DNA replication (Bos taurus)

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1-3Cdt1Mcm5Orc complexOriginMcm10Orc3Mcm3Mcm7Orc complexMcm5Cdc6Ubiquitinated Orc1UbiquitinOrc2Mcm2Orc1RFC36Cdt1Degraded by proteasome in cytosolPre-replicative complexRFC38Cdc6RNA primer-DNA primer:origin duplex:PCNADNA polymerase alpha:primase: origin complexMcm 4,6,7 trimer forms andassociates with the replication forkCdt1Mcm2Phosphorylated Cdc6Cdc6Orc complexCdc6Pre-replicative complexDNAPolymerase ARFC37Mcm4Mcm7RNA primer-DNA primerCdt1RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc5Phosphorylation ofMcm 2-7 complexRNA primer-DNA primerRFC1401. Assembly of the pre-replicative complexp58Orc25. Leading/lagging strand synthesisp70RFC Heteropentamer:RNA primer-DNA primerMcm10UbiquitinMcm4Mcm6Orc2Phosphorylated Orc1Orc3Orc3Degraded byproteasomein cytosolOrc5Cdt1Ubiquitinated Cdc6RNA Primer3. DNA replication initiationp180Mcm6Orc5Processive complexp49GemininOrc42. Activation of the pre-replicative complexOrc complexPrimaseOrc24. Switching of origins to post-replicative stateRFC40Orc complexDNA polymerase alpha:primase: origin complexMcm3Orc3Orc4UBA52ATPGMNNRFC1GTPPOLEDBF4ADPdGTPRFC2CDC6POLA1PRIM1PCNACTPPOLD2ORC2LdUTPATPdCTPMCM6MCM5ORC3LRFC5CDK2POLE2RFC3UBCMCM7ORC6LRPA1ORC4LMCM4RPA3UTPPOLD3POLA2POLD1ORC1LRPA2dATPATPMCM10ADPORC5LRPA4CDC7CDC45LMCM2MCM3CDT1POLD4PRIM2ATPRFC4


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 69% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
129334view09:08, 27 March 2024MkutmonOntology Term : 'DNA replication pathway' added !
128701view17:08, 20 February 2024Khanspersremoved brackets and connected interactions
117497view11:03, 21 May 2021EweitzModified title
107078view14:16, 17 September 2019MaintBotChEBI identifier normalization
96303view18:26, 7 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
89896view13:12, 6 October 2016MkutmonModified description
89894view13:10, 6 October 2016MkutmonModified description
89892view13:08, 6 October 2016MkutmonReverted to version '15:28, 30 June 2015' by Mkutmon
89890view13:08, 6 October 2016MkutmonModified description
80850view15:28, 30 June 2015Mkutmonhomology conversion
71396view19:00, 17 October 2013MaintBotAutomated update of data sources
67167view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
63318view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
40499view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35220view15:52, 11 February 2010Thomasadded literature
35208view15:43, 11 February 2010ThomasModified description
35206view15:42, 11 February 2010ThomasModified description
33743view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
33627view10:04, 1 December 2009MaintBotRemoved group label
31638view22:25, 13 August 2009MaintBotFixed text labels
30552view22:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct507122 (Entrez Gene)
CDC6GeneProduct515301 (Entrez Gene)
CDC7GeneProduct516094 (Entrez Gene)
CDK2GeneProduct519217 (Entrez Gene)
CDT1GeneProduct519016 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct510916 (Entrez Gene)
GMNNGeneProduct526377 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct527595 (Entrez Gene)
MCM2GeneProduct510120 (Entrez Gene)
MCM3GeneProduct281302 (Entrez Gene)
MCM4GeneProduct504367 (Entrez Gene)
MCM5GeneProduct506970 (Entrez Gene)
MCM6GeneProduct517812 (Entrez Gene)
MCM7GeneProduct539924 (Entrez Gene)
ORC1LGeneProduct513523 (Entrez Gene)
ORC2LGeneProduct511281 (Entrez Gene)
ORC3LGeneProduct523714 (Entrez Gene)
ORC4LGeneProduct529245 (Entrez Gene)
ORC5LGeneProduct519409 (Entrez Gene)
ORC6LGeneProduct515476 (Entrez Gene)
PCNAGeneProduct515499 (Entrez Gene)
POLA1GeneProduct534848 (Entrez Gene)
POLA2GeneProduct514793 (Entrez Gene)
POLD1GeneProduct281990 (Entrez Gene)
POLD2GeneProduct281991 (Entrez Gene)
POLD3GeneProduct537616 (Entrez Gene)
POLD4GeneProduct617899 (Entrez Gene)
POLEGeneProduct
POLE2GeneProduct518653 (Entrez Gene)
PRIM1GeneProduct506240 (Entrez Gene)
PRIM2GeneProduct514682 (Entrez Gene)
RFC1GeneProduct
RFC2GeneProduct508652 (Entrez Gene)
RFC3GeneProduct515602 (Entrez Gene)
RFC4GeneProduct504637 (Entrez Gene)
RFC5GeneProduct508389 (Entrez Gene)
RPA1GeneProduct504844 (Entrez Gene)
RPA2GeneProduct507912 (Entrez Gene)
RPA3GeneProduct512754 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct615199 (Entrez Gene)
UBCGeneProduct444874 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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