Pentose phosphate pathway (Anopheles gambiae)

Jump to: navigation, search

The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. This metabolic pathway is parallel to glycolysis. It generates NADPH and pentoses (5-carbon sugars) as well as ribose 5-phosphate, the last one a precursor for the synthesis of nucleotides. While it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. The pathway is especially important in erythrocytes. There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars.

GenMAPP notes 

D. Voet & J.G. Voet (1990) Biochemistry, John Wiley & Sons, New York, pp. 577-583.

HomologyConvert 

This pathway was inferred from Homo sapiens pathway WP134(r30180) with a 62% conversion rate.