Calcium regulation in cardiac cells (Gallus gallus)

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ConnexinL-Type Ca2+ ChannelProtein Kinase ACaM kinaseGNa2+IP3 ReceptorsbgPKC inhibitor Protein-12+Repolarization2+MembraneDepolarizationgbeta ArrestinCaM kinase2+K+bGbCalreticulin-CaDAG2+Gap Junctions (Connexins)Ca2+2+Signaling2+PIP22+G alpha i/o/zCaCytosolIP3bbgAdrenergic ReceptorCaIP3 ReceptorsCalmodulinaPhopholambanGRKCaCytosolic Ca2+PKA InhibitorsCaADP + PiNa+Epinephrine2+IP4GCaProtein Kinase Carrestin/GRKCytosolic CaNa+Adrenergic ReceptorDihydropyridine-SensitiveSR2+Regulators of G-proteinADP + PiConnexinG alpha i/o/zAdenylyl CyclasesPProtein Kinase ACaK+2+Na+/K+ ATPasebK+GNa+/Ca2+ ExchangerCaEpinephrineFKBP122+Cytosolic Ca2+Calsequestrin S-CaM1 Muscarinic ReceptorPCyclasesAdenylylarrestin/GRKCalsequestrin C-CabgG2+CacAMPGNG13TPTECAMK2GRGS14SLC8A3ADCY4ADCY6GNAZGNG3GJC1GJB1RGS6ATPGNGT1GNAO1GNB5RGS4GNB4GJA1PRKAR2AADRB1KCNJ3RYR1CHRM3ADCY5ADRA1APRKCQGJB5ANXA6PRKCHATP2B3ATPCALM1GJA3RGS9GRK4ADPRGS10ADCY3FKBP1AGNB2GJB4ATPATP1A4GJB3PRKACACALM3ATPGJA10RGS2PRKCBGNAI3YWHAQPRKAR1BRGS11CACNA1SADCY9PRKCZATP2A3ATP1B2PLCB3ATP1B3AcetylcholineADRA1BITPR1ATP2A2GNAI2ATP1B1CAMK1PRKAR1AADCY1CACNB1YWHABADRA1DCACNB3PLNCAMK4CACNA1EGNASRGS7CHRM5GNG4YWHAHCACNA1AGNA11CALM2GNG5YWHAEGRK5CASQ2PRKCDCALR3GRK6CACNA1DFXYD2RGS19ADRB3ATP2B1GJB2PRKAR2BGNB3RCJMB04_5e12RCJMB04_5a10GNG12GNAI1RCJMB04_6n13CASQ1GNG7ARRB2RYR3GJC2PKIAPRKCGGNG8CAMK2DGNG2CAMK2BPRKCHCACNA1CRCJMB04_23b22ITPR2ADCY2ADCY7SFNRGS17CHRM1RCJMB04_11l21RGS3CAMK2ACHRM2RGS5GJA4GJA8ADRB2ATP2B2RCJMB04_12k21CACNA1BPKIBGJB6PRKCEKCNJ5PKIGRGS20GJD2PLCB3ADCY8RGS18RYR2GNG11CHRM4KCNB1RGS1ARRB1ITPR3PRKACBSLC8A1GJA5RGS16


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP536(r21808) with a 65% conversion rate.

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Ontology Terms

 

Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117190view10:31, 18 May 2021EweitzModified title
111029view21:30, 1 July 2020L DupuisConnected lines
107111view14:18, 17 September 2019MaintBotChEBI identifier normalization
106123view12:02, 16 August 2019MaintBotHMDB identifier normalization
95762view14:13, 19 January 2018MkutmonHomology conversion update
74230view16:25, 8 April 2014EgonwRemoved a data source where no ID was given.
72459view20:22, 16 November 2013AlexanderPicoPruned ChEBI prefix to support alias linkouts
72377view13:10, 13 November 2013EgonwAdded a bunch of missing metabolite identifiers.
68811view17:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
67776view14:00, 26 June 2013Christine ChichesterOntology Term : 'calcium/calcium-mediated signaling pathway' added !
47786view16:20, 6 April 2012Khanspersupdated xref
40945view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35447view11:43, 12 February 2010Thomasadded literature
35445view11:41, 12 February 2010ThomasModified description
33873view17:51, 9 December 2009MaintBotAutomatic update of empty xrefs
33482view15:07, 30 November 2009MaintBotRemoved group label
31531view21:44, 13 August 2009MaintBotFixed text labels
30377view21:01, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY1GeneProduct420788 (Entrez Gene) CYA1 HUMAN
ADCY2GeneProduct420935 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY3GeneProduct
ADCY4GeneProductThere is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY5GeneProduct395340 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY6GeneProduct
ADCY7GeneProduct415732 (Entrez Gene)
ADCY8GeneProduct420328 (Entrez Gene)
ADCY9GeneProduct395339 (Entrez Gene)
ADPGeneProduct
ADRA1AGeneProduct428203 (Entrez Gene)
ADRA1BGeneProduct373890 (Entrez Gene)
ADRA1DGeneProduct422933 (Entrez Gene)
ADRB1GeneProduct430991 (Entrez Gene)
ADRB2GeneProduct427623 (Entrez Gene)
ADRB3GeneProduct
ANXA6GeneProduct395481 (Entrez Gene)
ARRB1GeneProduct
ARRB2GeneProduct
ATP1A4GeneProduct
ATP1B1GeneProduct396529 (Entrez Gene)
ATP1B2GeneProduct
ATP1B3GeneProduct396549 (Entrez Gene)
ATP2A2GeneProduct396446 (Entrez Gene)
ATP2A3GeneProduct395707 (Entrez Gene)
ATP2B1GeneProduct374244 (Entrez Gene)
ATP2B2GeneProduct415958 (Entrez Gene)
ATP2B3GeneProduct
ATPGeneProduct
AcetylcholineGeneProduct
CACNA1AGeneProduct
CACNA1BGeneProduct374169 (Entrez Gene)
CACNA1CGeneProduct395891 (Entrez Gene)
CACNA1DGeneProduct395895 (Entrez Gene)
CACNA1EGeneProduct424412 (Entrez Gene)
CACNA1SGeneProduct
CACNB1GeneProduct
CACNB3GeneProduct
CALM1GeneProduct
CALM2GeneProduct
CALM3GeneProduct
CALR3GeneProduct420146 (Entrez Gene)
CAMK1GeneProduct
CAMK2AGeneProduct374175 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct422688 (Entrez Gene)
CAMK2GGeneProduct423737 (Entrez Gene)
CAMK4GeneProduct
CASQ1GeneProduct
CASQ2GeneProduct395198 (Entrez Gene)
CHRM1GeneProduct
CHRM2GeneProduct418126 (Entrez Gene)
CHRM3GeneProduct396364 (Entrez Gene)
CHRM4GeneProduct423195 (Entrez Gene)
CHRM5GeneProduct428881 (Entrez Gene)
FKBP1AGeneProduct
FXYD2GeneProduct
GJA10GeneProduct
GJA1GeneProduct395278 (Entrez Gene)
GJA3GeneProduct428084 (Entrez Gene)
GJA4GeneProduct404529 (Entrez Gene)
GJA5GeneProduct396502 (Entrez Gene)
GJA8GeneProduct395846 (Entrez Gene)
GJB1GeneProduct378797 (Entrez Gene)
GJB2GeneProduct
GJB3GeneProduct
GJB4GeneProduct
GJB5GeneProduct428225 (Entrez Gene)
GJB6GeneProduct395771 (Entrez Gene)
GJC1GeneProduct396501 (Entrez Gene)
GJC2GeneProduct420397 (Entrez Gene)
GJD2GeneProduct395273 (Entrez Gene)
GNA11GeneProduct374077 (Entrez Gene)
GNAI1GeneProduct396368 (Entrez Gene)
GNAI2GeneProduct396367 (Entrez Gene)
GNAI3GeneProduct374097 (Entrez Gene)
GNAO1GeneProduct415698 (Entrez Gene)
GNASGeneProduct419313 (Entrez Gene)
GNAZGeneProduct770226 (Entrez Gene)
GNB2GeneProduct
GNB3GeneProduct427945 (Entrez Gene)
GNB4GeneProduct
GNB5GeneProduct415417 (Entrez Gene)
GNG11GeneProduct771999 (Entrez Gene)
GNG12GeneProduct772239 (Entrez Gene)
GNG13GeneProduct771014 (Entrez Gene)
GNG2GeneProduct423581 (Entrez Gene)
GNG3GeneProduct
GNG4GeneProduct771582 (Entrez Gene)
GNG5GeneProduct424538 (Entrez Gene)
GNG7GeneProduct
GNG8GeneProduct
GNGT1GeneProduct
GRK4GeneProduct422879 (Entrez Gene)
GRK5GeneProduct423929 (Entrez Gene)
GRK6GeneProduct416361 (Entrez Gene)
ITPR1GeneProduct395412 (Entrez Gene)
ITPR2GeneProduct418212 (Entrez Gene)
ITPR3GeneProduct419910 (Entrez Gene)
KCNB1GeneProduct428146 (Entrez Gene)
KCNJ3GeneProduct396369 (Entrez Gene)
KCNJ5GeneProduct395925 (Entrez Gene)
PKIAGeneProduct396333 (Entrez Gene)
PKIBGeneProduct
PKIGGeneProduct
PLCB3GeneProduct
PLNGeneProduct
PRKACAGeneProduct
PRKACBGeneProduct424542 (Entrez Gene)
PRKAR1AGeneProduct417438 (Entrez Gene) KAP0 HUMAN
PRKAR1BGeneProduct416446 (Entrez Gene)
PRKAR2AGeneProduct416062 (Entrez Gene)
PRKAR2BGeneProduct769420 (Entrez Gene)
PRKCBGeneProduct416567 (Entrez Gene)
PRKCDGeneProduct415905 (Entrez Gene)
PRKCEGeneProduct421409 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PRKCGGeneProduct
PRKCHGeneProduct423518 (Entrez Gene)
PRKCQGeneProduct
PRKCZGeneProduct419399 (Entrez Gene)
RCJMB04_11l21GeneProduct425619 (Entrez Gene) PMID: 9861170 PMID: 1317796
RCJMB04_12k21GeneProduct423302 (Entrez Gene) KPCM HUMAN
RCJMB04_23b22GeneProduct427262 (Entrez Gene)
RCJMB04_5a10GeneProduct417430 (Entrez Gene)
RCJMB04_5e12GeneProduct427820 (Entrez Gene)
RCJMB04_6n13GeneProduct419402 (Entrez Gene)
RGS10GeneProduct423930 (Entrez Gene)
RGS11GeneProduct
RGS1GeneProduct424360 (Entrez Gene)
RGS14GeneProduct769193 (Entrez Gene)
RGS16GeneProduct424409 (Entrez Gene)
RGS17GeneProduct395645 (Entrez Gene)
RGS18GeneProduct424361 (Entrez Gene)
RGS19GeneProduct
RGS20GeneProduct395646 (Entrez Gene)
RGS2GeneProduct378912 (Entrez Gene)
RGS3GeneProduct
RGS4GeneProduct378901 (Entrez Gene)
RGS5GeneProduct769998 (Entrez Gene)
RGS6GeneProduct395618 (Entrez Gene)
RGS7GeneProduct395620 (Entrez Gene)
RGS9GeneProduct417433 (Entrez Gene)
RYR1GeneProduct
RYR2GeneProduct
RYR3GeneProduct396111 (Entrez Gene)
SFNGeneProduct
SLC8A1GeneProduct395760 (Entrez Gene)
SLC8A3GeneProduct395759 (Entrez Gene)
TPTEGeneProduct418885 (Entrez Gene)
YWHABGeneProduct419190 (Entrez Gene)
YWHAEGeneProduct417554 (Entrez Gene)
YWHAHGeneProduct416955 (Entrez Gene)
YWHAQGeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP808"