Acetylcholine synthesis (Bos taurus)

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1-3*Synaptic Cleft**Cytosol*CholineGlycerophosphocholinePhosphatidylethanolamineACHEAcetatePhosphorylcholineCytidine diphosphate cholineAcetylcholinePCYT1ACholineCHKACHATPyruvate from GlycolysisPEMTPDHA2Acetyl CoAPhosphatidylcholinePDHA1


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


This pathway was inferred from Homo sapiens pathway WP528(79855) with a 100.0% conversion rate.

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Ontology Terms



  1. Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, Pawełczyk T, Ronowska A; ''Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases.''; Neurochem Res, 2013 PubMed Europe PMC Scholia
  2. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed Europe PMC Scholia
  3. Angelini C, Baccetti B, Piomboni P, Trombino S, Aluigi MG, Stringara S, Gallus L, Falugi C; ''Acetylcholine synthesis and possible functions during sea urchin development.''; Eur J Histochem, 2004 PubMed Europe PMC Scholia


View all...
117472view10:58, 21 May 2021EweitzModified title
105950view11:48, 16 August 2019MaintBotHMDB identifier normalization
96211view10:47, 28 February 2018Asios OliaAdded Reference Angelini et al. 2003
96210view10:29, 28 February 2018Asios OliaAdded Reference (Szutowicz,2013)
80833view15:27, 30 June 2015Mkutmonhomology conversion
79214view19:46, 12 March 2015KhanspersReverted to version '17:59, 8 July 2013' by Khanspers
79213view19:45, 12 March 2015KhanspersReverted to version '04:09, 5 March 2015' by Khanspers
79146view05:51, 5 March 2015KhanspersModified title
79142view04:09, 5 March 2015KhanspersUpdated conversion from Hs
69053view17:59, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
67024view09:55, 26 June 2013Christine ChichesterOntology Term : 'acetylcholine metabolic pathway' added !
63461view17:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
40596view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35066view11:21, 11 February 2010Thomasadded literature reference, fixed annotations
33833view00:29, 9 December 2009MaintBotAutomatic update of empty xrefs
31673view11:42, 14 August 2009MaintBotFixed group labels
30603view22:16, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
ACHEGeneProductENSBTAG00000001139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:43
AcetateMetabolite64-19-7 (CAS)
Acetyl CoAMetabolite72-89-9 (CAS)
AcetylcholineMetabolite51-84-3 (CAS)
CHATGeneProductENSBTAG00000016814 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1103
CHKAGeneProductENSBTAG00000010304 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1119
CholineMetabolite62-49-7 (CAS)
Cytidine diphosphate cholineMetaboliteHMDB0001413 (HMDB)
GlycerophosphocholineMetabolite28319-77-9 (CAS)
PCYT1AGeneProductENSBTAG00000016979 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5130
PDHA1GeneProductENSBTAG00000019852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5160
PDHA2GeneProductENSBTAG00000026250 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5161
PEMTGeneProductENSBTAG00000016432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10400
PhosphatidylcholineMetaboliteHMDB0000564 (HMDB)
PhosphatidylethanolamineMetaboliteHMDB0060501 (HMDB)
PhosphorylcholineMetaboliteHMDB0001565 (HMDB)
Pyruvate from GlycolysisMetaboliteHMDB0000243 (HMDB)

Annotated Interactions

No annotated interactions
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