ADHD and autism (ASD) pathways (Homo sapiens)

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551645565128159154525553161, 164MitochondriaNucleusSynapticVesicleSynapticVesicleAdrenal VesicleAdrenal MedullaDisks large homologRTKLegendNote: enzymes color coded for readability CytoskeletalOrganizaitonRegulation of actin cytoskeletonexogenous cannabinoidIntestinCatecholamineSynthesisROSReactive OxygenStressFolateCycleSerotoninSynthesis(5-HT)Kynurenine Pathway (KP)MelatoninSynthesisAlex Madsen2023copyright (c) 2023CC0 1.0 Universal (CC0 1.0)Public Domain DedicationSynaptophysinSynaptobrevinComplexSynaptic Cleftcytosol (intracellular)MethionineCyclen.e.BH4SynthaseOpioid Receptorhydroxylation163Endocannabinoid System (ECS)IntercellularSCN2AGeneProductDRD4 VNTR exon III-7rGATMglycineEGFRSSRIs(fluoxetine, citalopram,sertraline, paroxetine,escitalopram)NMPEADAGINSRguanidinoacetateRHEBCALM3MetaboliteMAPK12-phenylacetaldehydephenylethylamine2-phenylethylaminePEATBCD7SNPsingle nucleotidepolymorphismPLCG1RHOAKITPDGFRAProteinL-ornithinecreatine22, 106, 115122, 1297182182182182182rs618938MN2+CNTN6rs113707025, 34, 48, 68, 79...NA AldehydeTHF-polyglutamate3-MT SOSCN1Ars656133332Imidazole-4-acetate57, 135a 1-(1-hydroxyalkyl)-sn-glycerol5FMN6rs4343132ALDH257rs1284353391rs237897NOX4H2O2rs105131238SCN4BDHMA1-O-(1,2-saturated-alkyl)-sn-glycerol5ADAM1035rs6280132q-BH267, 179HNMTrs7997012132, 162GABRA2ACE159angiotensin I159SAMSAMe181rs148727532PCBD167rs1087935232HCFC1 (cblX)64, 76PCBD267L-tryptophan119, 164SLC25A32AANAT14, 28, 153, 164SCN5Ars1117899738MAOAALDHserine92TYrs60261849NMN-SOCSADPPH424serotonin164rs10521432169PTS24sepiapterin170rs192388632MG2+NormetanephrineNMGABRB3rs205620213, 15rs68632THF92rs598968170, 177NOformate92MAOBL-citrulliners1950902145rs1465107104FADCBSGABRA3Metanephriners3785143116, 144rs74060169tyraminers207101012, 111GABRA5SLC18A1124, 132rs1023159rs165774GLS107SLC46A1CNTN1B6pyridoxineCPLX1PDXKglycine betaineFOLH1166SHMT2taurine5-MTHFMOPGALAdoCblMeCblOPRM140deamido-NAD+90CYP2D6L-histidinol135SCN10ACNTNAP4SLC17A6rs140694632ALDH5A1DHNTP24, 180DAG1L-cysteatemelatonin161, 164rs3622043-MTSULT1A3rs224244637, 126, 131rs229844412, 29GCATglycine92SLC25A12rs35062132rs2934966325-10MeTHF10-formyl-THF92MTRRO2−128DOPL157rs3601723, 123PNPO5, 10-MTHFPG92SCN7AHISN84-aminobutanoateNADSYN190AHCYL1rs2236225145rs237889rs590551169rs12843268103rs16976358132L-tyrosiners594902885MTHFD2LMN-SO4nicotinate D-ribonucleotide(2−)97N-METHYL-HISTAMINE17, 105B9rs302740779, 91SLC17A8RFK6dopamineDBHAOC1SIRT3161, 164cysteine sulfinateSAH181L-dopaNM Aldehyde pyridoxine 5'-phosphaters651646 149rs2270637132S-adenosyl-L-homocysteineMHPGMOPEGrs4130047132DOPET157rs4818FLAD1Biopterinrs378202532histamine105, 135GABRA11′-OXPH424, 112SCN8ASLC19A1NOS1rs1390938117, 132, 133PNMTrs17998362, 132, 169, 171rs632316GABRA4rs658207132rs2279709132AKR1B124rs626746BHMT18DHFR24, 180ALDH9A1rs2270641132H4gtpGPTrs37338903, 61HDCN-Methylhistamine17, 105imidazole-4-acetaldehyde57, 105pyridoxaminers165599GABRB1QPRT90FAAH2rs5906883 79, 91SOD2161, 164rs737865rs180119832rs66518062, 26, 169CNTNAP252rs59055122SCN2BSCN9Aq-H2BPT5, 148GABRG1SLC6A4132NAS164L-alanine5-MTFe2+rs17469669GABRG2ADGRL3GPCRsrs2268491rs1667627rs167271732rs7632287glycerolO2L-histidine135DOPAC138, 157rs265981GABRQfatty aldehydes121DHPGrs180054438, 49Alpha-dystroglycan109hemiacetals121SCN3BNOX1CNTN2TDCCNTNAP1GABRB2alkylglycerols121Xanthurenic acid119rs1051266SLC6A2147GCH124, 180rs594445132rs2838684063, 882-oxoglutarateMet181rs468046, 69rs229281313, 15rs3813034132rs197927712, 41, 133, 156CBCollybistin109, 140SLC52A2FOLR1noladin ether31, 82, 110, 148rs208810269MTHFD2SLC6A3STXBP1rs374654438QDPR67TAAR1137, 158rs378515763TYMS86SCN1Bpyridoxalrs556937NOX3DNMT1TCN2CNTN5rs77986745, 132rs53576acetateSLC52A1rs180508741, 132AGTR1rs4633NOS3SCN4AMOCOSPAHGABRDrs6269DHFAGMO5, 148MoCoL-glutamine107, 113rs151257822rs237902rs4291132ASMT153, 164(4aS,6R)-4a-hydroxy - BH4179rs25191560Derived From WP4159GABA receptor signaling5-HialDDCmoco sulfide rs674603020, 46HVAL138SOD175NCAM152RIT233TPH2179glycerol 3-phosphateMTR181SLC52A3Derived From WP4271Vitamin B12 disordersrs457062538Pharmacological Intervention(drug)Angiotensinogen159CNTN4MTHFRrs6318132hypotaurineNMNAT190DOPGALSCN11ASLC25A13ALDH1L1rs237887B26, 181rs4532132SCN3Ars135225032rs457062538GPHN109, 140OH-NOX5rs3027400104rs2129575156CDO1SLC17A7KYAT3ALDH1L2GKSYPFMO1REN159rs2710102132CTH6R-BH45adrenalineAKRAHCYCNTN3arachidonic acidcystathionineDOPEGSPR24, 1805-hydroxy-L-tryptophan164CNTNAP3rs7794745132rs179997140, 46, 165L-arginine182TPH1179GLUL146rs2254298ADHL-cysteiners4446909177L-phenylalanine2′-OXPH424, 112homocysteine181MAT1AMAT2BBH4179BH27,8-dihydrofolate179AKR1A1AKR1C324CBR124AKR1C1B95, 10-MTHFPG92SHMT110-formyl-THF92MTHFD1MTHFD1LTHF92NADPrs87665742180NOS2NADPNADPHONOO-serotoninDopamineReceptorsDRD3DRD5DRD4DRD2DRD1HTR4HTR5bHTR6HTR1D56HTR1EHTR7HTR2AHTR1FHTR5aHTR2BHTR1A56HTR1B56HTR2CADRA2CADRA1AADRB3aADRA1BADRA2AADRB1ADRA2BADRA1DADRB2AdrenergicReceptorsserotoninnorepinephrinedopaminers180113166, 132rs180113366, 132rs484604966rs180139419rs1532268rs3819331rs2518352rs121913223rs70991108norepinephriners167771174dopamineserotonindopamineVMAHVA138, 157COMT1575-HIAAnorepinephrineadrenalineClonidine178Guanfacine178Prazosin127L-glutamateL-AspL-Asprs90867013Ca2+SNAP25VAMP2SYT1STX1ACa2+GlutReceptAMPAAMPARPSDGlutamatereceptorionotropicNMDANMDARMetabotropicglutamatereceptormGluGRM8KCNA2KCNA1DLG3GRM6GRM5GRM3KCNA3GRIN2CDLG5DLGAP5109GRM4GRIN2BDLGAP3109GRIA1101GRIN1GRM2GRIN2ADLGAP4109KCNA4KCNA5DLG2KCNA6GRIA2GRM7DLGAP2109OXTR52MC4R52SHANK1154GRIA4101F-actin55NLGN1109S-SCAM55NRXN2109GRIN3BABL155HOMER255CTNNB1GRIN3ASHANK55DLG455SAPAP55NLGN2109DLGAP1109KCNA7HOMER55CBL55SRBS28Cortactin55GRIN2DNLGN4X109NRXN3109APP55SHANK352, 176GRIA3GRIP2HOMER355DLG1NRXN1109NLGN352, 77, 109PTK2B55P55HOMER155SHANK2154GRM1GRIP1CACNG255PSD9574, 108, 109, 152CTTN55F-actin55SAPAP55SHANK55Cortactin55F-actin55F-actin55SHANK55SAPAP55Cortactin55PSD9574, 108, 109, 152ABL255SHANK55SAPAP55HOMER55PSD9574, 108, 109, 152GKAP155P55P55S-SCAM55, 109Beta-dystroglycan109Potassium(k)channelPresynapticPostsynapticGABReceptors5-MTHFFOLR2HTR3AHTR3BHTR3CHTR3DHTR3Ers1543334175CACNG6CACNG7CACNG3CACNG4CACNG8CACNG5CACNG1GNAQ89PLCB89oxytocinOXTCACNA1C89angiotensin II159SOD275SOD375NADPHMAO InhibitorsMAOIsB95-MTHF5-10MeTHFrs619838rs6296381010101010, 13413413413413410, 13413413410, 13413413410, 13413410Glucocorticoid stimuliPro-inflammatorycytokines3-Hydroxykynurenine4, 119Kynurenic Acid119Picolinic Acid4IFNGKYNU3-Hydroxyanthranilic Acid4, 97, 119KAT1Quinolinic AcidQUIN90, 97, 119, 128Anthranilic Acid4, 119Kynurenine4, 97, 119NAD+90INFAKMOIDO1IDO2T23OKAT3AADATAATMTNFAQUINNitric Oxide (NO) SynthaseSynaptic CleftSynaptic CleftadrenalineNorepinephrineNAAdrenaline Synaptic VesicleadrenalineNeurotransmitter Catabolism (Breakdown)GABA Synaptic vesiclegamma-hydroxybutyrate L-glutamate107, 113GABAGABBR1SLC32A1succinate citrate cycleGAD2succinic semialdehydeALDH9A1ABATGAD1GABASLC6A1GABAGLS21072A-3OBUL-threonineFMO3HistamineSynthase &CatabolismCysteine Synthase &CatabolismPLPpyridoxal 5'-phosphateFADFADB2riboflavin6, 181PLPPLPPLPFMN6Lysosome1009459142cblJABCD4Succinyl-CoAMMUTCblCD320R-cob(III)alamincob(II)alamin151cob(I)alamincbLAMMAAMethylmalonyl-CoAMMADHCcblFLMBRD1cbLCMMACHCcbLCMMACHCFADFMN94MMABcblBPLPPLPPLPPLPPLPPLPR-cob(III)alaminCblD-1MMADHCCblD-2MMADHCCblDMMADHCCYP3A4CYP2C1936endogenous cannabinoidsPKACBD catabolismNeuronal cell of CNS(hyppocampus, cerebellum or basal ganglia)ADCY1CNR11, 31CYP2C911-OH-THCMAPK PhosphatidylethanolamineDAGLBcAMP NAPEPLD71ADCY798NAPEDAGLA71Arachidonic acidTHC1''-hydroxycannabidiol362-AG39FAAH71L-glutamate9ADORA2A58CNR2Ca2+ATPAEAAnti-inflammatory pathwaysCOOH-THC43CBD272''-hydroxycannabidiol 363''-hydroxycannabidiol 364''-hydroxycannabidiol 365''-hydroxycannabidiol 366a-hydroxycannabidiol 366b-hydroxycannabidiol 367-hydroxycannabidiol 36endogeneous cannabinoid synthesisPRKACBPRKACAPRKAR1APRKAR2BPRKAR1BPRKACGPRKAR2ACa2+CBDKUVAN(BH4 Supplement) 127Derived From WP3869Cannabinoid receptor signalingCatabolism(Vitamin B12)pathwayPLPPLPGlutamate Synaptic VesicleL-glutamate107adrenalineDextroamphetamine + Amphetamine (Adderall)Viloxazine(Qelbree)143rs2550936132rs13189021Ketamine 32AEA44, 73SNRIs(Desvenlafaxine, Duloxetine,Levomilnacipran, MilnacipranVenlafaxine)COMT Inhibitors21NRIs(Atomoxetine /Strattera,Reboxetine /Edronax & Vestra)Methylphenidate(Ritalin)2-AG127, 13939PLPSAMSAMe181SAH181SAMeSAH181NDRIBupropion (Wellbutrin)181127, 139SAMe181SAH181SAMeSAH181181Risperidone127SerotoninReceptorsrs91645551rs1800955Calciumchannels120PIK3AP1TSC1122AKT1122, 129PTEN122, 129PIP2122122, 129PIP3122, 129AKT2AKT3122, 129122, 129TSC2122, 129MTORPIK3R2 PIK3CB PIK3CA PIK3R1 PIK3CDPIK3R3PDGFRBPRKCD PRKCZ PRKCA 96PRKCB PLCG2PRKCG AKT1S1MLST8MTORRPTORDEPTORmTORC1mTORC1 complexMLST8mTORC2 complexAKT1S1RPTORDEPTORMTORMLST8MAPKAP1RICTORMTORMAPK3SAMeSAH181181


Description

Pathways associated with ADHD (attention deficit hyperactivity disorder) and autism spectrum disorder (ASD). Neurodivergent conditions linked in studies to these pathways include ADHD, autism, dyspraxia, dyslexia, dyscalculia, bipolar disorder, obsessive-compulsive disorder, sensory processing disorders, and Tourette syndrome. This aims to be a highly detailed, comprehensive map of the metabolic pathways associated with these disorders, from indicated input vitamins through synthesis to signaling across the synaptic gap, re-uptake, and catabolism receptors. This pathway is constructed with computational analysis and machine learning in mind. In cases where there is a trade-off between readability and parametric accuracy, parametric accuracy is prioritized. This pathway is inspired by Kimberly Kitzerow and her meta-analysis research on the biomechanisms and pathways behind invisible illnesses.

https://kimberly102347.com/the-chart/

Pathways included in this map: One-Carbon (1C), Metabolism Folate Cycle, Methionine Cycle, Tetrahydrobiopterin (BH4) Pathway, Neurotransmitter Synthesis, Reuptake, and Breakdown, Kynurenine Pathway (KP), Endocannabinoid System (ECS), Neuroreceptor Dynamics in the Synaptic Cleft,

ROS Reactive Oxygen Stress.

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History

View all...
CompareRevisionActionTimeUserComment
129599view17:29, 17 May 2024Alexmadsen1add beta blockers and connect adrenaline
129450view23:43, 22 April 2024EweitzModified title
128702view21:57, 20 February 2024EgonwFixed two datasources
128690view20:04, 19 February 2024EgonwRemoved redundant RHEA: prefix in two interaction identifiers
128491view01:18, 7 February 2024Alexmadsen1update
128483view04:10, 6 February 2024Alexmadsen1add Purine Synthesis cycle and connection and I connected in ADSL that is #22 on ASD/ADHD list.
128459view19:53, 4 February 2024Alexmadsen1updat PNMT SAD
128458view19:48, 4 February 2024Alexmadsen1add SNP
128312view19:35, 31 January 2024Khanspersupdate with latest changes from Alex Madsen
128112view19:42, 26 January 2024KhanspersReverted to version '19:33, 26 January 2024' by Khanspers
128111view19:39, 26 January 2024KhanspersLatest edits from Alex Madsen
128110view19:33, 26 January 2024KhanspersReverted to version '02:04, 6 January 2024' by Khanspers
128109view19:29, 26 January 2024KhanspersIncorporating latest changes from Alex Madsen
127881view02:04, 6 January 2024EweitzModified description
127879view23:55, 5 January 2024Alexmadsen1uodate TSC1/2 <-->AMPK <-> NOS
127878view23:13, 5 January 2024Alexmadsen1add GPT The linkage between AMPK, NOS, MECP2, PTEN, PRKCB, mTORC1, mTORC2, and their relationship to Autism Spectrum Disorder (ASD) represents a complex network of interactions critical for neuronal function and development.
127877view03:54, 5 January 2024Alexmadsen1added linkage between NOS and 5-MTH per https://doi.org/10.1159/000142363
127876view02:56, 5 January 2024Alexmadsen1added refrences for Cbl / b12 pathway and added methionine synthase interactome
127875view04:15, 4 January 2024Alexmadsen1final check in
127874view03:26, 4 January 2024Alexmadsen1add glycine > guanidinoacetate > creatine and several DOI refrences
127873view01:42, 4 January 2024Alexmadsen1
127869view03:20, 3 January 2024Alexmadsen1general cleanup
127868view03:16, 3 January 2024Alexmadsen1add mTORC1 and mTORC 2 complex and MAPK3 MAPK1
127867view01:01, 3 January 2024Alexmadsen1add PI3K/Akt/mTOR intracellular signaling pathway
127855view03:24, 2 January 2024Alexmadsen1reorganise gudimate recptors
127854view01:19, 2 January 2024Alexmadsen1
127850view18:45, 31 December 2023Alexmadsen1added DRD4 SNP and RD4 VNTR exon III-7 repeat (7R), rs916455, rs1800955
127849view02:16, 30 December 2023Alexmadsen1cleanup
127848view21:43, 28 December 2023Alexmadsen1removed incorrect linkage between DHF to THF and BH2 to BH4
127733view04:05, 30 November 2023Alexmadsen1add Risperidone
127724view04:16, 29 November 2023Alexmadsen1add SAMe to COMT Neurotransmitter Catabolism (Breakdown). Linked COMT SNP to PNMT.
127718view04:44, 28 November 2023Alexmadsen1add NDRI Bupropion (Wellbutrin), fix Guanfacine and Clonidine and other cleanup
127682view23:20, 21 November 2023EweitzModified description
127680view23:14, 21 November 2023EweitzModified title
127675view22:42, 19 November 2023Alexmadsen1clanup
127674view22:24, 19 November 2023Alexmadsen1general cleanup
127672view17:10, 18 November 2023Alexmadsen1add SAME to NA to NM with COMT
127671view05:38, 18 November 2023Alexmadsen1add SAM to SAH conversion for PNMT when convering Norepinephran to Epinephran
127665view02:51, 16 November 2023Alexmadsen1fix floating connections
127664view02:47, 16 November 2023Alexmadsen1add PEA,NMPEA,2-phenylacetaldehyde
127638view14:02, 11 November 2023EgonwFixed more reference identifiers
127637view13:33, 11 November 2023EgonwFixed a few references (removed a few duplicates) and added a missing slash is a DOI
127597view02:09, 3 November 2023Alexmadsen1clean up methods of action in synaptic gap
127596view01:46, 3 November 2023Alexmadsen1
127590view14:22, 28 October 2023LarsgwFix bp:ID and bp:DB of reference
127586view10:57, 26 October 2023EgonwNot a mim-conversion
127585view03:52, 26 October 2023Alexmadsen1correct SSRIs and SNRIs and add refrences.
127580view05:15, 25 October 2023EgonwFixed a typo (by me)
127570view06:31, 23 October 2023EgonwLast few DOIs
127569view06:22, 23 October 2023EgonwMore DOI updates

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(4aS,6R)-4a-hydroxy - BH4MetaboliteCHEBI:15642 (ChEBI)
1''-hydroxycannabidiolMetaboliteCHEBI:133056 (ChEBI)
1-O-(1,2-saturated-alkyl)-sn-glycerolMetaboliteCHEBI:83957 (ChEBI)
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
11-OH-THCMetaboliteHMDB0060906 (HMDB)
1′-OXPH4MetaboliteHMDB0013642 (HMDB) 1'-oxo-2'-hydroxypropyl-tetrahydropterin
2''-hydroxycannabidiol MetaboliteCHEBI:133058 (ChEBI)
2-AGMetaboliteCHEBI:52392 (ChEBI) 2-arachidonoylglycerol
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
2-phenylacetaldehydeMetaboliteCHEBI:16424 (ChEBI)
2A-3OBUMetaboliteCHEBI:78948 (ChEBI)
2′-OXPH4MetaboliteCHEBI:17248 (ChEBI) 1'-hydroxy-2'-oxopropyl-tetrahydropterin (2'-OXPH4)
3''-hydroxycannabidiol MetaboliteCHEBI:133059 (ChEBI)
3-Hydroxyanthranilic AcidMetaboliteCHEBI:15793 (ChEBI)
3-HydroxykynurenineMetaboliteCHEBI:1547 (ChEBI)
3-MT SOMetaboliteCHEBI:133708 (ChEBI)
3-MTMetaboliteCHEBI:1582 (ChEBI)
4''-hydroxycannabidiol MetaboliteCHEBI:133055 (ChEBI)
4-aminobutanoateMetaboliteCHEBI:30566 (ChEBI)
5''-hydroxycannabidiol MetaboliteCHEBI:133062 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-HIAAMetaboliteCHEBI:27823 (ChEBI) AKA 5-HIAA
5-HialMetaboliteCHEBI:50157 (ChEBI)
5-MTMetaboliteCHEBI:2089 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
5-hydroxy-L-tryptophanMetaboliteCHEBI:58266 (ChEBI)
6R-BH4MetaboliteCHEBI:59560 (ChEBI)
6a-hydroxycannabidiol MetaboliteCHEBI:133049 (ChEBI)
6b-hydroxycannabidiol MetaboliteCHEBI:133052 (ChEBI)
7-hydroxycannabidiol MetaboliteCHEBI:133053 (ChEBI)
AADATProteinQ8N5Z0 (Uniprot-TrEMBL)
AANATProteinQ16613 (Uniprot-TrEMBL)
AATMProteinP00505 (Uniprot-TrEMBL)
ABATProteinP80404 (Uniprot-TrEMBL) 4-Aminobutyrate aminotransferase
ABL1ProteinP00519 (Uniprot-TrEMBL)
ABL2ProteinP42684 (Uniprot-TrEMBL)
ACEGeneProductP12821 (Uniprot-TrEMBL)
ADAM10ProteinO14672 (Uniprot-TrEMBL)
ADCY1GeneProductCHEBI:58165 (Uniprot-TrEMBL)
ADCY7GeneProductADCY7 (Uniprot-TrEMBL)
ADGRL3 GPCRsProteinQ9HAR2 (Uniprot-TrEMBL)
ADHProteinEC 1.1.1.1 (KEGG Genes)
ADORA2AGeneProductP29274 (Uniprot-TrEMBL)
ADRA1AProteinP35348 (Uniprot-TrEMBL)
ADRA1BGeneProductP35368 (Uniprot-TrEMBL)
ADRA1DGeneProductP25100 (Uniprot-TrEMBL)
ADRA2AGeneProduct266750 (Entrez Gene)
ADRA2BGeneProduct266751 (Entrez Gene)
ADRA2CGeneProduct266752 (Entrez Gene)
ADRB1GeneProduct557194 (Entrez Gene)
ADRB2GeneProductP07550 (Uniprot-TrEMBL)
ADRB3aGeneProduct558248 (Entrez Gene)
AEAMetaboliteCHEBI:2700 (ChEBI) anandamide
AGMOProteinQ6ZNB7 (Uniprot-TrEMBL)
AGTR1ProteinP30556 (Uniprot-TrEMBL)
AHCYL1ProteinO43865 (Uniprot-TrEMBL)
AHCYProteinP23526 (Uniprot-TrEMBL)
AKRProtein
AKR1A1ProteinP14550 (Uniprot-TrEMBL)
AKR1B1ProteinP15121 (Uniprot-TrEMBL)
AKR1C1ProteinQ04828 (Uniprot-TrEMBL)
AKR1C3ProteinP42330 (Uniprot-TrEMBL)
AKT1GeneProductP31749 (Uniprot-TrEMBL)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AKT2GeneProductP31751 (Uniprot-TrEMBL)
AKT3GeneProductQ9Y243 (Uniprot-TrEMBL)
ALDHProtein
ALDH1L1ProteinO75891 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALDH2ProteinP05091 (Uniprot-TrEMBL)
ALDH5A1ProteinCHEBI:57706 (Uniprot-TrEMBL)
ALDH9A1ProteinP49189 (Uniprot-TrEMBL) 4-trimethylaminobutyraldehyde dehydrogenase
AOC1GeneProductP19801 (Uniprot-TrEMBL)
APPProteinP05067 (Uniprot-TrEMBL)
ASMTProteinP46597 (Uniprot-TrEMBL)
ATPMetaboliteHMDB0000538 (HMDB)
AdoCblMetaboliteCHEBI:18408 (ChEBI)
Alpha-dystroglycanProtein
AngiotensinogenMetaboliteCHEBI:2720 (ChEBI)
Anthranilic AcidMetaboliteCHEBI:16567 (ChEBI)
Anti-inflammatory pathwaysPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
B2 riboflavinMetaboliteCHEBI:17015 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B6 pyridoxineMetaboliteCHEBI:16709 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BH2 7,8-dihydrofolateMetaboliteCHEBI:64240 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
Beta-dystroglycanProtein
BiopterinMetaboliteCHEBI:15373 (ChEBI)
CACNA1CProteinQ13936 (Uniprot-TrEMBL)
CACNG1ProteinQ06432 (Uniprot-TrEMBL)
CACNG2ProteinQ9Y698 (Uniprot-TrEMBL)
CACNG3ProteinO60359 (Uniprot-TrEMBL)
CACNG4ProteinQ9UBN1 (Uniprot-TrEMBL)
CACNG5ProteinQ9UF02 (Uniprot-TrEMBL)
CACNG6ProteinQ9BXT2 (Uniprot-TrEMBL)
CACNG7ProteinP62955 (Uniprot-TrEMBL)
CACNG8ProteinQ8WXS5 (Uniprot-TrEMBL)
CALM3GeneProductP0DP23 (Uniprot-TrEMBL)
CB CollybistinProtein
CBDMetaboliteCHEBI:69478 (ChEBI)
CBLProteinP22681 (Uniprot-TrEMBL)
CBR1ProteinP16152 (Uniprot-TrEMBL)
CBSProteinP35520 (Uniprot-TrEMBL)
CD320ProteinQ9NPF0 (Uniprot-TrEMBL) Aka CD320 receptor
CDO1GeneProductQ16878 (Uniprot-TrEMBL)
CNR1GeneProductP21554 (Uniprot-TrEMBL) CB1
CNR2GeneProductP34972 (Uniprot-TrEMBL) CB2
CNTN1GeneProductQ9UQ52 (Uniprot-TrEMBL)
CNTN2GeneProductO94779 (Uniprot-TrEMBL)
CNTN3GeneProductQ8IWV2 (Uniprot-TrEMBL)
CNTN4GeneProductQ9P232 (Uniprot-TrEMBL)
CNTN5GeneProductQ02246 (Uniprot-TrEMBL)
CNTN6GeneProductQ12860 (Uniprot-TrEMBL)
CNTNAP1GeneProductP78357 (Uniprot-TrEMBL)
CNTNAP2GeneProductQ9UHC6 (Uniprot-TrEMBL)
CNTNAP3GeneProductQ9BZ76 (Uniprot-TrEMBL)
CNTNAP4GeneProductQ9C0A0 (Uniprot-TrEMBL)
COMT InhibitorsMetabolite
COMTProteinP21964 (Uniprot-TrEMBL) AKA Catechol-O- metyltransferase
COOH-THCMetaboliteCHEBI:77273 (ChEBI)
CPLX1ProteinO14810 (Uniprot-TrEMBL)
CSADProteinQ9Y600 (Uniprot-TrEMBL)
CTHProteinP32929 (Uniprot-TrEMBL)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTTNProteinQ14247 (Uniprot-TrEMBL)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP2D6ProteinP10635 (Uniprot-TrEMBL)
CYP3A4GeneProductENSG00000160868 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CblD MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-1 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-2 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblMetaboliteQ3329800 (Wikidata)
ClonidineMetaboliteCHEBI:46631 (ChEBI)
CortactinGeneProductENSG00000085733 (Ensembl)
DAG1GeneProductQ14118 (Uniprot-TrEMBL)
DAGMetaboliteC00165 (KEGG Drug)
DAGLAGeneProductENSG00000134780 (Ensembl)
DAGLBGeneProductENSG00000164535 (Ensembl)
DBHProteinP09172 (Uniprot-TrEMBL)
DDCProteinP20711 (Uniprot-TrEMBL)
DEPTORGeneProductENSG00000155792 (Ensembl)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DHMAMetaboliteCHEBI:27637 (ChEBI)
DHNTPMetaboliteCHEBI:18372 (ChEBI)
DHPGMetaboliteCHEBI:1387 (ChEBI)
DLG1ProteinQ12959 (Uniprot-TrEMBL)
DLG2ProteinQ15700 (Uniprot-TrEMBL)
DLG3ProteinQ92796 (Uniprot-TrEMBL)
DLG4ProteinP78352 (Uniprot-TrEMBL)
DLG5ProteinQ8TDM6 (Uniprot-TrEMBL)
DLGAP1GeneProductO14490 (Uniprot-TrEMBL)
DLGAP2GeneProductQ9P1A6 (Uniprot-TrEMBL)
DLGAP3GeneProductO95886 (Uniprot-TrEMBL)
DLGAP4GeneProductQ9Y2H0 (Uniprot-TrEMBL)
DLGAP5GeneProductQ15398 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
DOPACMetaboliteCHEBI:41941 (ChEBI)
DOPEGMetaboliteCHEBI:1387 (ChEBI)
DOPETMetaboliteCHEBI:68889 (ChEBI)
DOPGAL MetaboliteCHEBI:180943 (ChEBI)
DOPLMetaboliteCHEBI:27978 (ChEBI)
DRD1GeneProduct568126 (Entrez Gene)
DRD2GeneProductP14416 (Uniprot-TrEMBL)
DRD3GeneProduct282554 (Entrez Gene)
DRD4 VNTR exon III-7rRna
DRD4GeneProductP21917 (Uniprot-TrEMBL)
DRD5ProteinP21918 (Uniprot-TrEMBL)
Derived From WP3869 Cannabinoid receptor signalingPathwayWP3869 (WikiPathways)
Derived From WP4159 GABA receptor signalingPathwayWP4159 (WikiPathways)
Derived From WP4271 Vitamin B12 disordersPathwayWP4271 (WikiPathways)
Dextroamphetamine + Amphetamine (Adderall)MetaboliteCHEBI:2679 (ChEBI)
EGFRProteinP00533 (Uniprot-TrEMBL)
F-actinGeneProduct
FAAH2GeneProductQ6GMR7 (Uniprot-TrEMBL)
FAAHGeneProductENSG00000117480 (Ensembl)
FADMetaboliteCHEBI:57692 (ChEBI) cofactor
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetabolitecHEBI:58210 (ChEBI) cofactor
FMO1GeneProductQ01740 (Uniprot-TrEMBL)
FMO3GeneProductQ01740 (Uniprot-TrEMBL)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
GABAMetaboliteCHEBI:59888 (ChEBI)
GABBR1ProteinQ9UBS5 (Uniprot-TrEMBL)
GABRA1ProteinP14867 (Uniprot-TrEMBL)
GABRA2ProteinP47869 (Uniprot-TrEMBL)
GABRA3ProteinP34903 (Uniprot-TrEMBL)
GABRA4ProteinP48169 (Uniprot-TrEMBL)
GABRA5ProteinP31644 (Uniprot-TrEMBL)
GABRB1ProteinP18505 (Uniprot-TrEMBL)
GABRB2ProteinP47870 (Uniprot-TrEMBL)
GABRB3ProteinP28472 (Uniprot-TrEMBL)
GABRDProteinO14764 (Uniprot-TrEMBL)
GABRG1ProteinQ8N1C3 (Uniprot-TrEMBL)
GABRG2ProteinP18507 (Uniprot-TrEMBL)
GABRQProteinQ9UN88 (Uniprot-TrEMBL)
GAD1GeneProductQ99259 (Uniprot-TrEMBL)
GAD2GeneProductQ05329 (Uniprot-TrEMBL)
GATMGeneProductP50440 (Uniprot-TrEMBL)
GCATGeneProductO75600 (Uniprot-TrEMBL)
GCH1ProteinP30793 (Uniprot-TrEMBL)
GKAP1GeneProductQ5VSY0 (Uniprot-TrEMBL)
GKProteinP32189 (Uniprot-TrEMBL)
GLS2ProteinQ9UI32 (Uniprot-TrEMBL)
GLSProteinO94925 (Uniprot-TrEMBL)
GLULGeneProductP15104 (Uniprot-TrEMBL)
GNAQProteinP50148 (Uniprot-TrEMBL)
GPHNProteinQ9NQX3 (Uniprot-TrEMBL)
GRIA1ProteinP42261 (Uniprot-TrEMBL)
GRIA2ProteinP42262 (Uniprot-TrEMBL)
GRIA3ProteinP42263 (Uniprot-TrEMBL)
GRIA4ProteinP48058 (Uniprot-TrEMBL)
GRIN1ProteinQ05586 (Uniprot-TrEMBL)
GRIN2AProteinQ12879 (Uniprot-TrEMBL)
GRIN2BProteinQ13224 (Uniprot-TrEMBL)
GRIN2CProteinQ14957 (Uniprot-TrEMBL)
GRIN2DProteinO15399 (Uniprot-TrEMBL)
GRIN3AProteinQ8TCU5 (Uniprot-TrEMBL)
GRIN3BProteinO60391 (Uniprot-TrEMBL)
GRIP1ProteinQ9Y3R0 (Uniprot-TrEMBL)
GRIP2ProteinQ9C0E4 (Uniprot-TrEMBL)
GRM1ProteinQ13255 (Uniprot-TrEMBL)
GRM2ProteinQ14416 (Uniprot-TrEMBL)
GRM3ProteinQ14832 (Uniprot-TrEMBL)
GRM4ProteinQ14833 (Uniprot-TrEMBL)
GRM5ProteinP41594 (Uniprot-TrEMBL)
GRM6ProteinO15303 (Uniprot-TrEMBL)
GRM7ProteinQ14831 (Uniprot-TrEMBL)
GRM8ProteinO00222 (Uniprot-TrEMBL)
GeneProductGeneProduct
GuanfacineMetaboliteHMDB15153 (HMDB)
H2O2Metabolite16240 (ChEBI)
H4gtp GPTMetaboliteCHEBI: (ChEBI)
HCFC1 (cblX)GeneProductP51610 (Uniprot-TrEMBL)
HDCGeneProductP19113 (Uniprot-TrEMBL)
HISN8ProteinQ9C5U8 (Uniprot-TrEMBL)
HNMTGeneProductP50135 (Uniprot-TrEMBL)
HOMERGeneProduct
HOMER1ProteinQ86YM7 (Uniprot-TrEMBL)
HOMER2ProteinQ9NSB8 (Uniprot-TrEMBL)
HOMER3ProteinQ9NSC5 (Uniprot-TrEMBL)
HTR1AProtein100001828 (Entrez Gene)
HTR1BProtein561647 (Entrez Gene)
HTR1DProteinP28221 (Uniprot-TrEMBL)
HTR1EProteinP28566 (Uniprot-TrEMBL)
HTR1FProteinP30939 (Uniprot-TrEMBL)
HTR2AProteinP28223 (Uniprot-TrEMBL)
HTR2BProteinP41595 (Uniprot-TrEMBL)
HTR2CProtein
HTR3AProteinP40227 (Uniprot-TrEMBL)
HTR3BProteinO95264 (Uniprot-TrEMBL)
HTR3CProteinQ8WXA8 (Uniprot-TrEMBL)
HTR3DProteinQ70Z44 (Uniprot-TrEMBL)
HTR3EProteinA5X5Y0 (Uniprot-TrEMBL)
HTR4ProteinQ13639 (Uniprot-TrEMBL)
HTR5aProtein100038775 (Entrez Gene)
HTR5bProtein
HTR6ProteinP50406 (Uniprot-TrEMBL)
HTR7ProteinP34969 (Uniprot-TrEMBL)
HVAMetaboliteCHEBI:545959 (ChEBI) AKA HVA
HVALMetaboliteCHEBI:173769 (ChEBI) HVAL = Homovanillyl = alcohol(4-Hydroxy-3-methoxyphenyl)ethanol
IDO1ProteinP14902 (Uniprot-TrEMBL)
IDO2ProteinQ6ZQW0 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
INFAProtein
INSRProteinP06213 (Uniprot-TrEMBL)
Imidazole-4-acetateMetaboliteCHEBI:16974 (ChEBI)
KAT1ProteinQ16773 (Uniprot-TrEMBL)
KAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KCNA1ProteinQ09470 (Uniprot-TrEMBL)
KCNA2ProteinP16389 (Uniprot-TrEMBL)
KCNA3ProteinP22001 (Uniprot-TrEMBL)
KCNA4ProteinP22459 (Uniprot-TrEMBL)
KCNA5ProteinP22460 (Uniprot-TrEMBL)
KCNA6ProteinP17658 (Uniprot-TrEMBL)
KCNA7ProteinQ96RP8 (Uniprot-TrEMBL)
KITProteinP10721 (Uniprot-TrEMBL)
KMOProteinO15229 (Uniprot-TrEMBL)
KUVAN (BH4 Supplement) MetaboliteCHEBI:15372 (ChEBI)
KYAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KYNUProteinQ16719 (Uniprot-TrEMBL)
Ketamine MetaboliteCHEBI:6121 (ChEBI)
Kynurenic AcidMetaboliteCHEBI:58454 (ChEBI)
KynurenineMetaboliteCHEBI:57959 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-alanineMetabolite57972 (ChEBI)
L-arginineMetaboliteCHEBI:32682 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
L-cysteateMetaboliteCHEBI:58090 (ChEBI)
L-cysteineMetaboliteCHEBI:35235 (ChEBI)
L-dopaMetaboliteCHEBI:57504 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
L-glutamineMetaboliteCHEBI:58359 (ChEBI)
L-histidineMetaboliteCHEBI:57595 (ChEBI)
L-histidinolMetaboliteCHEBI:57699 (ChEBI)
L-ornithineMetaboliteCHEBI:46911 (ChEBI)
L-phenylalanineMetaboliteCHEBI:58095 (ChEBI)
L-threonineMetaboliteCHEBI:57926 (ChEBI)
L-tryptophanMetaboliteCHEBI:57912 (ChEBI)
L-tyrosineMetaboliteCHEBI:58315 (ChEBI)
MAO Inhibitors MAOIsMetabolite
MAOAProteinP21397 (Uniprot-TrEMBL)
MAOBProteinP27338 (Uniprot-TrEMBL)
MAPK GeneProduct2.7.11.24 (Enzyme Nomenclature)
MAPK1ProteinP28482 (dbSNP)
MAPK3ProteinP27361 (dbSNP)
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MC4RProteinP32245 (Uniprot-TrEMBL)
MG2+MetaboliteCHEBI:18420 (ChEBI)
MHPG MOPEGMetaboliteCHEBI:1576 (ChEBI)
MLST8GeneProductENSG00000167965 (Ensembl)
MMAB cblBProtein60488 (Uniprot-TrEMBL) gene: MMAB
MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
MMUTProteinP22033 (Uniprot-TrEMBL) aka methylmalonyl-CoA mutase or MCM
MN-SO4MetaboliteHMDB0240719 (HMDB)
MN2+MetaboliteCHEBI:29035 (ChEBI)
MOCOSProteinQ96EN8 (Uniprot-TrEMBL)
MOPGALMetabolite27932 (ChEBI)
MTHFD1LProteinQ6UB35 (Uniprot-TrEMBL)
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFD2LProteinQ9H903 (Uniprot-TrEMBL)
MTHFD2ProteinP13995 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl)
  • effect of AKT on MTOR is indirect
  • Part of two multiprotein complexes, TORC 1 and TORC 2
MTORProteinP42345 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCblMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
MetaboliteMetabolite
MetanephrineMetaboliteCHEBI:89633 (ChEBI)
Methylmalonyl-CoAMetaboliteCHEBI:16625 (ChEBI)
Methylphenidate(Ritalin)MetaboliteHMDB14566 (HMDB)
MoCoMetabolite71302 (ChEBI)
N-METHYL-HISTAMINEMetaboliteCHEBI:58600 (ChEBI)
N-MethylhistamineMetaboliteCHEBI:29009 (ChEBI)
NA AldehydeMetabolite
NAD+MetaboliteCHEBI:13389 (ChEBI)
NADPMetaboliteCHEBI:58349 (ChEBI)
NADPHMetaboliteCHEBI:57783 (ChEBI)
NADSYN1ProteinQ6IA69 (Uniprot-TrEMBL)
NAPEMetaboliteCHEBI:61232 (ChEBI)
NAPEPLDProteinNAPEPLD (Uniprot-TrEMBL)
NASMetaboliteCHEBI:17697 (ChEBI)
NCAM1ProteinP13591 (Uniprot-TrEMBL)
NDRI Bupropion (Wellbutrin)MetaboliteDB01156 (DrugBank)
NLGN1ProteinQ8N2Q7 (Uniprot-TrEMBL)
NLGN2ProteinQ8NFZ4 (Uniprot-TrEMBL)
NLGN3ProteinQ9NZ94 (Uniprot-TrEMBL)
NLGN4XProteinQ8N0W4 (Uniprot-TrEMBL)
NM Aldehyde Metabolite
NMN-SOMetaboliteHMDB0240719 (HMDB)
NMNAT1ProteinQ9HAN9 (Uniprot-TrEMBL)
NMPEAMetaboliteCHEMBL45763 (ChEMBL compound)
NOMetabolite16480 (ChEBI)
NOS1ProteinP29475 (Uniprot-TrEMBL)
NOS2ProteinP35228 (Uniprot-TrEMBL)
NOS3ProteinP29474 (Uniprot-TrEMBL)
NOX1ProteinQ9Y5S8 (Uniprot-TrEMBL)
NOX3ProteinQ9HBY0 (Uniprot-TrEMBL)
NOX4ProteinQ9NPH5 (Uniprot-TrEMBL)
NOX5ProteinQ96PH1 (Uniprot-TrEMBL)
NRIs

(Atomoxetine /Strattera,

Reboxetine /Edronax & Vestra)		Metabolite
NRXN1ProteinQ9ULB1 (Uniprot-TrEMBL)
NRXN2ProteinP58401 (Uniprot-TrEMBL)
NRXN3ProteinQ9HDB5 (Uniprot-TrEMBL)
Norepinephrine NAMetaboliteCHEBI:72587 (ChEBI)
Normetanephrine NMMetaboliteCHEBI:89951 (ChEBI)
O2MetaboliteCHEBI:5379 (ChEBI)
O2−MetaboliteCHEBI:18421 (ChEBI)
OH-MetaboliteCHEBI:16234 (ChEBI)
ONOO-MetaboliteCHEBI:25941 (ChEBI)
OPRM1ProteinP35372 (Uniprot-TrEMBL)
OXTProteinP01178 (Uniprot-TrEMBL)
OXTRProteinP30559 (Uniprot-TrEMBL)
P
PAHProteinP00439 (Uniprot-TrEMBL)
PCBD1ProteinP61457 (Uniprot-TrEMBL)
PCBD2ProteinQ9H0N5 (Uniprot-TrEMBL)
PDGFRAProteinP16234 (Uniprot-TrEMBL)
PDGFRBProteinP09619 (Uniprot-TrEMBL)
PDXKProteinO00764 (Uniprot-TrEMBL)
PIK3AP1GeneProductQ6ZUJ8 (Uniprot-TrEMBL)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3CDProteinO00329 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PIK3R3ProteinQ92569 (Uniprot-TrEMBL)
PIP2MetaboliteQ413692 (Wikidata)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLCBGeneProductP50148 (Uniprot-TrEMBL)
PLCG1GeneProductP19174 (Uniprot-TrEMBL)
PLCG2GeneProductP16885 (Uniprot-TrEMBL)
PLP pyridoxal 5'-phosphateMetaboliteCHEBI:597326 (ChEBI)
PLPMetaboliteCHEBI:597326 (ChEBI)
PNMTProteinP11086 (Uniprot-TrEMBL)
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
PPH4MetaboliteCHEBI:17804 (ChEBI)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (EMBL)
PRKAR2BGeneProductENSG00000005249 (Ensembl)
PRKCA ProteinP17252 (Uniprot-TrEMBL)
PRKCB ProteinP05771 (Uniprot-TrEMBL)
PRKCD ProteinQ05655 (Uniprot-TrEMBL)
PRKCG ProteinP05129 (Uniprot-TrEMBL)
PRKCZ ProteinQ05513 (Uniprot-TrEMBL)
PSD95GeneProductP78352 (Uniprot-TrEMBL)
PTENGeneProductP60484 (Uniprot-TrEMBL)
PTK2BProteinQ14289 (Uniprot-TrEMBL)
PTSProteinQ03393 (Uniprot-TrEMBL)
Pharmacological

Intervention

(drug)
PhosphatidylethanolamineMetaboliteHMDB0060501 (HMDB)
Picolinic AcidMetaboliteCHEBI:28747 (ChEBI)
PrazosinMetaboliteHMDB14600 (HMDB)
ProteinProtein
QDPRProteinP09417 (Uniprot-TrEMBL)
QPRTProteinQ15274 (Uniprot-TrEMBL)
QUINMetaboliteCHEBI:16675 (ChEBI)
Quinolinic Acid QUINMetaboliteCHEBI:16675 (ChEBI)
R-cob(III)alaminMetaboliteCHEBI:140785 (ChEBI)
RENProteinP00797 (Uniprot-TrEMBL)
RFKProteinQ969G6 (Uniprot-TrEMBL)
RHEBProteinQ15382 (Uniprot-TrEMBL)
RHOAProteinP61586 (Uniprot-TrEMBL)
RICTORGeneProductENSG00000164327 (Ensembl)
RIT2ProteinQ99578 (Uniprot-TrEMBL)
RPTORGeneProductENSG00000141564 (Ensembl)
RisperidoneMetaboliteDB00734 (DrugBank)
S-SCAMGeneProduct
S-adenosyl-L-homocysteineMetaboliteCHEBI:57856 (ChEBI)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAM

SAMe

MetaboliteCHEBI:59789 (ChEBI)
SAMe MetaboliteCHEBI:59789 (ChEBI)
SAPAPGeneProduct
SCN10AProteinQ9Y5Y9 (Uniprot-TrEMBL)
SCN11AProteinQ9UI33 (Uniprot-TrEMBL)
SCN1AProteinP35498 (Uniprot-TrEMBL)
SCN1BProteinQ07699 (Uniprot-TrEMBL)
SCN2AProteinQ99250 (Uniprot-TrEMBL)
SCN2BProteinO60939 (Uniprot-TrEMBL)
SCN3AProteinQ9NY46 (Uniprot-TrEMBL)
SCN3BProteinQ9NY72 (Uniprot-TrEMBL)
SCN4AProteinP35499 (Uniprot-TrEMBL)
SCN4BProteinQ8IWT1 (Uniprot-TrEMBL)
SCN5AProteinQ14524 (Uniprot-TrEMBL)
SCN7AProteinQ01118 (Uniprot-TrEMBL)
SCN8AProteinQ9UQD0 (Uniprot-TrEMBL)
SCN9AProteinQ15858 (Uniprot-TrEMBL)
SHANKGeneProduct
SHANK1ProteinQ9Y566 (Uniprot-TrEMBL)
SHANK2ProteinQ9UPX8 (Uniprot-TrEMBL)
SHANK3ProteinQ9BYB0 (Uniprot-TrEMBL)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SHMT2ProteinP34897 (Uniprot-TrEMBL)
SIRT3GeneProductQ9NTG7 (Uniprot-TrEMBL)
SLC17A6GeneProductQ9P2U8 (Uniprot-TrEMBL)
SLC17A7ProteinQ9P2U8 (Uniprot-TrEMBL) Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).
SLC17A8GeneProductQ9P2U8 (Uniprot-TrEMBL)
SLC18A1ProteinP54219 (Uniprot-TrEMBL)
SLC19A1ProteinP41440 (Uniprot-TrEMBL)
SLC25A12ProteinO75746 (Uniprot-TrEMBL)
SLC25A13ProteinQ9UJS0 (Uniprot-TrEMBL)
SLC25A32ProteinQ9H2D1 (Uniprot-TrEMBL)
SLC32A1ProteinQ9H598 (Uniprot-TrEMBL) Vesicular inhibitory amino acid transporter
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC6A1GeneProductP30531 (Uniprot-TrEMBL)
SLC6A2ProteinP23975 (Uniprot-TrEMBL)
SLC6A3ProteinQ01959 (Uniprot-TrEMBL) Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3. AKA DAT1
SLC6A4ProteinP31645 (Uniprot-TrEMBL)
SNAP25ProteinP60880 (Uniprot-TrEMBL)
SNP

single nucleotide

polymorphism		Rna
SNRIs

(Desvenlafaxine, Duloxetine, Levomilnacipran, Milnacipran

Venlafaxine)		Metabolite
SOD1ProteinP00441 (Uniprot-TrEMBL)
SOD2ProteinP04179 (Uniprot-TrEMBL)
SOD3ProteinP08294 (Uniprot-TrEMBL)
SPRProteinP35270 (Uniprot-TrEMBL)
SRBS2ProteinO94875 (Uniprot-TrEMBL)
SSRIs

(fluoxetine, citalopram, sertraline, paroxetine,

escitalopram)		Metabolite
STX1AProteinQ16623 (Uniprot-TrEMBL)
STXBP1ProteinP61764 (Uniprot-TrEMBL)
SULT1A3ProteinP0DMM9 (Uniprot-TrEMBL)
SYPProteinP08247 (Uniprot-TrEMBL)
SYT1ProteinP21579 (Uniprot-TrEMBL)
Succinyl-CoAMetaboliteCHEBI:15380 (ChEBI)
T23OProteinP48775 (Uniprot-TrEMBL)
TAAR1ProteinQ96RJ0 (Uniprot-TrEMBL)
TBCD7ProteinNon-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex
TCN2ProteinP20062 (Uniprot-TrEMBL)
TDC Protein
THCMetaboliteHMDB0041865 (HMDB)

  • Tetrahydrocannabinol (THC) is the primary psychoactive compound found in cannabis plants. Its effects on cannabinoid receptors CNR1 (CB1) and CNR2 (CB2) are well-documented:

    CB1 Receptor Interaction:

    THC is a partial agonist at the CB1 receptor. When it binds to the CB1 receptor, it activates the receptor to a degree, eliciting a psychoactive response which is often associated with the "high" experienced from cannabis consumption. CB2 Receptor Interaction:

    THC is also a partial agonist at the CB2 receptor, although its affinity for the CB2 receptor is less compared to the CB1 receptor. The activation of CB2 receptors by THC is associated with some of the medicinal properties of cannabis, such as its anti-inflammatory effects.

    In summary, THC acts as a partial agonist at both CB1 and CB2 receptors, stimulating these receptors to produce a variety of effects in the body, including psychoactive and potential therapeutic effects. Unlike CBD, THC does not act as an antagonist or inhibitor at these receptors, and its binding and activation of CB1 and CB2 receptors are central to its effects.
  • Type your comment here
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TNFAProteinP01375 (Uniprot-TrEMBL)
TPH1ProteinP17752 (Uniprot-TrEMBL)
TPH2ProteinQ8IWU9 (Uniprot-TrEMBL)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2ProteinP49815 (Uniprot-TrEMBL)
TYMSProteinP04818 (Uniprot-TrEMBL)
TYProteinP07101 (Uniprot-TrEMBL)
VAMP2ProteinP63027 (Uniprot-TrEMBL)
VMAMetaboliteCHEBI:27622 (ChEBI)
Viloxazine (Qelbree)MetaboliteCHEBI:94405 (ChEBI)
Xanthurenic acidMetaboliteCHEBI:10072 (ChEBI)
a 1-(1-hydroxyalkyl)-sn-glycerolMetaboliteCHEBI:73418 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
adrenalineMetaboliteCHEBI:28918 (ChEBI)
alkylglycerolsMetaboliteCHEBI:52575 (ChEBI)
angiotensin IMetaboliteCHEBI:147350 (ChEBI)
angiotensin IIMetaboliteCHEBI:58506 (ChEBI)
arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
cAMP MetaboliteCHEBI:58165 (ChEBI)
cbLA MMAAProteinQ8IVH4 (Uniprot-TrEMBL) Gene: MMAA
cbLC MMACHCProteinQ9Y4U1 (Uniprot-TrEMBL) Gene is called MMAC
cblF LMBRD1ProteinQ9NUN5 (Uniprot-TrEMBL)
cblJ ABCD4ProteinO14678 (Uniprot-TrEMBL)
citrate cyclePathwayWP78 (WikiPathways)
cob(I)alaminMetaboliteCHEBI:15982 (ChEBI)
cob(II)alaminMetaboliteCHEBI:16304 (ChEBI) Should be cob(II)alamin according to literature
creatineMetaboliteCHEBI:57947 (ChEBI)
cystathionineMetaboliteCHEBI:58161 (ChEBI)
cysteine sulfinateMetaboliteCHEBI:61085 (ChEBI)
deamido-NAD+MetaboliteCHEBI:58437 (ChEBI)
dopamineMetaboliteCHEBI:59905 (ChEBI)
fatty aldehydesMetaboliteCHEBI:35746 (ChEBI)
formateMetaboliteCHEBI:15740 (ChEBI)
gamma-hydroxybutyrate MetaboliteQ207920 (Wikidata)
glycerol 3-phosphateMetaboliteCHEBI:57597 (ChEBI)
glycerolMetaboliteCHEBI:17754 (ChEBI)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
guanidinoacetateMetaboliteCHEBI:57742 (ChEBI)
hemiacetalsMetaboliteCHEBI:5653 (ChEBI)
histamineMetaboliteCHEBI:58432 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
hypotaurineMetaboliteCHEBI:57853 (ChEBI)
imidazole-4-acetaldehydeMetaboliteCHEBI:27398 (ChEBI)
mTORC1 complexComplexCPX-503 (Complex Portal)
mTORC2 complexComplexCPX-4402 (Complex Portal)
melatoninMetaboliteCHEBI:16796 (ChEBI)
moco sulfide Metabolite82685 (ChEBI)
nicotinate D-ribonucleotide(2−)MetaboliteCHEBI:57502 (ChEBI)
noladin etherMetaboliteCHEBI:75913 (ChEBI)
norepinephrineMetaboliteCHEBI:72587 (ChEBI)
oxytocinMetaboliteCHEBI:7872 (ChEBI)
phenylethylamine

2-phenylethylamine PEA

MetaboliteCHEBI:225237 (ChEBI)
pyridoxalMetaboliteCHEBI:17310 (ChEBI)
pyridoxamineMetaboliteCHEBI:57761 (ChEBI)
pyridoxine 5'-phosphateMetaboliteCHEBI:58589 (ChEBI)
q-BH2MetaboliteCHEBI:43029 (ChEBI)
q-H2BPTMetaboliteCHEBI:43120 (ChEBI)
rs1023159Rnars1023159 (dbSNP)
rs1051266Rnars1051266 (dbSNP)
rs1051312Rnars1051312 (dbSNP)
rs10521432Rnars10521432 (dbSNP)
rs10879352Rnars10879352 (dbSNP)
rs11178997Rnars11178997 (dbSNP)
rs1137070Rnars1137070 (dbSNP)
rs121913223Rnars121913223 (dbSNP)
rs12843268Rnars12843268 (dbSNP)
rs12843533Rnars12843533 (dbSNP)
rs13189021Rna
rs1352250Rnars1352250 (dbSNP)
rs1390938Rnars1390938 (dbSNP)
rs1406946Rnars1406946 (dbSNP)
rs1465107Rnars1465107 (dbSNP)
rs1487275Rnars1487275 (dbSNP)
rs151257822GeneProductrs151257822 (dbSNP)
rs1532268Rnars1532268 (dbSNP)
rs1543334Rnars1543334 (dbSNP)
rs165599Rnars165599 (dbSNP)
rs165774Rnars165774 (dbSNP)
rs1667627Rnars1950902 (dbSNP)
rs1672717Rnars1672717 (dbSNP)
rs167771Rnars167771 (dbSNP)
rs16976358Rnars16976358 (dbSNP)
rs174696Rnars174696 (dbSNP)
rs1799836Rnars1799836 (dbSNP)
rs1799971Rnars1799971 (dbSNP)
rs1800544Rnars1800544 (dbSNP)
rs1800955Rnars1800955 (dbSNP)
rs1801131Rnars1801131 (dbSNP)
rs1801133Rnars1801133 (dbSNP)
rs1801198Rnars1801198 (dbSNP)
rs1801394Rnars1801394 (dbSNP)
rs1805087Rnars1805087 (dbSNP)
rs1923886Rnars1923886 (dbSNP)
rs1950902Rnars1950902 (dbSNP)
rs1979277Rnars1979277 (dbSNP)
rs2056202Rnars2056202 (dbSNP)
rs2071010Rnars2071010 (dbSNP)
rs2088102Rnars2088102 (dbSNP)
rs2129575Rnars2129575 (dbSNP) rs2129575
rs2236225Rnars2236225 (dbSNP)
rs2242446Rnars2242446 (dbSNP)
rs2254298GeneProductrs2254298 (dbSNP)
rs2268491GeneProductrs2268491 (dbSNP)
rs2270637Rnars2270637 (dbSNP)
rs2270641Rnars2270641 (dbSNP)
rs2279709Rnars2279709 (dbSNP)
rs2292813Rnars2292813 (dbSNP)
rs2298444Rnars2298444 (dbSNP)
rs237887GeneProductrs237887 (dbSNP)
rs237889GeneProductrs237889 (dbSNP)
rs237897GeneProductrs237897 (dbSNP)
rs237902GeneProductrs237902 (dbSNP)
rs2518352Rnars2518352 (dbSNP)
rs251915Rnars251915 (dbSNP)
rs2550936Rna
rs265981Rnars265981 (dbSNP)
rs2710102Rnars2710102 (dbSNP)
rs28386840Rnars28386840 (dbSNP)
rs2934966Rnars2934966 (dbSNP)
rs3027400Rnars3027400 (dbSNP)
rs3027407Rnars3027407 (dbSNP)
rs35062132GeneProductrs35062132 (dbSNP)
rs36017Rnars36017 (dbSNP)
rs362204Rnars362204 (dbSNP)
rs3733890Rnars3733890 (dbSNP)
rs3746544Rnars3746544 (dbSNP)
rs3782025Rnars3782025 (dbSNP)
rs3785143Rnars3785143 (dbSNP)
rs3785157Rnars3785157 (dbSNP)
rs3813034Rnars3813034 (dbSNP)
rs3819331Rnars3819331 (dbSNP)
rs4130047Rnars4130047 (dbSNP)
rs4291Rnars4291 (dbSNP)
rs4343Rnars4343 (dbSNP)
rs4446909Rnars4446909 (dbSNP)
rs4532Rnars4532 (dbSNP)
rs4570625Rnars4570625 (dbSNP)
rs4633Rnars4633 (dbSNP)
rs4680Rnars4680 (dbSNP)
rs4818RnaRS4818 (dbSNP)
rs4846049Rnars4846049 (dbSNP)
rs53576GeneProductrs53576 (dbSNP)
rs5569Rnars5569 (dbSNP)
rs5905512Rnars5905512 (dbSNP)
rs590551Rnars590551 (dbSNP)
rs5906883 Rnars5906883  (dbSNP)
rs594445Rnars594445 (dbSNP)
rs5949028Rnars5949028 (dbSNP)
rs5989681Rnars5989681 (dbSNP)
rs602618Rnars602618 (dbSNP)
rs6189Rnars6189 (dbSNP)
rs6198Rnars6198 (dbSNP)
rs6267RnaRS6267 (dbSNP)
rs6269Rnars6269 (dbSNP)
rs6280Rnars6280 (dbSNP)
rs6296Rnars6296 (dbSNP)
rs6318Rnars6318 (dbSNP)
rs6323Rnars5906883 (dbSNP)
rs651646 Rnars651646  (dbSNP)
rs6561333Rnars6561333 (dbSNP)
rs6582071Rnars6582071 (dbSNP)
rs6651806Rnars6651806 (dbSNP)
rs6746030Rnars6746030 (dbSNP)
rs686Rnars686 (dbSNP)
rs70991108Rnars70991108 (dbSNP)
rs737865Rnars737865 (dbSNP)
rs740601Rnars740601 (dbSNP)
rs7632287GeneProductrs7632287 (dbSNP)
rs7794745Rnars7794745 (dbSNP)
rs779867Rnars779867 (dbSNP)
rs7997012Rnars7997012 (dbSNP)
rs876657421Rnars876657421 (dbSNP)
rs908670Rnars908670 (dbSNP)
rs916455Rnars916455 (dbSNP)
sepiapterinMetaboliteCHEBI:16095 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
serotoninMetaboliteCHEBI:350546 (ChEBI)
succinate MetaboliteQ213050 (Wikidata)
succinic semialdehydeMetaboliteCHEBI:57706 (ChEBI)
taurineMetaboliteCHEBI:507393 (ChEBI)
tyramineMetaboliteCHEBI:327995 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5420"