EPO receptor signaling (Bos taurus)

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EPORJAK2SRCEPOR1, 2PBox-1PPPPPPPPPPY343Y479Box-2DNACell membraneY343Y460PPBox-2Box-1PY431SHC1AKT1PIK3CGGRB2MAPK1MAP2K2PDK1MAPK3MAP2K1EPOSTAT1EPOSOCS1STAT5BCISHSTAT5ASTAT3STAT3STAT1PTPRCPTPRUPPPGRB2RAF1SOS1IRS2JAK2IRS1RASA1RAF1SOS1RASA1


Description

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia This pathway is based on ScienceSlides.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP581(r22574) with a 97% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed Europe PMC Scholia
  2. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117505view11:05, 21 May 2021EweitzModified title
80789view15:26, 30 June 2015Mkutmonhomology conversion
67202view10:20, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
63457view17:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
40592view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35095view12:58, 11 February 2010Thomasadded literature
33637view10:06, 1 December 2009MaintBotRemoved group label
30565view22:04, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
CISHGeneProduct616753 (Entrez Gene)
EPOGeneProduct280784 (Entrez Gene)
EPORGeneProduct281144 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
IRS1GeneProduct538598 (Entrez Gene)
IRS2GeneProduct
JAK2GeneProduct525246 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
PDK1GeneProduct528655 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PTPRCGeneProduct407152 (Entrez Gene)
PTPRUGeneProduct535675 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RASA1GeneProduct282032 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)

Annotated Interactions

No annotated interactions
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