Cholesterol biosynthesis (Saccharomyces cerevisiae)

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1-7Squalene-2,3-Epoxide7-dehydro CholesterolMevalonate-5-PPLanosterolMevalonateHMG-CoAtrans-trans-farnesyl-pp(R)-5-PhosphomevalonateDelta-Isopentenyl-5-PPDiMethylally-PPGeranyl-PPFatty Acid DegradationERG9ERG7ERG12Acetyl-CoAERG3HMG1IDI1DHCR7ERG26MVD1ERG11SqualeneERG25ERG1PMVKLathosterolERG20CholesterolERG13ERG20


Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia

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  1. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.''; J Biochem, 1997 PubMed Europe PMC Scholia
  2. Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.''; J Biochem, 1993 PubMed Europe PMC Scholia
  3. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.''; Nat Genet, 1999 PubMed Europe PMC Scholia
  4. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T; ''Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  5. Li L, Kaplan J; ''Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  6. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  7. Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC Scholia


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117277view10:45, 20 May 2021EweitzModified title
97391view05:02, 14 May 2018Khanspersconnected interaction and cleanup
97091view08:06, 27 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97073view15:46, 26 April 2018Eveline1705squalene id added
97072view15:46, 26 April 2018Eveline1705added lanosterol id
97069view15:44, 26 April 2018Eveline1705Updated the 5-phosphomevalonate label
97068view15:40, 26 April 2018Eveline1705Added identifier for Mevalonate metabolite
97066view15:38, 26 April 2018Eveline1705Connected the lines, enzymes and labeled the metabollites
77403view22:37, 5 September 2014MaintBotremoved homology mapp label
71341view18:01, 17 October 2013MaintBotAutomated update of data sources
69758view11:01, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69591view20:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67112view10:08, 26 June 2013Christine ChichesterOntology Term : 'cholesterol biosynthetic pathway' added !
41820view04:49, 2 March 2011MaintBotRemoved redundant pathway information and comments
35140view14:09, 11 February 2010ThomasModified description
35139view14:09, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
35138view14:08, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
35137view14:07, 11 February 2010ThomasModified description
20959view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Cholesterol Biosynthesis]] moved to [[Pathway:WP132]]: Moved to stable identifier
12670view07:57, 17 May 2008MaintBotautomated metabolite conversion
8663view14:06, 7 January 2008MaintBotAdded to category $category
19408view14:06, 7 January 2008N.ManteiUploaded new pathway
8661view14:06, 7 January 2008M.LiebermanUploaded new pathway

External references


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NameTypeDatabase referenceComment
(R)-5-PhosphomevalonateMetaboliteCHEBI:17436 (ChEBI)
7-dehydro CholesterolMetabolite
Acetyl-CoAMetabolite72-89-9 (CAS)
CholesterolMetabolite57-88-5 (CAS)
ERG11GeneProduct856398 (Entrez Gene)
ERG12GeneProduct855248 (Entrez Gene)
ERG13GeneProduct854913 (Entrez Gene)
ERG1GeneProduct853086 (Entrez Gene)
ERG20GeneProduct853272 (Entrez Gene)
ERG25GeneProduct852951 (Entrez Gene)
ERG26GeneProduct852883 (Entrez Gene) NAD(P) dependent steroid dehydrogenase-like
ERG3GeneProduct850745 (Entrez Gene)
ERG7GeneProduct856470 (Entrez Gene)
ERG9GeneProduct856597 (Entrez Gene)
HMG-CoAMetaboliteCHEBI:15467 (ChEBI)
HMG1GeneProduct854900 (Entrez Gene)
IDI1GeneProduct855986 (Entrez Gene)
LanosterolMetaboliteCHEBI:16521 (ChEBI)
LathosterolMetabolite80-99-9 (CAS)
MVD1GeneProduct855779 (Entrez Gene)
SqualeneMetaboliteCHEBI:15440 (ChEBI)

Annotated Interactions

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