G1 to S cell cycle control (Bos taurus)

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1Cyclin DsuRbphosphorylation of proteinsinvolved in G1/S transitionCell cycle DNA replication genesG1/S transition CyclinDependent KinasesTTTCC/GCGCDegradationcakpepDNA polymerasesinactivepG1/S transition PhaseCheckpointuDNA replicationG2 Phase-M phaseCyclinDG1 PhasebpCyclin Esdp1G1 CyclinDependant CyclasesG1/S Cell Cycleeorigin recognition complexE2fpbupMCM4TP53E2fCCNE2CDKCDK2CREB3CCNE1TFDP1E2F6CDK7E2F4CDKE2F3RB1CDK6MYCRBL1E2F2ORC4CREB1CCNHRPA3ORC5CCND2RPA2POLE2MYT1CCNA1CDC45ORC6CDK4ATMORC2MCM7CREB3L3E2F5PRIM2TP53CDKN1ARPA1ATF6BPOLA2CREB3L1CDKN2CCCNE1RB1POLECCND3CDKN1CCDKN1BPCNACCND1MDM2RB1CCNE1CDK2CDKN2BTFDP2CDKN2DE2F1ORC1WEE1CDKN2AE2fMNAT1CDK1MCM6GADD45ACCNB1CDK4MCM5PRIM1CREB3L4CDK7ORC3MCM2TFDP1MCM3CCNG2CDK6CDC25ACdKCyclinDCdK


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP45 (r95145) with a 95.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95747view13:54, 19 January 2018MkutmonHomology conversion update
80826view15:27, 30 June 2015Mkutmonhomology conversion
67265view10:28, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
63326view21:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
48129view05:48, 9 May 2012MaintBotUpdating from human to fix xref duplication
40507view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35825view21:59, 17 February 2010KhanspersAdded lit ref
35824view21:59, 17 February 2010KhanspersModified description
33750view23:58, 8 December 2009MaintBotAutomatic update of empty xrefs
32529view12:59, 17 August 2009MaintBotFixed text labels
32216view12:44, 15 August 2009MaintBotFixed text labels
31711view11:52, 14 August 2009MaintBotFixed group labels
31227view19:43, 13 August 2009MaintBotFixed text labels
30647view22:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF6BGeneProductENSBTAG00000008794 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1388
ATMGeneProductENSBTAG00000003111 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:472
CCNA1GeneProductENSBTAG00000007284 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8900
CCNB1GeneProductENSBTAG00000014239 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:891
CCND1GeneProductENSBTAG00000017514 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:595
CCND2GeneProductENSBTAG00000016649 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:894
CCND3GeneProductENSBTAG00000010106 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:896
CCNE1GeneProductENSBTAG00000004735 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:898
CCNE2GeneProductENSBTAG00000004906 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9134
CCNG2GeneProductENSBTAG00000021768 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:901
CCNHGeneProductENSBTAG00000011650 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:902
CDC25AGeneProductENSBTAG00000009586 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:993
CDC45GeneProductENSBTAG00000004286 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8318
CDKGeneProduct
CDK1GeneProductENSBTAG00000010109 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:983
CDK2GeneProductENSBTAG00000004021 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1017
CDK4GeneProductENSBTAG00000046091 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1019
CDK6GeneProductENSBTAG00000044023 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1021
CDK7GeneProductENSBTAG00000011046 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1022
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1027
CDKN1CGeneProductENSBTAG00000031184 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1028
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1029
CDKN2BGeneProductENSBTAG00000016412 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1030
CDKN2CGeneProductENSBTAG00000011059 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1031
CDKN2DGeneProductENSBTAG00000010731 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1032
CREB1GeneProductENSBTAG00000005474 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1385
CREB3GeneProductENSBTAG00000011429 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10488
CREB3L1GeneProductENSBTAG00000006143 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:90993
CREB3L3GeneProductENSBTAG00000010215 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84699
CREB3L4GeneProductENSBTAG00000014692 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:148327
E2F1GeneProductENSBTAG00000003971 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1869
E2F2GeneProductENSBTAG00000014400 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1870
E2F3GeneProductENSBTAG00000021045 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1871
E2F4GeneProductENSBTAG00000012063 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1874
E2F5GeneProductENSBTAG00000009378 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1875
E2F6GeneProductENSBTAG00000048286 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1876
E2fGeneProduct
GADD45AGeneProductENSBTAG00000013860 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1647
MCM2GeneProductENSBTAG00000014380 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4171
MCM3GeneProductENSBTAG00000010721 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4172
MCM4GeneProductENSBTAG00000046325 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4173
MCM5GeneProductENSBTAG00000015595 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4174
MCM6GeneProductENSBTAG00000015172 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4175
MCM7GeneProductENSBTAG00000030965 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4176
MDM2GeneProductENSBTAG00000010422 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4193
MNAT1GeneProductENSBTAG00000030801 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4331
MYCGeneProductENSBTAG00000008409 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4609
MYT1GeneProductENSBTAG00000006352 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4661
ORC1GeneProductENSBTAG00000002719 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4998
ORC2GeneProductENSBTAG00000031473 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4999
ORC3GeneProductENSBTAG00000016969 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23595
ORC4GeneProductENSBTAG00000015291 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5000
ORC5GeneProductENSBTAG00000040058 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5001
ORC6GeneProductENSBTAG00000001872 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23594
PCNAGeneProductENSBTAG00000006065 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5111
POLA2GeneProductENSBTAG00000011455 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23649
POLE2GeneProductENSBTAG00000004931 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5427
POLEGeneProductENSBTAG00000000590 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5426
PRIM1GeneProductENSBTAG00000044000 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5557
PRIM2GeneProductENSBTAG00000007937 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5558
RB1GeneProductENSBTAG00000006640 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5925
RBL1GeneProductENSBTAG00000011541 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5933
RPA1GeneProductENSBTAG00000009711 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6117
RPA2GeneProductENSBTAG00000006225 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6118
RPA3GeneProductENSBTAG00000013168 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6119
TFDP1GeneProductENSBTAG00000019645 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7027
TFDP2GeneProductENSBTAG00000006222 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7029
TP53GeneProductENSBTAG00000001069 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157
WEE1GeneProductENSBTAG00000005278 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7465

Annotated Interactions

No annotated interactions
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