EPO receptor signaling (Pan troglodytes)

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EPORJAK2SRCEPOR1, 2PBox-1PPPPPPPPPPY343Y479Box-2DNACell membraneY343Y460PPBox-2Box-1PY431MAP2K1EPOSTAT1EPOMAPK3PDK1AKT1SHC1PIK3CGMAP2K2MAPK1GRB2SOCS1STAT5BCISHSTAT5ASTAT3STAT3STAT1PTPRCPTPRUPPPGRB2RAF1SOS1IRS2JAK2IRS1RASA1RAF1SOS1RASA1


Description

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia This pathway is based on ScienceSlides.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP581(r22574) with a 88% conversion rate.

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Ontology Terms

 

Bibliography

  1. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed Europe PMC Scholia
  2. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117390view10:32, 21 May 2021EweitzModified title
69292view18:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67201view10:20, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
41602view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
35094view12:57, 11 February 2010Thomasadded literature
34331view22:15, 9 December 2009MaintBotAutomatic update of empty xrefs
33542view09:38, 1 December 2009MaintBotRemoved group label
30447view21:25, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
CISHGeneProduct470819 (Entrez Gene)
EPOGeneProduct463609 (Entrez Gene)
EPORGeneProduct455728 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
IRS1GeneProduct459985 (Entrez Gene)
IRS2GeneProduct452657 (Entrez Gene)
JAK2GeneProduct464979 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K2GeneProduct456390 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
PDK1GeneProduct459743 (Entrez Gene)
PIK3CGGeneProduct463649 (Entrez Gene)
PTPRCGeneProduct457607 (Entrez Gene)
PTPRUGeneProduct456692 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RASA1GeneProduct461762 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
SOCS1GeneProduct737070 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
SRCGeneProduct458229 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
STAT5AGeneProduct454681 (Entrez Gene)
STAT5BGeneProduct454679 (Entrez Gene)

Annotated Interactions

No annotated interactions
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