Wnt signaling pathway (Bos taurus)

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(Protein-protein interaction)DesumoylationNucleusActivationCY->PMCY->PMReceptorExtracellularPhosphorylationControlComplex formationPlasma membraneMolecule in the pathwayCY->NUDMitochondrionPalmitoylationDephosphorylationGolgi apparatusEnzyme ComplexDAcetylationProteins in a complex interactionDEndoplasmic reticulumCY->PMMTReaction through unknowm mechanisms/moleculesCYCY->NUDAccession Number: NetPath_8; cellmap:8CY->PMCY->NUDInhibitionENCY->NUGOUbiquitinationPMDERGlycosylationLigandDDDemethylationMolecular AssociationDCytoplasmCY->NURecruitmentAutophosphorylationGene SymbolECMethylationNU->CYNUTranslocationDeacetylationPM->CYEndosomeProteolytic cleavageDeubiquitinationSumoylationCUL1LEF1LOC539203LOC785291WNT4RHOAFZD1NR5A1APCSALL1CTNNBIP1CTBP2CAMK2AWNT3APAX2DKK1WNT1HIPK2CSNK2A2APCFZD9SFRP1WNT3AGSK3BDVL2TCF4SOX1TCF3FZD4CSNK1A1GSK3BPPP2CAMAPK8CDC2LRP6LEF1WNT1WNT1WNT2CAMK2GCTBP1DAB2FZD8APCAXIN1MAP3K7MAPK1NKD1SMAD4PRKCBAXIN1CSNK1DFZD1RAC1CAMK2DEP300TBPBTRCPIAS4CTNNB1PRKCABTRCAKT1MAPK3DVL1BRD7LOC511264MAP3K7SUMO1WNT1AXIN2BCL9RUNX2FRAT2LRP5CTNNB1SUMO2FZD1VANGL2JUPWNT4CDH1FZD1CSNK1EDVL1FZD7APCAPCSMAD3SOX9DVL2AXIN1CSNK2A2MAPK8IP1CSNK2BWNT5AWNT3MARK2NLKFZD2TFAP2ARUVBL1LOC100137840ARRB2CXXC4CTNNB1FZD4CAMK2BCSNK2A1ANKRD6MAGI3AKT1DLG2SFRP2LRP6CDC2DVL1ROR2FHL2ARRB1MAPK9MYBPRKCGRAF1WNT7AWNT1ARRB2CCND1LRP1TAX1BP3MAP1BPIN1CRYBB2FRAT1DAAM1CSNK2A1WNT2FZD6CDC25CJUNSENP2FZD5


Description

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NethPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

Comments

GenMAPP notes 
NetPath_8; cellmap:8 - Wnt Signaling Pathway. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP363(r28127) with a 88% conversion rate.

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120584view18:13, 17 December 2021EweitzModified title
117626view11:44, 21 May 2021EweitzModified title
115940view08:16, 21 March 2021EgonwCopied the NetPath paper into the literature list
115931view08:08, 21 March 2021EgonwModified description
80668view15:21, 30 June 2015Mkutmonhomology conversion
63375view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40547view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
35032view09:18, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35024view09:14, 11 February 2010ThomasModified description
33787view00:11, 9 December 2009MaintBotAutomatic update of empty xrefs
31637view22:24, 13 August 2009MaintBotFixed text labels
30549view21:59, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
ANKRD6GeneProduct516065 (Entrez Gene)
APCGeneProduct533233 (Entrez Gene)
ARRB1GeneProduct281637 (Entrez Gene)
ARRB2GeneProduct281638 (Entrez Gene)
AXIN1GeneProduct504357 (Entrez Gene)
AXIN2GeneProduct511619 (Entrez Gene)
BCL9GeneProduct
BRD7GeneProduct526153 (Entrez Gene)
BTRCGeneProduct534072 (Entrez Gene)
CAMK2AGeneProduct530719 (Entrez Gene)
CAMK2BGeneProduct525416 (Entrez Gene)
CAMK2DGeneProduct532713 (Entrez Gene)
CAMK2GGeneProduct282162 (Entrez Gene)
CCND1GeneProduct524530 (Entrez Gene)
CDC2GeneProduct281061 (Entrez Gene)
CDC25CGeneProduct507731 (Entrez Gene)
CDH1GeneProduct282637 (Entrez Gene)
CRYBB2GeneProduct287011 (Entrez Gene)
CSNK1A1GeneProduct282684 (Entrez Gene)
CSNK1DGeneProduct523542 (Entrez Gene)
CSNK1EGeneProduct768234 (Entrez Gene)
CSNK2A1GeneProduct282419 (Entrez Gene)
CSNK2A2GeneProduct282420 (Entrez Gene)
CSNK2BGeneProduct539235 (Entrez Gene)
CTBP1GeneProduct513131 (Entrez Gene)
CTBP2GeneProduct281730 (Entrez Gene)
CTNNB1GeneProduct539003 (Entrez Gene)
CTNNBIP1GeneProduct614630 (Entrez Gene)
CUL1GeneProduct539792 (Entrez Gene)
CXXC4GeneProduct
DAAM1GeneProduct513742 (Entrez Gene)
DAB2GeneProduct509221 (Entrez Gene)
DKK1GeneProduct504445 (Entrez Gene)
DLG2GeneProduct505383 (Entrez Gene)
DVL1GeneProduct523325 (Entrez Gene)
DVL2GeneProduct614312 (Entrez Gene)
EP300GeneProduct
FHL2GeneProduct510008 (Entrez Gene)
FRAT1GeneProduct505664 (Entrez Gene)
FRAT2GeneProduct539144 (Entrez Gene)
FZD1GeneProduct445417 (Entrez Gene)
FZD2GeneProduct538507 (Entrez Gene)
FZD4GeneProduct445416 (Entrez Gene)
FZD5GeneProduct538536 (Entrez Gene)
FZD6GeneProduct445418 (Entrez Gene)
FZD7GeneProduct524255 (Entrez Gene)
FZD8GeneProduct616913 (Entrez Gene)
FZD9GeneProduct521364 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
HIPK2GeneProduct510158 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
JUPGeneProduct445543 (Entrez Gene)
LEF1GeneProduct535399 (Entrez Gene)
LOC100137840GeneProduct100137840 (Entrez Gene)
LOC511264GeneProduct511264 (Entrez Gene)
LOC539203GeneProduct539203 (Entrez Gene)
LOC785291GeneProduct785291 (Entrez Gene)
LRP1GeneProduct
LRP5GeneProduct534450 (Entrez Gene)
LRP6GeneProduct536328 (Entrez Gene)
MAGI3GeneProduct532952 (Entrez Gene)
MAP1BGeneProduct514739 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK8IP1GeneProduct524806 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MARK2GeneProduct535197 (Entrez Gene)
MYBGeneProduct317776 (Entrez Gene)
NKD1GeneProduct618586 (Entrez Gene)
NLKGeneProduct507204 (Entrez Gene)
NR5A1GeneProduct281948 (Entrez Gene)
PAX2GeneProduct617341 (Entrez Gene)
PIAS4GeneProduct534722 (Entrez Gene)
PIN1GeneProduct535470 (Entrez Gene)
PPP2CAGeneProduct282320 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RHOAGeneProduct338049 (Entrez Gene)
ROR2GeneProduct785924 (Entrez Gene)
RUNX2GeneProduct
RUVBL1GeneProduct511475 (Entrez Gene)
SALL1GeneProduct514467 (Entrez Gene)
SENP2GeneProduct539639 (Entrez Gene)
SFRP1GeneProduct282068 (Entrez Gene)
SFRP2GeneProduct510821 (Entrez Gene)
SMAD3GeneProduct515125 (Entrez Gene)
SMAD4GeneProduct540248 (Entrez Gene)
SOX1GeneProduct618135 (Entrez Gene)
SOX9GeneProduct
SUMO1GeneProduct788060 (Entrez Gene)
SUMO2GeneProduct286807 (Entrez Gene)
TAX1BP3GeneProduct514852 (Entrez Gene)
TBPGeneProduct516578 (Entrez Gene)
TCF3GeneProduct530616 (Entrez Gene)
TCF4GeneProduct
TFAP2AGeneProduct505849 (Entrez Gene)
VANGL2GeneProduct520544 (Entrez Gene)
WNT1GeneProduct540662 (Entrez Gene)
WNT2GeneProduct493729 (Entrez Gene)
WNT3GeneProduct540753 (Entrez Gene)
WNT3AGeneProduct522467 (Entrez Gene)
WNT4GeneProduct
WNT5AGeneProduct530005 (Entrez Gene)
WNT7AGeneProduct533782 (Entrez Gene)

Annotated Interactions

No annotated interactions
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