IL-6 signaling pathway (Bos taurus)

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InhibitionCY->ENSumoylationEndosomeProteolytic cleavageDNUDDephosphorylationAccession Number: NetPath 18Enzyme complexAcetylationERDDComplex formationMethylationEndoplasmic reticulumCY->NUDGOECDeacetylationDCytoplasmCY->NUDControlExtracellularRecruitmentPMPalmitoylationProteins in a complex interactionCY->NUCY->NUUbiquitinationNucleusMolecule in the pathwayReceptorReactions through unknown mechanisms/moleculesDCY->NUDDDesumoylationLigandDMitochondrionDActivationAutophosphorylation(Protein-Protein interaction)DMolecular associationEarly EndosomesDeubiquitinationTranslocationDemethylationCYGolgi apparatusENCY->NUMTGene SymbolGlycosylationDPhosphorylationPlasma membraneMAP3K4NCOA1MAP2K1CEBPBJAK1FOXO4PPP2R5BCREBBPHNF1AHSPB1MAPK1PXNMAP2K4STAT1RB1PIK3R1PPP2R5CTECMAP2K2STAT3MAPK14PPP2R2CIL6RPPP2R5EIL6RHDAC1GSK3BCD40PPP2R2BSGK1MAPTRAF1INPPL1STAT1RAC1PTK2BFOXO3PLCG1MAPK3JUNLOC506618NFKB1GRB2EIF4ESTAT5AMAP3K7PRKCDPPP2R1ACDK5STAT3LOC100138150STAT3STAT1PTPN11PPP2R5ABADHSPCAPPP2R3ASGK1MAP3K7PIK3R2HCKEIF2AIL6STSTAT3STAT3MAP2K6ERBB3CASP9IL6IL6NFKB1BTKIL6STEP300CASP3FGRSTAT3GAB1CEBPBFOSLYNSTAT5BPTK2PPP2CBFYNBMXCDK5R1STAT1MAPKAPK2ERBB2EIF4EBP1STAT3CDK9NLKFESHRASJAK2STAT3ARAKT1PPP2R4GAB2PPP2R2ADAXXRPS6KB1MAPK8SHC1VAV1RPS6KA2TYK2MAPK14SOCS3PPP2CAPPP2R5DPPP2R3BINPP5DSOS1


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP364(r28142) with a 89% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115832view20:19, 17 March 2021EgonwModified description
115828view08:11, 17 March 2021EgonwCopied the NetPath paper into the bibliography
89835view12:09, 6 October 2016MkutmonOntology Term : 'Interleukin mediated signaling pathway' added !
89834view12:09, 6 October 2016MkutmonOntology Term : 'interleukin-6 signaling pathway' added !
89833view12:08, 6 October 2016MkutmonModified description
80777view15:25, 30 June 2015Mkutmonhomology conversion
63400view00:07, 10 May 2013MaintBotUpdated to 2013 gpml schema
40574view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33812view00:21, 9 December 2009MaintBotAutomatic update of empty xrefs
31635view22:23, 13 August 2009MaintBotFixed text labels
30545view21:57, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
ARGeneProduct280675 (Entrez Gene)
BADGeneProduct615013 (Entrez Gene)
BMXGeneProduct531514 (Entrez Gene)
BTKGeneProduct533459 (Entrez Gene)
CASP3GeneProduct408016 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CD40GeneProduct286849 (Entrez Gene)
CDK5GeneProduct281066 (Entrez Gene)
CDK5R1GeneProduct282173 (Entrez Gene)
CDK9GeneProduct
CEBPBGeneProduct338319 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
DAXXGeneProduct504336 (Entrez Gene)
EIF2AGeneProduct614746 (Entrez Gene)
EIF4EGeneProduct281751 (Entrez Gene)
EIF4EBP1GeneProduct509613 (Entrez Gene)
EP300GeneProduct
ERBB2GeneProduct
ERBB3GeneProduct785655 (Entrez Gene)
FESGeneProduct507304 (Entrez Gene)
FGRGeneProduct516133 (Entrez Gene)
FOSGeneProduct280795 (Entrez Gene)
FOXO3GeneProduct535530 (Entrez Gene)
FOXO4GeneProduct618793 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GAB1GeneProduct540085 (Entrez Gene)
GAB2GeneProduct529346 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
HCKGeneProduct280814 (Entrez Gene)
HDAC1GeneProduct404126 (Entrez Gene)
HNF1AGeneProduct503578 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
HSPB1GeneProduct516099 (Entrez Gene)
HSPCAGeneProduct281832 (Entrez Gene)
IL6GeneProduct280826 (Entrez Gene)
IL6RGeneProduct507359 (Entrez Gene)
IL6STGeneProduct522155 (Entrez Gene)
INPP5DGeneProduct507329 (Entrez Gene)
INPPL1GeneProduct783833 (Entrez Gene)
JAK1GeneProduct537201 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
LOC100138150GeneProduct100138150 (Entrez Gene)
LOC506618GeneProduct506618 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP2K6GeneProduct286883 (Entrez Gene)
MAP3K4GeneProduct511779 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
MAPTGeneProduct281296 (Entrez Gene)
NCOA1GeneProduct525346 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
NLKGeneProduct507204 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PLCG1GeneProduct281987 (Entrez Gene)
PPP2CAGeneProduct282320 (Entrez Gene)
PPP2CBGeneProduct524361 (Entrez Gene)
PPP2R1AGeneProduct535321 (Entrez Gene)
PPP2R2AGeneProduct508045 (Entrez Gene)
PPP2R2BGeneProduct509290 (Entrez Gene)
PPP2R2CGeneProduct782110 (Entrez Gene)
PPP2R3AGeneProduct521584 (Entrez Gene)
PPP2R3BGeneProduct
PPP2R4GeneProduct514460 (Entrez Gene)
PPP2R5AGeneProduct533788 (Entrez Gene)
PPP2R5BGeneProduct505915 (Entrez Gene)
PPP2R5CGeneProduct505757 (Entrez Gene)
PPP2R5DGeneProduct100134966 (Entrez Gene)
PPP2R5EGeneProduct533617 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PTK2GeneProduct506270 (Entrez Gene)
PTK2BGeneProduct541008 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PXNGeneProduct517456 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RB1GeneProduct534712 (Entrez Gene)
RPS6KA2GeneProduct517953 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
SGK1GeneProduct515854 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
TECGeneProduct504733 (Entrez Gene)
TYK2GeneProduct512484 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)

Annotated Interactions

No annotated interactions
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