ||
| Line 4,011: | Line 4,011: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FAD" GraphId="b9e31" Type="Metabolite" GroupRef="db1ac"> | <DataNode TextLabel="FAD" GraphId="b9e31" Type="Metabolite" GroupRef="db1ac"> | ||
<Comment>cofactor</Comment> | <Comment>cofactor</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57692" /> | + | <Xref Database="ChEBI" ID="CHEBI:57692"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMADHC" GraphId="a0f6b" Type="Protein" GroupRef="caa18"> | <DataNode TextLabel="MMADHC" GraphId="a0f6b" Type="Protein" GroupRef="caa18"> | ||
| Line 4,024: | Line 4,024: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="cob(II)alamin" GraphId="a2cd9" Type="Metabolite" GroupRef="caa18"> | <DataNode TextLabel="cob(II)alamin" GraphId="a2cd9" Type="Metabolite" GroupRef="caa18"> | ||
<Comment>Should be cob(II)alamin according to literature</Comment> | <Comment>Should be cob(II)alamin according to literature</Comment> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16304" /> | + | <Xref Database="ChEBI" ID="CHEBI:16304"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMACHC" GraphId="fa899" Type="Protein" GroupRef="caa18"> | <DataNode TextLabel="MMACHC" GraphId="fa899" Type="Protein" GroupRef="caa18"> | ||
| Line 4,037: | Line 4,037: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FMN" GraphId="b13f1" Type="Metabolite" GroupRef="caa18"> | <DataNode TextLabel="FMN" GraphId="b13f1" Type="Metabolite" GroupRef="caa18"> | ||
<BiopaxRef>dae</BiopaxRef> | <BiopaxRef>dae</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="cHEBI:58210" /> | + | <Xref Database="ChEBI" ID="cHEBI:58210"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMADHC" GraphId="b54c6" Type="Protein" GroupRef="d9458"> | <DataNode TextLabel="MMADHC" GraphId="b54c6" Type="Protein" GroupRef="d9458"> | ||
| Line 4,050: | Line 4,050: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
| - | <Graphics CenterX="1780.7905678883064" CenterY="998.1555806547844" Width="69.70075434611438" Height="22.224824324441542" ZOrder="34771" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="1780.7905678883064" CenterY="998.1555806547844" Width="69.70075434611438" Height="22.224824324441542" ZOrder="34771" FontSize="12" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9H3L0"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="cob(II)alamin" GraphId="cee91" Type="Metabolite" GroupRef="d9458"> | <DataNode TextLabel="cob(II)alamin" GraphId="cee91" Type="Metabolite" GroupRef="d9458"> | ||
<Comment>Should be cob(II)alamin according to literature</Comment> | <Comment>Should be cob(II)alamin according to literature</Comment> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16304" /> | + | <Xref Database="ChEBI" ID="CHEBI:16304"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMACHC" GraphId="fa0d0" Type="Protein" GroupRef="d9458"> | <DataNode TextLabel="MMACHC" GraphId="fa0d0" Type="Protein" GroupRef="d9458"> | ||
| Line 4,063: | Line 4,063: | ||
<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
<BiopaxRef>b51</BiopaxRef> | <BiopaxRef>b51</BiopaxRef> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9Y4U1"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FMN" GraphId="bdcc6" Type="Metabolite" GroupRef="d9458"> | <DataNode TextLabel="FMN" GraphId="bdcc6" Type="Metabolite" GroupRef="d9458"> | ||
<BiopaxRef>dae</BiopaxRef> | <BiopaxRef>dae</BiopaxRef> | ||
| - | <Graphics CenterX="1779.3670803438217" CenterY="979.0455728881783" Width="35.00000000000003" Height="15.000000000000037" ZOrder="34775" FontSize="12" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="1779.3670803438217" CenterY="979.0455728881783" Width="35.00000000000003" Height="15.000000000000037" ZOrder="34775" FontSize="12" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="cHEBI:58210" /> | + | <Xref Database="ChEBI" ID="cHEBI:58210"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MMAA" GraphId="dcf83" Type="Protein" GroupRef="c5c43"> | <DataNode TextLabel="MMAA" GraphId="dcf83" Type="Protein" GroupRef="c5c43"> | ||
<Comment>cbLA</Comment> | <Comment>cbLA</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
| - | <Graphics CenterX="1520.4880671770832" CenterY="786.3142434344384" Width="50.0" Height="19.999999999999964" ZOrder="34776" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="1520.4880671770832" CenterY="786.3142434344384" Width="50.0" Height="19.999999999999964" ZOrder="34776" FontSize="12" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="Q8IVH4" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q8IVH4"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TCN2" GraphId="cb0f8" Type="Protein"> | <DataNode TextLabel="TCN2" GraphId="cb0f8" Type="Protein"> | ||
<Comment>aka Transcobalamin 2</Comment> | <Comment>aka Transcobalamin 2</Comment> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P20062" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P20062"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TCN1" GraphId="a4900" Type="Protein"> | <DataNode TextLabel="TCN1" GraphId="a4900" Type="Protein"> | ||
| Line 4,086: | Line 4,086: | ||
<Comment>Produced in saliva and stomach</Comment> | <Comment>Produced in saliva and stomach</Comment> | ||
<BiopaxRef>af9</BiopaxRef> | <BiopaxRef>af9</BiopaxRef> | ||
| - | <Graphics CenterX="392.69606007388137" CenterY="1449.4094701668962" Width="55.0" Height="20.0" ZOrder="34813" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="392.69606007388137" CenterY="1449.4094701668962" Width="55.0" Height="20.0" ZOrder="34813" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P20061" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P20061"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CUBN" GraphId="c6826" Type="Protein" GroupRef="bc4c5"> | <DataNode TextLabel="CUBN" GraphId="c6826" Type="Protein" GroupRef="bc4c5"> | ||
<Comment>aka cubilin</Comment> | <Comment>aka cubilin</Comment> | ||
| - | <Graphics CenterX="386.42166673029817" CenterY="1307.1857665068308" Width="55.0" Height="20.0" ZOrder="34814" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="386.42166673029817" CenterY="1307.1857665068308" Width="55.0" Height="20.0" ZOrder="34814" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="O60494" /> | + | <Xref Database="Uniprot-TrEMBL" ID="O60494"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cbl" GraphId="b475f" Type="Metabolite" GroupRef="b8033"> | <DataNode TextLabel="Cbl" GraphId="b475f" Type="Metabolite" GroupRef="b8033"> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1482.3172964054756" Width="55.0" Height="20.0" ZOrder="34815" FontSize="14" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1482.3172964054756" Width="55.0" Height="20.0" ZOrder="34815" FontSize="14" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
</DataNode> | </DataNode> | ||
| - | <DataNode TextLabel="cobalamins&# | + | <DataNode TextLabel="cobalamins " GraphId="ecb8c" Type="Metabolite" GroupRef="f0895"> |
| - | <Graphics CenterX="304.4845966082104" CenterY="1574.593972598219" Width="81.31597946455234" Height="20.0" ZOrder="34816" FontSize="14" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="304.4845966082104" CenterY="1574.593972598219" Width="81.31597946455234" Height="20.0" ZOrder="34816" FontSize="14" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TCN1" GraphId="ee828" Type="Protein" GroupRef="b8033"> | <DataNode TextLabel="TCN1" GraphId="ee828" Type="Protein" GroupRef="b8033"> | ||
<Comment>aka haptocorrin or transcobalamin 1</Comment> | <Comment>aka haptocorrin or transcobalamin 1</Comment> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1502.3172964054756" Width="55.0" Height="20.0" ZOrder="34817" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1502.3172964054756" Width="55.0" Height="20.0" ZOrder="34817" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P20061" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P20061"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cbl" GraphId="e8b1a" Type="Metabolite"> | <DataNode TextLabel="Cbl" GraphId="e8b1a" Type="Metabolite"> | ||
<BiopaxRef>af9</BiopaxRef> | <BiopaxRef>af9</BiopaxRef> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1420.207000790871" Width="55.0" Height="20.0" ZOrder="34818" FontSize="14" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1420.207000790871" Width="55.0" Height="20.0" ZOrder="34818" FontSize="14" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cbl" GraphId="fc51a" Type="Metabolite" GroupRef="fba28"> | <DataNode TextLabel="Cbl" GraphId="fc51a" Type="Metabolite" GroupRef="fba28"> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1338.8840327933358" Width="55.0" Height="20.0" ZOrder="34820" FontSize="14" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1338.8840327933358" Width="55.0" Height="20.0" ZOrder="34820" FontSize="14" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CBLIF" GraphId="d6766" Type="Protein"> | <DataNode TextLabel="CBLIF" GraphId="d6766" Type="Protein"> | ||
<Comment>aka (gastric) intrinsic factor, transcobalamin III</Comment> | <Comment>aka (gastric) intrinsic factor, transcobalamin III</Comment> | ||
<Comment>Located in gastric parietal cells</Comment> | <Comment>Located in gastric parietal cells</Comment> | ||
| - | <Graphics CenterX="382.0284089822242" CenterY="1401.8952812158736" Width="55.0" Height="20.0" ZOrder="34821" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="382.0284089822242" CenterY="1401.8952812158736" Width="55.0" Height="20.0" ZOrder="34821" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P27352" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P27352"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CBLIF" GraphId="cc254" Type="Protein" GroupRef="fba28"> | <DataNode TextLabel="CBLIF" GraphId="cc254" Type="Protein" GroupRef="fba28"> | ||
<Comment>aka intrinsic factor</Comment> | <Comment>aka intrinsic factor</Comment> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1358.8840327933358" Width="55.0" Height="20.0" ZOrder="34822" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1358.8840327933358" Width="55.0" Height="20.0" ZOrder="34822" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P27352" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P27352"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cbl" GraphId="c8629" Type="Metabolite" GroupRef="ea5ad"> | <DataNode TextLabel="Cbl" GraphId="c8629" Type="Metabolite" GroupRef="ea5ad"> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1231.4213390546824" Width="55.0" Height="20.0" ZOrder="34825" FontSize="14" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1231.4213390546824" Width="55.0" Height="20.0" ZOrder="34825" FontSize="14" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CBLIF" GraphId="e71d9" Type="Protein" GroupRef="ea5ad"> | <DataNode TextLabel="CBLIF" GraphId="e71d9" Type="Protein" GroupRef="ea5ad"> | ||
<Comment>aka intrinsic factor</Comment> | <Comment>aka intrinsic factor</Comment> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1251.4213390546827" Width="55.0" Height="20.0" ZOrder="34826" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1251.4213390546827" Width="55.0" Height="20.0" ZOrder="34826" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P27352" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P27352"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="AMN" GraphId="da282" Type="Protein" GroupRef="bc4c5"> | <DataNode TextLabel="AMN" GraphId="da282" Type="Protein" GroupRef="bc4c5"> | ||
<Comment>aka amnionless</Comment> | <Comment>aka amnionless</Comment> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9BXJ7" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9BXJ7"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cbl" GraphId="c6a20" Type="Metabolite" GroupRef="c6d0b"> | <DataNode TextLabel="Cbl" GraphId="c6a20" Type="Metabolite" GroupRef="c6d0b"> | ||
| - | <Graphics CenterX="189.22399541493468" CenterY="1070.2361789804527" Width="55.0" Height="20.0" ZOrder="34842" FontSize="14" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="189.22399541493468" CenterY="1070.2361789804527" Width="55.0" Height="20.0" ZOrder="34842" FontSize="14" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TCN2" GraphId="c1b85" Type="Protein" GroupRef="c6d0b"> | <DataNode TextLabel="TCN2" GraphId="c1b85" Type="Protein" GroupRef="c6d0b"> | ||
<Comment>aka Transcobalamin 2</Comment> | <Comment>aka Transcobalamin 2</Comment> | ||
<BiopaxRef>af9</BiopaxRef> | <BiopaxRef>af9</BiopaxRef> | ||
| - | <Graphics CenterX="189.22399541493468" CenterY="1090.2361789804527" Width="55.0" Height="20.0" ZOrder="34843" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="189.22399541493468" CenterY="1090.2361789804527" Width="55.0" Height="20.0" ZOrder="34843" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P20062" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P20062"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CBLIF" GraphId="a6060" Type="Protein"> | <DataNode TextLabel="CBLIF" GraphId="a6060" Type="Protein"> | ||
<Comment>aka (gastric) intrinsic factor, transcobalamin III</Comment> | <Comment>aka (gastric) intrinsic factor, transcobalamin III</Comment> | ||
<Comment>Located in gastric parietal cells</Comment> | <Comment>Located in gastric parietal cells</Comment> | ||
| - | <Graphics CenterX="200.27413754129384" CenterY="1309.9469754039096" Width="55.0" Height="20.0" ZOrder="34845" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="200.27413754129384" CenterY="1309.9469754039096" Width="55.0" Height="20.0" ZOrder="34845" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P27352" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P27352"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TCN1" GraphId="ed76f" Type="Protein"> | <DataNode TextLabel="TCN1" GraphId="ed76f" Type="Protein"> | ||
| Line 4,161: | Line 4,161: | ||
<Comment>Produced in saliva and stomach</Comment> | <Comment>Produced in saliva and stomach</Comment> | ||
<BiopaxRef>af9</BiopaxRef> | <BiopaxRef>af9</BiopaxRef> | ||
| - | <Graphics CenterX="376.86372659435955" CenterY="1541.6530730258025" Width="55.0" Height="20.0" ZOrder="34847" FontSize="14" Valign="Middle" /> | + | <Graphics CenterX="376.86372659435955" CenterY="1541.6530730258025" Width="55.0" Height="20.0" ZOrder="34847" FontSize="14" Valign="Middle"/> |
| - | <Xref Database="Uniprot-TrEMBL" ID="P20061" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P20061"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="B2" GraphId="d0faa" Type="Metabolite"> | <DataNode TextLabel="B2" GraphId="d0faa" Type="Metabolite"> | ||
| Line 4,168: | Line 4,168: | ||
<BiopaxRef>dae</BiopaxRef> | <BiopaxRef>dae</BiopaxRef> | ||
<BiopaxRef>e60</BiopaxRef> | <BiopaxRef>e60</BiopaxRef> | ||
| - | <Graphics CenterX="533.6392864583058" CenterY="1330.7449763304496" Width="35.0" Height="20.0" ZOrder="34848" FontSize="12" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="533.6392864583058" CenterY="1330.7449763304496" Width="35.0" Height="20.0" ZOrder="34848" FontSize="12" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:17015" /> | + | <Xref Database="ChEBI" ID="CHEBI:17015"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="B2" GraphId="b6e2b" Type="Metabolite"> | <DataNode TextLabel="B2" GraphId="b6e2b" Type="Metabolite"> | ||
| Line 4,175: | Line 4,175: | ||
<BiopaxRef>dae</BiopaxRef> | <BiopaxRef>dae</BiopaxRef> | ||
<BiopaxRef>e60</BiopaxRef> | <BiopaxRef>e60</BiopaxRef> | ||
| - | <Graphics CenterX="531.5384461221713" CenterY="1218.593459117012" Width="35.0" Height="20.0" ZOrder="34849" FontSize="12" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="531.5384461221713" CenterY="1218.593459117012" Width="35.0" Height="20.0" ZOrder="34849" FontSize="12" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:17015" /> | + | <Xref Database="ChEBI" ID="CHEBI:17015"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cbl" GraphId="ba08e" Type="Metabolite"> | <DataNode TextLabel="Cbl" GraphId="ba08e" Type="Metabolite"> | ||
<BiopaxRef>af9</BiopaxRef> | <BiopaxRef>af9</BiopaxRef> | ||
| - | <Graphics CenterX="305.68443985319203" CenterY="1175.7485160370827" Width="55.0" Height="20.0" ZOrder="34850" FontSize="14" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="305.68443985319203" CenterY="1175.7485160370827" Width="55.0" Height="20.0" ZOrder="34850" FontSize="14" Valign="Middle" Color="0000ff"/> |
| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cbl" GraphId="f212a" Type="Metabolite"> | <DataNode TextLabel="Cbl" GraphId="f212a" Type="Metabolite"> | ||
<BiopaxRef>af9</BiopaxRef> | <BiopaxRef>af9</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:23334" /> | + | <Xref Database="ChEBI" ID="CHEBI:23334"/> |
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<DataNode TextLabel="PLP" GraphId="f0ef2" Type="Metabolite"> | <DataNode TextLabel="PLP" GraphId="f0ef2" Type="Metabolite"> | ||
| Line 4,192: | Line 4,192: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>f9c</BiopaxRef> | <BiopaxRef>f9c</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
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<DataNode TextLabel="PMP" GraphId="daeee" Type="Metabolite"> | <DataNode TextLabel="PMP" GraphId="daeee" Type="Metabolite"> | ||
| Line 4,199: | Line 4,199: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:18335" /> | + | <Xref Database="ChEBI" ID="CHEBI:18335"/> |
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<DataNode TextLabel="PNP" GraphId="c779c" Type="Metabolite"> | <DataNode TextLabel="PNP" GraphId="c779c" Type="Metabolite"> | ||
| Line 4,206: | Line 4,206: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:28803" /> | + | <Xref Database="ChEBI" ID="CHEBI:28803"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PNG" GraphId="d3c66" Type="Metabolite"> | <DataNode TextLabel="PNG" GraphId="d3c66" Type="Metabolite"> | ||
| Line 4,213: | Line 4,213: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17382" /> | + | <Xref Database="ChEBI" ID="CHEBI:17382"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PL" GraphId="c1fea" Type="Metabolite"> | <DataNode TextLabel="PL" GraphId="c1fea" Type="Metabolite"> | ||
<Comment>pyridoxal</Comment> | <Comment>pyridoxal</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17310" /> | + | <Xref Database="ChEBI" ID="CHEBI:17310"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PM" GraphId="b8fe1" Type="Metabolite"> | <DataNode TextLabel="PM" GraphId="b8fe1" Type="Metabolite"> | ||
<Comment>pyridoxamine</Comment> | <Comment>pyridoxamine</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57761" /> | + | <Xref Database="ChEBI" ID="CHEBI:57761"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PN" GraphId="e3a48" Type="Metabolite"> | <DataNode TextLabel="PN" GraphId="e3a48" Type="Metabolite"> | ||
| Line 4,232: | Line 4,232: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:28803" /> | + | <Xref Database="ChEBI" ID="CHEBI:28803"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Zn2+" GraphId="c16b7" Type="Metabolite" GroupRef="c4d77"> | <DataNode TextLabel="Zn2+" GraphId="c16b7" Type="Metabolite" GroupRef="c4d77"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:29105" /> | + | <Xref Database="ChEBI" ID="CHEBI:29105"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Mg2+" GraphId="be977" Type="Metabolite" GroupRef="c4d77"> | <DataNode TextLabel="Mg2+" GraphId="be977" Type="Metabolite" GroupRef="c4d77"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:18420" /> | + | <Xref Database="ChEBI" ID="CHEBI:18420"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Ca2+" GraphId="bcffe" Type="Metabolite" GroupRef="c4d77"> | <DataNode TextLabel="Ca2+" GraphId="bcffe" Type="Metabolite" GroupRef="c4d77"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:29108" /> | + | <Xref Database="ChEBI" ID="CHEBI:29108"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PL" GraphId="dd019" Type="Metabolite"> | <DataNode TextLabel="PL" GraphId="dd019" Type="Metabolite"> | ||
<Comment>pyridoxal</Comment> | <Comment>pyridoxal</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17310" /> | + | <Xref Database="ChEBI" ID="CHEBI:17310"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PM" GraphId="fa0ac" Type="Metabolite"> | <DataNode TextLabel="PM" GraphId="fa0ac" Type="Metabolite"> | ||
<Comment>pyridoxamine</Comment> | <Comment>pyridoxamine</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57761" /> | + | <Xref Database="ChEBI" ID="CHEBI:57761"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PN" GraphId="e7c2a" Type="Metabolite"> | <DataNode TextLabel="PN" GraphId="e7c2a" Type="Metabolite"> | ||
| Line 4,263: | Line 4,263: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:28803" /> | + | <Xref Database="ChEBI" ID="CHEBI:28803"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PL" GraphId="b293f" Type="Metabolite"> | <DataNode TextLabel="PL" GraphId="b293f" Type="Metabolite"> | ||
<Comment>pyridoxal</Comment> | <Comment>pyridoxal</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17310" /> | + | <Xref Database="ChEBI" ID="CHEBI:17310"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PM" GraphId="d2e0e" Type="Metabolite"> | <DataNode TextLabel="PM" GraphId="d2e0e" Type="Metabolite"> | ||
<Comment>pyridoxamine</Comment> | <Comment>pyridoxamine</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57761" /> | + | <Xref Database="ChEBI" ID="CHEBI:57761"/> |
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<DataNode TextLabel="PN" GraphId="c8939" Type="Metabolite"> | <DataNode TextLabel="PN" GraphId="c8939" Type="Metabolite"> | ||
| Line 4,282: | Line 4,282: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:28803" /> | + | <Xref Database="ChEBI" ID="CHEBI:28803"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PDXK" GraphId="b0085" Type="Protein"> | <DataNode TextLabel="PDXK" GraphId="b0085" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="O00764" /> | + | <Xref Database="Uniprot-TrEMBL" ID="O00764"/> |
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<DataNode TextLabel="PLP" GraphId="a0d9a" Type="Metabolite"> | <DataNode TextLabel="PLP" GraphId="a0d9a" Type="Metabolite"> | ||
| Line 4,293: | Line 4,293: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>f9c</BiopaxRef> | <BiopaxRef>f9c</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:597326" /> | + | <Xref Database="ChEBI" ID="CHEBI:597326"/> |
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<DataNode TextLabel="PMP" GraphId="de14b" Type="Metabolite"> | <DataNode TextLabel="PMP" GraphId="de14b" Type="Metabolite"> | ||
| Line 4,300: | Line 4,300: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:18335" /> | + | <Xref Database="ChEBI" ID="CHEBI:18335"/> |
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<DataNode TextLabel="PNP" GraphId="ffeb8" Type="Metabolite"> | <DataNode TextLabel="PNP" GraphId="ffeb8" Type="Metabolite"> | ||
| Line 4,307: | Line 4,307: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:28803" /> | + | <Xref Database="ChEBI" ID="CHEBI:28803"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PLP" GraphId="e8ea5" Type="Metabolite"> | <DataNode TextLabel="PLP" GraphId="e8ea5" Type="Metabolite"> | ||
| Line 4,314: | Line 4,314: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>f9c</BiopaxRef> | <BiopaxRef>f9c</BiopaxRef> | ||
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</DataNode> | </DataNode> | ||
<DataNode TextLabel="SLC?" GraphId="e0aeb" Type="Protein"> | <DataNode TextLabel="SLC?" GraphId="e0aeb" Type="Protein"> | ||
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| - | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
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<DataNode TextLabel="PLP" GraphId="bb56d" Type="Metabolite"> | <DataNode TextLabel="PLP" GraphId="bb56d" Type="Metabolite"> | ||
| Line 4,325: | Line 4,325: | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>f9c</BiopaxRef> | <BiopaxRef>f9c</BiopaxRef> | ||
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<DataNode TextLabel="ALPL" GraphId="e9441" Type="Protein" GroupRef="e96dc"> | <DataNode TextLabel="ALPL" GraphId="e9441" Type="Protein" GroupRef="e96dc"> | ||
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<DataNode TextLabel="Zn2+" GraphId="d610e" Type="Metabolite" GroupRef="e96dc"> | <DataNode TextLabel="Zn2+" GraphId="d610e" Type="Metabolite" GroupRef="e96dc"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:29105" /> | + | <Xref Database="ChEBI" ID="CHEBI:29105"/> |
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<DataNode TextLabel="Mg2+" GraphId="f7259" Type="Metabolite" GroupRef="e96dc"> | <DataNode TextLabel="Mg2+" GraphId="f7259" Type="Metabolite" GroupRef="e96dc"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:18420" /> | + | <Xref Database="ChEBI" ID="CHEBI:18420"/> |
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<DataNode TextLabel="Ca2+" GraphId="f0b41" Type="Metabolite" GroupRef="e96dc"> | <DataNode TextLabel="Ca2+" GraphId="f0b41" Type="Metabolite" GroupRef="e96dc"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:29108" /> | + | <Xref Database="ChEBI" ID="CHEBI:29108"/> |
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<DataNode TextLabel="PL" GraphId="c6837" Type="Metabolite"> | <DataNode TextLabel="PL" GraphId="c6837" Type="Metabolite"> | ||
<Comment>pyridoxal</Comment> | <Comment>pyridoxal</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>f9c</BiopaxRef> | <BiopaxRef>f9c</BiopaxRef> | ||
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<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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<Comment>pyridoxal</Comment> | <Comment>pyridoxal</Comment> | ||
<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
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<Comment>Type your comment here</Comment> | <Comment>Type your comment here</Comment> | ||
<BiopaxRef>f9c</BiopaxRef> | <BiopaxRef>f9c</BiopaxRef> | ||
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<BiopaxRef>d6a</BiopaxRef> | <BiopaxRef>d6a</BiopaxRef> | ||
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<BiopaxRef>bf2</BiopaxRef> | <BiopaxRef>bf2</BiopaxRef> | ||
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<BiopaxRef>f35</BiopaxRef> | <BiopaxRef>f35</BiopaxRef> | ||
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<DataNode TextLabel="glycine" GraphId="f1b36" Type="Metabolite"> | <DataNode TextLabel="glycine" GraphId="f1b36" Type="Metabolite"> | ||
<BiopaxRef>de7</BiopaxRef> | <BiopaxRef>de7</BiopaxRef> | ||
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<DataNode TextLabel="ADA" GraphId="b96a6" Type="Protein"> | <DataNode TextLabel="ADA" GraphId="b96a6" Type="Protein"> | ||
<Comment>aka Adenosine deaminase</Comment> | <Comment>aka Adenosine deaminase</Comment> | ||
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<DataNode TextLabel="Succinyladenosine" GraphId="c2809" Type="Metabolite"> | <DataNode TextLabel="Succinyladenosine" GraphId="c2809" Type="Metabolite"> | ||
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<DataNode TextLabel="dATP" GraphId="fb6fb" Type="Metabolite"> | <DataNode TextLabel="dATP" GraphId="fb6fb" Type="Metabolite"> | ||
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<DataNode TextLabel="AICARP" GraphId="da47a" Type="Metabolite"> | <DataNode TextLabel="AICARP" GraphId="da47a" Type="Metabolite"> | ||
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<DataNode TextLabel="2,8-Dihydroxyadenine" GraphId="f89ab" Type="Metabolite"> | <DataNode TextLabel="2,8-Dihydroxyadenine" GraphId="f89ab" Type="Metabolite"> | ||
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<DataNode TextLabel="dADP" GraphId="da668" Type="Metabolite"> | <DataNode TextLabel="dADP" GraphId="da668" Type="Metabolite"> | ||
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<DataNode TextLabel="Adenosine" GraphId="f61f1" Type="Metabolite"> | <DataNode TextLabel="Adenosine" GraphId="f61f1" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16335" /> | + | <Xref Database="ChEBI" ID="CHEBI:16335"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="dAMP" GraphId="f2f7d" Type="Metabolite"> | <DataNode TextLabel="dAMP" GraphId="f2f7d" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:58245" /> | + | <Xref Database="ChEBI" ID="CHEBI:58245"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ITP" GraphId="a9a94" Type="Metabolite"> | <DataNode TextLabel="ITP" GraphId="a9a94" Type="Metabolite"> | ||
<Comment>is a nucleoside triphosphate(4−)</Comment> | <Comment>is a nucleoside triphosphate(4−)</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:61402" /> | + | <Xref Database="ChEBI" ID="CHEBI:61402"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ADSS" GraphId="b4b55" Type="Protein"> | <DataNode TextLabel="ADSS" GraphId="b4b55" Type="Protein"> | ||
<Comment>Adenylosuccinate synthetase isozyme 2</Comment> | <Comment>Adenylosuccinate synthetase isozyme 2</Comment> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P30520" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P30520"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Hypoxanthine" GraphId="ab436" Type="Metabolite"> | <DataNode TextLabel="Hypoxanthine" GraphId="ab436" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17368" /> | + | <Xref Database="ChEBI" ID="CHEBI:17368"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Guanosine" GraphId="a948f" Type="Metabolite"> | <DataNode TextLabel="Guanosine" GraphId="a948f" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16750" /> | + | <Xref Database="ChEBI" ID="CHEBI:16750"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ADSL" GraphId="ae4ee" Type="Protein"> | <DataNode TextLabel="ADSL" GraphId="ae4ee" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P30566" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P30566"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="IMPDH1" GraphId="d1167" Type="Protein"> | <DataNode TextLabel="IMPDH1" GraphId="d1167" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P20839" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P20839"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="HPRT1" GraphId="a62c7" Type="Protein"> | <DataNode TextLabel="HPRT1" GraphId="a62c7" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P00492" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P00492"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="S-AMP" GraphId="faa4d" Type="Metabolite"> | <DataNode TextLabel="S-AMP" GraphId="faa4d" Type="Metabolite"> | ||
<Comment>succinyladenosine monophosphate</Comment> | <Comment>succinyladenosine monophosphate</Comment> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57567" /> | + | <Xref Database="ChEBI" ID="CHEBI:57567"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Xanthine" GraphId="b1e9c" Type="Metabolite"> | <DataNode TextLabel="Xanthine" GraphId="b1e9c" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17712" /> | + | <Xref Database="ChEBI" ID="CHEBI:17712"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ADP" GraphId="ff392" Type="Metabolite"> | <DataNode TextLabel="ADP" GraphId="ff392" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:456216" /> | + | <Xref Database="ChEBI" ID="CHEBI:456216"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DGUOK" GraphId="eedb8" Type="Protein"> | <DataNode TextLabel="DGUOK" GraphId="eedb8" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q16854" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q16854"/> |
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<DataNode TextLabel="GTP" GraphId="e8b2e" Type="Metabolite"> | <DataNode TextLabel="GTP" GraphId="e8b2e" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:37565" /> | + | <Xref Database="ChEBI" ID="CHEBI:37565"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="dGTP" GraphId="f7476" Type="Metabolite"> | <DataNode TextLabel="dGTP" GraphId="f7476" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16497" /> | + | <Xref Database="ChEBI" ID="CHEBI:16497"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="AMPD1" GraphId="c8457" Type="Protein"> | <DataNode TextLabel="AMPD1" GraphId="c8457" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P23109" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P23109"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Urate" GraphId="a0681" Type="Metabolite"> | <DataNode TextLabel="Urate" GraphId="a0681" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17775" /> | + | <Xref Database="ChEBI" ID="CHEBI:17775"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ITPA" GraphId="ca56f" Type="Protein"> | <DataNode TextLabel="ITPA" GraphId="ca56f" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="Q9BY32" /> | + | <Xref Database="Uniprot-TrEMBL" ID="Q9BY32"/> |
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<DataNode TextLabel="Adenine" GraphId="a2c68" Type="Metabolite"> | <DataNode TextLabel="Adenine" GraphId="a2c68" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16708" /> | + | <Xref Database="ChEBI" ID="CHEBI:16708"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Guanine" GraphId="daba4" Type="Metabolite"> | <DataNode TextLabel="Guanine" GraphId="daba4" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:16235" /> | + | <Xref Database="ChEBI" ID="CHEBI:16235"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="RR" GraphId="dbea8" Type="Protein"> | <DataNode TextLabel="RR" GraphId="dbea8" Type="Protein"> | ||
<Comment>ribonucleotide reductase</Comment> | <Comment>ribonucleotide reductase</Comment> | ||
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| - | <Xref Database="Enzyme Nomenclature" ID="1.17.4.1" /> | + | <Xref Database="Enzyme Nomenclature" ID="1.17.4.1"/> |
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<DataNode TextLabel="dGMP" GraphId="b2e36" Type="Metabolite"> | <DataNode TextLabel="dGMP" GraphId="b2e36" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:57673" /> | + | <Xref Database="ChEBI" ID="CHEBI:57673"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FAICARP" GraphId="b4251" Type="Metabolite"> | <DataNode TextLabel="FAICARP" GraphId="b4251" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:58467" /> | + | <Xref Database="ChEBI" ID="CHEBI:58467"/> |
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<DataNode TextLabel="2-Deoxyguanosine" GraphId="beab7" Type="Metabolite"> | <DataNode TextLabel="2-Deoxyguanosine" GraphId="beab7" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:17172" /> | + | <Xref Database="ChEBI" ID="CHEBI:17172"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="GMP" GraphId="f8947" Type="Metabolite"> | <DataNode TextLabel="GMP" GraphId="f8947" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:58115" /> | + | <Xref Database="ChEBI" ID="CHEBI:58115"/> |
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<DataNode TextLabel="2'-deoxyinosine" GraphId="dfdc1" Type="Metabolite"> | <DataNode TextLabel="2'-deoxyinosine" GraphId="dfdc1" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:28997" /> | + | <Xref Database="ChEBI" ID="CHEBI:28997"/> |
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<DataNode TextLabel="IMP" GraphId="a0bf1" Type="Metabolite"> | <DataNode TextLabel="IMP" GraphId="a0bf1" Type="Metabolite"> | ||
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| - | <Xref Database="ChEBI" ID="CHEBI:58053" /> | + | <Xref Database="ChEBI" ID="CHEBI:58053"/> |
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<DataNode TextLabel="PNP" GraphId="f559f" Type="Protein"> | <DataNode TextLabel="PNP" GraphId="f559f" Type="Protein"> | ||
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| - | <Xref Database="Uniprot-TrEMBL" ID="P00491" /> | + | <Xref Database="Uniprot-TrEMBL" ID="P00491"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="HPRT1" GraphId="e01ba" Type="Protein"> | <DataNode TextLabel="HPRT1" GraphId="e01ba" Type="Protein"> | ||
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<DataNode TextLabel="XO" GraphId="e6983" Type="Protein"> | <DataNode TextLabel="XO" GraphId="e6983" Type="Protein"> | ||
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<DataNode TextLabel="SLC25A39" GraphId="e521e" Type="GeneProduct" GroupRef="d1b80"> | <DataNode TextLabel="SLC25A39" GraphId="e521e" Type="GeneProduct" GroupRef="d1b80"> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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<DataNode TextLabel="SLC25A40" GraphId="fe87a" Type="Protein" GroupRef="d1b80"> | <DataNode TextLabel="SLC25A40" GraphId="fe87a" Type="Protein" GroupRef="d1b80"> | ||
<BiopaxRef>c40</BiopaxRef> | <BiopaxRef>c40</BiopaxRef> | ||
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<DataNode TextLabel="serine" GraphId="cee1e" Type="Metabolite"> | <DataNode TextLabel="serine" GraphId="cee1e" Type="Metabolite"> | ||
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<Comment>Receptor mediated endocytosis</Comment> | <Comment>Receptor mediated endocytosis</Comment> | ||
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| Line 13,534: | Line 13,534: | ||
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25777072</bp:ID> | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25777072</bp:ID> | ||
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fbf"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fbf"> | ||
| Line 13,545: | Line 13,545: | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ec3"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ec3"> | ||
| - | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI: 10.1038/s41398-020-0755-4</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI: 10.1038/s41398-020-0755-4</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
| Line 13,555: | Line 13,555: | ||
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.1016/j.tips.2017.04.001</bp:ID> | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.1016/j.tips.2017.04.001</bp:ID> | ||
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI</bp:DB> | ||
| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI: 10.1016/j.tips.2017.04.001</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI: 10.1016/j.tips.2017.04.001</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
| Line 13,563: | Line 13,563: | ||
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.1084/jem.20181965</bp:ID> | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.1084/jem.20181965</bp:ID> | ||
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI</bp:DB> | ||
| - | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
| - | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string" | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> |
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI: 10.1084/jem.20181965</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI: 10.1084/jem.20181965</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
</Biopax> | </Biopax> | ||
</Pathway> | </Pathway> | ||
Current revision
Error rendering pathway page
This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.
Pathway history
View all... |
Error details
exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/c/c5/WP5420_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
at org.pathvisio.core.Engine.importPathway(Unknown Source)
at org.pathvisio.core.util.Converter.main(Unknown Source)
<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/c/c5/WP5420_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 129450)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
