Blood clotting cascade (Canis familiaris)

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1Tissue InjuryFactor IXaFactor VaThrombinFibrin MonomerPlasminFactor XIIaFibrin PolymerExtrinsic PathwayFactor XIaTissue Factor+Fibrin Split ProductsIntrinsic PathwayFactor XIIIaFactor VIIa Factor Xa ThrombolysisFactor VIIIaF8A1PLAUSERPINF2F11F5F13BFGBVWFF9F10SERPINB2PLGF10F2PLATProthrombinase ComplexFGGFGAFibrinF12F8F7SERPINE1


Description

Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP272(r30179) with a 73% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Luchtman-Jones L, Broze GJ Jr; ''The current status of coagulation.''; Ann Med, 1995 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117440view10:51, 21 May 2021EweitzModified title
71470view19:17, 17 October 2013MaintBotAutomated update of data sources
68552view22:37, 5 July 2013MaintBotUpdated to 2013 gpml schema
67092view10:05, 26 June 2013Christine ChichesterOntology Term : 'coagulation cascade pathway' added !
62719view03:17, 2 May 2013MaintBotUpdated UniProt data source
40709view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
35084view12:30, 11 February 2010Thomasadded literature, removed braces
35073view12:03, 11 February 2010ThomasModified description
33989view18:34, 9 December 2009MaintBotAutomatic update of empty xrefs
31747view12:02, 14 August 2009MaintBotFixed group labels
30691view22:46, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
F10GeneProduct476993 (Entrez Gene)
F11GeneProduct475623 (Entrez Gene)
F12GeneProduct489090 (Entrez Gene)
F13BGeneProduct490261 (Entrez Gene)
F2GeneProduct
F5GeneProduct
F7GeneProduct607661 (Entrez Gene)
F8GeneProduct403875 (Entrez Gene)
F8A1GeneProduct
F9GeneProduct404015 (Entrez Gene)
FGAGeneProduct475473 (Entrez Gene)
FGBGeneProduct475472 (Entrez Gene)
FGGGeneProduct475474 (Entrez Gene)
FibrinMetabolite
PLATGeneProduct482840 (Entrez Gene)
PLAUGeneProduct403426 (Entrez Gene)
PLGGeneProduct403602 (Entrez Gene)
Prothrombinase ComplexGeneProduct
SERPINB2GeneProduct609604 (Entrez Gene)
SERPINE1GeneProduct403476 (Entrez Gene)
SERPINF2GeneProduct611266 (Entrez Gene)
VWFGeneProduct399544 (Entrez Gene)

Annotated Interactions

No annotated interactions
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