p53 signal pathway (Rattus norvegicus)

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131321ROSG2 arrestGenesDNA-damageG1 arrestApoptosisCell cycle arrestDNAMdm2SiahCdk4Gtse1Tp53PIGsScotinPhenobarbitalIGFcasp8SFNIGF-BP3dexamethazonePAG608Tp53p21NoxaParp1casp3Cyclin ECasp9BidPumaBaxCdk2Gadd45Cytochrome C1Apaf 1Reprimocyclin B3Cyclin DPERPCdc2Fas


Description

We've used the following pathway as a reference: http://www.genome.jp/dbget-bin/show_pathway?rno04115+58918

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Quality Tags

Ontology Terms

 

Bibliography

  1. Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD; ''p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.''; Toxicol Sci, 2006 PubMed Europe PMC Scholia
  2. Simbulan-Rosenthal CM, Rosenthal DS, Ding R, Bhatia K, Smulson ME; ''Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression.''; Biochem Biophys Res Commun, 1998 PubMed Europe PMC Scholia
  3. Malanga M, Pleschke JM, Kleczkowska HE, Althaus FR; ''Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions.''; J Biol Chem, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
107003view13:46, 17 September 2019MaintBotHMDB identifier normalization
87405view11:05, 22 July 2016MaintBotadded missing graphids
83038view03:46, 18 November 2015Mkutmonadded ref to WP apoptosis pathway
83037view03:44, 18 November 2015Mkutmonremove test comment
83036view03:44, 18 November 2015Mkutmonfix outdated identifiers, connected interactions and improved layout
71284view04:57, 17 October 2013MaintBotUpdated Uniprot-TrEMBL datasources
69340view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67574view11:28, 26 June 2013DdiglesOntology Term : 'p53-dependent G1/S DNA damage checkpoint pathway' added !
58920view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48274view23:22, 17 May 2012KhanspersUpdating PubChem xrefs
48263view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41652view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
33398view14:46, 30 November 2009MaintBotRemoved group label
32821view15:27, 9 September 2009JinggaoSpecify description
32820view15:20, 9 September 2009Jinggaotest
29867view15:16, 8 June 2009Thomasremoved whitespace from some ensembl ids
29752view23:06, 1 June 2009KhanspersModified categories
28536view14:38, 11 February 2009EmmaververModified description
28535view14:37, 11 February 2009EmmaververSpecify description
28531view14:32, 11 February 2009EmmaververSpecify description
28529view14:30, 11 February 2009EmmaververPeriodical save, work in progress
28527view14:27, 11 February 2009EmmaververSpecify description
28523view14:19, 11 February 2009EmmaververPeriodical save, work in progress
28517view14:09, 11 February 2009EmmaververPeriodical save, work in progress
28509view13:59, 11 February 2009EmmaververPeriodical save, work in progress
28498view13:49, 11 February 2009EmmaververPeriodical save, work in progress
28489view13:39, 11 February 2009EmmaververPeriodical save, work in progress
28473view13:18, 11 February 2009EmmaververPeriodical save, work in progress
28463view13:07, 11 February 2009EmmaververPeriodical save, work in progress
28455view12:57, 11 February 2009EmmaververPeriodical save, work in progress
28446view12:48, 11 February 2009EmmaververSpecify description
28444view12:47, 11 February 2009EmmaververPeriodical save, work in progress
28434view12:37, 11 February 2009EmmaververPeriodical save, work in progress
28425view12:27, 11 February 2009EmmaververPeriodical save, work in progress
28411view12:07, 11 February 2009EmmaververNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apaf 1GeneProductENSRNOG00000008022 (Ensembl)
BaxGeneProductENSRNOG00000020876 (Ensembl)
BidGeneProductENSRNOG00000012439 (Ensembl)
Casp9GeneProductENSRNOG00000012944 (Ensembl)
Cdc2GeneProductENSRNOG00000000632 (Ensembl)
Cdk2GeneProductENSRNOG00000006469 (Ensembl)
Cdk4GeneProductENSRNOG00000025602 (Ensembl)
Cyclin DGeneProductP48961 (Uniprot/TrEMBL)
Cyclin EGeneProductENSRNOG00000014786 (Ensembl)
Cytochrome C1Metabolite44144406 (PubChem-compound)
FasGeneProductENSRNOG00000019142 (Ensembl)
Gadd45GeneProductENSRNOG00000013090 (Ensembl)
Gtse1GeneProductENSRNOG00000016148 (Ensembl)
IGF-BP3GeneProductENSRNOG00000008645 (Ensembl)
IGFGeneProductENSRNOG00000004517 (Ensembl)
Mdm2GeneProductENSRNOG00000006304 (Ensembl)
NoxaGeneProductENSRNOG00000018770 (Ensembl)
PAG608GeneProductENSRNOG00000010119 (Ensembl)
PERPGeneProductENSRNOG00000011994 (Ensembl)
PIGsGeneProductENSRNOG00000030391 (Ensembl)
Parp1GeneProductENSRNOG00000003084 (Ensembl)
PhenobarbitalMetabolite4763 (PubChem-compound)
PumaGeneProductQ80ZG6 (Uniprot/TrEMBL)
ReprimoGeneProductENSRNOG00000005109 (Ensembl)
SFNGeneProductENSRNOG00000008679 (Ensembl)
ScotinGeneProductENSRNOG00000020667 (Ensembl)
SiahGeneProductENSRNOG00000015143 (Ensembl)
Tp53GeneProductENSRNOG00000010756 (Ensembl)
casp3GeneProductENSRNOG00000010475 (Ensembl)
casp8GeneProductENSRNOG00000012331 (Ensembl)
cyclin B3GeneProductENSRNOG00000002951 (Ensembl)
dexamethazoneMetabolite5743 (PubChem-compound)
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p21GeneProduct24525 (Entrez Gene)

Annotated Interactions

No annotated interactions

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