Folate metabolism (Bos taurus)

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69, 137, 169, 181, 267...284, 29420, 15444, 69, 173, 174, 31917411755129, 2613, 13814645, 10591, 118, 31682270StimulationConversionCatalysisOther proteinsMetabolitesLipoprotein melabolismProtein with polymorphismLEGENDis composed ofMicronutrientsReactionLipid peroxidationNecessary stimulationProstaglandins metabolismTranscription factorProtein tyrosine nitrationEnzymesOverarching processBiomarker forProcess or metabolism involved in Se PathwayGlycogenesisSelenoproteinsCofactor conversionBindingSelenium statusCleavageProtein*Negative EffectInhibitionCofactorsFrom intracellular part to the plasmaIntracellularDNA oxidationApoptosisMethylation reactionsNovo purine biosynthetic pathwayPlasmaSLC46A1PGE1PGE2FOLR4NFKB2PGE1NFKB1PGF2aCCL2F2-Isoprostane8-Isoprostaglandin F2aRELASLC19A1FOLR3CCL2FOLR28-Isoprostaglandin F2aThromboxane A2PGE2PGF2aTP53Thromboxane B2FOLR1Thromboxane B2F2-Isoprostane170, 226611672247, 2546171226247, 254116116711166172, 156, 254254, 325717210, 82, 304, 316, 319...71254, 3256MTHFD1DHFRMTRAHCYSHMT2MAT1AMTHFD2MTRR105, 21232, 159, 186105105, 1961028249, 10815, 49, 120, 133CBS15, 194NADP+NADP+NADP+NADP+NADP+NADP+NADP+MPOCATMPONOS44, 93, 195, 31817044, 93, 195, 318174, 227CysteineCysteineSERPINE1F2PLGPLATF2PLGPLATF7F7SERPINE1197, 23037, 197197, 23026037, 197260260260260260GPX 4H2O2GAR5,10-Methylene-THF10-Formyl-THF(11S)-hydroxymethylene-THF5,10-Methenyl-THF5-Formyl-THFDihydrofolateFGAR(11R)-hydroxymethylene-THF18610545, 105105105, 18610510545, 1051055-methyl-THFFolate5-methyl-THFFolate120, 1866, 41, 61, 65, 82...186SOD3SOD3RFK147H2OGPX3GPX3CTH15Heme174, 194, 227THF186NADPHNADPHNADPHNADPHNADPHNADPHNADPHGPX6ManganeseManganeseFolic acidFolic acid46, 133, 18646, 133, 186GPX2GPX 1RNS55, 174SHMT1MTHFRGARTMTHFS45, 105105105133, 186HomocysteineHomocysteine376, 37, 69, 91, 120...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate86, 170, 28986, 289L-ArginineSerineGlycineGlycine105, 19641105, 196105, 196APOBHDLSAA4LDLVLDLSAA2VLDL-TAGCholesterolSERPINA3-7HDL-CSAA3SERPINA3-7HDL-CABCA1HDL/APOA1CholesteroloxLDLAPOA1APOA1FMNSAA1HDLoxLDLHDL/SAAVLDL-TAGSCARB1APOBLDLLDLRVLDL/APOBAPOA1TAGTAGVLDL26183261255, 26125, 16251, 93, 129, 20326116242, 259255, 26116216265, 2611622626151, 65, 93, 129, 20365, 26126, 261255, 26126116226118326151, 93, 129, 20342, 259259162255, 26126, 255, 26125, 16251, 65, 93, 129, 203162O2138FADCob(I)alaminCob(I)alaminCob(II)alaminFAD8-OHdG8-OHdG49, 108, 20427027049, 108, 2044949, 108183ADPADPChlorineMagnesiumMagnesiumChlorineS-nitrosohomocysteineCystathionine122SOD2Serine105, 196ATPZincZincNOO3HOClHNO2NO2NO195, 318122, 195, 316, 318IL6FibrinogenIL4D-dimerTNFIFNGICAM1IL4CSF1IL1BALBINSALBHbA1cINSRFibrinCRPIL2HBGIFNGIL2CSF1IFNGIL1BHBAD-dimerINSIL6IFNGHbA1cFibrinogenFibrinTNF21769, 137, 266, 328116242, 32825, 146, 328154, 209154, 209181, 26625, 146, 32832069, 32018121710, 69, 209, 267304230, 26010, 267116169, 3043, 51, 92, 152, 170...2788921734, 266, 326230, 260169, 30430427817, 2608917, 260217137Riboflavin222O2 S-Adenosylmethionine S-Adenosylhomocysteine S-AdenosylmethionineMethionineMethionine S-Adenosylhomocysteine120, 186, 287287186, 20749, 82, 85, 186186, 20749, 85, 186ADPONOO/ONOOHNitrotyrosineNitrotyrosineTetrahydrobiopterin415555ATPATPFructosamineGlucoseGlucoseFructosamine89146, 217146, 21789IronIron322322FLAD1147, 153


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP176_96337 with a 82.0% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
120905view14:16, 29 January 2022EgonwReplaced an old HMDB identifier with the current one
120356view15:27, 28 November 2021EgonwFixed a PubMed ID
117520view11:08, 21 May 2021EweitzModified title
107053view14:14, 17 September 2019MaintBotChEBI identifier normalization
106009view11:53, 16 August 2019MaintBotHMDB identifier normalization
98246view14:20, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
96339view15:36, 8 March 2018MkutmonUpdated homology conversion
96338view15:35, 8 March 2018MkutmonOntology Term : 'folate metabolic pathway' added !
86818view16:41, 11 July 2016EgonwConnecting lines.
85065view11:31, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82706view08:57, 23 October 2015EgonwoxLDL has a separate identifier.
80891view15:30, 30 June 2015Mkutmonhomology conversion
74466view16:08, 24 April 2014EgonwFixed a PubMed ID.
72574view15:52, 23 November 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
72367view09:46, 13 November 2013EgonwReplaced old PubChem data sources with their new equivalents.
72366view09:40, 13 November 2013EgonwFixed the type of two proteins.
71408view19:01, 17 October 2013MaintBotAutomated update of data sources
63348view22:21, 9 May 2013MaintBotUpdated to 2013 gpml schema
58813view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40522view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
33765view00:04, 9 December 2009MaintBotAutomatic update of empty xrefs
33195view18:18, 5 November 2009KhanspersModified categories
32527view12:58, 17 August 2009MaintBotFixed text labels
32214view12:44, 15 August 2009MaintBotFixed text labels
31708view11:51, 14 August 2009MaintBotFixed group labels
31225view19:43, 13 August 2009MaintBotFixed text labels
30644view22:31, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
(11R)-hydroxymethylene-THFMetabolite(11R)-hydroxymethylenetetrahydrofolate
(11S)-hydroxymethylene-THFMetabolite(11S)-hydroxymethylenetetrahydrofolate
10-Formyl-THFMetaboliteHMDB0000972 (HMDB) 10-formyltetrahydrofolate
5,10-Methenyl-THFMetaboliteHMDB0001354 (HMDB) 5,10-Methenyltetrahydrofolic acid
5,10-Methylene-THFMetaboliteHMDB0001533 (HMDB) 5,10-Methylenetetrahydrofolate
5-Formyl-THFMetaboliteHMDB0001562 (HMDB) 5-Formyltetrahydrofolate
5-methyl-THFMetaboliteHMDB0001396 (HMDB)
  • 5-methyltetrahydrofolate
  • Predominant food folate
8-Isoprostaglandin F2aMetaboliteHMDB0005083 (HMDB)
8-OHdGMetaboliteHMDB0003333 (HMDB) 8-Hydroxy-deoxyguanosine
ABCA1ProteinENSBTAG00000020661 (Ensembl)
  • ATP-binding cassette, sub-family A (ABC1), member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:19
ADPMetaboliteHMDB0001341 (HMDB) Adenosine diphosphate
AHCYProteinENSBTAG00000018101 (Ensembl)
  • EC 3.3.1.1
  • Adenosylhomocysteinase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:191
ALBProteinENSBTAG00000017121 (Ensembl)
  • albumin
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:213
APOA1ProteinENSBTAG00000002258 (Ensembl)
  • Nitrotyrosinated apolipoprotein A-I
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:335
APOBProteinENSBTAG00000008505 (Ensembl)
  • apolipoprotein B
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:338
ATPMetaboliteHMDB0000538 (HMDB) Adenosine triphosphate
CATProteinENSBTAG00000020980 (Ensembl)
  • EC 1.11.1.6
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:847
CBSProteinENSBTAG00000000160 (Ensembl)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:875
CCL2GeneProductENSBTAG00000037811 (Ensembl)
  • Monocyte Chemotactic Protein 1
  • CCL2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6347
CRPProteinENSBTAG00000013907 (Ensembl)
  • C-reactive protein, pentraxin-related
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1401
CSF1ProteinENSBTAG00000000283 (Ensembl)
  • colony stimulating factor 1 (macrophage)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1435
CTHProteinENSBTAG00000014791 (Ensembl)
  • EC 4.4.1.1
  • cystathionase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1491
ChlorineMetaboliteHMDB0000492 (HMDB)
CholesterolMetaboliteHMDB0000067 (HMDB)
Cob(I)alaminMetaboliteHMDB0002174 (HMDB) Reduced cobalamin
Cob(II)alaminMetaboliteHMDB0002174 (HMDB) oxidized cobalamin
CystathionineMetaboliteHMDB0000099 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
D-dimerProteinhttp://en.wikipedia.org/wiki/Fibrin_degradation_product
DHFRProteinENSBTAG00000007681 (Ensembl)
  • EC 1.5.1.3
  • Dihydrofolate reductase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1719
DihydrofolateMetaboliteHMDB0001056 (HMDB)
F2-IsoprostaneMetaboliteQ33659470 (Wikidata)
F2ProteinENSBTAG00000007148 (Ensembl)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2147
F7ProteinENSBTAG00000007411 (Ensembl)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2155
FADMetaboliteHMDB0001248 (HMDB) Flavin adenine dinucleotide
FGARMetaboliteCHEBI:18272 (ChEBI) formylglycinamide ribonucleotide
FLAD1ProteinENSBTAG00000000186 (Ensembl)
  • EC 2.7.7.2
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:80308
FMNMetaboliteHMDB0001520 (HMDB) Flavin Mononucleotide
FOLR1GeneProductENSBTAG00000021007 (Ensembl)
  • folate receptor 1 (adult)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2348
FOLR2GeneProductENSBTAG00000027684 (Ensembl)
  • folate receptor 2 (fetal)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2350
FOLR3GeneProduct
  • folate receptor 3 (gamma)
  • No homologues found for original id L:2352
FOLR4GeneProduct
  • folate receptor 4 (delta) homolog (mouse)
  • No homologues found for original id L:390243
FibrinProtein
FibrinogenProtein
FolateMetaboliteCHEBI:37445 (ChEBI) Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).
Folic acidMetaboliteHMDB0000121 (HMDB) Synthetic folate
FructosamineMetaboliteHMDB0002030 (HMDB)
GARMetaboliteHMDB0002022 (HMDB) glycinamide ribonucleotide
GARTProteinENSBTAG00000009188 (Ensembl)
  • EC 2.1.2.2
  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2618
GPX 1Protein
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 1
  • No homologues found for original id L:2876
GPX 4ProteinENSBTAG00000046926 (Ensembl)
  • EC 1.11.1.12
  • Selenoprotein-glutathione peroxidase 4
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2879
GPX2ProteinENSBTAG00000048112 (Ensembl)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2877
GPX3ProteinENSBTAG00000043553 (Ensembl)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 3
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2878
GPX6ProteinENSBTAG00000012023 (Ensembl)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 6
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:257202
GlucoseMetaboliteHMDB0000122 (HMDB)
GlycineMetaboliteHMDB0000123 (HMDB)
H2O2MetaboliteHMDB0003125 (HMDB) Hydrogen peroxide
H2OMetaboliteHMDB0002111 (HMDB) Glutathione disulfide
HBAProteinENSBTAG00000026418 (Ensembl)
  • hemoglobin, alpha 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3039
HBGProteinENSBTAG00000037644 (Ensembl)
  • hemoglobin, beta
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3043
HDL-CMetaboliteCHEBI:47775 (ChEBI)
  • high-density lipoprotein cholesterol
  • Cholesterol transport
HDL/APOA1MetaboliteCHEBI:39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetaboliteCHEBI:39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetaboliteCHEBI:39025 (ChEBI) high-density lipoprotein
HNO2MetaboliteCHEBI:25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB0001050 (HMDB) Hypochlorite
HbA1cProtein
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
ICAM1ProteinENSBTAG00000010303 (Ensembl)
  • soluble intercellular adhesion molecule 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3383
IFNGProteinENSBTAG00000012529 (Ensembl)
  • interferon, gamma
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3458
IL1BProteinENSBTAG00000001321 (Ensembl)
  • interleukin 1, beta
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3553
IL2ProteinENSBTAG00000020883 (Ensembl)
  • interleukin 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3558
IL4ProteinENSBTAG00000015957 (Ensembl)
  • interleukin 4
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3565
IL6ProteinENSBTAG00000014921 (Ensembl)
  • interleukin 6 (interferon, beta 2)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3569
INSProtein
  • Insulin
  • No homologues found for original id L:3630
INSRProteinENSBTAG00000012687 (Ensembl)
  • Insulin receptor
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3643
IronMetaboliteHMDB0000692 (HMDB)
L-ArginineMetaboliteHMDB0000517 (HMDB)
LDLMetaboliteCHEBI:39026 (ChEBI) low-density lipoprotein
LDLRProteinENSBTAG00000012314 (Ensembl)
  • low density lipoprotein receptor
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3949
MAT1AProteinENSBTAG00000005963 (Ensembl)
  • EC 2.5.1.6
  • Methionine adenosyltransferase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4143
MPOProteinENSBTAG00000011616 (Ensembl)
  • EC 1.11.1.7
  • Myeloperoxidase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4353
MTHFD1ProteinENSBTAG00000009641 (Ensembl)
  • EC 1.5.1.5
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4522
MTHFD2ProteinENSBTAG00000004881 (Ensembl)
  • EC 3.5.4.9
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10797
MTHFRProteinENSBTAG00000020698 (Ensembl)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
  • Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4524
MTHFSProteinENSBTAG00000020023 (Ensembl)
  • EC 6.3.3.2
  • 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10588
MTRProteinENSBTAG00000012251 (Ensembl)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
  • Also known as MS
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4548
MTRRProteinENSBTAG00000009401 (Ensembl)
  • EC 1.16.1.8
  • 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4552
MagnesiumMetaboliteHMDB0000547 (HMDB)
ManganeseMetaboliteHMDB0001333 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
NADP+MetaboliteHMDB0000217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB0000221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFKB1GeneProductENSBTAG00000020270 (Ensembl)
  • nuclear factor NF-kappa-B p50 subunit
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2GeneProductENSBTAG00000006017 (Ensembl)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4791
NO2MetaboliteCHEBI:33101 (ChEBI) Nitrogen dioxide
NOMetaboliteHMDB0003378 (HMDB) Nitric oxide
NOSProteinNitric oxide synthase
NitrotyrosineMetaboliteHMDB0001904 (HMDB)
O2MetaboliteHMDB0001377 (HMDB)
O2MetaboliteHMDB0002168 (HMDB) Superoxide
O3MetaboliteCHEBI:25812 (ChEBI) ozone
ONOO/ONOOHMetaboliteHMDB0002179 (HMDB) Peroxynitrite
PGE1MetaboliteHMDB0001442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB0001220 (HMDB) Prostaglandin E2
PGF2aMetaboliteHMDB0001139 (HMDB) Prostaglandin F2a
PLATProteinENSBTAG00000001244 (Ensembl)
  • EC 3.4.21.68
  • plasminogen activator, tissue
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5327
PLGProteinENSBTAG00000001271 (Ensembl)
  • EC 3.4.21.7
  • Plasminogen
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5340
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB) Vitamin B6
RELAGeneProductENSBTAG00000013895 (Ensembl)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5970
RFKProteinENSBTAG00000019345 (Ensembl)
  • EC 2.7.1.26
  • riboflavin kinase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55312
RNSMetaboliteCHEBI:62764 (ChEBI)
  • reactive nitrogen species
  • http://en.wikipedia.org/wiki/Reactive_nitrogen_species
RiboflavinMetaboliteHMDB0000244 (HMDB)
S-nitrosohomocysteineMetabolite3035701 (PubChem-compound)
SAA1Protein
  • serum amyloid A1
  • No homologues found for original id L:6288
SAA2Protein
  • serum amyloid A2
  • No homologues found for original id L:6289
SAA3Protein
  • serum amyloid A3 pseudogene
  • No homologues found for original id L:6290
SAA4ProteinENSBTAG00000002963 (Ensembl)
  • serum amyloid A4, constitutive
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6291
SCARB1ProteinENSBTAG00000014269 (Ensembl)
  • scavenger receptor class B, member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:949
SERPINA3-7ProteinENSBTAG00000026917 (Ensembl)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:12
SERPINE1ProteinENSBTAG00000014465 (Ensembl)
  • Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5054
SHMT1ProteinENSBTAG00000017094 (Ensembl)
  • EC 2.1.2.1
  • Serine hydroxymethyltransferase 1 (soluble)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6470
SHMT2ProteinENSBTAG00000031500 (Ensembl)
  • EC 2.1.2.1
  • Serine hydroxymethyltransferase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6472
SLC19A1GeneProductENSBTAG00000024162 (Ensembl)
  • solute carrier family 19 (folate transporter), member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6573
SLC46A1GeneProductENSBTAG00000002817 (Ensembl)
  • solute carrier family 46 (folate transporter), member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:113235
SOD1ProteinENSBTAG00000027412 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6647
SOD2ProteinENSBTAG00000006523 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6648
SOD3ProteinENSBTAG00000013980 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6649
SerineMetaboliteHMDB0000187 (HMDB)
TAGMetaboliteCHEBI:17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
THFMetaboliteHMDB0001846 (HMDB) Tetrahydrofolic acid
TNFProteinENSBTAG00000025471 (Ensembl)
  • tumor necrosis factor (TNF superfamily, member 2)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7124
TP53GeneProductENSBTAG00000001069 (Ensembl)
  • tumor protein p53
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157
TetrahydrobiopterinMetaboliteHMDB0000027 (HMDB) H4B
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
VLDL-TAGMetaboliteCHEBI:47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetaboliteCHEBI:39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetaboliteCHEBI:39027 (ChEBI) very-low-density lipoprotein
ZincMetaboliteHMDB0015532 (HMDB)
oxLDLMetaboliteCHEBI:60151 (ChEBI) oxidized low-density lipoprotein

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1075"
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