Calcium regulation in cardiac cells (Pan troglodytes)

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1GG alpha i/o/zProtein Kinase Cbarrestin/GRKCabCytosolic CaSignalingProtein Kinase AIP3 ReceptorsG2+CytosolAdenylylPKC inhibitor Protein-1FKBP12ConnexinCabgPIP2bgADP + PiIP3 Receptors2+PAdrenergic ReceptorM1 Muscarinic ReceptorCaM kinaseCytosolic Ca2+CalmodulinCagCa2+CaM kinaseCa2+2+PKA InhibitorsIP3CyclasesCaNa2+K+L-Type Ca2+ ChannelNa+Cabeta ArrestinCalreticulin-CaEpinephrineRepolarization2+bg2+Na+arrestin/GRKCaIP4GRKPhopholamban2+DAGADP + PiDihydropyridine-SensitiveEpinephrineAdrenergic ReceptorMembraneDepolarizationCytosolic CaG2+G alpha i/o/zNa+/K+ ATPaseGap Junctions (Connexins)Calsequestrin S-CaaNa+/Ca2+ Exchanger2+K+2+CaCalsequestrin C-Ca2+Protein Kinase APSRGAdenylyl Cyclases2+Regulators of G-proteinK+2+bConnexincAMPbGPRKCZCALM1ADPGNG3ADRA1BGJB2RGS3FKBP1AGNG5RGS7SLC8A3LOC472115ADCY3ATPCALM3PRKAR2ARGS17GJC2ADCY2RGS6RGS1GNASPRKCAGNAZCACNA1DKCNB1GRK6LOC748633RGS18PRKCQADCY9LOC100611408LOC100612078RYR1GRK5ATPGNB5PRKD1CACNA1SRGS9RGS20GRK4GNB4CAMK2DADRB2GJA3CHRM4ARRB2PRKCBRGS5GJA4GNAO1LOC458272ATPKCNJ5LOC100610291ADCY5PRKACBADCY6GNG4GNG13ITPR3PRKACAPKIGATP1B2ADRA1ARGS11ATP1B1ITPR2YWHAQATP1B3YWHAHCACNA1APLCB3PRKAR2BSLC8A1CACNB1ATP2A2GJA1RGS4CALRGJA6PRKCHADRB1LOC750343CACNA1BGJA8GNG2GNG8PRKAR1ALOC459203GJA5PRKAR1BANXA6GNAI2CHRM2RGS19FXYD2ADCY7ITPR1GNAI1PRKCGARRB1ADCY4CHRM3LOC100613044CAMK2BLOC100609944CACNA1CRYR2RGS2GNAI3CHRM5LOC100609242GNB1ADRB3GJD2ATP2B1AcetylcholineGJC1CACNB3GNA11SFNYWHAZCASQ2YWHAECHRM1ATP2B2PRKCDATP2A3CAMK2GPRKCHGNGT1LOC453296YWHAGCAMK4CAMK1LOC472962LOC100615296PLCB3ATP2B3CALM2KCNJ3CASQ1GJB4RGS14ADRA1DCAMK2AATP1A4GJB1CACNA1EGNB2GNG11RGS10GJB3ADCY1ATPGNG7


Description

Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP536(r44983) with a 86% conversion rate.

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Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117383view10:31, 21 May 2021EweitzModified title
107227view14:32, 17 September 2019MaintBotChEBI identifier normalization
106937view13:40, 17 September 2019MaintBotHMDB identifier normalization
95763view14:13, 19 January 2018MkutmonHomology conversion update
69294view18:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67777view14:01, 26 June 2013Christine ChichesterOntology Term : 'calcium/calcium-mediated signaling pathway' added !
48162view19:01, 9 May 2012MaintBotUpdating from human to fix xrefs
41604view02:02, 2 March 2011MaintBotRemoved redundant pathway information and comments
35450view11:45, 12 February 2010ThomasModified description
35448view11:44, 12 February 2010Thomasadded literature
34333view22:16, 9 December 2009MaintBotAutomatic update of empty xrefs
33578view09:48, 1 December 2009MaintBotRemoved group label
31600view22:08, 13 August 2009MaintBotFixed text labels
30492view21:39, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY1GeneProduct463392 (Entrez Gene) CYA1 HUMAN
ADCY2GeneProductThere is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY3GeneProduct459070 (Entrez Gene)
ADCY4GeneProduct452819 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY5GeneProduct470905 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY6GeneProduct451866 (Entrez Gene)
ADCY7GeneProduct473278 (Entrez Gene)
ADCY9GeneProduct453869 (Entrez Gene)
ADPMetabolite58-64-0 (CAS)
ADRA1AGeneProduct472723 (Entrez Gene)
ADRA1BGeneProduct736934 (Entrez Gene)
ADRA1DGeneProduct469869 (Entrez Gene)
ADRB1GeneProduct466206 (Entrez Gene)
ADRB2GeneProduct471690 (Entrez Gene)
ADRB3GeneProduct464113 (Entrez Gene)
ANXA6GeneProduct462198 (Entrez Gene)
ARRB1GeneProduct451424 (Entrez Gene)
ARRB2GeneProduct454450 (Entrez Gene)
ATPMetabolite1927-31-7 (CAS)
ATP1A4GeneProduct458010 (Entrez Gene)
ATP1B1GeneProduct457497 (Entrez Gene)
ATP1B2GeneProduct749043 (Entrez Gene)
ATP1B3GeneProduct746692 (Entrez Gene)
ATP2A2GeneProduct452231 (Entrez Gene)
ATP2A3GeneProduct
ATP2B1GeneProduct
ATP2B2GeneProduct460168 (Entrez Gene)
ATP2B3GeneProduct
AcetylcholineMetabolite51-84-3 (CAS)
CACNA1AGeneProduct455766 (Entrez Gene)
CACNA1BGeneProduct464893 (Entrez Gene)
CACNA1CGeneProduct466914 (Entrez Gene)
CACNA1DGeneProduct460447 (Entrez Gene)
CACNA1EGeneProduct
CACNA1SGeneProduct469635 (Entrez Gene)
CACNB1GeneProduct
CACNB3GeneProduct451867 (Entrez Gene)
CALM1GeneProduct
CALM2GeneProduct
CALM3GeneProduct
CALRGeneProduct455756 (Entrez Gene)
CAMK1GeneProduct460153 (Entrez Gene)
CAMK2AGeneProduct462189 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct461445 (Entrez Gene)
CAMK2GGeneProduct738330 (Entrez Gene)
CAMK4GeneProduct461992 (Entrez Gene)
CASQ1GeneProduct746678 (Entrez Gene)
CASQ2GeneProduct457150 (Entrez Gene)
CHRM1GeneProduct451272 (Entrez Gene)
CHRM2GeneProduct463758 (Entrez Gene)
CHRM3GeneProduct469725 (Entrez Gene)
CHRM4GeneProduct
CHRM5GeneProduct503515 (Entrez Gene)
FKBP1AGeneProduct749347 (Entrez Gene)
FXYD2GeneProduct
GJA1GeneProduct744245 (Entrez Gene)
GJA3GeneProduct467218 (Entrez Gene)
GJA4GeneProduct469273 (Entrez Gene)
GJA5GeneProduct457250 (Entrez Gene)
GJA6GeneProduct
GJA8GeneProduct469474 (Entrez Gene)
GJB1GeneProduct465696 (Entrez Gene)
GJB2GeneProduct467220 (Entrez Gene)
GJB3GeneProduct
GJB4GeneProduct469272 (Entrez Gene)
GJC1GeneProduct454736 (Entrez Gene)
GJC2GeneProduct739535 (Entrez Gene)
GJD2GeneProduct453306 (Entrez Gene)
GNA11GeneProduct
GNAI1GeneProduct472425 (Entrez Gene)
GNAI2GeneProduct744773 (Entrez Gene)
GNAI3GeneProduct457093 (Entrez Gene)
GNAO1GeneProduct450173 (Entrez Gene)
GNASGeneProduct469986 (Entrez Gene)
GNAZGeneProduct458693 (Entrez Gene)
GNB1GeneProduct469458 (Entrez Gene)
GNB2GeneProduct739897 (Entrez Gene)
GNB4GeneProduct460862 (Entrez Gene)
GNB5GeneProduct745402 (Entrez Gene)
GNG11GeneProduct747185 (Entrez Gene)
GNG13GeneProduct749882 (Entrez Gene)
GNG2GeneProduct467457 (Entrez Gene)
GNG3GeneProduct740869 (Entrez Gene)
GNG4GeneProduct743331 (Entrez Gene)
GNG5GeneProduct456977 (Entrez Gene)
GNG7GeneProduct744391 (Entrez Gene)
GNG8GeneProduct
GNGT1GeneProduct747170 (Entrez Gene)
GRK4GeneProduct461082 (Entrez Gene)
GRK5GeneProduct466217 (Entrez Gene)
GRK6GeneProduct471760 (Entrez Gene)
ITPR1GeneProduct460134 (Entrez Gene)
ITPR2GeneProduct473389 (Entrez Gene)
ITPR3GeneProduct462618 (Entrez Gene)
KCNB1GeneProduct469965 (Entrez Gene)
KCNJ3GeneProduct737029 (Entrez Gene)
KCNJ5GeneProduct451660 (Entrez Gene)
LOC100609242GeneProduct100609242 (Entrez Gene)
LOC100609944GeneProduct100609944 (Entrez Gene)
LOC100610291GeneProduct100610291 (Entrez Gene)
LOC100611408GeneProduct100611408 (Entrez Gene)
LOC100612078GeneProduct100612078 (Entrez Gene)
LOC100613044GeneProduct100613044 (Entrez Gene)
LOC100615296GeneProduct100615296 (Entrez Gene)
LOC453296GeneProduct453296 (Entrez Gene)
LOC458272GeneProduct458272 (Entrez Gene)
LOC459203GeneProduct459203 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
LOC472115GeneProduct472115 (Entrez Gene)
LOC472962GeneProduct472962 (Entrez Gene)
LOC748633GeneProduct748633 (Entrez Gene)
LOC750343GeneProduct750343 (Entrez Gene)
PKIGGeneProduct
PLCB3GeneProduct451290 (Entrez Gene)
PRKACAGeneProduct455776 (Entrez Gene)
PRKACBGeneProduct469367 (Entrez Gene)
PRKAR1AGeneProduct454845 (Entrez Gene) KAP0 HUMAN
PRKAR1BGeneProduct
PRKAR2AGeneProduct
PRKAR2BGeneProduct744011 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCBGeneProduct453993 (Entrez Gene)
PRKCDGeneProduct460442 (Entrez Gene)
PRKCGGeneProduct456276 (Entrez Gene)
PRKCHGeneProduct746068 (Entrez Gene)
PRKCQGeneProduct450288 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PRKD1GeneProduct452834 (Entrez Gene) KPCM HUMAN
RGS10GeneProduct
RGS11GeneProduct453788 (Entrez Gene)
RGS14GeneProduct471758 (Entrez Gene)
RGS1GeneProduct457594 (Entrez Gene)
RGS17GeneProduct737204 (Entrez Gene)
RGS18GeneProduct457592 (Entrez Gene)
RGS19GeneProduct458459 (Entrez Gene)
RGS20GeneProduct740330 (Entrez Gene)
RGS2GeneProduct469623 (Entrez Gene)
RGS3GeneProduct473028 (Entrez Gene)
RGS4GeneProduct457470 (Entrez Gene)
RGS5GeneProduct457471 (Entrez Gene)
RGS6GeneProduct453009 (Entrez Gene)
RGS7GeneProduct469729 (Entrez Gene)
RGS9GeneProduct454829 (Entrez Gene)
RYR1GeneProduct100612063 (Entrez Gene)
RYR2GeneProduct457846 (Entrez Gene)
SFNGeneProduct737412 (Entrez Gene)
SLC8A1GeneProduct470358 (Entrez Gene)
SLC8A3GeneProduct467491 (Entrez Gene)
YWHAEGeneProduct454409 (Entrez Gene)
YWHAGGeneProduct463489 (Entrez Gene)
YWHAHGeneProduct458778 (Entrez Gene)
YWHAQGeneProduct470302 (Entrez Gene)
YWHAZGeneProduct472830 (Entrez Gene) PMID: 9861170 PMID: 1317796

Annotated Interactions

No annotated interactions
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