Non-homologous end joining (Bos taurus)

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NP_001095611.1NP_001095611.1NP_001095611.1IPI00691799.2NP_001095611.1Ligase VNP_001095611.1NP_001095611.1IPI00691799.2Q3ZBM3_BOVINQ3ZBM3_BOVINQ3ZBM3_BOVINQ3ZBM3_BOVINNbs1 ?NP_001095611.1Q3ZBM3_BOVINQ3ZBM3_BOVINQ3ZBM3_BOVINIPI00691799.2NP_001068861.1NHEJ1IPI00695059.4Q3ZBM3_BOVINIPI00691799.2Q3ZBM3_BOVINIPI00691799.2Q3ZBM3_BOVINRAD50NP_001075084.1NP_001095611.1NP_001095611.1NP_001095611.1IPI00691799.2NP_001075084.1Ligase VIPI00691799.2IPI00691799.2


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 89% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
80791view15:26, 30 June 2015Mkutmonhomology conversion
63364view22:23, 9 May 2013MaintBotUpdated to 2013 gpml schema
58819view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40536view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35399view09:53, 12 February 2010MartijnVanIerselModified description
33777view00:08, 9 December 2009MaintBotAutomatic update of empty xrefs
33623view10:03, 1 December 2009MaintBotRemoved group label
30548view21:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
IPI00691799.2GeneProductENSBTAG00000017019 (Ensembl)
IPI00695059.4GeneProductENSBTAG00000008925 (Ensembl)
Ligase VGeneProduct
NHEJ1GeneProduct509157 (Entrez Gene)
NP_001068861.1GeneProductENSBTAG00000031041 (Ensembl)
NP_001075084.1GeneProductENSBTAG00000024275 (Ensembl)
NP_001095611.1GeneProductENSBTAG00000010426 (Ensembl)
Nbs1 ?GeneProduct
Q3ZBM3_BOVINGeneProductENSBTAG00000006103 (Ensembl)
RAD50GeneProduct788127 (Entrez Gene)

Annotated Interactions

No annotated interactions