Complement activation (Homo sapiens)

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1antigen/antibodycomplexComplexFormationPlasmaMembraneaggregated IgG,IgM-antigen complex,polyanions, RNA, DNAlipopolysaccharidesCytoplasmIonsMembraneattack complexProteolytic CleavageC1 complexPrevents Complement AttackC8AC3DAFC1QGC1RC1QBH2OC5MASP1C6C7C1QAC9C4BC1SC4AC8BC2


Description

The complement system is a biochemical cascade that helps, or “complements”, the ability of antibodies to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. The Classical pathway of activation of the complement system is a group of blood proteins that mediate the specific antibody response. [source: Wikipedia)

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Ontology Terms

 

Bibliography

  1. Brook E, Herbert AP, Jenkins HT, Soares DC, Barlow PN; ''Opportunities for new therapies based on the natural regulators of complement activation.''; Ann N Y Acad Sci, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128162view17:14, 28 January 2024EweitzModified description
128161view17:12, 28 January 2024EweitzRefine label margin
128160view17:11, 28 January 2024EweitzStandardize case
126244view04:18, 18 April 2023EgonwLicense is CCZero
116815view10:12, 14 May 2021EweitzModified title
106816view13:29, 17 September 2019MaintBotHMDB identifier normalization
106364view23:04, 22 August 2019KhanspersModified description
105557view06:16, 9 August 2019KhanspersModified description
89636view06:10, 22 September 2016EgonwConnected lines.
87260view14:39, 20 July 2016MaintBotmissing graphids
82142view01:23, 9 September 2015AlexanderPicofixed C1Q complex
82141view01:19, 9 September 2015AlexanderPicoModified description
82140view01:13, 9 September 2015AlexanderPicoModified title
82139view01:13, 9 September 2015AlexanderPicoAdded other pathways
82136view00:08, 9 September 2015AlexanderPicoAdded MASP2
82135view00:05, 9 September 2015AlexanderPicoModified description
82134view00:04, 9 September 2015AlexanderPicoModified description
82133view23:58, 8 September 2015AlexanderPicoModified description
82132view23:58, 8 September 2015AlexanderPicoModified description
82131view23:57, 8 September 2015AlexanderPicoModified description
82130view23:46, 8 September 2015AlexanderPicoresolved curved interaction
82129view23:42, 8 September 2015AlexanderPicoadjusting inhibition tbar
82128view23:41, 8 September 2015AlexanderPicoadjusting inhibition tbar
82127view23:39, 8 September 2015AlexanderPicoFinished update of layout and components
82126view22:37, 8 September 2015AlexanderPicoin progress
82125view21:59, 8 September 2015AlexanderPicoUpdating layout and component details (in progress)
72062view17:25, 24 October 2013Mkutmonupdated annotation for C1R
69756view10:50, 11 July 2013Mkutmonreplace annotation lines with graphical lines (instead of interactions)
67122view10:09, 26 June 2013Christine ChichesterOntology Term : 'classical complement pathway' added !
63169view20:26, 8 May 2013MaintBotUpdating gpml version
41148view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
37346view17:20, 28 May 2010KhanspersConnectors
35499view13:11, 12 February 2010MichielModified description
35496view13:09, 12 February 2010MichielAdded ref
32462view17:26, 15 August 2009MaintBotFixed text labels
32145view13:59, 14 August 2009MaintBotFixed group labels
21826view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Complement Activation Classical]] moved to [[Pathway:WP545]]: Moved to stable identifier
15395view22:31, 27 May 2008Khanspersconnectors
14776view01:17, 24 May 2008KhanspersAdded connectors and metabolite
14774view01:09, 24 May 2008KhanspersPeriodical save, work in progress
12932view10:41, 17 May 2008MaintBotSticky edges patch by Sjoerd
7966view13:46, 7 January 2008MaintBot[[Pathway:Human:Complement Activation Classical]] moved to [[Pathway:Homo sapiens:Complement Activation Classical]]: Renaming species
7607view16:03, 18 December 2007MaintBotfixed category names
7464view12:42, 4 November 2007MaintBotAdded categories to GPML
6304view22:17, 22 May 2007Nsalomonisgpml file for [[Human:Complement_Activation_Classical]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
C1QAGeneProduct712 (Entrez Gene) update: C1QA HUMAN
C1QBGeneProduct713 (Entrez Gene)
C1QGGeneProduct714 (Entrez Gene) update C1QC HUMAN
C1RGeneProductENSG00000159403 (Ensembl)
C1SGeneProduct716 (Entrez Gene)
C2GeneProduct717 (Entrez Gene)
C3GeneProduct718 (Entrez Gene)
C4AGeneProduct720 (Entrez Gene)
C4BGeneProduct721 (Entrez Gene)
C5GeneProduct727 (Entrez Gene)
C6GeneProduct729 (Entrez Gene)
C7GeneProduct730 (Entrez Gene)
C8AGeneProduct731 (Entrez Gene)
C8BGeneProduct732 (Entrez Gene)
C9GeneProduct735 (Entrez Gene)
DAFGeneProduct1604 (Entrez Gene)
H2OMetaboliteHMDB02111 (HMDB)
MASP1GeneProduct5648 (Entrez Gene)

Annotated Interactions

No annotated interactions

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