Statin pathway (Rattus norvegicus)

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1Liver cellPlasmaCholesterolTriglyceridesCholesterolTissuesCholesterol EsterPhospholipidIDLCholic AcidCell MembraneVLDLacetylCoAHmgcrAbca1Apoc3PtlpApoeLDLLrp1Free FAStatinCetpHDLLplApoa4Soat1Apoc1Apoa1Apoc2Dgat1MttpLipcLdlrScarb1Cyp7a1Lcat


Description

What are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway

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Quality Tags

Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117047view14:15, 16 May 2021EweitzOntology Term : 'hepatocyte' added !
117046view14:14, 16 May 2021EweitzModified title
109395view16:09, 16 March 2020L DupuisConverted interactions to graphical lines
79447view07:26, 22 March 2015EgonwConnected dots and added a few metabolite identifiers.
79446view07:06, 22 March 2015EgonwRemoved Entrez Gene xref where the 'Cetp' gene name was used (no orthology...) and used the identifier for 'Ptlp'.
77393view11:47, 5 September 2014EgonwConverted a few labels into metabolite DataNodes with an ChEBI identifier.
69350view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
67657view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
41661view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
38715view19:31, 23 September 2010AlexanderPico
35544view14:20, 12 February 2010Thomasremoved genmapp remark
35543view14:19, 12 February 2010ThomasModified description
35536view14:16, 12 February 2010Thomasadded literature
20987view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Statin Pathway PharmGKB]] moved to [[Pathway:WP145]]: Moved to stable identifier
11891view18:23, 8 May 2008KhanspersChanged contact info
8406view13:46, 7 January 2008MaintBot[[Pathway:Rat:Statin Pathway PharmGKB]] moved to [[Pathway:Rattus norvegicus:Statin Pathway PharmGKB]]: Renaming species
7820view16:20, 18 December 2007MaintBotfixed category names
7397view12:42, 4 November 2007MaintBotAdded categories to GPML
19545view22:20, 22 May 2007BruceConklingpml file for [[Rat:Statin_Pathway_PharmGKB]]
6596view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Statin_Pathway_PharmGKB]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abca1GeneProduct313210 (Entrez Gene)
Apoa1GeneProduct25081 (Entrez Gene)
Apoa4GeneProduct25080 (Entrez Gene)
Apoc1GeneProduct25292 (Entrez Gene)
Apoc2GeneProduct25384 (Entrez Gene)
Apoc3GeneProduct24207 (Entrez Gene)
ApoeGeneProduct25728 (Entrez Gene)
CetpGeneProduct
Cholesterol EsterMetaboliteCHEBI:17002 (ChEBI)
CholesterolMetaboliteCHEBI:16113 (ChEBI)
Cholic AcidMetaboliteCHEBI:16359 (ChEBI)
Cyp7a1GeneProduct25428 (Entrez Gene)
Dgat1GeneProduct84497 (Entrez Gene)
Free FAMetaboliteCHEBI:35366 (ChEBI)
HDLMetaboliteCHEBI:39025 (ChEBI)
HmgcrGeneProduct25675 (Entrez Gene)
LDLMetaboliteCHEBI:39026 (ChEBI)
LcatGeneProduct24530 (Entrez Gene)
LdlrGeneProduct300438 (Entrez Gene)
LipcGeneProduct24538 (Entrez Gene)
LplGeneProduct24539 (Entrez Gene)
Lrp1GeneProduct299858 (Entrez Gene)
MttpGeneProduct310900 (Entrez Gene)
PhospholipidMetaboliteCHEBI:16247 (ChEBI)
PtlpGeneProduct296371 (Entrez Gene)
Scarb1GeneProduct25073 (Entrez Gene)
Soat1GeneProduct81782 (Entrez Gene)
StatinMetabolite
TriglyceridesMetaboliteCHEBI:17855 (ChEBI)
acetylCoAMetaboliteCHEBI:15351 (ChEBI)

Annotated Interactions

No annotated interactions

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