Adipogenesis (Canis familiaris)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Inhibitors of Preadipocyte to Adipocyte TransitionTranscription Factors/ModulatorsGrowth Factors/HormonesFully Differentiated Adipocyte MarkersMiscellaneousPreadipocyteDifferentiated adipocyteAdipocyte Secretory ProductsPossible Lipodystrophy GenesInsulin Action GenesIGF1PTGISPPARDCREB1MIXL1GH1ID3WNT10BSTAT5ASTAT5BDLK1NR3C1DDIT3LIFCEBPBLOC486804LOC483120RXRARARANR1H3LPLSREBF1FASRBL1GATA3GATA2PPARGMEF2AMEF2BMEF2CMEF2DASIPTNFMIFTGFB1SERPINE1SLC2A4SCDTWIST1LEPRETNCFDGTF3ARB1RBL2ADIPOQADFPAGTCDKN1AE2F1SP1HMGA1PLINIL6GADD45AGADD45BCEBPDBMP1BMP2BMP3BMP4NDNFOXO1KLF5FOXC2PPARGC1ANCOA1NCOA2PPARASTAT3STAT2STAT1STAT6SOCS1SOCS3CNTFRLIFRIL6STMBNL1OSMCTNNB1UCP1WNT5BWNT1SMAD3FZD1DVL1HNF1ARXRGFRZBINSNAMPTSPOCK1TRIB3GATA4NR2F1NRIP1RORAPRLRPNPLA3CUGBP1HIF1AKLF6KLF7SFRP4NCOR1NCOR2KLF15EGR2EBF1EPAS1AHRCISD1WWTR1GDF10IRS1IRS4BSCL2LMNAAGPAT2ZMPSTE24LPIN1LPIN2LIPEPCK1PCK2CEBPAIRS2IRS3LLPIN3E2F4Name: AdipogenesisOrganism: Canis familiaris


Description

The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP236(r28133) with a 90% conversion rate.

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Quality Tags

Image:NonTypical.pngAnnotated lists
Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Bibliography

  1. Rosen ED, Spiegelman BM; ''Molecular regulation of adipogenesis.''; Annu Rev Cell Dev Biol, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
87031
Approved
view14:50, 15 July 2016MkutmonOntology Term : 'signaling pathway pertinent to development' added !
68532view22:17, 5 July 2013MaintBotUpdated to 2013 gpml schema
40688view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
35349view09:01, 12 February 2010MartijnVanIerselModified description
35345view08:58, 12 February 2010MartijnVanIerseladded lit. ref.
33974view18:29, 9 December 2009MaintBotAutomatic update of empty xrefs
30674view22:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
ADFPGeneProduct474720 (Entrez Gene)
ADIPOQGeneProduct403625 (Entrez Gene)
AGPAT2GeneProduct491249 (Entrez Gene)
AGTGeneProduct403783 (Entrez Gene)
AHRGeneProduct475251 (Entrez Gene)
ASIPGeneProduct492296 (Entrez Gene)
BMP1GeneProduct486127 (Entrez Gene)
BMP2GeneProduct477162 (Entrez Gene)
BMP3GeneProduct487826 (Entrez Gene)
BMP4GeneProduct490695 (Entrez Gene)
BSCL2GeneProduct476054 (Entrez Gene)
CDKN1AGeneProduct474890 (Entrez Gene)
CEBPAGeneProduct
CEBPBGeneProduct
CEBPDGeneProduct606783 (Entrez Gene)
CFDGeneProduct485095 (Entrez Gene)
CISD1GeneProduct479212 (Entrez Gene)
CNTFRGeneProduct442941 (Entrez Gene)
CREB1GeneProduct607922 (Entrez Gene)
CTNNB1GeneProduct477032 (Entrez Gene)
CUGBP1GeneProduct475979 (Entrez Gene)
DDIT3GeneProduct607439 (Entrez Gene)
DLK1GeneProduct490860 (Entrez Gene)
DVL1GeneProduct489593 (Entrez Gene)
E2F1GeneProduct485839 (Entrez Gene)
E2F4GeneProduct611243 (Entrez Gene)
EBF1GeneProduct479312 (Entrez Gene)
EGR2GeneProduct479219 (Entrez Gene)
EPAS1GeneProduct474578 (Entrez Gene)
FASGeneProduct486469 (Entrez Gene)
FOXC2GeneProduct489671 (Entrez Gene)
FOXO1GeneProduct477295 (Entrez Gene)
FRZBGeneProduct
FZD1GeneProduct482294 (Entrez Gene)
GADD45AGeneProduct
GADD45BGeneProduct485069 (Entrez Gene)
GATA2GeneProduct484626 (Entrez Gene)
GATA3GeneProduct487134 (Entrez Gene)
GATA4GeneProduct486079 (Entrez Gene)
GDF10GeneProduct611168 (Entrez Gene)
GH1GeneProduct
GTF3AGeneProduct477329 (Entrez Gene)
HIF1AGeneProduct480348 (Entrez Gene)
HMGA1GeneProduct442946 (Entrez Gene)
HNF1AGeneProduct486303 (Entrez Gene)
ID3GeneProduct403547 (Entrez Gene)
IGF1GeneProduct610255 (Entrez Gene)
IL6GeneProduct403985 (Entrez Gene)
IL6STGeneProduct403545 (Entrez Gene)
INSGeneProduct483665 (Entrez Gene)
IRS1GeneProduct486148 (Entrez Gene)
IRS2GeneProduct485548 (Entrez Gene)
IRS3LGeneProduct
IRS4GeneProduct492059 (Entrez Gene)
KLF15GeneProduct609067 (Entrez Gene)
KLF5GeneProduct612788 (Entrez Gene)
KLF6GeneProduct487151 (Entrez Gene)
KLF7GeneProduct478885 (Entrez Gene)
LEPGeneProduct403616 (Entrez Gene)
LIFGeneProduct403449 (Entrez Gene)
LIFRGeneProduct449478 (Entrez Gene)
LIPEGeneProduct403607 (Entrez Gene)
LMNAGeneProduct480124 (Entrez Gene)
LOC483120GeneProduct483120 (Entrez Gene)
LOC486804GeneProduct486804 (Entrez Gene)
LPIN1GeneProduct475670 (Entrez Gene)
LPIN2GeneProduct607640 (Entrez Gene)
LPIN3GeneProduct485876 (Entrez Gene)
LPLGeneProduct403626 (Entrez Gene)
MBNL1GeneProduct477116 (Entrez Gene)
MEF2AGeneProduct479021 (Entrez Gene)
MEF2BGeneProduct609739 (Entrez Gene)
MEF2CGeneProduct479155 (Entrez Gene)
MEF2DGeneProduct
MIFGeneProduct595146 (Entrez Gene)
MIXL1GeneProduct
NAMPTGeneProduct483267 (Entrez Gene)
NCOA1GeneProduct475684 (Entrez Gene)
NCOA2GeneProduct486989 (Entrez Gene)
NCOR1GeneProduct479515 (Entrez Gene)
NCOR2GeneProduct486242 (Entrez Gene)
NDNGeneProduct488693 (Entrez Gene)
NR1H3GeneProduct483625 (Entrez Gene)
NR2F1GeneProduct488908 (Entrez Gene)
NR3C1GeneProduct478047 (Entrez Gene)
NRIP1GeneProduct478385 (Entrez Gene)
OSMGeneProduct611921 (Entrez Gene)
PCK1GeneProduct403560 (Entrez Gene)
PCK2GeneProduct480255 (Entrez Gene)
PLINGeneProduct488735 (Entrez Gene)
PNPLA3GeneProduct609368 (Entrez Gene)
PPARAGeneProduct403654 (Entrez Gene)
PPARDGeneProduct481756 (Entrez Gene)
PPARGGeneProduct403606 (Entrez Gene)
PPARGC1AGeneProduct479127 (Entrez Gene)
PRLRGeneProduct479363 (Entrez Gene)
PTGISGeneProduct485919 (Entrez Gene)
RARAGeneProduct480526 (Entrez Gene)
RB1GeneProduct476915 (Entrez Gene)
RBL1GeneProduct477221 (Entrez Gene)
RBL2GeneProduct478127 (Entrez Gene)
RETNGeneProduct611540 (Entrez Gene)
RORAGeneProduct478328 (Entrez Gene)
RXRAGeneProduct491278 (Entrez Gene)
RXRGGeneProduct478989 (Entrez Gene)
SCDGeneProduct486839 (Entrez Gene)
SERPINE1GeneProduct403476 (Entrez Gene)
SFRP4GeneProduct483258 (Entrez Gene)
SLC2A4GeneProduct403673 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SP1GeneProduct486507 (Entrez Gene)
SPOCK1GeneProduct474688 (Entrez Gene)
SREBF1GeneProduct403475 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT2GeneProduct481111 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
STAT6GeneProduct100142679 (Entrez Gene)
TGFB1GeneProduct403998 (Entrez Gene)
TNFGeneProduct403922 (Entrez Gene)
TRIB3GeneProduct485819 (Entrez Gene)
TWIST1GeneProduct609156 (Entrez Gene)
UCP1GeneProduct403574 (Entrez Gene)
WNT10BGeneProduct486561 (Entrez Gene)
WNT1GeneProduct486560 (Entrez Gene)
WNT5BGeneProduct486756 (Entrez Gene)
WWTR1GeneProduct609743 (Entrez Gene)
ZMPSTE24GeneProduct482460 (Entrez Gene)

Annotated Interactions

No annotated interactions
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