Apoptosis (Rattus norvegicus)

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123CaspActivator of Cell DeathpFas LigandpApoptosisDNA FragmentationDegradationbbeMitochondrionIGF1R signaling pathwaybInterferon regulatory factorsep53 RelatedInhibitor of Cell DeathMIR29APmaip1MIR29B1Casp9Mdm2Bak1Traf3Irf1Nfkb1FasBirc2LOC100360940Akt1Gzmbl1Tnfrsf21BadNfkbiaCasp1Ripk1Irf2NfkbibLtaCasp4Irf6Casp3Prf1Tnfrsf1aIgf1rRelaChukBaxApaf1Tnfrsf1bCASP10Birc3BidTnfrsf25Mapk10Traf1IkbkbIrf5DffaAABR07071968.1NfkbibBBC3Irf3Casp2HRKTp73LOC688906Casp7MycLOC103694380Igf2CraddIkbkgBokTraf2CflarBcl2l2Pik3r1TraddBirc5Igf1Tnfrsf10bJunBnip3lDffbTraddBcl2Tnfrsf1aIrf7RelaBcl2l1-ps1Irf4NfkbieTp534Map2k4Ripk1CDKN2ACasp8XiapBadNfkbiaFaslgTnfsf10NfkbieLOC100911660Nfkb1FaddMCL1Casp6Bcl2l11LOC100912399Tp63MIR29B2


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP254 (r95107) with a 91.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  2. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  3. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia
  4. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95785view14:37, 19 January 2018MkutmonHomology conversion update
71796view20:33, 17 October 2013MaintBotAutomated update of data sources
69417view19:02, 8 July 2013MaintBotUpdated to 2013 gpml schema
67050view09:59, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
47760view05:06, 6 April 2012Khanspersupdated xrefs
41740view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
35104view13:11, 11 February 2010MartijnVanIerselAdded lit. ref.
34113view19:24, 9 December 2009MaintBotAutomatic update of empty xrefs
31891view12:43, 14 August 2009MaintBotFixed group labels
30964view00:47, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AABR07071968.1GeneProductENSRNOG00000033924 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:54205
Akt1GeneProductENSRNOG00000028629 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:207
Apaf1GeneProductENSRNOG00000008022 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:317
BBC3GeneProductNo homologues found for original id L:27113
BadGeneProductENSRNOG00000021147 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:572
Bak1GeneProductENSRNOG00000000485 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:578
BaxGeneProductENSRNOG00000020876 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:581
Bcl2GeneProductENSRNOG00000002791 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:596
Bcl2l1-ps1GeneProductENSRNOG00000018503 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:598
Bcl2l11GeneProductENSRNOG00000016551 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10018
Bcl2l2GeneProductENSRNOG00000015732 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:599
BidGeneProductENSRNOG00000012439 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:637
Birc2GeneProductENSRNOG00000010602 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:329
Birc3GeneProductENSRNOG00000005731 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:330
Birc5GeneProductENSRNOG00000050819 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:332
Bnip3lGeneProductENSRNOG00000009820 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:665
BokGeneProductENSRNOG00000018214 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:666
CASP10GeneProductNo homologues found for original id L:843
CDKN2AGeneProductNo homologues found for original id L:1029
Casp1GeneProductENSRNOG00000007372 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:834
Casp2GeneProductENSRNOG00000016707 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:835
Casp3GeneProductENSRNOG00000010475 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:836
Casp4GeneProductENSRNOG00000033697 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:837
Casp6GeneProductENSRNOG00000009508 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:839
Casp7GeneProductENSRNOG00000056216 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:840
Casp8GeneProductENSRNOG00000012331 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:841
Casp9GeneProductENSRNOG00000012944 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:842
CflarGeneProductENSRNOG00000012473 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8837
ChukGeneProductENSRNOG00000022485 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1147
CraddGeneProductENSRNOG00000008507 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8738
DffaGeneProductENSRNOG00000013603 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1676
DffbGeneProductENSRNOG00000025030 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1677
FaddGeneProductENSRNOG00000047035 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8772
FasGeneProductENSRNOG00000019142 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:355
FaslgGeneProductENSRNOG00000002978 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:356
Gzmbl1GeneProductENSRNOG00000050198 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3002
HRKGeneProductNo homologues found for original id L:8739
Igf1GeneProductENSRNOG00000004517 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3479
Igf1rGeneProductENSRNOG00000014187 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3480
Igf2GeneProductENSRNOG00000020369 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3481
IkbkbGeneProductENSRNOG00000019073 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3551
IkbkgGeneProductENSRNOG00000060936 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8517
Irf1GeneProductENSRNOG00000008144 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3659
Irf2GeneProductENSRNOG00000009824 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3660
Irf3GeneProductENSRNOG00000043388 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3661
Irf4GeneProductENSRNOG00000061070 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3662
Irf5GeneProductENSRNOG00000007437 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3663
Irf6GeneProductENSRNOG00000005082 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3664
Irf7GeneProductENSRNOG00000017414 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3665
JunGeneProductENSRNOG00000026293 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3725
LOC100360940GeneProductENSRNOG00000008548 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:56616
LOC100911660GeneProductENSRNOG00000047692 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3070
LOC100912399GeneProductENSRNOG00000013177 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4214
LOC103694380GeneProductENSRNOG00000000837 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7124
LOC688906GeneProductENSRNOG00000005263 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9169
LtaGeneProductENSRNOG00000000838 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4049
MCL1GeneProductNo homologues found for original id L:4170
MIR29AGeneProduct
MIR29B1GeneProduct
MIR29B2GeneProduct
Map2k4GeneProductENSRNOG00000003834 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6416
Mapk10GeneProductENSRNOG00000002079 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5602
Mdm2GeneProductENSRNOG00000006304 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4193
MycGeneProductENSRNOG00000004500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609
Nfkb1GeneProductENSRNOG00000023258 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4790
NfkbiaGeneProductENSRNOG00000007390 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4792
NfkbibGeneProductENSRNOG00000020063 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4793
NfkbieGeneProductENSRNOG00000019907 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4794
Pik3r1GeneProductENSRNOG00000018903 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5295
Pmaip1GeneProductENSRNOG00000018770 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5366
Prf1GeneProductENSRNOG00000000562 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5551
RelaGeneProductENSRNOG00000030888 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5970
Ripk1GeneProductENSRNOG00000017787 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8737
Tnfrsf10bGeneProductENSRNOG00000038483 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8795
Tnfrsf1aGeneProductENSRNOG00000031312 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7132
Tnfrsf1bGeneProductENSRNOG00000016575 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7133
Tnfrsf21GeneProductENSRNOG00000011517 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:27242
Tnfrsf25GeneProductENSRNOG00000021814 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8718
Tnfsf10GeneProductENSRNOG00000013269 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8743
Tp53GeneProductENSRNOG00000010756 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157
Tp63GeneProductENSRNOG00000001924 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8626
Tp73GeneProductENSRNOG00000024707 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7161
TraddGeneProductENSRNOG00000015179 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8717
Traf1GeneProductENSRNOG00000048914 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7185
Traf2GeneProductENSRNOG00000006238 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7186
Traf3GeneProductENSRNOG00000008145 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7187
XiapGeneProductENSRNOG00000006967 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:331

Annotated Interactions

No annotated interactions
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