Eukaryotic transcription initiation (Anopheles gambiae)

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5(large ribosomal RNAs)5RNA polymerase ITFIIATFIIETFIIFRNA polymerase IIRNA polymerase IIISteps 2) Association of TIFs and RNA polymeraseSteps 3) DNA melting by association with TFIIHGene Regulatory Proteins3dsDNARNA pol II5TFIID55(mRNA, snRNPs)3cell growthSteps 5) RNA elongation with CDT phosphorylation53TFIIDTATA3(small stable RNAs)3TATA Box bindingproteinTFIIATFIIE3355TATAPrimary RNA transcriptTFIIH35(recognize surface DNA geometry)TFIIFTATASteps 1) TBP binds TATA boxTFIIB5TFIIHTranscription Initiation Factors (TIFs)Steps 4) Transcription elongation by NTPs3TFIIFTFIIBAgaP_AGAP003135AgaP_AGAP002646AgaP_AGAP007810AgaP_AGAP008991AgaP_AGAP009539AgaP_AGAP008045AgaP_AGAP011110AgaP_AGAP002121AgaP_AGAP007002AgaP_AGAP012122AgaP_AGAP011678AgaP_AGAP010321AgaP_AGAP008151AgaP_AGAP006573AgaP_AGAP010493AgaP_AGAP005382AgaP_AGAP010559POLR1AAgaP_AGAP008417AgaP_AGAP009558AgaP_AGAP004370AgaP_AGAP003648AgaP_AGAP010984POLR3KAgaP_AGAP008522AgaP_AGAP003094AgaP_AGAP012397AgaP_AGAP008393AgaP_AGAP002988AgaP_AGAP010958AgaP_AGAP005922AgaP_AGAP004480AgaP_AGAP001792AgaP_AGAP009209POLR2KAgaP_AGAP006355AgaP_AGAP010064AgaP_AGAP012169POLR1DAgaP_AGAP004254AgaP_AGAP005873


In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia


GenMAPP notes 
This pathway was inferred from Homo sapiens pathway WP405(r29565) with a 90% conversion rate.

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117221view09:29, 19 May 2021EweitzModified title
67210view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
63238view23:46, 8 May 2013AnweshaConverted interactions to graphical lines
63237view23:41, 8 May 2013AnweshaPeriodical save, work in progress
63236view23:31, 8 May 2013AnweshaPeriodical save, work in progress
63235view23:22, 8 May 2013AnweshaOpened to convert to GPML 2013
40459view18:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
35523view13:55, 12 February 2010Thomasadded literature
35510view13:48, 12 February 2010ThomasModified description
32289view13:11, 15 August 2009MaintBotFixed text labels
31843view12:30, 14 August 2009MaintBotFixed group labels
31317view20:16, 13 August 2009MaintBotFixed text labels
30807view23:49, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
AgaP_AGAP001792GeneProduct1281323 (Entrez Gene)
AgaP_AGAP002121GeneProduct1281372 (Entrez Gene)
AgaP_AGAP002646GeneProduct1273315 (Entrez Gene)
AgaP_AGAP002988GeneProduct1272969 (Entrez Gene)
AgaP_AGAP003094GeneProduct1273770 (Entrez Gene)
AgaP_AGAP003135GeneProduct1273807 (Entrez Gene)
AgaP_AGAP003648GeneProduct1274316 (Entrez Gene)
AgaP_AGAP004254GeneProduct1274098 (Entrez Gene)
AgaP_AGAP004370GeneProduct1274516 (Entrez Gene)
AgaP_AGAP004480GeneProduct3291022 (Entrez Gene)
AgaP_AGAP005382GeneProduct1276084 (Entrez Gene)
AgaP_AGAP005873GeneProduct1276540 (Entrez Gene)
AgaP_AGAP005922GeneProduct1276589 (Entrez Gene)
AgaP_AGAP006355GeneProduct1276961 (Entrez Gene)
AgaP_AGAP006573GeneProduct1277157 (Entrez Gene)
AgaP_AGAP007002GeneProduct1270098 (Entrez Gene)
AgaP_AGAP007810GeneProduct1278148 (Entrez Gene)
AgaP_AGAP008045GeneProduct1277907 (Entrez Gene)
AgaP_AGAP008151GeneProduct1277811 (Entrez Gene)
AgaP_AGAP008393GeneProduct1277585 (Entrez Gene)
AgaP_AGAP008417GeneProduct1277560 (Entrez Gene)
AgaP_AGAP008522GeneProduct1277449 (Entrez Gene)
AgaP_AGAP008991GeneProduct1279954 (Entrez Gene)
AgaP_AGAP009209GeneProduct1280168 (Entrez Gene)
AgaP_AGAP009539GeneProduct1271371 (Entrez Gene)
AgaP_AGAP009558GeneProduct1271351 (Entrez Gene)
AgaP_AGAP010064GeneProduct1279496 (Entrez Gene)
AgaP_AGAP010321GeneProduct1278625 (Entrez Gene)
AgaP_AGAP010493GeneProduct1275232 (Entrez Gene)
AgaP_AGAP010559GeneProduct1275295 (Entrez Gene)
AgaP_AGAP010958GeneProduct1271006 (Entrez Gene)
AgaP_AGAP010984GeneProduct1270972 (Entrez Gene)
AgaP_AGAP011110GeneProduct1270814 (Entrez Gene)
AgaP_AGAP011678GeneProduct1280962 (Entrez Gene)
AgaP_AGAP012122GeneProduct1280555 (Entrez Gene)
AgaP_AGAP012169GeneProduct1280516 (Entrez Gene)
AgaP_AGAP012397GeneProduct1280317 (Entrez Gene)

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