Effects of MFN2 mutation (Homo sapiens)

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   <Comment Source="WikiPathways-description">Mutation in mitofusin-2 (MFN2) and all the proteins that are consequently changed.</Comment>
   <Comment Source="WikiPathways-description">Mutation in mitofusin-2 (MFN2) and all the proteins that are consequently changed.</Comment>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milbrandt J</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fortunato F</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Baloh RH</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bordoni A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stuppia G</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Del Bo R</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Piga D</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fato R</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bresolin N</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Comi GP</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Corti S</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f96">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f96">
Line 546: Line 579:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yan SS</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yan SS</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ea6">
+
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">34602978</bp:ID>
+
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">apoptotic cell death pathway</bp:TERM>
-
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000009</bp:ID>
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MFN2 Deficiency Impairs Mitochondrial Transport and Downregulates Motor Protein Expression in Human Spinal Motor Neurons.</bp:TITLE>
+
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Front Mol Neurosci</bp:SOURCE>
+
    </bp:openControlledVocabulary>
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2021</bp:YEAR>
+
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mou Y</bp:AUTHORS>
+
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">altered cellular autophagy</bp:TERM>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dein J</bp:AUTHORS>
+
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002403</bp:ID>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen Z</bp:AUTHORS>
+
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jagdale M</bp:AUTHORS>
+
     </bp:openControlledVocabulary>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li XJ</bp:AUTHORS>
+
-
     </bp:PublicationXref>
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ed8">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ed8">
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22232700</bp:ID>
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22232700</bp:ID>
Line 567: Line 598:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Medress ZA</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Medress ZA</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Barres BA</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Barres BA</bp:AUTHORS>
-
    </bp:PublicationXref>
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dc5">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30649465</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hum Mol Genet</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Larrea D</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pera M</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gonnelli A</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quintana-Cabrera R</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Akman HO</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guardia-Laguarta C</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Velasco KR</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Area-Gomez E</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dal Bello F</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De Stefani D</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Horvath R</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shy ME</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schon EA</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giacomello M</bp:AUTHORS>
 
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a5b">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a5b">
Line 600: Line 610:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milbrandt J</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milbrandt J</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d36">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ea6">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20335458</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">34602978</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MFN2 Deficiency Impairs Mitochondrial Transport and Downregulates Motor Protein Expression in Human Spinal Motor Neurons.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Neurosci</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Front Mol Neurosci</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2021</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Misko A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mou Y</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jiang S</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dein J</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wegorzewska I</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen Z</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milbrandt J</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jagdale M</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Baloh RH</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li XJ</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">altered cellular autophagy</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002403</bp:ID>
 
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">altered transport pathway</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000545</bp:ID>
 
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Revision as of 01:56, 23 April 2024

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
129470view02:26, 23 April 2024EweitzEconomize layout
129465view01:56, 23 April 2024EweitzImprove interaction alignment
129464view01:55, 23 April 2024EweitzDisambiguate interaction source, economize layout
129463view01:52, 23 April 2024EweitzRemove superfluous descriptor
129462view01:50, 23 April 2024EweitzUse standard pathway color
129461view01:43, 23 April 2024EweitzOntology Term : 'altered transport pathway' added !
129460view01:42, 23 April 2024EweitzEconomize layout, improve alignment
129457view00:58, 23 April 2024EweitzOntology Term : 'altered cellular autophagy' added !
129456view00:58, 23 April 2024EweitzOntology Term : 'apoptotic cell death pathway' added !
129455view00:57, 23 April 2024EweitzModified title
129454view00:55, 23 April 2024EweitzModified description
129453view00:53, 23 April 2024EweitzEconomize layout
129452view00:47, 23 April 2024EweitzEconomize layout
129451view00:29, 23 April 2024EweitzEconomize layout, standardize shapes
129014view10:48, 6 March 2024JordyG02Improved arrows
129000view18:15, 28 February 2024JordyG02removed opa1 and mtor
128999view15:39, 28 February 2024JordyG02New pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/f/f5/WP5443_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/f/f5/WP5443_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 129465)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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