Insulin signaling (Bos taurus)

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1p90 Rsk Kinasesp70 S6 KinasesPI 3-KinaseRas-MAPK SignalingMetabolic RegulationTranscriptional Regulators & Immediate Early GenesPDK/Akt SignalingInsulin Receptor SubstratesVesicular TraffickingMEK/MAP KinasesModulators of Insulin ActionTor SignalingTranslation RegulationGlucose TransportGYG1SRFPIK3C3PTPRFPRKAA1IRS1MAP3K5MAP3K13PRKCHPIK3CAPTPN11LOC100139219EIF4EBP1LIPERPS6KA6GSK3BGYS2MAP4K4SGK1MAP2K7CRKINSRRPS6KA5MAP3K4RPS6KB1IGF1RMAPK8SNAP25CBLCHRASSLC2A4CBLBFLOT1MAPK4FOSIKBKBRHOJKIF5BINPP4AMAPK10MAPK14MAP3K1PIK3R4MAP3K8RPS6KA1PIK3R2CBLMAP3K14MINK1FOXO3RAC1Grb10RAC2PIK3CBAKT2EHD1SGK3XBP1STXBP1FLOT2MAP2K1MAP4K1RAF1AKT1STX4TSC2MAP2K2STXBP3MAPK1STXBP2SOS1GYS1RAPGEF1PRKCISHC3MAPK8KIF3APRKCAENPP1MAP4K2RRADMAPK13MAPK12MAPK6SLC2A1LOC615374MAP3K11PIK3CDSOCS3CAP1EGR1MAP3K12RPS6KA3PFKLMAP2K5MAP2K3JUNSGK2LOC789318STXBP4SNAP23LOC100138102PRKCQRPS6KA2TSC1GRB14EIF4ELOC537790ELK1MAP2K6ARF6MAP3K9MAP3K3EHD2RPS6KB2MAP3K2PIK3CGMAPK9MAPK11GRB2RPS6KA4IRS2MAP3K7PFKMGSK3AMAP2K4SHC1PRKCZSNX26TBC1D4ARF1SHC2SORBS1LOC513301LOC506618TRIB3SOCS1PIK3R3GAB1MAP4K5INPPL1PTENMAP3K6PRKCBMAP3K10PSCD3LOC100138040RAB4AMAPK7PTPN1MAPK3PRKCDSH2B2LOC100139988VAMP2IRS4MYO1CMAP4K3PRKAA2PPP1R3APIK3R1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r28132) with a 92% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
  2. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia
  3. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116790view09:59, 14 May 2021EweitzModified title
95776view14:28, 19 January 2018MkutmonHomology conversion update
80882view15:29, 30 June 2015Mkutmonhomology conversion
78838view23:00, 4 February 2015ZariModified title
78837view22:58, 4 February 2015ZariPeriodical save, work in progress
71280view04:14, 17 October 2013MaintBotRemoved buggy complexes
63393view00:04, 10 May 2013MaintBotUpdated to 2013 gpml schema
48134view05:52, 9 May 2012MaintBotUpdating from human to fix xref duplication
40566view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33804view00:18, 9 December 2009MaintBotAutomatic update of empty xrefs
33615view10:00, 1 December 2009MaintBotRemoved group label
31628view22:21, 13 August 2009MaintBotFixed text labels
30535view21:54, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
AKT2GeneProduct534923 (Entrez Gene)
ARF1GeneProduct338058 (Entrez Gene)
ARF6GeneProduct614161 (Entrez Gene)
CAP1GeneProduct504519 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CBLBGeneProduct525906 (Entrez Gene)
CBLCGeneProduct615866 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
EGR1GeneProduct407125 (Entrez Gene)
EHD1GeneProduct511908 (Entrez Gene)
EHD2GeneProduct538348 (Entrez Gene)
EIF4EGeneProduct281751 (Entrez Gene)
EIF4EBP1GeneProduct509613 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
ENPP1GeneProduct615535 (Entrez Gene)
FLOT1GeneProduct532573 (Entrez Gene)
FLOT2GeneProduct615679 (Entrez Gene)
FOSGeneProduct280795 (Entrez Gene)
FOXO3GeneProduct535530 (Entrez Gene)
GAB1GeneProduct540085 (Entrez Gene)
GRB14GeneProduct497029 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GSK3AGeneProduct536561 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
GYG1GeneProduct280812 (Entrez Gene)
GYS1GeneProduct786335 (Entrez Gene)
GYS2GeneProduct537451 (Entrez Gene)
Grb10GeneProduct407210 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
IGF1RGeneProduct281848 (Entrez Gene)
IKBKBGeneProduct281854 (Entrez Gene)
INPP4AGeneProduct535487 (Entrez Gene)
INPPL1GeneProduct783833 (Entrez Gene)
INSRGeneProduct408017 (Entrez Gene)
IRS1GeneProduct538598 (Entrez Gene)
IRS2GeneProduct
IRS4GeneProduct514607 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
KIF3AGeneProduct541246 (Entrez Gene)
KIF5BGeneProduct514261 (Entrez Gene)
LIPEGeneProduct286879 (Entrez Gene)
LOC100138040GeneProduct100138040 (Entrez Gene)
LOC100138102GeneProduct100138102 (Entrez Gene)
LOC100139219GeneProduct100139219 (Entrez Gene)
LOC100139988GeneProduct100139988 (Entrez Gene)
LOC506618GeneProduct506618 (Entrez Gene)
LOC513301GeneProduct513301 (Entrez Gene)
LOC537790GeneProduct537790 (Entrez Gene)
LOC615374GeneProduct615374 (Entrez Gene)
LOC789318GeneProduct789318 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP2K3GeneProduct516039 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP2K5GeneProduct
MAP2K6GeneProduct286883 (Entrez Gene)
MAP2K7GeneProduct787278 (Entrez Gene)
MAP3K10GeneProduct781037 (Entrez Gene)
MAP3K11GeneProduct514210 (Entrez Gene)
MAP3K12GeneProduct505427 (Entrez Gene)
MAP3K13GeneProduct505369 (Entrez Gene)
MAP3K14GeneProduct508367 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K2GeneProduct504592 (Entrez Gene)
MAP3K3GeneProduct508943 (Entrez Gene)
MAP3K4GeneProduct511779 (Entrez Gene)
MAP3K5GeneProduct537380 (Entrez Gene)
MAP3K6GeneProduct614598 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAP3K8GeneProduct535622 (Entrez Gene)
MAP3K9GeneProduct
MAP4K1GeneProduct522002 (Entrez Gene)
MAP4K2GeneProduct520058 (Entrez Gene)
MAP4K3GeneProduct507624 (Entrez Gene)
MAP4K4GeneProduct
MAP4K5GeneProduct781335 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MAPK11GeneProduct618906 (Entrez Gene)
MAPK12GeneProduct512943 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK13GeneProduct535327 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK4GeneProduct529183 (Entrez Gene)
MAPK6GeneProduct538094 (Entrez Gene)
MAPK7GeneProduct537703 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MINK1GeneProduct519558 (Entrez Gene)
MYO1CGeneProduct281937 (Entrez Gene)
PFKLGeneProduct508683 (Entrez Gene)
PFKMGeneProduct506544 (Entrez Gene)
PIK3C3GeneProduct534815 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CBGeneProduct517948 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PIK3R3GeneProduct286865 (Entrez Gene)
PIK3R4GeneProduct507414 (Entrez Gene)
PPP1R3AGeneProduct784877 (Entrez Gene)
PRKAA1GeneProduct540404 (Entrez Gene)
PRKAA2GeneProduct538954 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCIGeneProduct528478 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PSCD3GeneProduct
PTENGeneProduct540786 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN1GeneProduct508658 (Entrez Gene)
PTPRFGeneProduct512072 (Entrez Gene)
RAB4AGeneProduct615849 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAC2GeneProduct327671 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAPGEF1GeneProduct520454 (Entrez Gene)
RHOJGeneProduct540619 (Entrez Gene)
RPS6KA1GeneProduct533908 (Entrez Gene)
RPS6KA2GeneProduct517953 (Entrez Gene)
RPS6KA3GeneProduct511190 (Entrez Gene)
RPS6KA4GeneProduct
RPS6KA5GeneProduct504408 (Entrez Gene)
RPS6KA6GeneProduct526227 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
RPS6KB2GeneProduct506083 (Entrez Gene)
RRADGeneProduct505165 (Entrez Gene)
SGK1GeneProduct515854 (Entrez Gene)
SGK2GeneProduct517909 (Entrez Gene)
SGK3GeneProduct504480 (Entrez Gene)
SH2B2GeneProduct617840 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SHC2GeneProduct533455 (Entrez Gene)
SHC3GeneProduct512696 (Entrez Gene)
SLC2A1GeneProduct282356 (Entrez Gene)
SLC2A4GeneProduct282359 (Entrez Gene)
SNAP23GeneProduct522423 (Entrez Gene)
SNAP25GeneProduct540853 (Entrez Gene)
SNX26GeneProduct
SOCS1GeneProduct518795 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SORBS1GeneProduct504625 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SRFGeneProduct533039 (Entrez Gene)
STX4GeneProduct508675 (Entrez Gene)
STXBP1GeneProduct282378 (Entrez Gene)
STXBP2GeneProduct515618 (Entrez Gene)
STXBP3GeneProduct512490 (Entrez Gene)
STXBP4GeneProduct537963 (Entrez Gene)
TBC1D4GeneProduct534649 (Entrez Gene)
TRIB3GeneProduct538465 (Entrez Gene)
TSC1GeneProduct533440 (Entrez Gene)
TSC2GeneProduct504985 (Entrez Gene)
VAMP2GeneProduct282116 (Entrez Gene)
XBP1GeneProduct541236 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP966"