Artemisinin inhibition of uveal melanoma (Homo sapiens)

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1GrowthMitochondrialpotentialIncreaseAKTLegendReceptor tyrosine kinaseApoptosisArtemisininPI3KMTORMigrationInvasionAKT1AKT2AKT3Decrease


Description

Farhan et al. (2021) note: "By acting in PI3K/AKT/mTOR, a pathway with recognized importance in cancer, artemisinin was shown to be able to impair the migration, invasion, and proliferation of UM cells." This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8684509__OMCL2021-9911537.012.html.

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Ontology Terms

 

Bibliography

  1. Farhan M, Silva M, Xingan X, Zhou Z, Zheng W; ''Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway.''; Oxid Med Cell Longev, 2021 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128501view13:41, 10 February 2024EweitzCenter group labels in legend
128500view13:23, 10 February 2024EweitzShow PI3K family by class in legend
128490view23:01, 6 February 2024EweitzLegend AKT members, refine AKT node type
128489view21:54, 6 February 2024EweitzLeft-flush label and nodes for inner groups
128488view21:47, 6 February 2024EweitzApply stack horizontal center to RTK members
128487view21:43, 6 February 2024EweitzComplete raw nodes for RTK family genes, by class
128486view21:17, 6 February 2024EweitzDraft RTK gene family members
128485view21:15, 6 February 2024EweitzReverted to version '23:58, 5 February 2024' by Eweitz
128484view21:14, 6 February 2024EweitzReverted to version '23:56, 5 February 2024' by Eweitz
128482view23:58, 5 February 2024EweitzModified description
128481view23:56, 5 February 2024EweitzPer feedback: connect RTK and PI3K, delegend AKT, legend triangles (https://github.com/wikipathways/wikipathways-help/issues/104)
128352view13:39, 2 February 2024EweitzAdd mitochondrion graphic
128351view13:35, 2 February 2024EweitzRefine identifiers, add legend, enrich level triangles
128348view04:59, 2 February 2024EweitzOntology Term : 'drug pathway' added !
128347view04:58, 2 February 2024EweitzOntology Term : 'melanoma' added !
128346view04:58, 2 February 2024EweitzOntology Term : 'uveal cancer' added !
128345view04:57, 2 February 2024EweitzOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
128344view04:33, 2 February 2024EweitzIdentify nodes
128343view03:26, 2 February 2024EweitzModified description
128342view03:25, 2 February 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
ArtemisininMetabolite223316 (ChEBI)
MTORGeneProductENSG00000198793 (Ensembl)
PI3KGeneProduct2.7.1.137 (Enzyme Nomenclature)
Receptor

tyrosine

kinase		GeneProduct2.7.10.1 (Enzyme Nomenclature)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5441"
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