Heme biosynthesis (Rattus norvegicus)

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rate limiting stepBlack - reactantsdelta-aminolevulinatesuccinyl-CoA + glycineH+delta-aminolevulinateprotoporphyrinogen IXFe2+Red - side productsFechCO2H2OCO2AladO2H2O2CO2ALAS1HmbsO2Alas2CoACpoxcoproporphyrinogen IIIH2OhydroxymethylbilaneNH3PpoxUrosuroporphyrinogen IIIprotoporphyrin IXUrodH2OprotohemePorphobilinogenporphobilinogen


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP561(r21860) with a 53% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
116978view10:42, 16 May 2021EweitzModified title
107007view13:46, 17 September 2019MaintBotHMDB identifier normalization
89925view13:34, 6 October 2016MkutmonModified description
71829view19:35, 18 October 2013MaintBotremoved data source from nodes without identifier
70694view14:40, 28 August 2013EgonwAdded more ChemSpider IDs for metabolites previously only available as Label.
70005view23:32, 11 July 2013MaintBotupdated to 2013 schema
67336view10:39, 26 June 2013Christine ChichesterOntology Term : 'heme biosynthetic pathway' added !
41679view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
35288view22:50, 11 February 2010Mills42Modified description
34069view19:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33527view09:33, 1 December 2009MaintBotRemoved group label
30916view00:32, 30 July 2009MaintBotConverted from Homo sapiens
20861view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Heme Biosynthesis]] moved to [[Pathway:WP86]]: Moved to stable identifier
8136view13:46, 7 January 2008MaintBot[[Pathway:Rat:Heme Biosynthesis]] moved to [[Pathway:Rattus norvegicus:Heme Biosynthesis]]: Renaming species
7689view16:09, 18 December 2007MaintBotfixed category names
7374view12:42, 4 November 2007MaintBotAdded categories to GPML
6556view22:20, 22 May 2007Kdahlquistgpml file for [[Rat:Heme_Biosynthesis]]

External references

DataNodes

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NameTypeDatabase referenceComment
ALAS1GeneProduct
AladGeneProduct25374 (Entrez Gene)
Alas2GeneProduct25748 (Entrez Gene)
CO2MetaboliteHMDB01967 (HMDB)
CoAMetaboliteHMDB01423 (HMDB)
CpoxGeneProduct304024 (Entrez Gene)
FechGeneProduct361338 (Entrez Gene)
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HmbsGeneProduct25709 (Entrez Gene)
NH3MetaboliteHMDB00051 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
PorphobilinogenMetaboliteHMDB00245 (HMDB)
PpoxGeneProduct289219 (Entrez Gene)
UrodGeneProduct29421 (Entrez Gene)
UrosGeneProduct309070 (Entrez Gene)
coproporphyrinogen IIIGeneProduct
hydroxymethylbilaneGeneProduct
porphobilinogenGeneProduct
protohemeGeneProduct
protoporphyrin IXGeneProduct
uroporphyrinogen IIIGeneProduct

Annotated Interactions

No annotated interactions
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